#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P16410	uniprotkb:Q13905	intact:EBI-1030991|uniprotkb:Q53TD5|uniprotkb:Q8WXJ1|uniprotkb:Q96P43|uniprotkb:Q9UKN9|ensembl:ENSP00000497102|uniprotkb:A0N1S0|uniprotkb:E9PDH0|uniprotkb:Q0PP65|uniprotkb:Q52MC1|uniprotkb:Q5S005|uniprotkb:O95653	intact:EBI-976876|ensembl:ENSP00000361263|uniprotkb:Q5JUE4|uniprotkb:Q68DL3|uniprotkb:Q8IV73|intact:EBI-11072310	psi-mi:ctla4_human(display_long)|uniprotkb:CTLA4(gene name)|psi-mi:CTLA4(display_short)|uniprotkb:CD152(gene name synonym)|uniprotkb:Cytotoxic T-lymphocyte-associated antigen 4(gene name synonym)	psi-mi:rpgf1_human(display_long)|uniprotkb:Guanine nucleotide-releasing factor 2(gene name synonym)|uniprotkb:Protein C3G(gene name synonym)|uniprotkb:CRK SH3-binding GNRP(gene name synonym)|uniprotkb:RAPGEF1(gene name)|psi-mi:RAPGEF1(display_short)|uniprotkb:GRF2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kloog et al. (2014)	imex:IM-24134|pubmed:24396067	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10770610|imex:IM-24134-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000648405(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0098636"(protein complex involved in cell adhesion)|ensembl:ENSG00000163599(gene)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR008096(Cytotoxic T-lymphocyte antigen 4)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040216|rcsb pdb:1AH1|rcsb pdb:1H6E|rcsb pdb:1I85|rcsb pdb:1I8L|rcsb pdb:2X44|rcsb pdb:3BX7|rcsb pdb:3OSK|rcsb pdb:5GGV|rcsb pdb:5TRU|rcsb pdb:5XJ3|rcsb pdb:6RP8|rcsb pdb:6RPJ|rcsb pdb:6RQM|rcsb pdb:6XY2|rcsb pdb:7CIO|rcsb pdb:7ELX|reactome:R-HSA-389513|reactome:R-HSA-8877330|refseq:NP_001032720.1|refseq:NP_005205.2|dip:DIP-35607N	go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|ensembl:ENSG00000107263(gene)|ensembl:ENST00000372189(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR019804|interpro:IPR023578|interpro:IPR036964|mint:Q13905|rcsb pdb:5L23|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-9013423|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:NP_005303.2|refseq:NP_001291204.1|refseq:NP_941372.1|dip:DIP-29392N	-	-	-	figure legend:f4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-jurkat)|taxid:9606(Homo sapiens)	-	2015/04/08	2015/04/29	rogid:PeBR/2EG/cFzR4DKWuX80TsgBw49606	rogid:WZp5ILq2aJ9P07oY9ieRfytDL0w9606	rigid:QXfdtOdByzKPhsPwNDgbKekgFTQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)