#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P63166	uniprotkb:Q9WTN3	intact:EBI-80152|uniprotkb:P55856|uniprotkb:Q3TX92|uniprotkb:Q93068|ensembl:ENSMUSP00000088935	intact:EBI-5273743|uniprotkb:Q3U458|uniprotkb:Q3UDJ3|uniprotkb:Q5SRX5|uniprotkb:Q8C733|uniprotkb:Q99JK7|ensembl:ENSMUSP00000020846	psi-mi:sumo1_mouse(display_long)|uniprotkb:Sumo1(gene name)|psi-mi:Sumo1(display_short)|uniprotkb:Smt3c(gene name synonym)|uniprotkb:Smt3h3(gene name synonym)|uniprotkb:Ubl1(gene name synonym)|uniprotkb:Ubiquitin-like protein SMT3C(gene name synonym)|uniprotkb:SMT3 homolog 3(gene name synonym)|uniprotkb:Ubiquitin-homology domain protein PIC1(gene name synonym)	psi-mi:srbp1_mouse(display_long)|uniprotkb:Srebf1(gene name)|psi-mi:Srebf1(display_short)|uniprotkb:Srebp1(gene name synonym)|uniprotkb:Sterol regulatory element-binding transcription factor 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2014)	imex:IM-24052|pubmed:24379443	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10764236|imex:IM-24052-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033486.1|reactome:R-MMU-4755510|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-5696395|reactome:R-MMU-69473|reactome:R-MMU-877312|reactome:R-MMU-8866904|reactome:R-MMU-9615933|ensembl:ENSMUSG00000026021(gene)|ensembl:ENSMUST00000091374(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008134"(transcription factor binding)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030578"(PML body organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0001741"(XY body)|go:"GO:0034605"(cellular response to heat)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050821"(protein stabilization)|go:"GO:0060021"(roof of mouth development)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0090204"(protein localization to nuclear pore)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|reactome:R-MMU-3065676|reactome:R-MMU-3065678|reactome:R-MMU-3065679|reactome:R-MMU-3108214|reactome:R-MMU-3108232|reactome:R-MMU-3232118|reactome:R-MMU-3232142|reactome:R-MMU-3899300|reactome:R-MMU-4085377|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-4570464|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|reactome:R-MMU-4615885|reactome:R-MMU-4655427|dip:DIP-29278N	refseq:NP_035610.1|refseq:NP_001300908.1|refseq:XP_006532778.1|ensembl:ENSMUSG00000020538(gene)|ensembl:ENSMUST00000020846(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003062"(regulation of heart rate by chemical signal)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007568"(aging)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010876"(lipid localization)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030324"(lung development)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032094"(response to food)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0032810"(sterol response element binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033762"(response to glucagon)|go:"GO:0042493"|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051591"(response to cAMP)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|reactome:R-MMU-1655829	-	-	-	figure legend:f6a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hepatocyte)|taxid:10090(Mouse hepatocyte)	-	2015/04/08	2015/04/09	rogid:mflrn+v4fHL8UdmLodfZBZA6eAQ10090	rogid:poshjAAi/h+PPSRMcBhjR0enVQA10090	rigid:tSQVcYKvzR/uLplr0q3pMPR7tSs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63166	uniprotkb:Q9WTN3	intact:EBI-80152|uniprotkb:P55856|uniprotkb:Q3TX92|uniprotkb:Q93068|ensembl:ENSMUSP00000088935	intact:EBI-5273743|uniprotkb:Q3U458|uniprotkb:Q3UDJ3|uniprotkb:Q5SRX5|uniprotkb:Q8C733|uniprotkb:Q99JK7|ensembl:ENSMUSP00000020846	psi-mi:sumo1_mouse(display_long)|uniprotkb:Sumo1(gene name)|psi-mi:Sumo1(display_short)|uniprotkb:Smt3c(gene name synonym)|uniprotkb:Smt3h3(gene name synonym)|uniprotkb:Ubl1(gene name synonym)|uniprotkb:Ubiquitin-like protein SMT3C(gene name synonym)|uniprotkb:SMT3 homolog 3(gene name synonym)|uniprotkb:Ubiquitin-homology domain protein PIC1(gene name synonym)	psi-mi:srbp1_mouse(display_long)|uniprotkb:Srebf1(gene name)|psi-mi:Srebf1(display_short)|uniprotkb:Srebp1(gene name synonym)|uniprotkb:Sterol regulatory element-binding transcription factor 1(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Lee et al. (2014)	imex:IM-24052|pubmed:24379443	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-10764247|imex:IM-24052-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033486.1|reactome:R-MMU-4755510|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-5696395|reactome:R-MMU-69473|reactome:R-MMU-877312|reactome:R-MMU-8866904|reactome:R-MMU-9615933|ensembl:ENSMUSG00000026021(gene)|ensembl:ENSMUST00000091374(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008134"(transcription factor binding)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030578"(PML body organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0001741"(XY body)|go:"GO:0034605"(cellular response to heat)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050821"(protein stabilization)|go:"GO:0060021"(roof of mouth development)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0090204"(protein localization to nuclear pore)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|reactome:R-MMU-3065676|reactome:R-MMU-3065678|reactome:R-MMU-3065679|reactome:R-MMU-3108214|reactome:R-MMU-3108232|reactome:R-MMU-3232118|reactome:R-MMU-3232142|reactome:R-MMU-3899300|reactome:R-MMU-4085377|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-4570464|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|reactome:R-MMU-4615885|reactome:R-MMU-4655427|dip:DIP-29278N	refseq:NP_035610.1|refseq:NP_001300908.1|refseq:XP_006532778.1|ensembl:ENSMUSG00000020538(gene)|ensembl:ENSMUST00000020846(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003062"(regulation of heart rate by chemical signal)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007568"(aging)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010876"(lipid localization)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030324"(lung development)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032094"(response to food)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0032810"(sterol response element binding)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033762"(response to glucagon)|go:"GO:0042493"|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051591"(response to cAMP)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|reactome:R-MMU-1655829	-	-	-	figure legend:f6d|comment:"To explore these results at the cellular level,  we investigated SREBP1c sumoylation via in situ proximity ligation  assay (PLA), which allowed us to monitor protein modifications  and, indirectly, physical interactions. As shown in Fig. 6D and E, SREBP1c sumoylation was detected in endogenous and  exogenous SREBP1c protein from mouse primary hepatocytes  and HeLa cells, respectively. Although PLA-positive signals  (shown in red) indicated relatively weak SREBP1c sumoylation in  primary hepatocytes, the mean number of PLA-positive red clusters  per cell was augmented by forskolin, whereas these signals were decreased by H89 pretreatment (Fig. 6D and data not  shown)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-hepatocyte)|taxid:10090(Mouse hepatocyte)	-	2015/04/08	2015/04/09	rogid:mflrn+v4fHL8UdmLodfZBZA6eAQ10090	rogid:poshjAAi/h+PPSRMcBhjR0enVQA10090	rigid:tSQVcYKvzR/uLplr0q3pMPR7tSs	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)