#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Z2X8	uniprotkb:Q60795	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fukutomi et al. (2014)	pubmed:24366543|imex:IM-24039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10759951|imex:IM-24039-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	-	-	-	figure legend:f2b f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/30	2015/03/30	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rigid:lCpo/D5zRkKEw9bWahZUdpC5SfI	false	his tag:?-?	binding-associated region:1-56|tandem tag:?-?|mutation disrupting interaction:24-24	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q9Z2X8	uniprotkb:Q60795	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fukutomi et al. (2014)	pubmed:24366543|imex:IM-24039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10759963|imex:IM-24039-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	-	-	-	figure legend:f2b f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/30	2015/03/30	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rigid:lCpo/D5zRkKEw9bWahZUdpC5SfI	false	his tag:?-?	binding-associated region:1-56|tandem tag:?-?|mutation disrupting interaction:24-24	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q9Z2X8	uniprotkb:Q60795	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fukutomi et al. (2014)	pubmed:24366543|imex:IM-24039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10759975|imex:IM-24039-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	-	-	-	figure legend:f2b f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/30	2015/03/30	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rigid:lCpo/D5zRkKEw9bWahZUdpC5SfI	false	his tag:?-?	binding-associated region:1-56|tandem tag:?-?|mutation disrupting interaction:26-26	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q9Z2X8	uniprotkb:Q60795	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fukutomi et al. (2014)	pubmed:24366543|imex:IM-24039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10759987|imex:IM-24039-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	-	-	-	figure legend:f2b f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/30	2015/03/30	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rigid:lCpo/D5zRkKEw9bWahZUdpC5SfI	false	his tag:?-?	binding-associated region:1-56|tandem tag:?-?|mutation disrupting interaction:27-27	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q9Z2X8	uniprotkb:Q60795	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fukutomi et al. (2014)	pubmed:24366543|imex:IM-24039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10759999|imex:IM-24039-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	-	-	-	figure legend:f2b f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/30	2015/03/30	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rigid:lCpo/D5zRkKEw9bWahZUdpC5SfI	false	his tag:?-?	binding-associated region:1-56|tandem tag:?-?|mutation disrupting interaction:28-28	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q9Z2X8	uniprotkb:Q60795	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fukutomi et al. (2014)	pubmed:24366543|imex:IM-24039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10760011|imex:IM-24039-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	-	-	-	figure legend:f2b f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/30	2015/03/30	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rigid:lCpo/D5zRkKEw9bWahZUdpC5SfI	false	his tag:?-?	binding-associated region:1-56|tandem tag:?-?|mutation disrupting interaction:29-29	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q9Z2X8	uniprotkb:Q60795	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fukutomi et al. (2014)	pubmed:24366543|imex:IM-24039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10760023|imex:IM-24039-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	-	-	-	figure legend:f2b f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/30	2015/03/30	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rigid:lCpo/D5zRkKEw9bWahZUdpC5SfI	false	his tag:?-?	binding-associated region:1-56|tandem tag:?-?|mutation disrupting interaction:29-29	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q9Z2X8	uniprotkb:Q60795	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fukutomi et al. (2014)	pubmed:24366543|imex:IM-24039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10760035|imex:IM-24039-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	-	-	-	figure legend:f2b f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/30	2015/03/30	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rigid:lCpo/D5zRkKEw9bWahZUdpC5SfI	false	his tag:?-?	binding-associated region:1-56|tandem tag:?-?|mutation disrupting interaction:30-30	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q9Z2X8	uniprotkb:Q60795	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fukutomi et al. (2014)	pubmed:24366543|imex:IM-24039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10760047|imex:IM-24039-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	-	-	-	figure legend:f2b f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/30	2015/03/30	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rigid:lCpo/D5zRkKEw9bWahZUdpC5SfI	false	his tag:?-?	binding-associated region:1-56|tandem tag:?-?|mutation disrupting interaction:31-31	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q9Z2X8	uniprotkb:Q60795	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fukutomi et al. (2014)	pubmed:24366543|imex:IM-24039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10760059|imex:IM-24039-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	-	-	-	figure legend:f2b f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/30	2015/03/30	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rigid:lCpo/D5zRkKEw9bWahZUdpC5SfI	false	his tag:?-?	binding-associated region:1-56|tandem tag:?-?|mutation disrupting interaction:32-32	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q9Z2X8	uniprotkb:Q60795	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fukutomi et al. (2014)	pubmed:24366543|imex:IM-24039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10760071|imex:IM-24039-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	-	-	-	figure legend:f2b f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/30	2015/03/30	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rigid:lCpo/D5zRkKEw9bWahZUdpC5SfI	false	his tag:?-?	binding-associated region:1-56|tandem tag:?-?|mutation disrupting interaction:34-34	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q9Z2X8	uniprotkb:Q60795	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fukutomi et al. (2014)	pubmed:24366543|imex:IM-24039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10760083|imex:IM-24039-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	-	-	-	figure legend:f2b f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/30	2015/03/30	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rigid:lCpo/D5zRkKEw9bWahZUdpC5SfI	false	his tag:?-?	binding-associated region:1-56|tandem tag:?-?|mutation disrupting interaction:23-23	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q9Z2X8	uniprotkb:Q60795	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fukutomi et al. (2014)	pubmed:24366543|imex:IM-24039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10760095|imex:IM-24039-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	-	-	-	figure legend:f2b f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/30	2015/03/30	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rigid:lCpo/D5zRkKEw9bWahZUdpC5SfI	false	his tag:?-?	binding-associated region:1-56|tandem tag:?-?|mutation increasing interaction:33-33	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q9Z2X8	uniprotkb:Q60795	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fukutomi et al. (2014)	pubmed:24366543|imex:IM-24039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10760107|imex:IM-24039-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	-	-	-	figure legend:f2b f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/30	2015/03/30	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rigid:lCpo/D5zRkKEw9bWahZUdpC5SfI	false	his tag:?-?	binding-associated region:1-56|tandem tag:?-?|mutation increasing interaction:43-43	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q9Z2X8	uniprotkb:Q60795	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fukutomi et al. (2014)	pubmed:24366543|imex:IM-24039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10760126|imex:IM-24039-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	-	-	-	figure legend:f3|comment:"the combined deletion analysis revealed that the region spanning Met17 to Tyr46 is essential and sufficient for Keap1 binding (Fig. 3B). We refer to this region as Nrf2-DLG. The results also indicate that the region corresponding to Met17 to Gln51 retains slightly stronger Keap1-binding activity. Therefore, we designated Met17 to Gln51 as the extended DLG motif of Nrf2 (Nrf2-DLGex) in this study."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/30	2015/03/30	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rigid:lCpo/D5zRkKEw9bWahZUdpC5SfI	false	his tag:?-?	sufficient binding region:17-46|tandem tag:?-?	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q60795	uniprotkb:Q9Z2X8	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:"MI:1235"(thermal shift binding)	Fukutomi et al. (2014)	pubmed:24366543|imex:IM-24039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10760150|imex:IM-24039-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	-	-	-	figure legend:f4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/30	2015/03/30	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rigid:lCpo/D5zRkKEw9bWahZUdpC5SfI	false	binding-associated region:75-84	binding-associated region:321-609	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q60795	uniprotkb:Q9Z2X8	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:"MI:1235"(thermal shift binding)	Fukutomi et al. (2014)	pubmed:24366543|imex:IM-24039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10760159|imex:IM-24039-34	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	-	-	-	figure legend:f4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/30	2015/03/30	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rigid:lCpo/D5zRkKEw9bWahZUdpC5SfI	false	binding-associated region:17-51	binding-associated region:321-609	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q60795	uniprotkb:Q9Z2X8	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Fukutomi et al. (2014)	pubmed:24366543|imex:IM-24039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10760611|imex:IM-24039-36	-	-	psi-mi:"MI:0919"(acceptor)	psi-mi:"MI:0919"(acceptor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	-	-	-	figure legend:f5 t1|comment:"ka (106 M-1) 38"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/30	2015/03/31	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rigid:lCpo/D5zRkKEw9bWahZUdpC5SfI	false	binding-associated region:75-84	binding-associated region:321-609	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q60795	uniprotkb:Q9Z2X8	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Fukutomi et al. (2014)	pubmed:24366543|imex:IM-24039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10760629|imex:IM-24039-38	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	-	-	-	figure legend:f5 t1|comment:"ka (106 M-1) 1.9"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/30	2015/03/31	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rigid:lCpo/D5zRkKEw9bWahZUdpC5SfI	false	binding-associated region:17-51	binding-associated region:321-609	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q60795	uniprotkb:Q9Z2X8	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Fukutomi et al. (2014)	pubmed:24366543|imex:IM-24039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10760678|imex:IM-24039-40	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	rcsb pdb:3wn7	-	-	figure legend:t2 f6 f7|comment:"we crystallized Keap1-DC in complex with a long DLG peptide,  DLGex(Met17-Gln51), and analyzed the crystal by X-ray diffraction  at a 1.6 Å resolution (Table 2). The asymmetric unit  contains two heterodimers of Keap1-DC-DLGex (chains A to B  and L to M)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/30	2015/03/31	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rigid:lCpo/D5zRkKEw9bWahZUdpC5SfI	false	binding-associated region:17-51	binding-associated region:321-609	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q60795	uniprotkb:Q9Z2X8	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Fukutomi et al. (2014)	pubmed:24366543|imex:IM-24039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10760698|imex:IM-24039-42	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	-	-	-	figure legend:f8 t3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/30	2015/03/31	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rigid:lCpo/D5zRkKEw9bWahZUdpC5SfI	false	binding-associated region:75-84	binding-associated region:321-609	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q60795	uniprotkb:Q9Z2X8	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Fukutomi et al. (2014)	pubmed:24366543|imex:IM-24039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10760709|imex:IM-24039-44	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	-	-	-	figure legend:f8 t3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/30	2015/03/31	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rigid:lCpo/D5zRkKEw9bWahZUdpC5SfI	false	binding-associated region:17-51	binding-associated region:321-609	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0396"(predetermined participant)