#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P46946	uniprotkb:P46946	intact:EBI-16440|uniprotkb:D6VTX7|ensemblfungi:YGL175C	intact:EBI-16440|uniprotkb:D6VTX7|ensemblfungi:YGL175C	psi-mi:com1_yeast(display_long)|uniprotkb:SAE2(gene name)|psi-mi:SAE2(display_short)|uniprotkb:YGL175C(locus name)|uniprotkb:G1639(orf name)|uniprotkb:COM1(gene name synonym)|uniprotkb:Completion of meiotic recombination protein 1(gene name synonym)|uniprotkb:Sporulation in the absence of SPO11 protein 2(gene name synonym)	psi-mi:com1_yeast(display_long)|uniprotkb:SAE2(gene name)|psi-mi:SAE2(display_short)|uniprotkb:YGL175C(locus name)|uniprotkb:G1639(orf name)|uniprotkb:COM1(gene name synonym)|uniprotkb:Completion of meiotic recombination protein 1(gene name synonym)|uniprotkb:Sporulation in the absence of SPO11 protein 2(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Fu et al. (2014)	pubmed:24344201|imex:IM-24028	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10713947|imex:IM-24028-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011340.1|sgd:S000003143|ensemblfungi:YGL175C(gene)|ensemblfungi:YGL175C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0030870"(Mre11 complex)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|go:"GO:1905779"(positive regulation of exonuclease activity)|dip:DIP-1603N|mint:P46946	refseq:NP_011340.1|sgd:S000003143|ensemblfungi:YGL175C(gene)|ensemblfungi:YGL175C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0030870"(Mre11 complex)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|go:"GO:1905779"(positive regulation of exonuclease activity)|dip:DIP-1603N|mint:P46946	-	crc64:284D57A3C11DD92B|comment:"mutation of all five putative  Tel1 phosphorylation sites (14) to aspartic acid together with S267E (5D/S267E) caused the distribution of Sae2 to change dramatically:  the multimer peak nearly disappeared, and the monomer-  size protein species increased in abundance (quantified in  Fig. 1C)."	crc64:284D57A3C11DD92B|comment:"mutation of all five putative  Tel1 phosphorylation sites (14) to aspartic acid together with S267E (5D/S267E) caused the distribution of Sae2 to change dramatically:  the multimer peak nearly disappeared, and the monomer-  size protein species increased in abundance (quantified in  Fig. 1C)."	figure legend:f1b f1c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/23	2015/03/24	rogid:qbdWneAqVxcKr+NJwaMMaCGJ+3c559292	rogid:qbdWneAqVxcKr+NJwaMMaCGJ+3c559292	rigid:r1MQCN8OdPCAwdn1IRDPgkQXbEo	false	his tag:?-?	his tag:?-?	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46946	uniprotkb:P46946	intact:EBI-16440|uniprotkb:D6VTX7|ensemblfungi:YGL175C	intact:EBI-16440|uniprotkb:D6VTX7|ensemblfungi:YGL175C	psi-mi:com1_yeast(display_long)|uniprotkb:SAE2(gene name)|psi-mi:SAE2(display_short)|uniprotkb:YGL175C(locus name)|uniprotkb:G1639(orf name)|uniprotkb:COM1(gene name synonym)|uniprotkb:Completion of meiotic recombination protein 1(gene name synonym)|uniprotkb:Sporulation in the absence of SPO11 protein 2(gene name synonym)	psi-mi:com1_yeast(display_long)|uniprotkb:SAE2(gene name)|psi-mi:SAE2(display_short)|uniprotkb:YGL175C(locus name)|uniprotkb:G1639(orf name)|uniprotkb:COM1(gene name synonym)|uniprotkb:Completion of meiotic recombination protein 1(gene name synonym)|uniprotkb:Sporulation in the absence of SPO11 protein 2(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Fu et al. (2014)	pubmed:24344201|imex:IM-24028	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10714341|imex:IM-24028-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_011340.1|sgd:S000003143|ensemblfungi:YGL175C(gene)|ensemblfungi:YGL175C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0030870"(Mre11 complex)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|go:"GO:1905779"(positive regulation of exonuclease activity)|dip:DIP-1603N|mint:P46946	refseq:NP_011340.1|sgd:S000003143|ensemblfungi:YGL175C(gene)|ensemblfungi:YGL175C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0030870"(Mre11 complex)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|go:"GO:1905779"(positive regulation of exonuclease activity)|dip:DIP-1603N|mint:P46946	-	crc64:284D57A3C11DD92B	crc64:284D57A3C11DD92B|comment:"mutation of all five putative  Tel1 phosphorylation sites (14) to aspartic acid together with S267E (5D/S267E) caused the distribution of Sae2 to change dramatically:  the multimer peak nearly disappeared, and the monomer-  size protein species increased in abundance (quantified in  Fig. 1C)."	figure legend:f1b f1c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/03/23	2015/03/24	rogid:qbdWneAqVxcKr+NJwaMMaCGJ+3c559292	rogid:qbdWneAqVxcKr+NJwaMMaCGJ+3c559292	rigid:cViAIMbsE7xAuH45M7r+HkEuzLY	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)