#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-10918206	uniprotkb:P19793	-	intact:EBI-78598|uniprotkb:Q2V504|uniprotkb:B3KY83|uniprotkb:Q2NL52|ensembl:ENSP00000419692	psi-mi:fxr_re_probe_ir1_motif_fgf19_gene(display_short)|psi-mi:EBI-10918206(display_long)	psi-mi:rxra_human(display_long)|uniprotkb:RXRA(gene name)|psi-mi:RXRA(display_short)|uniprotkb:NR2B1(gene name synonym)|uniprotkb:Retinoid X receptor alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 2 group B member 1(gene name synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Miyata et al. (2014)	imex:IM-25009|pubmed:24321096	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10918208|imex:IM-25009-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002948.1|refseq:NP_001278850.1|dip:DIP-641N|ensembl:ENSG00000186350(gene)|ensembl:ENST00000481739(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050692"(DNA binding domain binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000003(Retinoid X receptor)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR021780|interpro:IPR035500|mint:P19793|rcsb pdb:1BY4|rcsb pdb:1DSZ|rcsb pdb:1FBY|rcsb pdb:1FM6|rcsb pdb:1FM9|rcsb pdb:1G1U|rcsb pdb:1G5Y|rcsb pdb:1K74|rcsb pdb:1MV9|rcsb pdb:1MVC|rcsb pdb:1MZN|rcsb pdb:1R0N|rcsb pdb:1RDT|rcsb pdb:1RXR|rcsb pdb:1XLS|rcsb pdb:1XV9|rcsb pdb:1XVP|rcsb pdb:1YNW|rcsb pdb:2ACL|rcsb pdb:2NLL|rcsb pdb:2P1T|rcsb pdb:2P1U|rcsb pdb:2P1V|rcsb pdb:2ZXZ|rcsb pdb:2ZY0|rcsb pdb:3DZU|rcsb pdb:3DZY|rcsb pdb:3E00|rcsb pdb:3E94|rcsb pdb:3FAL|rcsb pdb:3FC6|rcsb pdb:3FUG|rcsb pdb:3H0A|rcsb pdb:3KWY|rcsb pdb:3NSP|rcsb pdb:3NSQ|rcsb pdb:3OAP|rcsb pdb:3OZJ|rcsb pdb:3PCU|rcsb pdb:3R2A|rcsb pdb:3R5M|rcsb pdb:3UVV|rcsb pdb:4CN2|rcsb pdb:4CN3|rcsb pdb:4CN5|rcsb pdb:4CN7|rcsb pdb:4J5W|rcsb pdb:4J5X|rcsb pdb:4K4J|rcsb pdb:4K6I|rcsb pdb:4M8E|rcsb pdb:4M8H|rcsb pdb:4N5G|rcsb pdb:4N8R|rcsb pdb:4NQA|rcsb pdb:4OC7|rcsb pdb:4POH|rcsb pdb:4POJ|rcsb pdb:4PP3|rcsb pdb:4PP5|rcsb pdb:4RFW|rcsb pdb:4RMC|rcsb pdb:4RMD|rcsb pdb:4RME|rcsb pdb:4ZO1|rcsb pdb:4ZSH|rcsb pdb:5EC9|rcsb pdb:5JI0|rcsb pdb:5LYQ|rcsb pdb:5MJ5|rcsb pdb:5MK4|rcsb pdb:5MKJ|rcsb pdb:5MKU|rcsb pdb:5MMW|rcsb pdb:5TBP|rcsb pdb:5UAN|rcsb pdb:5Z12|rcsb pdb:5ZQU|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6FBQ|rcsb pdb:6FBR|rcsb pdb:6HN6|rcsb pdb:6JNO|rcsb pdb:6JNR|rcsb pdb:6L6K|rcsb pdb:6LB4|rcsb pdb:6LB5|rcsb pdb:6LB6|rcsb pdb:6SJM|rcsb pdb:6STI|rcsb pdb:6XWG|rcsb pdb:6XWH|rcsb pdb:7A77|rcsb pdb:7B88|rcsb pdb:7B9O|rcsb pdb:7CFO|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-159418|reactome:R-HSA-192105|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-200425|reactome:R-HSA-204174|reactome:R-HSA-211976|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-4090294|reactome:R-HSA-5362517|reactome:R-HSA-5617472|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9616222|reactome:R-HSA-9623433|reactome:R-HSA-9632974|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:3R29	-	-	-	figure legend:3 B/C|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/09	2015/07/22	-	rogid:gKnKFur3dYudXOAePzqRZJxqzYQ9606	-	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
intact:EBI-10918206	uniprotkb:Q96RI1	-	intact:EBI-1250177|uniprotkb:B7ZM06|intact:EBI-1760291|uniprotkb:Q8NFP5|uniprotkb:Q8NFP6|uniprotkb:Q92943|intact:EBI-1965365|uniprotkb:A1L4K5|uniprotkb:B7Z412|uniprotkb:F8VYG8|ensembl:ENSP00000447149	psi-mi:fxr_re_probe_ir1_motif_fgf19_gene(display_short)|psi-mi:EBI-10918206(display_long)	psi-mi:nr1h4_human(display_long)|uniprotkb:NR1H4(gene name)|psi-mi:NR1H4(display_short)|uniprotkb:BAR(gene name synonym)|uniprotkb:FXR(gene name synonym)|uniprotkb:HRR1(gene name synonym)|uniprotkb:RIP14(gene name synonym)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Miyata et al. (2014)	imex:IM-25009|pubmed:24321096	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10918208|imex:IM-25009-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001193906.1|refseq:NP_001193907.1|refseq:NP_001193908.1|refseq:NP_001193921.1|refseq:NP_001193922.1|refseq:NP_005114.1|refseq:XP_011537342.1|dip:DIP-39370N|ensembl:ENSG00000012504(gene)|ensembl:ENST00000551379(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001080"(nitrogen catabolite activation of transcription from RNA polymerase II promoter)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0032052"(bile acid binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSH|rcsb pdb:1OSK|rcsb pdb:3BEJ|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3FLI|rcsb pdb:3FXV|rcsb pdb:3GD2|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3L1B|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:4OIV|rcsb pdb:4QE6|rcsb pdb:4QE8|rcsb pdb:4WVD|rcsb pdb:5IAW|rcsb pdb:5ICK|rcsb pdb:5Q0I|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q17|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5Q1D|rcsb pdb:5Q1E|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5WZX|rcsb pdb:5Y1J|rcsb pdb:5Y44|rcsb pdb:5Y49|rcsb pdb:5YXB|rcsb pdb:5YXD|rcsb pdb:5YXJ|rcsb pdb:5YXL|rcsb pdb:5Z12|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6HL0|rcsb pdb:6HL1|rcsb pdb:6ITM|rcsb pdb:7D42|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-192105	-	-	-	figure legend:3 B/C|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/09	2015/07/22	-	rogid:YK2REhPI+svM13WdnDQAmL+QMxQ9606	-	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
intact:EBI-10918206	uniprotkb:Q12772	-	intact:EBI-465059|uniprotkb:Q86V36|uniprotkb:Q6GTH7|uniprotkb:Q9UH04|ensembl:ENSP00000354476|uniprotkb:Q05BD5	psi-mi:fxr_re_probe_ir1_motif_fgf19_gene(display_short)|psi-mi:EBI-10918206(display_long)	psi-mi:srbp2_human(display_long)|uniprotkb:SREBF2(gene name)|psi-mi:SREBF2(display_short)|uniprotkb:SREBP2(gene name synonym)|uniprotkb:Sterol regulatory element-binding transcription factor 2(gene name synonym)|uniprotkb:BHLHD2(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 2(gene name synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Miyata et al. (2014)	imex:IM-25009|pubmed:24321096	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10918217|imex:IM-25009-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000198911(gene)|ensembl:ENST00000361204(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005829"(cytosol)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0070888"(E-box binding)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|rcsb pdb:1UKL|reactome:R-HSA-1655829|reactome:R-HSA-1989781|reactome:R-HSA-2426168|reactome:R-HSA-381340|reactome:R-HSA-9619665|refseq:NP_004590.2|dip:DIP-263N	-	-	-	figure legend:3Bi|comment:The SREBP-2-mediated reduction in binding disappeared when the amount of FXR, but not RXRa, was increased.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/09	2015/07/22	-	rogid:OkTB/ZjBgPVLKu333KVw2AKrE5M9606	-	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
intact:EBI-10918206	uniprotkb:P19793	-	intact:EBI-78598|uniprotkb:Q2V504|uniprotkb:B3KY83|uniprotkb:Q2NL52|ensembl:ENSP00000419692	psi-mi:fxr_re_probe_ir1_motif_fgf19_gene(display_short)|psi-mi:EBI-10918206(display_long)	psi-mi:rxra_human(display_long)|uniprotkb:RXRA(gene name)|psi-mi:RXRA(display_short)|uniprotkb:NR2B1(gene name synonym)|uniprotkb:Retinoid X receptor alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 2 group B member 1(gene name synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Miyata et al. (2014)	imex:IM-25009|pubmed:24321096	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10918217|imex:IM-25009-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002948.1|refseq:NP_001278850.1|dip:DIP-641N|ensembl:ENSG00000186350(gene)|ensembl:ENST00000481739(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050692"(DNA binding domain binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000003(Retinoid X receptor)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR021780|interpro:IPR035500|mint:P19793|rcsb pdb:1BY4|rcsb pdb:1DSZ|rcsb pdb:1FBY|rcsb pdb:1FM6|rcsb pdb:1FM9|rcsb pdb:1G1U|rcsb pdb:1G5Y|rcsb pdb:1K74|rcsb pdb:1MV9|rcsb pdb:1MVC|rcsb pdb:1MZN|rcsb pdb:1R0N|rcsb pdb:1RDT|rcsb pdb:1RXR|rcsb pdb:1XLS|rcsb pdb:1XV9|rcsb pdb:1XVP|rcsb pdb:1YNW|rcsb pdb:2ACL|rcsb pdb:2NLL|rcsb pdb:2P1T|rcsb pdb:2P1U|rcsb pdb:2P1V|rcsb pdb:2ZXZ|rcsb pdb:2ZY0|rcsb pdb:3DZU|rcsb pdb:3DZY|rcsb pdb:3E00|rcsb pdb:3E94|rcsb pdb:3FAL|rcsb pdb:3FC6|rcsb pdb:3FUG|rcsb pdb:3H0A|rcsb pdb:3KWY|rcsb pdb:3NSP|rcsb pdb:3NSQ|rcsb pdb:3OAP|rcsb pdb:3OZJ|rcsb pdb:3PCU|rcsb pdb:3R2A|rcsb pdb:3R5M|rcsb pdb:3UVV|rcsb pdb:4CN2|rcsb pdb:4CN3|rcsb pdb:4CN5|rcsb pdb:4CN7|rcsb pdb:4J5W|rcsb pdb:4J5X|rcsb pdb:4K4J|rcsb pdb:4K6I|rcsb pdb:4M8E|rcsb pdb:4M8H|rcsb pdb:4N5G|rcsb pdb:4N8R|rcsb pdb:4NQA|rcsb pdb:4OC7|rcsb pdb:4POH|rcsb pdb:4POJ|rcsb pdb:4PP3|rcsb pdb:4PP5|rcsb pdb:4RFW|rcsb pdb:4RMC|rcsb pdb:4RMD|rcsb pdb:4RME|rcsb pdb:4ZO1|rcsb pdb:4ZSH|rcsb pdb:5EC9|rcsb pdb:5JI0|rcsb pdb:5LYQ|rcsb pdb:5MJ5|rcsb pdb:5MK4|rcsb pdb:5MKJ|rcsb pdb:5MKU|rcsb pdb:5MMW|rcsb pdb:5TBP|rcsb pdb:5UAN|rcsb pdb:5Z12|rcsb pdb:5ZQU|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6FBQ|rcsb pdb:6FBR|rcsb pdb:6HN6|rcsb pdb:6JNO|rcsb pdb:6JNR|rcsb pdb:6L6K|rcsb pdb:6LB4|rcsb pdb:6LB5|rcsb pdb:6LB6|rcsb pdb:6SJM|rcsb pdb:6STI|rcsb pdb:6XWG|rcsb pdb:6XWH|rcsb pdb:7A77|rcsb pdb:7B88|rcsb pdb:7B9O|rcsb pdb:7CFO|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-159418|reactome:R-HSA-192105|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-200425|reactome:R-HSA-204174|reactome:R-HSA-211976|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-4090294|reactome:R-HSA-5362517|reactome:R-HSA-5617472|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9616222|reactome:R-HSA-9623433|reactome:R-HSA-9632974|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:3R29	-	-	-	figure legend:3Bi|comment:The SREBP-2-mediated reduction in binding disappeared when the amount of FXR, but not RXRa, was increased.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/09	2015/07/22	-	rogid:gKnKFur3dYudXOAePzqRZJxqzYQ9606	-	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
intact:EBI-10918206	uniprotkb:Q96RI1	-	intact:EBI-1250177|uniprotkb:B7ZM06|intact:EBI-1760291|uniprotkb:Q8NFP5|uniprotkb:Q8NFP6|uniprotkb:Q92943|intact:EBI-1965365|uniprotkb:A1L4K5|uniprotkb:B7Z412|uniprotkb:F8VYG8|ensembl:ENSP00000447149	psi-mi:fxr_re_probe_ir1_motif_fgf19_gene(display_short)|psi-mi:EBI-10918206(display_long)	psi-mi:nr1h4_human(display_long)|uniprotkb:NR1H4(gene name)|psi-mi:NR1H4(display_short)|uniprotkb:BAR(gene name synonym)|uniprotkb:FXR(gene name synonym)|uniprotkb:HRR1(gene name synonym)|uniprotkb:RIP14(gene name synonym)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Miyata et al. (2014)	imex:IM-25009|pubmed:24321096	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10918217|imex:IM-25009-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001193906.1|refseq:NP_001193907.1|refseq:NP_001193908.1|refseq:NP_001193921.1|refseq:NP_001193922.1|refseq:NP_005114.1|refseq:XP_011537342.1|dip:DIP-39370N|ensembl:ENSG00000012504(gene)|ensembl:ENST00000551379(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001080"(nitrogen catabolite activation of transcription from RNA polymerase II promoter)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0032052"(bile acid binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSH|rcsb pdb:1OSK|rcsb pdb:3BEJ|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3FLI|rcsb pdb:3FXV|rcsb pdb:3GD2|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3L1B|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:4OIV|rcsb pdb:4QE6|rcsb pdb:4QE8|rcsb pdb:4WVD|rcsb pdb:5IAW|rcsb pdb:5ICK|rcsb pdb:5Q0I|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q17|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5Q1D|rcsb pdb:5Q1E|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5WZX|rcsb pdb:5Y1J|rcsb pdb:5Y44|rcsb pdb:5Y49|rcsb pdb:5YXB|rcsb pdb:5YXD|rcsb pdb:5YXJ|rcsb pdb:5YXL|rcsb pdb:5Z12|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6HL0|rcsb pdb:6HL1|rcsb pdb:6ITM|rcsb pdb:7D42|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-192105	-	-	-	figure legend:3Bi|comment:The SREBP-2-mediated reduction in binding disappeared when the amount of FXR, but not RXRa, was increased.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/09	2015/07/22	-	rogid:YK2REhPI+svM13WdnDQAmL+QMxQ9606	-	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q12772	intact:EBI-10918228	intact:EBI-465059|uniprotkb:Q86V36|uniprotkb:Q6GTH7|uniprotkb:Q9UH04|ensembl:ENSP00000354476|uniprotkb:Q05BD5	-	psi-mi:srbp2_human(display_long)|uniprotkb:SREBF2(gene name)|psi-mi:SREBF2(display_short)|uniprotkb:SREBP2(gene name synonym)|uniprotkb:Sterol regulatory element-binding transcription factor 2(gene name synonym)|uniprotkb:BHLHD2(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 2(gene name synonym)	psi-mi:sre_probe_human_ldlr_gene_promoter(display_short)|psi-mi:EBI-10918228(display_long)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Miyata et al. (2014)	imex:IM-25009|pubmed:24321096	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10918230|imex:IM-25009-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	ensembl:ENSG00000198911(gene)|ensembl:ENST00000361204(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005829"(cytosol)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0070888"(E-box binding)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|rcsb pdb:1UKL|reactome:R-HSA-1655829|reactome:R-HSA-1989781|reactome:R-HSA-2426168|reactome:R-HSA-381340|reactome:R-HSA-9619665|refseq:NP_004590.2|dip:DIP-263N	-	-	-	-	figure legend:3C|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/09	2015/07/22	rogid:OkTB/ZjBgPVLKu333KVw2AKrE5M9606	-	-	false	-	32p radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
ensembl:ENSG00000162344	uniprotkb:Q96RI1	intact:EBI-10918248	intact:EBI-1250177|uniprotkb:B7ZM06|intact:EBI-1760291|uniprotkb:Q8NFP5|uniprotkb:Q8NFP6|uniprotkb:Q92943|intact:EBI-1965365|uniprotkb:A1L4K5|uniprotkb:B7Z412|uniprotkb:F8VYG8|ensembl:ENSP00000447149	uniprotkb:FGF19(gene name)|psi-mi:FGF19(display_short)|ensembl:fgf19_human_gene(shortlabel)|psi-mi:ENSG00000162344(display_long)	psi-mi:nr1h4_human(display_long)|uniprotkb:NR1H4(gene name)|psi-mi:NR1H4(display_short)|uniprotkb:BAR(gene name synonym)|uniprotkb:FXR(gene name synonym)|uniprotkb:HRR1(gene name synonym)|uniprotkb:RIP14(gene name synonym)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Miyata et al. (2014)	imex:IM-25009|pubmed:24321096	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10918245|imex:IM-25009-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	refseq:NP_005108.1	refseq:NP_001193906.1|refseq:NP_001193907.1|refseq:NP_001193908.1|refseq:NP_001193921.1|refseq:NP_001193922.1|refseq:NP_005114.1|refseq:XP_011537342.1|dip:DIP-39370N|ensembl:ENSG00000012504(gene)|ensembl:ENST00000551379(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001080"(nitrogen catabolite activation of transcription from RNA polymerase II promoter)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0032052"(bile acid binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSH|rcsb pdb:1OSK|rcsb pdb:3BEJ|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3FLI|rcsb pdb:3FXV|rcsb pdb:3GD2|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3L1B|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:4OIV|rcsb pdb:4QE6|rcsb pdb:4QE8|rcsb pdb:4WVD|rcsb pdb:5IAW|rcsb pdb:5ICK|rcsb pdb:5Q0I|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q17|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5Q1D|rcsb pdb:5Q1E|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5WZX|rcsb pdb:5Y1J|rcsb pdb:5Y44|rcsb pdb:5Y49|rcsb pdb:5YXB|rcsb pdb:5YXD|rcsb pdb:5YXJ|rcsb pdb:5YXL|rcsb pdb:5Z12|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6HL0|rcsb pdb:6HL1|rcsb pdb:6ITM|rcsb pdb:7D42|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-192105	-	-	-	figure legend:3E|agonist:"cholesterol (CHEBI:16113)  and 25-hydroxycholesterol (CHEBI:42977)."|causality statement:"CHEBI:16113  and   CHEBI:42977  increases binding of  Q96RI1  to   ENSG00000162344."|causality statement:"CHEBI:16113  and   CHEBI:42977  decreases expression at protein level of  ENSG00000198911."|causality statement:"CHEBI:16113  and   CHEBI:42977  increases expression at RNA level of  ENSG00000162344."|causality statement:Q12772  decreases expression at RNA level of  ENSG00000162344|comment:"GW4064 (CHEBI:79997) is a non-steroidal agonist of the  nuclear receptor FXR."|causality statement:"CHEBI:79997  increases expression at RNA level of  ENSG00000162344"|causality statement:"Q12772  decreases activity of  CHEBI:79997"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ls147t)|taxid:9606(Homo sapiens)	-	2015/07/09	2015/07/22	-	rogid:YK2REhPI+svM13WdnDQAmL+QMxQ9606	-	false	sufficient binding region:?-?	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
uniprotkb:Q96RI1	uniprotkb:Q12772	intact:EBI-1250177|uniprotkb:B7ZM06|intact:EBI-1760291|uniprotkb:Q8NFP5|uniprotkb:Q8NFP6|uniprotkb:Q92943|intact:EBI-1965365|uniprotkb:A1L4K5|uniprotkb:B7Z412|uniprotkb:F8VYG8|ensembl:ENSP00000447149	intact:EBI-465059|uniprotkb:Q86V36|uniprotkb:Q6GTH7|uniprotkb:Q9UH04|ensembl:ENSP00000354476|uniprotkb:Q05BD5	psi-mi:nr1h4_human(display_long)|uniprotkb:NR1H4(gene name)|psi-mi:NR1H4(display_short)|uniprotkb:BAR(gene name synonym)|uniprotkb:FXR(gene name synonym)|uniprotkb:HRR1(gene name synonym)|uniprotkb:RIP14(gene name synonym)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)	psi-mi:srbp2_human(display_long)|uniprotkb:SREBF2(gene name)|psi-mi:SREBF2(display_short)|uniprotkb:SREBP2(gene name synonym)|uniprotkb:Sterol regulatory element-binding transcription factor 2(gene name synonym)|uniprotkb:BHLHD2(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Miyata et al. (2014)	imex:IM-25009|pubmed:24321096	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10918268|imex:IM-25009-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193906.1|refseq:NP_001193907.1|refseq:NP_001193908.1|refseq:NP_001193921.1|refseq:NP_001193922.1|refseq:NP_005114.1|refseq:XP_011537342.1|dip:DIP-39370N|ensembl:ENSG00000012504(gene)|ensembl:ENST00000551379(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001080"(nitrogen catabolite activation of transcription from RNA polymerase II promoter)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0032052"(bile acid binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|rcsb pdb:1OSH|rcsb pdb:1OSK|rcsb pdb:3BEJ|rcsb pdb:3DCT|rcsb pdb:3DCU|rcsb pdb:3FLI|rcsb pdb:3FXV|rcsb pdb:3GD2|rcsb pdb:3HC5|rcsb pdb:3HC6|rcsb pdb:3L1B|rcsb pdb:3OKH|rcsb pdb:3OKI|rcsb pdb:3OLF|rcsb pdb:3OMK|rcsb pdb:3OMM|rcsb pdb:3OOF|rcsb pdb:3OOK|rcsb pdb:3P88|rcsb pdb:3P89|rcsb pdb:3RUT|rcsb pdb:3RUU|rcsb pdb:3RVF|rcsb pdb:4OIV|rcsb pdb:4QE6|rcsb pdb:4QE8|rcsb pdb:4WVD|rcsb pdb:5IAW|rcsb pdb:5ICK|rcsb pdb:5Q0I|rcsb pdb:5Q0J|rcsb pdb:5Q0K|rcsb pdb:5Q0L|rcsb pdb:5Q0M|rcsb pdb:5Q0N|rcsb pdb:5Q0O|rcsb pdb:5Q0P|rcsb pdb:5Q0Q|rcsb pdb:5Q0R|rcsb pdb:5Q0S|rcsb pdb:5Q0T|rcsb pdb:5Q0U|rcsb pdb:5Q0V|rcsb pdb:5Q0W|rcsb pdb:5Q0X|rcsb pdb:5Q0Y|rcsb pdb:5Q0Z|rcsb pdb:5Q10|rcsb pdb:5Q11|rcsb pdb:5Q12|rcsb pdb:5Q13|rcsb pdb:5Q14|rcsb pdb:5Q15|rcsb pdb:5Q16|rcsb pdb:5Q17|rcsb pdb:5Q18|rcsb pdb:5Q19|rcsb pdb:5Q1A|rcsb pdb:5Q1B|rcsb pdb:5Q1C|rcsb pdb:5Q1D|rcsb pdb:5Q1E|rcsb pdb:5Q1F|rcsb pdb:5Q1G|rcsb pdb:5Q1H|rcsb pdb:5Q1I|rcsb pdb:5WZX|rcsb pdb:5Y1J|rcsb pdb:5Y44|rcsb pdb:5Y49|rcsb pdb:5YXB|rcsb pdb:5YXD|rcsb pdb:5YXJ|rcsb pdb:5YXL|rcsb pdb:5Z12|rcsb pdb:6A5W|rcsb pdb:6A5X|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6HL0|rcsb pdb:6HL1|rcsb pdb:6ITM|rcsb pdb:7D42|reactome:R-HSA-159418|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-192105	ensembl:ENSG00000198911(gene)|ensembl:ENST00000361204(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005829"(cytosol)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0070888"(E-box binding)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|rcsb pdb:1UKL|reactome:R-HSA-1655829|reactome:R-HSA-1989781|reactome:R-HSA-2426168|reactome:R-HSA-381340|reactome:R-HSA-9619665|refseq:NP_004590.2|dip:DIP-263N	-	-	-	figure legend:4|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/09	2015/07/30	rogid:YK2REhPI+svM13WdnDQAmL+QMxQ9606	rogid:OkTB/ZjBgPVLKu333KVw2AKrE5M9606	rigid:YN2OT57jNAXnEYE7hib1eoVKxuw	false	-	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)