#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q60641	intact:EBI-11362172	intact:EBI-11359946|uniprotkb:E9QJW2|uniprotkb:Q60642|uniprotkb:Q60643|uniprotkb:D3YTT2|ensembl:ENSMUSP00000100933	-	psi-mi:nr1h4_mouse(display_long)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)|uniprotkb:Nr1h4(gene name)|psi-mi:Nr1h4(display_short)|uniprotkb:Bar(gene name synonym)|uniprotkb:Fxr(gene name synonym)|uniprotkb:Rip14(gene name synonym)	psi-mi:er-8_distal_promoter_nr3c1_gene_probe(display_short)|psi-mi:EBI-11362172(display_long)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Renga et al. (2013)	imex:IM-24713|pubmed:24004655	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11362174|imex:IM-24713-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_001157172.1|refseq:NP_001156976.1|refseq:XP_006513454.1|refseq:XP_006513456.1|ensembl:ENSMUSG00000047638(gene)|ensembl:ENSMUST00000105296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001080"(nitrogen catabolite activation of transcription from RNA polymerase II promoter)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006109"(regulation of carbohydrate metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0032052"(bile acid binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035690"|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0071873"(response to norepinephrine)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|go:"GO:2001250"(positive regulation of ammonia assimilation cycle)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|reactome:R-MMU-159418|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-192105|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046965"(retinoid X receptor binding)|reactome:R-MMU-193368|go:"GO:0050728"(negative regulation of inflammatory response)|reactome:R-MMU-193807|reactome:R-MMU-211976|reactome:R-MMU-383280|reactome:R-MMU-4090294|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-443N	-	-	-	-	figure legend:6B|agonist:"Using nuclear extracts from Raw264.7 cells stimulated with 6-EDCA (CHEBI:43602) increased the interaction."|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/09/30	2015/11/09	rogid:LynOv9in3vUOon7KHdYMNhd9zrc10090	-	-	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
ensembl:ENSMUSG00000024431	uniprotkb:Q60641	intact:EBI-11362212	intact:EBI-11359946|uniprotkb:E9QJW2|uniprotkb:Q60642|uniprotkb:Q60643|uniprotkb:D3YTT2|ensembl:ENSMUSP00000100933	uniprotkb:Nr3c1(gene name)|psi-mi:Nr3c1(display_short)|ensembl:nr3c1_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000024431(display_long)	psi-mi:nr1h4_mouse(display_long)|uniprotkb:Farnesoid X-activated receptor(gene name synonym)|uniprotkb:Farnesol receptor HRR-1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 4(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein 14(gene name synonym)|uniprotkb:Nr1h4(gene name)|psi-mi:Nr1h4(display_short)|uniprotkb:Bar(gene name synonym)|uniprotkb:Fxr(gene name synonym)|uniprotkb:Rip14(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Renga et al. (2013)	imex:IM-24713|pubmed:24004655	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11362198|imex:IM-24713-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	refseq:NP_032199.3|refseq:XP_006525729.1	refseq:NP_001157172.1|refseq:NP_001156976.1|refseq:XP_006513454.1|refseq:XP_006513456.1|ensembl:ENSMUSG00000047638(gene)|ensembl:ENSMUST00000105296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001080"(nitrogen catabolite activation of transcription from RNA polymerase II promoter)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006109"(regulation of carbohydrate metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010903"(negative regulation of very-low-density lipoprotein particle remodeling)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0030154"(cell differentiation)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0032052"(bile acid binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034255"(regulation of urea metabolic process)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035690"|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0038181"(bile acid receptor activity)|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0038185"(intracellular bile acid receptor signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0071873"(response to norepinephrine)|go:"GO:1902122"(chenodeoxycholic acid binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1903413"(cellular response to bile acid)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1905695"(positive regulation of phosphatidic acid biosynthetic process)|go:"GO:2000213"(positive regulation of glutamate metabolic process)|go:"GO:2001250"(positive regulation of ammonia assimilation cycle)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR044114|reactome:R-MMU-159418|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-192105|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046965"(retinoid X receptor binding)|reactome:R-MMU-193368|go:"GO:0050728"(negative regulation of inflammatory response)|reactome:R-MMU-193807|reactome:R-MMU-211976|reactome:R-MMU-383280|reactome:R-MMU-4090294|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-443N	-	-	-	figure legend:6C|agonist:"CHEBI:43602 / CHEMBL566315  (ECDCA)"|causality statement:"CHEBI:43602 increases the binding of Q60641 to ENSMUSG00000024431"|causality statement:"CHEBI:43602 increases the expression at RNA level of  ENSMUSG00000024431"|causality statement:"CHEBI:41879  increases the expression at RNA level of  ENSMUSG00000024431"|comment:The relative mRNA expression of Gr was significantly enhanced in cells co-stimulated with 6-ECDCA plus Dexa in comparison to cells stimulated only with 6-ECDCA or Dexa.|comment:"Agonist effect of 6-ECDCA (CHEBI:43602) is detected 1 hour after exposure and it is gone after 12 hours."|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264)	-	2015/09/30	2016/11/02	-	rogid:LynOv9in3vUOon7KHdYMNhd9zrc10090	-	false	sufficient binding region:?-?	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
ensembl:ENSMUSG00000024431	ensembl:ENSMUSG00000024431	intact:EBI-11362212	intact:EBI-11362212	uniprotkb:Nr3c1(gene name)|psi-mi:Nr3c1(display_short)|ensembl:nr3c1_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000024431(display_long)	uniprotkb:Nr3c1(gene name)|psi-mi:Nr3c1(display_short)|ensembl:nr3c1_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000024431(display_long)	psi-mi:"MI:1218"(chromosome conformation capture assay)	Renga et al. (2013)	imex:IM-24713|pubmed:24004655	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11363862|imex:IM-24713-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0250"(gene)	refseq:NP_032199.3|refseq:XP_006525729.1	refseq:NP_032199.3|refseq:XP_006525729.1	-	-	-	figure legend:7A|causality statement:"CHEBI:41879  and  CHEBI:43602  increased binding of ENSMUSG00000024431 to ENSMUSG00000024431"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264)	-	2015/09/30	2015/11/09	-	-	-	false	sufficient binding region:?-?	sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)