#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
ensembl:ENSMUSG00000039521	uniprotkb:Q9Z2E1	intact:EBI-10899641	intact:EBI-5716946|uniprotkb:E9QMV9|uniprotkb:Q811D9|uniprotkb:Q9Z2D9|ensembl:ENSMUSP00000073701	uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|ensembl:foxp3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000039521(display_long)	psi-mi:mbd2_mouse(display_long)|uniprotkb:Mbd2(gene name)|psi-mi:Mbd2(display_short)|uniprotkb:Methyl-CpG-binding protein MBD2(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Wang et al. (2013)	pubmed:23979593|imex:IM-24705	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11360915|imex:IM-24705-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1	refseq:NP_034903.2|refseq:NP_001298000.1|ensembl:ENSMUSG00000024513(gene)|ensembl:ENSMUST00000074058(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0034622"|go:"GO:0035197"(siRNA binding)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042711"(maternal behavior)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0048568"(embryonic organ development)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR025884|interpro:IPR032343|mint:Q9Z2E1|reactome:R-MMU-427413|reactome:R-MMU-73728	-	-	-	figure legend:4 A|causality statement:Q9Z2E1 increased the demethylation of  ENSMUSG00000039521|comment:The TSDR was fully demethylated in WT T-reg cells but was largely methylated in Mbd2−/− Treg cells as well as in WT or Mbd2−/− T-effector cells.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2015/09/29	2015/11/04	-	rogid:WxzH0gNkMXwFmBK/RWr2/RqWjXM10090	-	false	sufficient binding region:?-?	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:Q3URK3	ensembl:ENSMUSG00000039521	intact:EBI-4291699|uniprotkb:Q6ZPK2|uniprotkb:Q9CY36|ensembl:ENSMUSP00000059527	intact:EBI-10899641	psi-mi:tet1_mouse(display_long)|uniprotkb:Tet1(gene name)|psi-mi:Tet1(display_short)|uniprotkb:Cxxc6(gene name synonym)|uniprotkb:Kiaa1676(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 6(gene name synonym)|uniprotkb:Ten-eleven translocation 1 gene protein homolog(gene name synonym)	uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|ensembl:foxp3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000039521(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Wang et al. (2013)	pubmed:23979593|imex:IM-24705	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11360968|imex:IM-24705-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	ensembl:ENSMUSG00000047146(gene)|ensembl:ENSMUST00000050826(transcript)|go:"GO:0001826"(inner cell mass cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006211"(5-methylcytosine catabolic process)|go:"GO:0006325"(chromatin organization)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070579"(methylcytosine dioxygenase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0080111"(DNA demethylation)|go:"GO:0090310"(negative regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR024779|interpro:IPR040175|refseq:NP_081660.1	refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1	-	-	-	figure legend:4 H|causality statement:Q9Z2E1  increases the expression at protein level of  Q3URK3|causality statement:Q9Z2E1 increases the binding of Q3URK3 to ENSMUSG00000039521|causality statement:Q9Z2E1  increases the expression at protein level of  ENSMUSG00000039521|causality statement:Q9Z2E1  increases the expression at  RNA level of  ENSMUSG00000039521|causality statement:Q9Z2E1 increases the expression at RNA level of P09793|causality statement:Q9Z2E1 increases the expression at RNA level of P04202|causality statement:Q9Z2E1 increases the expression at RNA level of P18893|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2015/09/29	2015/11/04	rogid:Y9B8kHMSlMtrPh37jWKXDqfhVaA10090	-	-	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:Q4JK59	ensembl:ENSMUSG00000039521	intact:EBI-4291768|uniprotkb:Q3U5R5|uniprotkb:Q3U633|uniprotkb:Q3UAI0|uniprotkb:Q6ZPN2|uniprotkb:Q8K2K3|ensembl:ENSMUSP00000096203	intact:EBI-10899641	psi-mi:tet2_mouse(display_long)|uniprotkb:Tet2(gene name)|psi-mi:Tet2(display_short)|uniprotkb:Kiaa1546(gene name synonym)|uniprotkb:Protein Ayu17-449(gene name synonym)	uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|ensembl:foxp3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000039521(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Wang et al. (2013)	pubmed:23979593|imex:IM-24705	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11360983|imex:IM-24705-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	ensembl:ENSMUSG00000040943(gene)|ensembl:ENSMUST00000098603(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006211"(5-methylcytosine catabolic process)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019857"(5-methylcytosine metabolic process)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|refseq:NP_001035490.2|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048536"(spleen development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:0070579"(methylcytosine dioxygenase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0072576"(liver morphogenesis)|go:"GO:0080111"(DNA demethylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|interpro:IPR024779|interpro:IPR040175|refseq:NP_001333665.1	refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1	-	-	-	figure legend:4 Hi|causality statement:Q9Z2E1 increases the binding of  Q4JK59 to ENSMUSG00000039521|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell)	-	2015/09/29	2015/11/04	rogid:C/c8kKR/s/hwnwxNQUkxceYmoGA10090	-	-	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)