#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q02153	uniprotkb:Q02108	intact:EBI-6911707|ensembl:ENSP00000264424|uniprotkb:B7Z426|uniprotkb:Q86WY5	intact:EBI-3910037|uniprotkb:O43843|uniprotkb:D3DP19|uniprotkb:Q8TAH3|uniprotkb:D6RDW3|ensembl:ENSP00000296518|ensembl:ENSP00000412201|ensembl:ENSP00000421493|ensembl:ENSP00000424361|ensembl:ENSP00000426040	psi-mi:gcyb1_human(display_long)|uniprotkb:GUCY1B1(gene name)|psi-mi:GUCY1B1(display_short)|uniprotkb:GUC1B3(gene name synonym)|uniprotkb:GUCSB3(gene name synonym)|uniprotkb:GUCY1B3(gene name synonym)|uniprotkb:Guanylate cyclase soluble subunit beta-3(gene name synonym)|uniprotkb:Soluble guanylate cyclase small subunit(gene name synonym)	psi-mi:gcya1_human(display_long)|uniprotkb:GUCY1A1(gene name)|psi-mi:GUCY1A1(display_short)|uniprotkb:GUC1A3(gene name synonym)|uniprotkb:GUCSA3(gene name synonym)|uniprotkb:GUCY1A3(gene name synonym)|uniprotkb:Guanylate cyclase soluble subunit alpha-3(gene name synonym)|uniprotkb:Soluble guanylate cyclase large subunit(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Allerston et al. (2012)	imex:IM-24450|pubmed:23505436	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10949659|pdbe:3UVJ|imex:IM-24450-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000061918(gene)|ensembl:ENST00000264424(transcript)|go:"GO:0004016"(adenylate cyclase activity)|go:"GO:0004383"(guanylate cyclase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0006182"(cGMP biosynthetic process)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0008015"(blood circulation)|go:"GO:0008074"(guanylate cyclase complex, soluble)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020037"(heme binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0047805"(cytidylate cyclase activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099555"(trans-synaptic signaling by nitric oxide, modulating synaptic transmission)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR011644(Haem NO binding)|interpro:IPR011645(Haem NO binding associated)|interpro:IPR018297|interpro:IPR024096|interpro:IPR029787|interpro:IPR038158|interpro:IPR042463|rcsb pdb:2WZ1|rcsb pdb:3UVJ|rcsb pdb:4NI2|rcsb pdb:5MNW|go:"GO:0038060"(nitric oxide-cGMP-mediated signaling pathway)|rcsb pdb:6JT0|rcsb pdb:6JT1|rcsb pdb:6JT2|reactome:R-HSA-392154|reactome:R-HSA-445355|refseq:NP_000848.1|refseq:NP_001278881.1|refseq:NP_001278882.1|refseq:NP_001278883.1	refseq:NP_001243378.1|refseq:XP_006714259.1|refseq:XP_006714260.1|refseq:NP_000847.2|refseq:NP_001124154.1|refseq:NP_001124155.1|refseq:NP_001124156.1|refseq:NP_001124159.1|ensembl:ENSG00000164116(gene)|ensembl:ENST00000296518(transcript)|ensembl:ENST00000455639(transcript)|ensembl:ENST00000506455(transcript)|ensembl:ENST00000511108(transcript)|ensembl:ENST00000513574(transcript)|go:"GO:0004383"(guanylate cyclase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0006182"(cGMP biosynthetic process)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0008015"(blood circulation)|go:"GO:0008074"(guanylate cyclase complex, soluble)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0020037"(heme binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0098925"(retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR011644(Haem NO binding)|interpro:IPR011645(Haem NO binding associated)|interpro:IPR018297|interpro:IPR024096|interpro:IPR029787|interpro:IPR038158|interpro:IPR042463|rcsb pdb:3UVJ|rcsb pdb:4NI2|rcsb pdb:6JT0|rcsb pdb:6JT1|rcsb pdb:6JT2|reactome:R-HSA-392154|reactome:R-HSA-445355|refseq:XP_005263012.1	-	-	-	figure legend:Table 1|3d-resolution:2.08 Å|3d-r-factors:"R-working: 0.167 R-free: 0.209"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/29	2015/07/29	rogid:XG3K0TurvMfAZcp1KXRsltIvuS49606	rogid:n1bJF3ineAG9xCfwUXgS4zrHlqA9606	rigid:2PBDpkKdUXn9fTwgbe1USkkjfKE	false	sufficient binding region:408-619(IPR001054)|mutation:476-476,541-541	sufficient binding region:468-690	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02153	uniprotkb:Q02153	intact:EBI-6911707|ensembl:ENSP00000264424|uniprotkb:B7Z426|uniprotkb:Q86WY5	intact:EBI-6911707|ensembl:ENSP00000264424|uniprotkb:B7Z426|uniprotkb:Q86WY5	psi-mi:gcyb1_human(display_long)|uniprotkb:GUCY1B1(gene name)|psi-mi:GUCY1B1(display_short)|uniprotkb:GUC1B3(gene name synonym)|uniprotkb:GUCSB3(gene name synonym)|uniprotkb:GUCY1B3(gene name synonym)|uniprotkb:Guanylate cyclase soluble subunit beta-3(gene name synonym)|uniprotkb:Soluble guanylate cyclase small subunit(gene name synonym)	psi-mi:gcyb1_human(display_long)|uniprotkb:GUCY1B1(gene name)|psi-mi:GUCY1B1(display_short)|uniprotkb:GUC1B3(gene name synonym)|uniprotkb:GUCSB3(gene name synonym)|uniprotkb:GUCY1B3(gene name synonym)|uniprotkb:Guanylate cyclase soluble subunit beta-3(gene name synonym)|uniprotkb:Soluble guanylate cyclase small subunit(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Allerston et al. (2012)	imex:IM-24450|pubmed:23505436	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10949670|imex:IM-24450-3|pdbe:2wz1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000061918(gene)|ensembl:ENST00000264424(transcript)|go:"GO:0004016"(adenylate cyclase activity)|go:"GO:0004383"(guanylate cyclase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0006182"(cGMP biosynthetic process)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0008015"(blood circulation)|go:"GO:0008074"(guanylate cyclase complex, soluble)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020037"(heme binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0047805"(cytidylate cyclase activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099555"(trans-synaptic signaling by nitric oxide, modulating synaptic transmission)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR011644(Haem NO binding)|interpro:IPR011645(Haem NO binding associated)|interpro:IPR018297|interpro:IPR024096|interpro:IPR029787|interpro:IPR038158|interpro:IPR042463|rcsb pdb:2WZ1|rcsb pdb:3UVJ|rcsb pdb:4NI2|rcsb pdb:5MNW|go:"GO:0038060"(nitric oxide-cGMP-mediated signaling pathway)|rcsb pdb:6JT0|rcsb pdb:6JT1|rcsb pdb:6JT2|reactome:R-HSA-392154|reactome:R-HSA-445355|refseq:NP_000848.1|refseq:NP_001278881.1|refseq:NP_001278882.1|refseq:NP_001278883.1	ensembl:ENSG00000061918(gene)|ensembl:ENST00000264424(transcript)|go:"GO:0004016"(adenylate cyclase activity)|go:"GO:0004383"(guanylate cyclase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0006182"(cGMP biosynthetic process)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0008015"(blood circulation)|go:"GO:0008074"(guanylate cyclase complex, soluble)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020037"(heme binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0047805"(cytidylate cyclase activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099555"(trans-synaptic signaling by nitric oxide, modulating synaptic transmission)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR011644(Haem NO binding)|interpro:IPR011645(Haem NO binding associated)|interpro:IPR018297|interpro:IPR024096|interpro:IPR029787|interpro:IPR038158|interpro:IPR042463|rcsb pdb:2WZ1|rcsb pdb:3UVJ|rcsb pdb:4NI2|rcsb pdb:5MNW|go:"GO:0038060"(nitric oxide-cGMP-mediated signaling pathway)|rcsb pdb:6JT0|rcsb pdb:6JT1|rcsb pdb:6JT2|reactome:R-HSA-392154|reactome:R-HSA-445355|refseq:NP_000848.1|refseq:NP_001278881.1|refseq:NP_001278882.1|refseq:NP_001278883.1	-	-	-	3d-resolution:1.63 Å|3d-r-factors:"R-working: 0.184 R-free: 0.219"|figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/29	2015/07/29	rogid:XG3K0TurvMfAZcp1KXRsltIvuS49606	rogid:XG3K0TurvMfAZcp1KXRsltIvuS49606	rigid:RxXAhmlMX0kcC5vife2w+Y/CnCY	false	sufficient binding region:408-619(IPR001054)	sufficient binding region:408-619(IPR001054)	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02108	uniprotkb:Q02153	intact:EBI-3910037|uniprotkb:O43843|uniprotkb:D3DP19|uniprotkb:Q8TAH3|uniprotkb:D6RDW3|ensembl:ENSP00000296518|ensembl:ENSP00000412201|ensembl:ENSP00000421493|ensembl:ENSP00000424361|ensembl:ENSP00000426040	intact:EBI-6911707|ensembl:ENSP00000264424|uniprotkb:B7Z426|uniprotkb:Q86WY5	psi-mi:gcya1_human(display_long)|uniprotkb:GUCY1A1(gene name)|psi-mi:GUCY1A1(display_short)|uniprotkb:GUC1A3(gene name synonym)|uniprotkb:GUCSA3(gene name synonym)|uniprotkb:GUCY1A3(gene name synonym)|uniprotkb:Guanylate cyclase soluble subunit alpha-3(gene name synonym)|uniprotkb:Soluble guanylate cyclase large subunit(gene name synonym)	psi-mi:gcyb1_human(display_long)|uniprotkb:GUCY1B1(gene name)|psi-mi:GUCY1B1(display_short)|uniprotkb:GUC1B3(gene name synonym)|uniprotkb:GUCSB3(gene name synonym)|uniprotkb:GUCY1B3(gene name synonym)|uniprotkb:Guanylate cyclase soluble subunit beta-3(gene name synonym)|uniprotkb:Soluble guanylate cyclase small subunit(gene name synonym)	psi-mi:"MI:0419"(gtpase assay)	Allerston et al. (2012)	imex:IM-24450|pubmed:23505436	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0883"(gtpase reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10955622|imex:IM-24450-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001243378.1|refseq:XP_006714259.1|refseq:XP_006714260.1|refseq:NP_000847.2|refseq:NP_001124154.1|refseq:NP_001124155.1|refseq:NP_001124156.1|refseq:NP_001124159.1|ensembl:ENSG00000164116(gene)|ensembl:ENST00000296518(transcript)|ensembl:ENST00000455639(transcript)|ensembl:ENST00000506455(transcript)|ensembl:ENST00000511108(transcript)|ensembl:ENST00000513574(transcript)|go:"GO:0004383"(guanylate cyclase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0006182"(cGMP biosynthetic process)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0008015"(blood circulation)|go:"GO:0008074"(guanylate cyclase complex, soluble)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0020037"(heme binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0098925"(retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR011644(Haem NO binding)|interpro:IPR011645(Haem NO binding associated)|interpro:IPR018297|interpro:IPR024096|interpro:IPR029787|interpro:IPR038158|interpro:IPR042463|rcsb pdb:3UVJ|rcsb pdb:4NI2|rcsb pdb:6JT0|rcsb pdb:6JT1|rcsb pdb:6JT2|reactome:R-HSA-392154|reactome:R-HSA-445355|refseq:XP_005263012.1	ensembl:ENSG00000061918(gene)|ensembl:ENST00000264424(transcript)|go:"GO:0004016"(adenylate cyclase activity)|go:"GO:0004383"(guanylate cyclase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0006182"(cGMP biosynthetic process)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0008015"(blood circulation)|go:"GO:0008074"(guanylate cyclase complex, soluble)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020037"(heme binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0047805"(cytidylate cyclase activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099555"(trans-synaptic signaling by nitric oxide, modulating synaptic transmission)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR011644(Haem NO binding)|interpro:IPR011645(Haem NO binding associated)|interpro:IPR018297|interpro:IPR024096|interpro:IPR029787|interpro:IPR038158|interpro:IPR042463|rcsb pdb:2WZ1|rcsb pdb:3UVJ|rcsb pdb:4NI2|rcsb pdb:5MNW|go:"GO:0038060"(nitric oxide-cGMP-mediated signaling pathway)|rcsb pdb:6JT0|rcsb pdb:6JT1|rcsb pdb:6JT2|reactome:R-HSA-392154|reactome:R-HSA-445355|refseq:NP_000848.1|refseq:NP_001278881.1|refseq:NP_001278882.1|refseq:NP_001278883.1	go:"GO:0003924"(GTPase activity)	-	-	figure legend:Table 2|comment:The enzyme active-site  is contributed to by  residues from both subunits, and lies at the interface between the two catalytic domains.|kinetics:"Specific Activity is 25-300 nmol/mg/min.   (full length bovine enzyme has a specific activity of 4300 nmol/mg/min.)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/29	2016/08/15	rogid:n1bJF3ineAG9xCfwUXgS4zrHlqA9606	rogid:XG3K0TurvMfAZcp1KXRsltIvuS49606	-	false	sufficient binding region:468-690	sufficient binding region:408-619(IPR001054)|mutation:476-476,541-541	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15996"	uniprotkb:Q02108	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-3910037|uniprotkb:O43843|uniprotkb:D3DP19|uniprotkb:Q8TAH3|uniprotkb:D6RDW3|ensembl:ENSP00000296518|ensembl:ENSP00000412201|ensembl:ENSP00000421493|ensembl:ENSP00000424361|ensembl:ENSP00000426040	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:gcya1_human(display_long)|uniprotkb:GUCY1A1(gene name)|psi-mi:GUCY1A1(display_short)|uniprotkb:GUC1A3(gene name synonym)|uniprotkb:GUCSA3(gene name synonym)|uniprotkb:GUCY1A3(gene name synonym)|uniprotkb:Guanylate cyclase soluble subunit alpha-3(gene name synonym)|uniprotkb:Soluble guanylate cyclase large subunit(gene name synonym)	psi-mi:"MI:0419"(gtpase assay)	Allerston et al. (2012)	imex:IM-24450|pubmed:23505436	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0883"(gtpase reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10955622|imex:IM-24450-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001243378.1|refseq:XP_006714259.1|refseq:XP_006714260.1|refseq:NP_000847.2|refseq:NP_001124154.1|refseq:NP_001124155.1|refseq:NP_001124156.1|refseq:NP_001124159.1|ensembl:ENSG00000164116(gene)|ensembl:ENST00000296518(transcript)|ensembl:ENST00000455639(transcript)|ensembl:ENST00000506455(transcript)|ensembl:ENST00000511108(transcript)|ensembl:ENST00000513574(transcript)|go:"GO:0004383"(guanylate cyclase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0006182"(cGMP biosynthetic process)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0008015"(blood circulation)|go:"GO:0008074"(guanylate cyclase complex, soluble)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0020037"(heme binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0098925"(retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR011644(Haem NO binding)|interpro:IPR011645(Haem NO binding associated)|interpro:IPR018297|interpro:IPR024096|interpro:IPR029787|interpro:IPR038158|interpro:IPR042463|rcsb pdb:3UVJ|rcsb pdb:4NI2|rcsb pdb:6JT0|rcsb pdb:6JT1|rcsb pdb:6JT2|reactome:R-HSA-392154|reactome:R-HSA-445355|refseq:XP_005263012.1	go:"GO:0003924"(GTPase activity)	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:Table 2|comment:The enzyme active-site  is contributed to by  residues from both subunits, and lies at the interface between the two catalytic domains.|kinetics:"Specific Activity is 25-300 nmol/mg/min.   (full length bovine enzyme has a specific activity of 4300 nmol/mg/min.)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/29	2016/08/15	-	rogid:n1bJF3ineAG9xCfwUXgS4zrHlqA9606	-	false	32p radiolabel:?-?	sufficient binding region:468-690	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)