#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q92736	uniprotkb:P68106	intact:EBI-1170425|uniprotkb:Q15411|uniprotkb:Q546N8|uniprotkb:Q5T3P2|ensembl:ENSP00000355533	intact:EBI-6693977|uniprotkb:Q13664|uniprotkb:Q16645|uniprotkb:Q53TM2|uniprotkb:Q9BQ40|ensembl:ENSP00000370373	psi-mi:ryr2_human(display_long)|uniprotkb:RYR2(gene name)|psi-mi:RYR2(display_short)|uniprotkb:Cardiac muscle ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Cardiac muscle ryanodine receptor(gene name synonym)|uniprotkb:Type 2 ryanodine receptor(gene name synonym)	psi-mi:fkb1b_human(display_long)|uniprotkb:FKBP1B(gene name)|psi-mi:FKBP1B(display_short)|uniprotkb:FKBP12.6(gene name synonym)|uniprotkb:FKBP1L(gene name synonym)|uniprotkb:FKBP9(gene name synonym)|uniprotkb:OTK4(gene name synonym)|uniprotkb:12.6 kDa FK506-binding protein(gene name synonym)|uniprotkb:FK506-binding protein 1B(gene name synonym)|uniprotkb:Immunophilin FKBP12.6(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:h-FKBP-12(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Oda et al. (2013)	imex:IM-24148|pubmed:23233753	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10815185|imex:IM-24148-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001026.2|refseq:XP_006711868.1|ensembl:ENSG00000198626(gene)|ensembl:ENST00000366574(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014701"(junctional sarcoplasmic reticulum membrane)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043924"(suramin binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051775"(response to redox state)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072599"(establishment of protein localization to endoplasmic reticulum)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086029"(Purkinje myocyte to ventricular cardiac muscle cell signaling)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR005821(Ion transport)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|rcsb pdb:4JKQ|rcsb pdb:6Y4O|rcsb pdb:6Y4P|rcsb pdb:7KL5|reactome:R-HSA-2672351|reactome:R-HSA-5578775|dip:DIP-38325N	refseq:NP_004107.1|refseq:NP_473374.1|ensembl:ENSG00000119782(gene)|ensembl:ENST00000380986(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0009749"(response to glucose)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030018"(Z disc)|go:"GO:0030073"(insulin secretion)|go:"GO:0030551"(cyclic nucleotide binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042026"(protein refolding)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051775"(response to redox state)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|rcsb pdb:1C9H|rcsb pdb:4C02|rcsb pdb:4IQ2|rcsb pdb:4IQC|rcsb pdb:5HKG|rcsb pdb:5L1D|rcsb pdb:5T15|rcsb pdb:5T9M|rcsb pdb:5T9N|rcsb pdb:5T9R|rcsb pdb:5T9S|rcsb pdb:5T9V|rcsb pdb:5TA3|rcsb pdb:5TAL|rcsb pdb:5TAM|rcsb pdb:5TAN|rcsb pdb:5TAP|rcsb pdb:5TAQ|rcsb pdb:5TAS|rcsb pdb:5TAT|rcsb pdb:5TAU|rcsb pdb:5TAV|rcsb pdb:5TAW|rcsb pdb:5TAX|rcsb pdb:5TAY|rcsb pdb:5TAZ|rcsb pdb:5TB0|rcsb pdb:5TB1|rcsb pdb:5TB2|rcsb pdb:5TB3|rcsb pdb:5TB4|rcsb pdb:6JGZ|rcsb pdb:6JH6|rcsb pdb:6JHN|rcsb pdb:6JI0|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRR|rcsb pdb:6JRS|rcsb pdb:6M2W|rcsb pdb:6W1N|rcsb pdb:6WOT|rcsb pdb:6WOU|rcsb pdb:6WOV|rcsb pdb:6X32|rcsb pdb:6X33|rcsb pdb:6X34|rcsb pdb:6X35|rcsb pdb:6X36|rcsb pdb:7CF9|rcsb pdb:7JMF|rcsb pdb:7JMG|rcsb pdb:6PV6|rcsb pdb:7JMH|rcsb pdb:7JMI|rcsb pdb:7JMJ|reactome:R-HSA-2672351|reactome:R-HSA-5578775|dip:DIP-48796N	go:"GO:0030018"(Z disc)	-	-	figure legend:2, 7, Online Fig 2,3|kinetics:The Kd value obtained based on enhanced acceptor fluorescence was 610±61 nmol/L, and the Kd  value based on donor fluorescence quench was 450±43 nmol/L|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-myocytes)|taxid:10116(Rattus norvegicus)	kd:4.5x10^-7(molar)	2015/04/27	2015/05/22	rogid:Z3eTbcvvaCLOKWelrdkxMso6IT89606	rogid:n8ztvcTI/NJmcWSVyVusxO2BEXY9606	rigid:rK9qDqDeym6rdWxEtiL/RoIyams	false	sufficient binding region:2459-2494|fluorescent dye label:?-?	mutation:77-77,15-15,23-23|alexa 568 label:15-15	1	1	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P62161	uniprotkb:P68106	intact:EBI-397530|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q61379|uniprotkb:Q61380|dip:DIP-29528N|refseq:NP_059022|uniprotkb:P0DP30	intact:EBI-6693977|uniprotkb:Q13664|uniprotkb:Q16645|uniprotkb:Q53TM2|uniprotkb:Q9BQ40|ensembl:ENSP00000370373	psi-mi:calm_rat(display_long)|uniprotkb:Calm1(gene name)|psi-mi:Calm1(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Cam(gene name synonym)|uniprotkb:Cam1(gene name synonym)|uniprotkb:Calm2(gene name)|psi-mi:Calm2(display_short)|uniprotkb:Cam2(gene name synonym)|uniprotkb:Camb(gene name synonym)|uniprotkb:Calm3(gene name)|psi-mi:Calm3(display_short)|uniprotkb:Cam3(gene name synonym)|uniprotkb:Camc(gene name synonym)|uniprotkb:CaMII(gene name synonym)	psi-mi:fkb1b_human(display_long)|uniprotkb:FKBP1B(gene name)|psi-mi:FKBP1B(display_short)|uniprotkb:FKBP12.6(gene name synonym)|uniprotkb:FKBP1L(gene name synonym)|uniprotkb:FKBP9(gene name synonym)|uniprotkb:OTK4(gene name synonym)|uniprotkb:12.6 kDa FK506-binding protein(gene name synonym)|uniprotkb:FK506-binding protein 1B(gene name synonym)|uniprotkb:Immunophilin FKBP12.6(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:h-FKBP-12(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Oda et al. (2013)	imex:IM-24148|pubmed:23233753	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10815239|imex:IM-24148-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4G27|rcsb pdb:4G28|go:"GO:0030426"(growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:4I2Y|rcsb pdb:4IL1|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|rcsb pdb:4RJD|go:"GO:0000922"(spindle pole)|go:"GO:0005246"(calcium channel regulator activity)|rgd:2257|rgd:2258|rgd:2259|refseq:NP_036650.1|refseq:NP_059022.1|refseq:NP_114175.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|rcsb pdb:1G4Y|rcsb pdb:1NIW|rcsb pdb:1QX5|rcsb pdb:1QX7|rcsb pdb:2HQW|rcsb pdb:2PQ3|rcsb pdb:3B32|rcsb pdb:3BXK|rcsb pdb:3BXL|rcsb pdb:3CLN|rcsb pdb:3EK4|rcsb pdb:3EK7|rcsb pdb:3EK8|rcsb pdb:3EKH|rcsb pdb:3EKJ|rcsb pdb:3EVR|rcsb pdb:3EVU|rcsb pdb:3EVV|rcsb pdb:3IFK|rcsb pdb:3SG2|rcsb pdb:3SG3|rcsb pdb:3SG4|rcsb pdb:3SG5|rcsb pdb:3SG6|rcsb pdb:3SG7|rcsb pdb:3SJQ|rcsb pdb:4QNH|go:"GO:0005509"(calcium ion binding)|reactome:R-RNO-2672351|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5576892|reactome:R-RNO-5578775|reactome:R-RNO-936837|rcsb pdb:4OY4|go:"GO:0005829"(cytosol)|rcsb pdb:2YGG|go:"GO:0005886"(plasma membrane)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030017"(sarcomere)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034704"(calcium channel complex)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|reactome:R-RNO-8876725|go:"GO:0001975"(response to amphetamine)|go:"GO:0051412"(response to corticosterone)|rcsb pdb:4EHQ|rcsb pdb:4J9Y|rcsb pdb:4J9Z|reactome:R-RNO-163615|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0048306"(calcium-dependent protein binding)|rcsb pdb:2MGU|ensembl:ENSRNOT00000022603|ensembl:ENSRNOT00000064679|rcsb pdb:3WLC|rcsb pdb:3WLD|reactome:R-RNO-111932|reactome:R-RNO-111933|reactome:R-RNO-111957|reactome:R-RNO-114608|reactome:R-RNO-1474151|reactome:R-RNO-1855204|reactome:R-RNO-203615|reactome:R-RNO-2514859|reactome:R-RNO-2871809|reactome:R-RNO-4086398|reactome:R-RNO-442717|reactome:R-RNO-442729|reactome:R-RNO-442745|reactome:R-RNO-442982|reactome:R-RNO-445355|reactome:R-RNO-451308|reactome:R-RNO-5218920|reactome:R-RNO-5607763|reactome:R-RNO-5626467|reactome:R-RNO-5627123|reactome:R-RNO-5673001|reactome:R-RNO-70221|ensembl:ENSRNOG00000004060|ensembl:ENSRNOG00000016770|ensembl:ENSRNOP00000022603|ensembl:ENSRNOP00000063822|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)	refseq:NP_004107.1|refseq:NP_473374.1|ensembl:ENSG00000119782(gene)|ensembl:ENST00000380986(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0009749"(response to glucose)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030018"(Z disc)|go:"GO:0030073"(insulin secretion)|go:"GO:0030551"(cyclic nucleotide binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042026"(protein refolding)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051775"(response to redox state)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|rcsb pdb:1C9H|rcsb pdb:4C02|rcsb pdb:4IQ2|rcsb pdb:4IQC|rcsb pdb:5HKG|rcsb pdb:5L1D|rcsb pdb:5T15|rcsb pdb:5T9M|rcsb pdb:5T9N|rcsb pdb:5T9R|rcsb pdb:5T9S|rcsb pdb:5T9V|rcsb pdb:5TA3|rcsb pdb:5TAL|rcsb pdb:5TAM|rcsb pdb:5TAN|rcsb pdb:5TAP|rcsb pdb:5TAQ|rcsb pdb:5TAS|rcsb pdb:5TAT|rcsb pdb:5TAU|rcsb pdb:5TAV|rcsb pdb:5TAW|rcsb pdb:5TAX|rcsb pdb:5TAY|rcsb pdb:5TAZ|rcsb pdb:5TB0|rcsb pdb:5TB1|rcsb pdb:5TB2|rcsb pdb:5TB3|rcsb pdb:5TB4|rcsb pdb:6JGZ|rcsb pdb:6JH6|rcsb pdb:6JHN|rcsb pdb:6JI0|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRR|rcsb pdb:6JRS|rcsb pdb:6M2W|rcsb pdb:6W1N|rcsb pdb:6WOT|rcsb pdb:6WOU|rcsb pdb:6WOV|rcsb pdb:6X32|rcsb pdb:6X33|rcsb pdb:6X34|rcsb pdb:6X35|rcsb pdb:6X36|rcsb pdb:7CF9|rcsb pdb:7JMF|rcsb pdb:7JMG|rcsb pdb:6PV6|rcsb pdb:7JMH|rcsb pdb:7JMI|rcsb pdb:7JMJ|reactome:R-HSA-2672351|reactome:R-HSA-5578775|dip:DIP-48796N	go:"GO:0030018"(Z disc)	-	-	figure legend:6A, Online Fig 6|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-myocytes)|taxid:10116(Rattus norvegicus)	-	2015/04/27	2015/05/05	rogid:tTYcOd9bOh211njZVz7cYVybAMQ10116	rogid:n8ztvcTI/NJmcWSVyVusxO2BEXY9606	rigid:0NXYTv5uMQBPE43ws2Wd5BGdEoc	false	alexa 568 label:35-35|mutation:35-35	mutation:77-77,15-15,23-23|alexa 488 label:15-15	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P62161	uniprotkb:P68106	intact:EBI-397530|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q61379|uniprotkb:Q61380|dip:DIP-29528N|refseq:NP_059022|uniprotkb:P0DP30	intact:EBI-6693977|uniprotkb:Q13664|uniprotkb:Q16645|uniprotkb:Q53TM2|uniprotkb:Q9BQ40|ensembl:ENSP00000370373	psi-mi:calm_rat(display_long)|uniprotkb:Calm1(gene name)|psi-mi:Calm1(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Cam(gene name synonym)|uniprotkb:Cam1(gene name synonym)|uniprotkb:Calm2(gene name)|psi-mi:Calm2(display_short)|uniprotkb:Cam2(gene name synonym)|uniprotkb:Camb(gene name synonym)|uniprotkb:Calm3(gene name)|psi-mi:Calm3(display_short)|uniprotkb:Cam3(gene name synonym)|uniprotkb:Camc(gene name synonym)|uniprotkb:CaMII(gene name synonym)	psi-mi:fkb1b_human(display_long)|uniprotkb:FKBP1B(gene name)|psi-mi:FKBP1B(display_short)|uniprotkb:FKBP12.6(gene name synonym)|uniprotkb:FKBP1L(gene name synonym)|uniprotkb:FKBP9(gene name synonym)|uniprotkb:OTK4(gene name synonym)|uniprotkb:12.6 kDa FK506-binding protein(gene name synonym)|uniprotkb:FK506-binding protein 1B(gene name synonym)|uniprotkb:Immunophilin FKBP12.6(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:h-FKBP-12(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Oda et al. (2013)	imex:IM-24148|pubmed:23233753	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10815275|imex:IM-24148-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4G27|rcsb pdb:4G28|go:"GO:0030426"(growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:4I2Y|rcsb pdb:4IL1|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|rcsb pdb:4RJD|go:"GO:0000922"(spindle pole)|go:"GO:0005246"(calcium channel regulator activity)|rgd:2257|rgd:2258|rgd:2259|refseq:NP_036650.1|refseq:NP_059022.1|refseq:NP_114175.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|rcsb pdb:1G4Y|rcsb pdb:1NIW|rcsb pdb:1QX5|rcsb pdb:1QX7|rcsb pdb:2HQW|rcsb pdb:2PQ3|rcsb pdb:3B32|rcsb pdb:3BXK|rcsb pdb:3BXL|rcsb pdb:3CLN|rcsb pdb:3EK4|rcsb pdb:3EK7|rcsb pdb:3EK8|rcsb pdb:3EKH|rcsb pdb:3EKJ|rcsb pdb:3EVR|rcsb pdb:3EVU|rcsb pdb:3EVV|rcsb pdb:3IFK|rcsb pdb:3SG2|rcsb pdb:3SG3|rcsb pdb:3SG4|rcsb pdb:3SG5|rcsb pdb:3SG6|rcsb pdb:3SG7|rcsb pdb:3SJQ|rcsb pdb:4QNH|go:"GO:0005509"(calcium ion binding)|reactome:R-RNO-2672351|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5576892|reactome:R-RNO-5578775|reactome:R-RNO-936837|rcsb pdb:4OY4|go:"GO:0005829"(cytosol)|rcsb pdb:2YGG|go:"GO:0005886"(plasma membrane)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030017"(sarcomere)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034704"(calcium channel complex)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|reactome:R-RNO-8876725|go:"GO:0001975"(response to amphetamine)|go:"GO:0051412"(response to corticosterone)|rcsb pdb:4EHQ|rcsb pdb:4J9Y|rcsb pdb:4J9Z|reactome:R-RNO-163615|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0048306"(calcium-dependent protein binding)|rcsb pdb:2MGU|ensembl:ENSRNOT00000022603|ensembl:ENSRNOT00000064679|rcsb pdb:3WLC|rcsb pdb:3WLD|reactome:R-RNO-111932|reactome:R-RNO-111933|reactome:R-RNO-111957|reactome:R-RNO-114608|reactome:R-RNO-1474151|reactome:R-RNO-1855204|reactome:R-RNO-203615|reactome:R-RNO-2514859|reactome:R-RNO-2871809|reactome:R-RNO-4086398|reactome:R-RNO-442717|reactome:R-RNO-442729|reactome:R-RNO-442745|reactome:R-RNO-442982|reactome:R-RNO-445355|reactome:R-RNO-451308|reactome:R-RNO-5218920|reactome:R-RNO-5607763|reactome:R-RNO-5626467|reactome:R-RNO-5627123|reactome:R-RNO-5673001|reactome:R-RNO-70221|ensembl:ENSRNOG00000004060|ensembl:ENSRNOG00000016770|ensembl:ENSRNOP00000022603|ensembl:ENSRNOP00000063822|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)	refseq:NP_004107.1|refseq:NP_473374.1|ensembl:ENSG00000119782(gene)|ensembl:ENST00000380986(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0009749"(response to glucose)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030018"(Z disc)|go:"GO:0030073"(insulin secretion)|go:"GO:0030551"(cyclic nucleotide binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042026"(protein refolding)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051775"(response to redox state)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|rcsb pdb:1C9H|rcsb pdb:4C02|rcsb pdb:4IQ2|rcsb pdb:4IQC|rcsb pdb:5HKG|rcsb pdb:5L1D|rcsb pdb:5T15|rcsb pdb:5T9M|rcsb pdb:5T9N|rcsb pdb:5T9R|rcsb pdb:5T9S|rcsb pdb:5T9V|rcsb pdb:5TA3|rcsb pdb:5TAL|rcsb pdb:5TAM|rcsb pdb:5TAN|rcsb pdb:5TAP|rcsb pdb:5TAQ|rcsb pdb:5TAS|rcsb pdb:5TAT|rcsb pdb:5TAU|rcsb pdb:5TAV|rcsb pdb:5TAW|rcsb pdb:5TAX|rcsb pdb:5TAY|rcsb pdb:5TAZ|rcsb pdb:5TB0|rcsb pdb:5TB1|rcsb pdb:5TB2|rcsb pdb:5TB3|rcsb pdb:5TB4|rcsb pdb:6JGZ|rcsb pdb:6JH6|rcsb pdb:6JHN|rcsb pdb:6JI0|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRR|rcsb pdb:6JRS|rcsb pdb:6M2W|rcsb pdb:6W1N|rcsb pdb:6WOT|rcsb pdb:6WOU|rcsb pdb:6WOV|rcsb pdb:6X32|rcsb pdb:6X33|rcsb pdb:6X34|rcsb pdb:6X35|rcsb pdb:6X36|rcsb pdb:7CF9|rcsb pdb:7JMF|rcsb pdb:7JMG|rcsb pdb:6PV6|rcsb pdb:7JMH|rcsb pdb:7JMI|rcsb pdb:7JMJ|reactome:R-HSA-2672351|reactome:R-HSA-5578775|dip:DIP-48796N	go:"GO:0030018"(Z disc)	-	-	figure legend:6B, Online fig 6|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-myocytes)|taxid:10116(Rattus norvegicus)	-	2015/04/27	2015/05/06	rogid:tTYcOd9bOh211njZVz7cYVybAMQ10116	rogid:n8ztvcTI/NJmcWSVyVusxO2BEXY9606	rigid:vpC+1vpmxC0lwC5GiMfrDISk+EM	false	alexa 568 label:35-35	mutation:77-77,15-15,23-23|alexa 488 label:15-15	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P62161	uniprotkb:B0LPN4	intact:EBI-397530|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q61379|uniprotkb:Q61380|dip:DIP-29528N|refseq:NP_059022|uniprotkb:P0DP30	intact:EBI-6694167|uniprotkb:D7UNT3	psi-mi:calm_rat(display_long)|uniprotkb:Calm1(gene name)|psi-mi:Calm1(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Cam(gene name synonym)|uniprotkb:Cam1(gene name synonym)|uniprotkb:Calm2(gene name)|psi-mi:Calm2(display_short)|uniprotkb:Cam2(gene name synonym)|uniprotkb:Camb(gene name synonym)|uniprotkb:Calm3(gene name)|psi-mi:Calm3(display_short)|uniprotkb:Cam3(gene name synonym)|uniprotkb:Camc(gene name synonym)|uniprotkb:CaMII(gene name synonym)	psi-mi:ryr2_rat(display_long)|uniprotkb:Ryr2(gene name)|psi-mi:Ryr2(display_short)|uniprotkb:Cardiac muscle ryanodine receptor(gene name synonym)|uniprotkb:Cardiac muscle ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Type 2 ryanodine receptor(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Oda et al. (2013)	imex:IM-24148|pubmed:23233753	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10815275|imex:IM-24148-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4G27|rcsb pdb:4G28|go:"GO:0030426"(growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:4I2Y|rcsb pdb:4IL1|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|rcsb pdb:4RJD|go:"GO:0000922"(spindle pole)|go:"GO:0005246"(calcium channel regulator activity)|rgd:2257|rgd:2258|rgd:2259|refseq:NP_036650.1|refseq:NP_059022.1|refseq:NP_114175.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|rcsb pdb:1G4Y|rcsb pdb:1NIW|rcsb pdb:1QX5|rcsb pdb:1QX7|rcsb pdb:2HQW|rcsb pdb:2PQ3|rcsb pdb:3B32|rcsb pdb:3BXK|rcsb pdb:3BXL|rcsb pdb:3CLN|rcsb pdb:3EK4|rcsb pdb:3EK7|rcsb pdb:3EK8|rcsb pdb:3EKH|rcsb pdb:3EKJ|rcsb pdb:3EVR|rcsb pdb:3EVU|rcsb pdb:3EVV|rcsb pdb:3IFK|rcsb pdb:3SG2|rcsb pdb:3SG3|rcsb pdb:3SG4|rcsb pdb:3SG5|rcsb pdb:3SG6|rcsb pdb:3SG7|rcsb pdb:3SJQ|rcsb pdb:4QNH|go:"GO:0005509"(calcium ion binding)|reactome:R-RNO-2672351|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5576892|reactome:R-RNO-5578775|reactome:R-RNO-936837|rcsb pdb:4OY4|go:"GO:0005829"(cytosol)|rcsb pdb:2YGG|go:"GO:0005886"(plasma membrane)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030017"(sarcomere)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034704"(calcium channel complex)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|reactome:R-RNO-8876725|go:"GO:0001975"(response to amphetamine)|go:"GO:0051412"(response to corticosterone)|rcsb pdb:4EHQ|rcsb pdb:4J9Y|rcsb pdb:4J9Z|reactome:R-RNO-163615|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0048306"(calcium-dependent protein binding)|rcsb pdb:2MGU|ensembl:ENSRNOT00000022603|ensembl:ENSRNOT00000064679|rcsb pdb:3WLC|rcsb pdb:3WLD|reactome:R-RNO-111932|reactome:R-RNO-111933|reactome:R-RNO-111957|reactome:R-RNO-114608|reactome:R-RNO-1474151|reactome:R-RNO-1855204|reactome:R-RNO-203615|reactome:R-RNO-2514859|reactome:R-RNO-2871809|reactome:R-RNO-4086398|reactome:R-RNO-442717|reactome:R-RNO-442729|reactome:R-RNO-442745|reactome:R-RNO-442982|reactome:R-RNO-445355|reactome:R-RNO-451308|reactome:R-RNO-5218920|reactome:R-RNO-5607763|reactome:R-RNO-5626467|reactome:R-RNO-5627123|reactome:R-RNO-5673001|reactome:R-RNO-70221|ensembl:ENSRNOG00000004060|ensembl:ENSRNOG00000016770|ensembl:ENSRNOP00000022603|ensembl:ENSRNOP00000063822|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)	reactome:R-RNO-2672351|reactome:R-RNO-5578775|rgd:620314|refseq:NP_001177972.1|refseq:NP_114467.1|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR011992(EF-Hand type)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR005821(Ion transport)|interpro:IPR016093(MIR motif)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|rcsb pdb:2K2F|go:"GO:0001666"(response to hypoxia)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007584"(response to nutrient)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031672"(A band)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043621"(protein self-association)|go:"GO:0043924"(suramin binding)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051775"(response to redox state)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060401"(cytosolic calcium ion transport)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072599"(establishment of protein localization to endoplasmic reticulum)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086029"(Purkinje myocyte to ventricular cardiac muscle cell signaling)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097159"(organic cyclic compound binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:0098904"(regulation of AV node cell action potential)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136	go:"GO:0030018"(Z disc)	-	-	figure legend:6B, Online fig 6|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-myocytes)|taxid:10116(Rattus norvegicus)	-	2015/04/27	2015/05/06	rogid:tTYcOd9bOh211njZVz7cYVybAMQ10116	rogid:V9CmJOi3lA72yqNlhw0JGerrKUc10116	rigid:vpC+1vpmxC0lwC5GiMfrDISk+EM	false	alexa 568 label:35-35	sufficient binding region:2449-2484	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:B0LPN4	uniprotkb:P62161	intact:EBI-6694167|uniprotkb:D7UNT3	intact:EBI-397530|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q61379|uniprotkb:Q61380|dip:DIP-29528N|refseq:NP_059022|uniprotkb:P0DP30	psi-mi:ryr2_rat(display_long)|uniprotkb:Ryr2(gene name)|psi-mi:Ryr2(display_short)|uniprotkb:Cardiac muscle ryanodine receptor(gene name synonym)|uniprotkb:Cardiac muscle ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Type 2 ryanodine receptor(gene name synonym)	psi-mi:calm_rat(display_long)|uniprotkb:Calm1(gene name)|psi-mi:Calm1(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Cam(gene name synonym)|uniprotkb:Cam1(gene name synonym)|uniprotkb:Calm2(gene name)|psi-mi:Calm2(display_short)|uniprotkb:Cam2(gene name synonym)|uniprotkb:Camb(gene name synonym)|uniprotkb:Calm3(gene name)|psi-mi:Calm3(display_short)|uniprotkb:Cam3(gene name synonym)|uniprotkb:Camc(gene name synonym)|uniprotkb:CaMII(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Oda et al. (2013)	imex:IM-24148|pubmed:23233753	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10815301|imex:IM-24148-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-2672351|reactome:R-RNO-5578775|rgd:620314|refseq:NP_001177972.1|refseq:NP_114467.1|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR011992(EF-Hand type)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR005821(Ion transport)|interpro:IPR016093(MIR motif)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|rcsb pdb:2K2F|go:"GO:0001666"(response to hypoxia)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007584"(response to nutrient)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031672"(A band)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043621"(protein self-association)|go:"GO:0043924"(suramin binding)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051775"(response to redox state)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060401"(cytosolic calcium ion transport)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072599"(establishment of protein localization to endoplasmic reticulum)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086029"(Purkinje myocyte to ventricular cardiac muscle cell signaling)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097159"(organic cyclic compound binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:0098904"(regulation of AV node cell action potential)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136	rcsb pdb:4G27|rcsb pdb:4G28|go:"GO:0030426"(growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:4I2Y|rcsb pdb:4IL1|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|rcsb pdb:4RJD|go:"GO:0000922"(spindle pole)|go:"GO:0005246"(calcium channel regulator activity)|rgd:2257|rgd:2258|rgd:2259|refseq:NP_036650.1|refseq:NP_059022.1|refseq:NP_114175.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|rcsb pdb:1G4Y|rcsb pdb:1NIW|rcsb pdb:1QX5|rcsb pdb:1QX7|rcsb pdb:2HQW|rcsb pdb:2PQ3|rcsb pdb:3B32|rcsb pdb:3BXK|rcsb pdb:3BXL|rcsb pdb:3CLN|rcsb pdb:3EK4|rcsb pdb:3EK7|rcsb pdb:3EK8|rcsb pdb:3EKH|rcsb pdb:3EKJ|rcsb pdb:3EVR|rcsb pdb:3EVU|rcsb pdb:3EVV|rcsb pdb:3IFK|rcsb pdb:3SG2|rcsb pdb:3SG3|rcsb pdb:3SG4|rcsb pdb:3SG5|rcsb pdb:3SG6|rcsb pdb:3SG7|rcsb pdb:3SJQ|rcsb pdb:4QNH|go:"GO:0005509"(calcium ion binding)|reactome:R-RNO-2672351|reactome:R-RNO-418359|reactome:R-RNO-425561|reactome:R-RNO-5576892|reactome:R-RNO-5578775|reactome:R-RNO-936837|rcsb pdb:4OY4|go:"GO:0005829"(cytosol)|rcsb pdb:2YGG|go:"GO:0005886"(plasma membrane)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030017"(sarcomere)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0034704"(calcium channel complex)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|reactome:R-RNO-8876725|go:"GO:0001975"(response to amphetamine)|go:"GO:0051412"(response to corticosterone)|rcsb pdb:4EHQ|rcsb pdb:4J9Y|rcsb pdb:4J9Z|reactome:R-RNO-163615|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0048306"(calcium-dependent protein binding)|rcsb pdb:2MGU|ensembl:ENSRNOT00000022603|ensembl:ENSRNOT00000064679|rcsb pdb:3WLC|rcsb pdb:3WLD|reactome:R-RNO-111932|reactome:R-RNO-111933|reactome:R-RNO-111957|reactome:R-RNO-114608|reactome:R-RNO-1474151|reactome:R-RNO-1855204|reactome:R-RNO-203615|reactome:R-RNO-2514859|reactome:R-RNO-2871809|reactome:R-RNO-4086398|reactome:R-RNO-442717|reactome:R-RNO-442729|reactome:R-RNO-442745|reactome:R-RNO-442982|reactome:R-RNO-445355|reactome:R-RNO-451308|reactome:R-RNO-5218920|reactome:R-RNO-5607763|reactome:R-RNO-5626467|reactome:R-RNO-5627123|reactome:R-RNO-5673001|reactome:R-RNO-70221|ensembl:ENSRNOG00000004060|ensembl:ENSRNOG00000016770|ensembl:ENSRNOP00000022603|ensembl:ENSRNOP00000063822|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)	go:"GO:0030018"(Z disc)	-	-	figure legend:6C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-myocytes)|taxid:10116(Rattus norvegicus)	-	2015/04/27	2015/05/06	rogid:V9CmJOi3lA72yqNlhw0JGerrKUc10116	rogid:tTYcOd9bOh211njZVz7cYVybAMQ10116	rigid:ty51sw9yt4jrMgWXnVs4tzdTm6w	false	sufficient binding region:2449-2484|fluorescent dye label:?-?	alexa 568 label:111-111	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92736	uniprotkb:P68106	intact:EBI-1170425|uniprotkb:Q15411|uniprotkb:Q546N8|uniprotkb:Q5T3P2|ensembl:ENSP00000355533	intact:EBI-6693977|uniprotkb:Q13664|uniprotkb:Q16645|uniprotkb:Q53TM2|uniprotkb:Q9BQ40|ensembl:ENSP00000370373	psi-mi:ryr2_human(display_long)|uniprotkb:RYR2(gene name)|psi-mi:RYR2(display_short)|uniprotkb:Cardiac muscle ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Cardiac muscle ryanodine receptor(gene name synonym)|uniprotkb:Type 2 ryanodine receptor(gene name synonym)	psi-mi:fkb1b_human(display_long)|uniprotkb:FKBP1B(gene name)|psi-mi:FKBP1B(display_short)|uniprotkb:FKBP12.6(gene name synonym)|uniprotkb:FKBP1L(gene name synonym)|uniprotkb:FKBP9(gene name synonym)|uniprotkb:OTK4(gene name synonym)|uniprotkb:12.6 kDa FK506-binding protein(gene name synonym)|uniprotkb:FK506-binding protein 1B(gene name synonym)|uniprotkb:Immunophilin FKBP12.6(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:h-FKBP-12(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Oda et al. (2013)	imex:IM-24148|pubmed:23233753	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10815656|imex:IM-24148-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001026.2|refseq:XP_006711868.1|ensembl:ENSG00000198626(gene)|ensembl:ENST00000366574(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014701"(junctional sarcoplasmic reticulum membrane)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043924"(suramin binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051775"(response to redox state)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072599"(establishment of protein localization to endoplasmic reticulum)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086029"(Purkinje myocyte to ventricular cardiac muscle cell signaling)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR005821(Ion transport)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|rcsb pdb:4JKQ|rcsb pdb:6Y4O|rcsb pdb:6Y4P|rcsb pdb:7KL5|reactome:R-HSA-2672351|reactome:R-HSA-5578775|dip:DIP-38325N	refseq:NP_004107.1|refseq:NP_473374.1|ensembl:ENSG00000119782(gene)|ensembl:ENST00000380986(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0009749"(response to glucose)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030018"(Z disc)|go:"GO:0030073"(insulin secretion)|go:"GO:0030551"(cyclic nucleotide binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042026"(protein refolding)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051775"(response to redox state)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|rcsb pdb:1C9H|rcsb pdb:4C02|rcsb pdb:4IQ2|rcsb pdb:4IQC|rcsb pdb:5HKG|rcsb pdb:5L1D|rcsb pdb:5T15|rcsb pdb:5T9M|rcsb pdb:5T9N|rcsb pdb:5T9R|rcsb pdb:5T9S|rcsb pdb:5T9V|rcsb pdb:5TA3|rcsb pdb:5TAL|rcsb pdb:5TAM|rcsb pdb:5TAN|rcsb pdb:5TAP|rcsb pdb:5TAQ|rcsb pdb:5TAS|rcsb pdb:5TAT|rcsb pdb:5TAU|rcsb pdb:5TAV|rcsb pdb:5TAW|rcsb pdb:5TAX|rcsb pdb:5TAY|rcsb pdb:5TAZ|rcsb pdb:5TB0|rcsb pdb:5TB1|rcsb pdb:5TB2|rcsb pdb:5TB3|rcsb pdb:5TB4|rcsb pdb:6JGZ|rcsb pdb:6JH6|rcsb pdb:6JHN|rcsb pdb:6JI0|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRR|rcsb pdb:6JRS|rcsb pdb:6M2W|rcsb pdb:6W1N|rcsb pdb:6WOT|rcsb pdb:6WOU|rcsb pdb:6WOV|rcsb pdb:6X32|rcsb pdb:6X33|rcsb pdb:6X34|rcsb pdb:6X35|rcsb pdb:6X36|rcsb pdb:7CF9|rcsb pdb:7JMF|rcsb pdb:7JMG|rcsb pdb:6PV6|rcsb pdb:7JMH|rcsb pdb:7JMI|rcsb pdb:7JMJ|reactome:R-HSA-2672351|reactome:R-HSA-5578775|dip:DIP-48796N	go:"GO:0030018"(Z disc)	-	-	figure legend:Online fig 7|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-myocytes)|taxid:10116(Rattus norvegicus)	-	2015/04/27	2015/05/22	rogid:Z3eTbcvvaCLOKWelrdkxMso6IT89606	rogid:n8ztvcTI/NJmcWSVyVusxO2BEXY9606	rigid:rK9qDqDeym6rdWxEtiL/RoIyams	false	sufficient binding region:2459-2494|fluorescent dye label:?-?	mutation:77-77,15-15,23-23|alexa 488 label:15-15	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)