#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
reactome:R-HSA-447217	uniprotkb:Q5VWK5	intact:EBI-9992716|wwpdb:5mj4|wwpdb:3qwr|chembl target:CHEMBL2364154|wwpdb:3d87|wwpdb:3duh	intact:EBI-10248005|uniprotkb:Q8NFQ9|uniprotkb:Q96AS1|uniprotkb:Q4VGP3|uniprotkb:Q8IW84|uniprotkb:Q4VGP5|uniprotkb:Q4VGP6|uniprotkb:Q4VGP2|uniprotkb:Q5VWK7|uniprotkb:Q4VGP1|uniprotkb:Q4VGP4|uniprotkb:C9JGX4|ensembl:ENSP00000321345	psi-mi:interleukin-23_human(display_short)|psi-mi:R-HSA-447217(display_long)|intact:IL-23 complex(complex synonym)|intact:Interleukin-23 complex(complex recommended name)|intact:"IL12B:IL23A"(complex systematic name)|intact:p19p40 complex(complex synonym)|intact:IL23 complex(complex synonym)|intact:p19-p40 complex(complex synonym)	psi-mi:il23r_human(display_long)|uniprotkb:IL23R(gene name)|psi-mi:IL23R(display_short)	psi-mi:"MI:0276"(blue native page)	Guo et al. (2011)	pubmed:23029144|imex:IM-24364	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10915922|imex:IM-24364-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:25516297(see-also)|intact:EBI-9633865(exp-evidence)|go:"GO:0005125"(cytokine activity)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|pubmed:19088061(see-also)|pubmed:12023369(see-also)|pubmed:12417590(see-also)|pubmed:16482511(see-also)|pubmed:11114383(see-also)|pubmed:18680750(see-also)|go:"GO:0045519"(interleukin-23 receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0006955"(immune response)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0070743"(interleukin-23 complex)|efo:"EFO:0000685"(see-also)|efo:"EFO:0002690"(see-also)|efo:"EFO:0000706"(see-also)|efo:"EFO:0000384"(see-also)|efo:"EFO:0003885"(see-also)|efo:"EFO:0000676"(see-also)|efo:"Orphanet:319558"(see-also)|evidence ontology:"ECO:0000353"|complex portal:CPX-3290(complex-primary)	refseq:NP_653302.2|refseq:XP_005270573.1|refseq:XP_011539092.1|refseq:XP_011539093.1|ensembl:ENSG00000162594(gene)|ensembl:ENST00000347310(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0038155"(interleukin-23-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043235"(receptor complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0072536"(interleukin-23 receptor complex)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|rcsb pdb:5MZV|rcsb pdb:6WDQ|reactome:R-HSA-6785807|reactome:R-HSA-9020933	-	disease:"Psoriasis [EFO:0000676]: a common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis."|disease:"Rheumatoid arthritis [EFO:0000685]: a rheumatologic autoimmune disease characterized especially by pain, stiffness, inflammation, swelling, and sometimes destruction of joints. Usually chronic, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures."|disease:"Mendelian susceptibility to mycobacterial diseases due to complete IL12B deficiency (MSMD) [Orphanet:319558]: an autosomal recessive disorder due to complete interleukin-12 subunit beta (IL12B) deficiency is a genetic variant of MSMD characterized by mild bacillus Calmette-Guerin (BCG) infections and recurrent Salmonella infections. Presents in early childhood. BCG is the most common infection encountered, usually after receiving the vaccination. Non-typhoidal Salmonella infections are also seen in half of all cases. Other infections have been reported, including chronic mucocutaneous candidiasis (CMC), nocardiosis, and klebsiellosis. Incomplete clinical penetrance observed in this immunodeficiency."|disease:"Crohn's disease [EFO:0000384]: a chronic transmural inflammation that may involve any part of the digestive tract from mouth to anus, mostly found in the ileum, the cecum, and the colon. In Crohn disease, the inflammation, extending through the intestinal wall from the mucosa to the serosa, is characteristically asymmetric and segmental. Epithelioid granulomas may be seen in some patients."|disease:"Spondyloarthropathy [EFO:0000706]: a heterogeneous group of arthritic diseases sharing clinical and radiologic features. They are associated with the HLA-B27 antigen and some with a triggering infection. Most involve the axial joints in the spine, particularly the sacroiliac joint, but can also involve asymmetric peripheral joints. Subsets include ankylosing spondylitis; reactive arthritis; psoratic arthritis; and others."|disease:"Systemic lupus erythematosus [EFO:0002690]: a chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow."|disease:"Multiple sclerosis [EFO:0003885]: an autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery but acute fulminating and chronic progressive forms also occur."|curated-complex:"Cytokine complex that activates and stimulates proliferation of a wide range of lymphocytes, in particular memory T cells and Th17 cells, upon binding to its receptor subunits IL12RB1 (P42701) and IL23R (Q5VWK5). Formation of the ligand-receptor complex (CPX-383) and tyrosine phosphorylation of the IL23R subunit initiates the JAK-STAT signaling cascade which ultimately activates transcription of interferon-gamma or Interleukin-17. Produced by antigen-presenting cells in response to Interleukin-18. Associated with the pathogenesis of autoimmune inflammations, including rheumatoid and Lyme arthritis, multiple sclerosis, psoriasis, and inflammatory bowel disease as well as mycobacterial diseases of varying severity, primarily bacillus Calmette-Guerin and Salmonella infections."|complex-assembly:Heterodimer	-	figure legend:2A|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/08	2015/07/20	-	rogid:j3Kjewnfoxv3Dvie81Sh0xkasn89606	-	false	sufficient binding region:21-189|sufficient binding region:23-328	sufficient binding region:124-313(IPR013783)	-	-	psi-mi:"MI:0817"(molecular weight estimation by silver staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)
reactome:R-HSA-447217	uniprotkb:Q5VWK5	intact:EBI-9992716|wwpdb:5mj4|wwpdb:3qwr|chembl target:CHEMBL2364154|wwpdb:3d87|wwpdb:3duh	intact:EBI-10248005|uniprotkb:Q8NFQ9|uniprotkb:Q96AS1|uniprotkb:Q4VGP3|uniprotkb:Q8IW84|uniprotkb:Q4VGP5|uniprotkb:Q4VGP6|uniprotkb:Q4VGP2|uniprotkb:Q5VWK7|uniprotkb:Q4VGP1|uniprotkb:Q4VGP4|uniprotkb:C9JGX4|ensembl:ENSP00000321345	psi-mi:interleukin-23_human(display_short)|psi-mi:R-HSA-447217(display_long)|intact:IL-23 complex(complex synonym)|intact:Interleukin-23 complex(complex recommended name)|intact:"IL12B:IL23A"(complex systematic name)|intact:p19p40 complex(complex synonym)|intact:IL23 complex(complex synonym)|intact:p19-p40 complex(complex synonym)	psi-mi:il23r_human(display_long)|uniprotkb:IL23R(gene name)|psi-mi:IL23R(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Guo et al. (2011)	pubmed:23029144|imex:IM-24364	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10904784|imex:IM-24364-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	pubmed:25516297(see-also)|intact:EBI-9633865(exp-evidence)|go:"GO:0005125"(cytokine activity)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|pubmed:19088061(see-also)|pubmed:12023369(see-also)|pubmed:12417590(see-also)|pubmed:16482511(see-also)|pubmed:11114383(see-also)|pubmed:18680750(see-also)|go:"GO:0045519"(interleukin-23 receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0006955"(immune response)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0070743"(interleukin-23 complex)|efo:"EFO:0000685"(see-also)|efo:"EFO:0002690"(see-also)|efo:"EFO:0000706"(see-also)|efo:"EFO:0000384"(see-also)|efo:"EFO:0003885"(see-also)|efo:"EFO:0000676"(see-also)|efo:"Orphanet:319558"(see-also)|evidence ontology:"ECO:0000353"|complex portal:CPX-3290(complex-primary)	refseq:NP_653302.2|refseq:XP_005270573.1|refseq:XP_011539092.1|refseq:XP_011539093.1|ensembl:ENSG00000162594(gene)|ensembl:ENST00000347310(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0038155"(interleukin-23-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043235"(receptor complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0072536"(interleukin-23 receptor complex)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|rcsb pdb:5MZV|rcsb pdb:6WDQ|reactome:R-HSA-6785807|reactome:R-HSA-9020933	-	disease:"Psoriasis [EFO:0000676]: a common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis."|disease:"Rheumatoid arthritis [EFO:0000685]: a rheumatologic autoimmune disease characterized especially by pain, stiffness, inflammation, swelling, and sometimes destruction of joints. Usually chronic, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures."|disease:"Mendelian susceptibility to mycobacterial diseases due to complete IL12B deficiency (MSMD) [Orphanet:319558]: an autosomal recessive disorder due to complete interleukin-12 subunit beta (IL12B) deficiency is a genetic variant of MSMD characterized by mild bacillus Calmette-Guerin (BCG) infections and recurrent Salmonella infections. Presents in early childhood. BCG is the most common infection encountered, usually after receiving the vaccination. Non-typhoidal Salmonella infections are also seen in half of all cases. Other infections have been reported, including chronic mucocutaneous candidiasis (CMC), nocardiosis, and klebsiellosis. Incomplete clinical penetrance observed in this immunodeficiency."|disease:"Crohn's disease [EFO:0000384]: a chronic transmural inflammation that may involve any part of the digestive tract from mouth to anus, mostly found in the ileum, the cecum, and the colon. In Crohn disease, the inflammation, extending through the intestinal wall from the mucosa to the serosa, is characteristically asymmetric and segmental. Epithelioid granulomas may be seen in some patients."|disease:"Spondyloarthropathy [EFO:0000706]: a heterogeneous group of arthritic diseases sharing clinical and radiologic features. They are associated with the HLA-B27 antigen and some with a triggering infection. Most involve the axial joints in the spine, particularly the sacroiliac joint, but can also involve asymmetric peripheral joints. Subsets include ankylosing spondylitis; reactive arthritis; psoratic arthritis; and others."|disease:"Systemic lupus erythematosus [EFO:0002690]: a chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow."|disease:"Multiple sclerosis [EFO:0003885]: an autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery but acute fulminating and chronic progressive forms also occur."|curated-complex:"Cytokine complex that activates and stimulates proliferation of a wide range of lymphocytes, in particular memory T cells and Th17 cells, upon binding to its receptor subunits IL12RB1 (P42701) and IL23R (Q5VWK5). Formation of the ligand-receptor complex (CPX-383) and tyrosine phosphorylation of the IL23R subunit initiates the JAK-STAT signaling cascade which ultimately activates transcription of interferon-gamma or Interleukin-17. Produced by antigen-presenting cells in response to Interleukin-18. Associated with the pathogenesis of autoimmune inflammations, including rheumatoid and Lyme arthritis, multiple sclerosis, psoriasis, and inflammatory bowel disease as well as mycobacterial diseases of varying severity, primarily bacillus Calmette-Guerin and Salmonella infections."|complex-assembly:Heterodimer	-	figure legend:2C|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/08	2015/07/20	-	rogid:j3Kjewnfoxv3Dvie81Sh0xkasn89606	-	false	sufficient binding region:21-189|sufficient binding region:23-328	sufficient binding region:124-313(IPR003961)	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)