#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q15049	uniprotkb:P05026	intact:EBI-8475277|uniprotkb:Q9UGY8|intact:MINT-8417695|uniprotkb:Q8TAG4|uniprotkb:Q96RP5|uniprotkb:Q5JZ83|uniprotkb:B3KW61|uniprotkb:B7Z659|ensembl:ENSP00000310375|ensembl:ENSP00000379216	intact:EBI-714630|ensembl:ENSP00000356789|ensembl:ENSP00000356790|uniprotkb:Q5TGZ3	psi-mi:mlc1_human(display_long)|uniprotkb:MLC1(gene name)|psi-mi:MLC1(display_short)|uniprotkb:KIAA0027(gene name synonym)|uniprotkb:WKL1(gene name synonym)	psi-mi:at1b1_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:ATP1B(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Lanciotti et al. (2012)	imex:IM-23856|pubmed:22328087	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10095331|imex:IM-23856-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_631941.1|refseq:NP_055981.1|refseq:XP_016884160.1|ensembl:ENSG00000100427(gene)|ensembl:ENST00000311597(transcript)|ensembl:ENST00000395876(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006811"(ion transport)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0072584"(caveolin-mediated endocytosis)|interpro:IPR033280|mint:Q15049	ensembl:ENSG00000143153(gene)|ensembl:ENST00000367815(transcript)|ensembl:ENST00000367816(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P05026|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001668.1	omim:60400(see-also)|go:"GO:0005886"(plasma membrane)	comment:mint|comment:homomint|comment:"MLC1 mutant ser246 (variant in MLC1) does colocalize at plasma membrane"	-	figure legend:3|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u251)|taxid:9606(Homo sapiens)	-	2015/01/23	2015/01/23	rogid:iUNxhRAjiFIKlH5ymoTQghg3B3A9606	rogid:kE/mTDRgwTdf/AWUD0ZFpPN4FkE9606	intact-crc:84623246255BBA19|rigid:diHi49s8zdpFN8+wUu8ok8li/cI	false	his tag:n-n|mutation disrupting interaction:125-125|mutation disrupting interaction:280-280	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
chebi:"CHEBI:472805"	uniprotkb:Q9HBA0	intact:EBI-10103896|chebi:"CHEBI:44461"|chebi:"CHEBI:7805"	intact:EBI-962786|uniprotkb:Q17R79|uniprotkb:Q2Y122|uniprotkb:Q2Y123|ensembl:ENSP00000261740|ensembl:ENSP00000406191|ensembl:ENSP00000502135|uniprotkb:Q2Y124|uniprotkb:B7ZKQ6|uniprotkb:Q86YZ6|uniprotkb:Q8NDY7|uniprotkb:Q8NG64|uniprotkb:Q96Q92|uniprotkb:Q96RS7|uniprotkb:Q9HBC0	psi-mi:ouabain(display_short)|psi-mi:"CHEBI:472805"(display_long)|intact:"3-(alpha-L-rhamnopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(synonym)|intact:G-Strophanthin(synonym)|intact:Ouabagenin L-Rhamnoside(synonym)|intact:Ouabagenin-L-rhamnosid(synonym)|intact:Ouabain(synonym)|intact:Ouabain anhydrous(synonym)|intact:Ouabaine(synonym)|intact:Oubain(synonym)|intact:Strodival(synonym)|intact:"3-(6-deoxy-alpha-L-mannopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(iupac name)	psi-mi:trpv4_human(display_long)|uniprotkb:TRPV4(gene name)|psi-mi:TRPV4(display_short)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:VRL2(gene name synonym)|uniprotkb:VROAC(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Lanciotti et al. (2012)	imex:IM-23856|pubmed:22328087	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10634050|imex:IM-23856-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:0050891"(multicellular organismal water homeostasis)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|rcsb pdb:4DX1|rcsb pdb:4DX2|reactome:R-HSA-3295583|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|ensembl:ENSG00000111199(gene)|ensembl:ENST00000261740(transcript)|ensembl:ENST00000418703(transcript)|ensembl:ENST00000675670(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0032587"(ruffle membrane)|refseq:NP_671737.1|refseq:NP_001170899.1|refseq:NP_001170902.1|refseq:NP_001170904.1|refseq:NP_067638.3|refseq:XP_016875263.1|refseq:XP_005253975.1|dip:DIP-35702N	omim:604004(see-also)	inchi key:LPMXVESGRSUGHW-HBYQJFLCSA-N	-	figure legend:Fig. 9|comment:"Copurification under isoosmotic conditions with wildtype MLC1 overexpressed (not shown on blot). Overexpression of MLC1 ser246arg resulted in copurification of aquaporin-4. Overexpressing  MLC1 ser280leu disrupted the copurifiction. Overexpressing MLC1 cys125arg resulted in less Aquaporin-4 copurified."|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u251)|taxid:9606(Homo sapiens)	-	2015/01/23	2015/02/16	-	rogid:R4tV4g+95OnxFkwxAKG51FeKNZA9606	intact-crc:3A93BB9563CA4B3C	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:472805"	uniprotkb:Q14CZ8	intact:EBI-10103896|chebi:"CHEBI:44461"|chebi:"CHEBI:7805"	intact:EBI-10104873|uniprotkb:Q67IP8|uniprotkb:Q6ZWL4|uniprotkb:Q8N7I3|uniprotkb:Q8ND35|ensembl:ENSP00000298251	psi-mi:ouabain(display_short)|psi-mi:"CHEBI:472805"(display_long)|intact:"3-(alpha-L-rhamnopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(synonym)|intact:G-Strophanthin(synonym)|intact:Ouabagenin L-Rhamnoside(synonym)|intact:Ouabagenin-L-rhamnosid(synonym)|intact:Ouabain(synonym)|intact:Ouabain anhydrous(synonym)|intact:Ouabaine(synonym)|intact:Oubain(synonym)|intact:Strodival(synonym)|intact:"3-(6-deoxy-alpha-L-mannopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(iupac name)	psi-mi:hecam_human(display_long)|uniprotkb:HEPACAM(gene name)|psi-mi:HEPACAM(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Lanciotti et al. (2012)	imex:IM-23856|pubmed:22328087	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10634050|imex:IM-23856-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_689935.2|ensembl:ENSG00000165478(gene)|ensembl:ENST00000298251(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0034613"(cellular protein localization)|go:"GO:0040008"(regulation of growth)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179	omim:604004(see-also)	inchi key:LPMXVESGRSUGHW-HBYQJFLCSA-N	-	figure legend:Fig. 9|comment:"Copurification under isoosmotic conditions with wildtype MLC1 overexpressed (not shown on blot). Overexpression of MLC1 ser246arg resulted in copurification of aquaporin-4. Overexpressing  MLC1 ser280leu disrupted the copurifiction. Overexpressing MLC1 cys125arg resulted in less Aquaporin-4 copurified."|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u251)|taxid:9606(Homo sapiens)	-	2015/01/23	2015/02/16	-	rogid:ovkHCS+FUtkzqf91owx0whXgAko9606	intact-crc:3A93BB9563CA4B3C	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:472805"	uniprotkb:Q9HBA0	intact:EBI-10103896|chebi:"CHEBI:44461"|chebi:"CHEBI:7805"	intact:EBI-962786|uniprotkb:Q17R79|uniprotkb:Q2Y122|uniprotkb:Q2Y123|ensembl:ENSP00000261740|ensembl:ENSP00000406191|ensembl:ENSP00000502135|uniprotkb:Q2Y124|uniprotkb:B7ZKQ6|uniprotkb:Q86YZ6|uniprotkb:Q8NDY7|uniprotkb:Q8NG64|uniprotkb:Q96Q92|uniprotkb:Q96RS7|uniprotkb:Q9HBC0	psi-mi:ouabain(display_short)|psi-mi:"CHEBI:472805"(display_long)|intact:"3-(alpha-L-rhamnopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(synonym)|intact:G-Strophanthin(synonym)|intact:Ouabagenin L-Rhamnoside(synonym)|intact:Ouabagenin-L-rhamnosid(synonym)|intact:Ouabain(synonym)|intact:Ouabain anhydrous(synonym)|intact:Ouabaine(synonym)|intact:Oubain(synonym)|intact:Strodival(synonym)|intact:"3-(6-deoxy-alpha-L-mannopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(iupac name)	psi-mi:trpv4_human(display_long)|uniprotkb:TRPV4(gene name)|psi-mi:TRPV4(display_short)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Vanilloid receptor-like channel 2(gene name synonym)|uniprotkb:Vanilloid receptor-like protein 2(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)|uniprotkb:Transient receptor potential protein 12(gene name synonym)|uniprotkb:VRL2(gene name synonym)|uniprotkb:VROAC(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Lanciotti et al. (2012)	imex:IM-23856|pubmed:22328087	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10104867|imex:IM-23856-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:0050891"(multicellular organismal water homeostasis)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|rcsb pdb:4DX1|rcsb pdb:4DX2|reactome:R-HSA-3295583|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|ensembl:ENSG00000111199(gene)|ensembl:ENST00000261740(transcript)|ensembl:ENST00000418703(transcript)|ensembl:ENST00000675670(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0032587"(ruffle membrane)|refseq:NP_671737.1|refseq:NP_001170899.1|refseq:NP_001170902.1|refseq:NP_001170904.1|refseq:NP_067638.3|refseq:XP_016875263.1|refseq:XP_005253975.1|dip:DIP-35702N	omim:604004(see-also)	inchi key:LPMXVESGRSUGHW-HBYQJFLCSA-N	-	figure legend:fig. 9|comment:Copurification under hypoosmotic conditions with MLC1 wildtype overexpressed. Overexpression of MLC1 ser246arg resulred in loss of aquaporin-4 and less Hepacam copurified. Overexpression of MLC1 ser280leu disrupted the copurification at all. Overexpression of MLC1 cys125arg resulted in less TRP4 and Hepacam and no aquaporin-4 copurified.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u251)|taxid:9606(Homo sapiens)	-	2015/01/23	2015/02/16	-	rogid:R4tV4g+95OnxFkwxAKG51FeKNZA9606	intact-crc:C7E829E98A9064AF	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:472805"	uniprotkb:P55087	intact:EBI-10103896|chebi:"CHEBI:44461"|chebi:"CHEBI:7805"	intact:EBI-10104898|uniprotkb:P78564|ensembl:ENSP00000372654|ensembl:ENSP00000500720	psi-mi:ouabain(display_short)|psi-mi:"CHEBI:472805"(display_long)|intact:"3-(alpha-L-rhamnopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(synonym)|intact:G-Strophanthin(synonym)|intact:Ouabagenin L-Rhamnoside(synonym)|intact:Ouabagenin-L-rhamnosid(synonym)|intact:Ouabain(synonym)|intact:Ouabain anhydrous(synonym)|intact:Ouabaine(synonym)|intact:Oubain(synonym)|intact:Strodival(synonym)|intact:"3-(6-deoxy-alpha-L-mannopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(iupac name)	psi-mi:aqp4_human(display_long)|uniprotkb:AQP4(gene name)|psi-mi:AQP4(display_short)|uniprotkb:Mercurial-insensitive water channel(gene name synonym)|uniprotkb:WCH4(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Lanciotti et al. (2012)	imex:IM-23856|pubmed:22328087	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10104867|imex:IM-23856-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001641.1|refseq:NP_004019.1|ensembl:ENSG00000171885(gene)|ensembl:ENST00000383168(transcript)|ensembl:ENST00000672188(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006833"(water transport)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0010008"(endosome membrane)|go:"GO:0015250"(water channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030104"(water homeostasis)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097450"(astrocyte end-foot)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR034294|rcsb pdb:3GD8|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-48842N	omim:604004(see-also)	inchi key:LPMXVESGRSUGHW-HBYQJFLCSA-N	-	figure legend:fig. 9|comment:Copurification under hypoosmotic conditions with MLC1 wildtype overexpressed. Overexpression of MLC1 ser246arg resulred in loss of aquaporin-4 and less Hepacam copurified. Overexpression of MLC1 ser280leu disrupted the copurification at all. Overexpression of MLC1 cys125arg resulted in less TRP4 and Hepacam and no aquaporin-4 copurified.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u251)|taxid:9606(Homo sapiens)	-	2015/01/23	2015/02/16	-	rogid:emloJNSTB0zSwtP91cSKBBr4PA89606	intact-crc:C7E829E98A9064AF	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:472805"	uniprotkb:Q14CZ8	intact:EBI-10103896|chebi:"CHEBI:44461"|chebi:"CHEBI:7805"	intact:EBI-10104873|uniprotkb:Q67IP8|uniprotkb:Q6ZWL4|uniprotkb:Q8N7I3|uniprotkb:Q8ND35|ensembl:ENSP00000298251	psi-mi:ouabain(display_short)|psi-mi:"CHEBI:472805"(display_long)|intact:"3-(alpha-L-rhamnopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(synonym)|intact:G-Strophanthin(synonym)|intact:Ouabagenin L-Rhamnoside(synonym)|intact:Ouabagenin-L-rhamnosid(synonym)|intact:Ouabain(synonym)|intact:Ouabain anhydrous(synonym)|intact:Ouabaine(synonym)|intact:Oubain(synonym)|intact:Strodival(synonym)|intact:"3-(6-deoxy-alpha-L-mannopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(iupac name)	psi-mi:hecam_human(display_long)|uniprotkb:HEPACAM(gene name)|psi-mi:HEPACAM(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Lanciotti et al. (2012)	imex:IM-23856|pubmed:22328087	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10104867|imex:IM-23856-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_689935.2|ensembl:ENSG00000165478(gene)|ensembl:ENST00000298251(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0034613"(cellular protein localization)|go:"GO:0040008"(regulation of growth)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179	omim:604004(see-also)	inchi key:LPMXVESGRSUGHW-HBYQJFLCSA-N	-	figure legend:fig. 9|comment:Copurification under hypoosmotic conditions with MLC1 wildtype overexpressed. Overexpression of MLC1 ser246arg resulred in loss of aquaporin-4 and less Hepacam copurified. Overexpression of MLC1 ser280leu disrupted the copurification at all. Overexpression of MLC1 cys125arg resulted in less TRP4 and Hepacam and no aquaporin-4 copurified.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u251)|taxid:9606(Homo sapiens)	-	2015/01/23	2015/02/16	-	rogid:ovkHCS+FUtkzqf91owx0whXgAko9606	intact-crc:C7E829E98A9064AF	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:472805"	uniprotkb:P05026	intact:EBI-10103896|chebi:"CHEBI:44461"|chebi:"CHEBI:7805"	intact:EBI-714630|ensembl:ENSP00000356789|ensembl:ENSP00000356790|uniprotkb:Q5TGZ3	psi-mi:ouabain(display_short)|psi-mi:"CHEBI:472805"(display_long)|intact:"3-(alpha-L-rhamnopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(synonym)|intact:G-Strophanthin(synonym)|intact:Ouabagenin L-Rhamnoside(synonym)|intact:Ouabagenin-L-rhamnosid(synonym)|intact:Ouabain(synonym)|intact:Ouabain anhydrous(synonym)|intact:Ouabaine(synonym)|intact:Oubain(synonym)|intact:Strodival(synonym)|intact:"3-(6-deoxy-alpha-L-mannopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(iupac name)	psi-mi:at1b1_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:ATP1B(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Lanciotti et al. (2012)	imex:IM-23856|pubmed:22328087	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10104795|imex:IM-23856-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000143153(gene)|ensembl:ENST00000367815(transcript)|ensembl:ENST00000367816(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P05026|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001668.1	omim:604004(see-also)	inchi key:LPMXVESGRSUGHW-HBYQJFLCSA-N	-	figure legend:4; 3rd and S2|comment:"Transfected and overexpressed MLC1 with ser280leu (variant in MLC1 (Leukoencephalopathy, megalencephalic, with subcortical cysts, 1; MIM:60400; UniProt FTId VAR_011702) was not copurified (isoosmotic and hypoosmotic conditions)"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u251)|taxid:9606(Homo sapiens)	-	2015/01/23	2015/02/04	-	rogid:kE/mTDRgwTdf/AWUD0ZFpPN4FkE9606	intact-crc:14B223E5566F00B8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:472805"	uniprotkb:Q15049	intact:EBI-10103896|chebi:"CHEBI:44461"|chebi:"CHEBI:7805"	intact:EBI-8475277|uniprotkb:Q9UGY8|intact:MINT-8417695|uniprotkb:Q8TAG4|uniprotkb:Q96RP5|uniprotkb:Q5JZ83|uniprotkb:B3KW61|uniprotkb:B7Z659|ensembl:ENSP00000310375|ensembl:ENSP00000379216	psi-mi:ouabain(display_short)|psi-mi:"CHEBI:472805"(display_long)|intact:"3-(alpha-L-rhamnopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(synonym)|intact:G-Strophanthin(synonym)|intact:Ouabagenin L-Rhamnoside(synonym)|intact:Ouabagenin-L-rhamnosid(synonym)|intact:Ouabain(synonym)|intact:Ouabain anhydrous(synonym)|intact:Ouabaine(synonym)|intact:Oubain(synonym)|intact:Strodival(synonym)|intact:"3-(6-deoxy-alpha-L-mannopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(iupac name)	psi-mi:mlc1_human(display_long)|uniprotkb:MLC1(gene name)|psi-mi:MLC1(display_short)|uniprotkb:KIAA0027(gene name synonym)|uniprotkb:WKL1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Lanciotti et al. (2012)	imex:IM-23856|pubmed:22328087	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10104774|imex:IM-23856-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_631941.1|refseq:NP_055981.1|refseq:XP_016884160.1|ensembl:ENSG00000100427(gene)|ensembl:ENST00000311597(transcript)|ensembl:ENST00000395876(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006811"(ion transport)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0072584"(caveolin-mediated endocytosis)|interpro:IPR033280|mint:Q15049	omim:604004(see-also)	inchi key:LPMXVESGRSUGHW-HBYQJFLCSA-N	comment:mint|comment:homomint	figure legend:4; 2nd and S2|comment:syntrophin was shown to be copurifying but cannot be mapped to UniProt as the used antibody is not specific|comment:copurification in isoosomotic and hypoosmotic conditions|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u251)|taxid:9606(Homo sapiens)	-	2015/01/23	2015/02/04	-	rogid:iUNxhRAjiFIKlH5ymoTQghg3B3A9606	intact-crc:5A8F7BAB62BC10FA	false	-	his tag:n-n|mutation:246-246	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:472805"	uniprotkb:P05026	intact:EBI-10103896|chebi:"CHEBI:44461"|chebi:"CHEBI:7805"	intact:EBI-714630|ensembl:ENSP00000356789|ensembl:ENSP00000356790|uniprotkb:Q5TGZ3	psi-mi:ouabain(display_short)|psi-mi:"CHEBI:472805"(display_long)|intact:"3-(alpha-L-rhamnopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(synonym)|intact:G-Strophanthin(synonym)|intact:Ouabagenin L-Rhamnoside(synonym)|intact:Ouabagenin-L-rhamnosid(synonym)|intact:Ouabain(synonym)|intact:Ouabain anhydrous(synonym)|intact:Ouabaine(synonym)|intact:Oubain(synonym)|intact:Strodival(synonym)|intact:"3-(6-deoxy-alpha-L-mannopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(iupac name)	psi-mi:at1b1_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:ATP1B(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Lanciotti et al. (2012)	imex:IM-23856|pubmed:22328087	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10104774|imex:IM-23856-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000143153(gene)|ensembl:ENST00000367815(transcript)|ensembl:ENST00000367816(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P05026|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001668.1	omim:604004(see-also)	inchi key:LPMXVESGRSUGHW-HBYQJFLCSA-N	-	figure legend:4; 2nd and S2|comment:syntrophin was shown to be copurifying but cannot be mapped to UniProt as the used antibody is not specific|comment:copurification in isoosomotic and hypoosmotic conditions|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u251)|taxid:9606(Homo sapiens)	-	2015/01/23	2015/02/04	-	rogid:kE/mTDRgwTdf/AWUD0ZFpPN4FkE9606	intact-crc:5A8F7BAB62BC10FA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:472805"	uniprotkb:Q15049	intact:EBI-10103896|chebi:"CHEBI:44461"|chebi:"CHEBI:7805"	intact:EBI-8475277|uniprotkb:Q9UGY8|intact:MINT-8417695|uniprotkb:Q8TAG4|uniprotkb:Q96RP5|uniprotkb:Q5JZ83|uniprotkb:B3KW61|uniprotkb:B7Z659|ensembl:ENSP00000310375|ensembl:ENSP00000379216	psi-mi:ouabain(display_short)|psi-mi:"CHEBI:472805"(display_long)|intact:"3-(alpha-L-rhamnopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(synonym)|intact:G-Strophanthin(synonym)|intact:Ouabagenin L-Rhamnoside(synonym)|intact:Ouabagenin-L-rhamnosid(synonym)|intact:Ouabain(synonym)|intact:Ouabain anhydrous(synonym)|intact:Ouabaine(synonym)|intact:Oubain(synonym)|intact:Strodival(synonym)|intact:"3-(6-deoxy-alpha-L-mannopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(iupac name)	psi-mi:mlc1_human(display_long)|uniprotkb:MLC1(gene name)|psi-mi:MLC1(display_short)|uniprotkb:KIAA0027(gene name synonym)|uniprotkb:WKL1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Lanciotti et al. (2012)	imex:IM-23856|pubmed:22328087	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10104814|imex:IM-23856-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_631941.1|refseq:NP_055981.1|refseq:XP_016884160.1|ensembl:ENSG00000100427(gene)|ensembl:ENST00000311597(transcript)|ensembl:ENST00000395876(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006811"(ion transport)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0072584"(caveolin-mediated endocytosis)|interpro:IPR033280|mint:Q15049	omim:604004(see-also)	inchi key:LPMXVESGRSUGHW-HBYQJFLCSA-N	comment:mint|comment:homomint	figure legend:4; 4th right and S2|comment:syntrophin was shown to be copurifying but cannot be mapped to UniProt as the used antibody is not specific|comment:MLC1 copurified in isoosmotic but not in hypoosmoti conditions|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u251)|taxid:9606(Homo sapiens)	-	2015/01/23	2015/02/04	-	rogid:iUNxhRAjiFIKlH5ymoTQghg3B3A9606	intact-crc:451690367FB8BD7D	false	-	mutation:125-125|his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:472805"	uniprotkb:P05026	intact:EBI-10103896|chebi:"CHEBI:44461"|chebi:"CHEBI:7805"	intact:EBI-714630|ensembl:ENSP00000356789|ensembl:ENSP00000356790|uniprotkb:Q5TGZ3	psi-mi:ouabain(display_short)|psi-mi:"CHEBI:472805"(display_long)|intact:"3-(alpha-L-rhamnopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(synonym)|intact:G-Strophanthin(synonym)|intact:Ouabagenin L-Rhamnoside(synonym)|intact:Ouabagenin-L-rhamnosid(synonym)|intact:Ouabain(synonym)|intact:Ouabain anhydrous(synonym)|intact:Ouabaine(synonym)|intact:Oubain(synonym)|intact:Strodival(synonym)|intact:"3-(6-deoxy-alpha-L-mannopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(iupac name)	psi-mi:at1b1_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:ATP1B(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Lanciotti et al. (2012)	imex:IM-23856|pubmed:22328087	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10104814|imex:IM-23856-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000143153(gene)|ensembl:ENST00000367815(transcript)|ensembl:ENST00000367816(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P05026|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001668.1	omim:604004(see-also)	inchi key:LPMXVESGRSUGHW-HBYQJFLCSA-N	-	figure legend:4; 4th right and S2|comment:syntrophin was shown to be copurifying but cannot be mapped to UniProt as the used antibody is not specific|comment:MLC1 copurified in isoosmotic but not in hypoosmoti conditions|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u251)|taxid:9606(Homo sapiens)	-	2015/01/23	2015/02/04	-	rogid:kE/mTDRgwTdf/AWUD0ZFpPN4FkE9606	intact-crc:451690367FB8BD7D	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:472805"	uniprotkb:Q15049	intact:EBI-10103896|chebi:"CHEBI:44461"|chebi:"CHEBI:7805"	intact:EBI-8475277|uniprotkb:Q9UGY8|intact:MINT-8417695|uniprotkb:Q8TAG4|uniprotkb:Q96RP5|uniprotkb:Q5JZ83|uniprotkb:B3KW61|uniprotkb:B7Z659|ensembl:ENSP00000310375|ensembl:ENSP00000379216	psi-mi:ouabain(display_short)|psi-mi:"CHEBI:472805"(display_long)|intact:"3-(alpha-L-rhamnopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(synonym)|intact:G-Strophanthin(synonym)|intact:Ouabagenin L-Rhamnoside(synonym)|intact:Ouabagenin-L-rhamnosid(synonym)|intact:Ouabain(synonym)|intact:Ouabain anhydrous(synonym)|intact:Ouabaine(synonym)|intact:Oubain(synonym)|intact:Strodival(synonym)|intact:"3-(6-deoxy-alpha-L-mannopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(iupac name)	psi-mi:mlc1_human(display_long)|uniprotkb:MLC1(gene name)|psi-mi:MLC1(display_short)|uniprotkb:KIAA0027(gene name synonym)|uniprotkb:WKL1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Lanciotti et al. (2012)	imex:IM-23856|pubmed:22328087	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10095367|imex:IM-23856-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_631941.1|refseq:NP_055981.1|refseq:XP_016884160.1|ensembl:ENSG00000100427(gene)|ensembl:ENST00000311597(transcript)|ensembl:ENST00000395876(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006811"(ion transport)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0072584"(caveolin-mediated endocytosis)|interpro:IPR033280|mint:Q15049	omim:604004(see-also)	inchi key:LPMXVESGRSUGHW-HBYQJFLCSA-N	comment:mint|comment:homomint	figure legend:4; 1st left and S2|comment:syntrophin was shown to be copurifying but cannot be mapped to UniProt as the used antibody is not specific|comment:MLC1 and ATP1B1 copurified in isoosmotic and hypoosmotic conditions|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u251)|taxid:9606(Homo sapiens)	-	2015/01/23	2015/02/04	-	rogid:iUNxhRAjiFIKlH5ymoTQghg3B3A9606	intact-crc:B14DCAC7A873D93B	false	-	his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:472805"	uniprotkb:P05026	intact:EBI-10103896|chebi:"CHEBI:44461"|chebi:"CHEBI:7805"	intact:EBI-714630|ensembl:ENSP00000356789|ensembl:ENSP00000356790|uniprotkb:Q5TGZ3	psi-mi:ouabain(display_short)|psi-mi:"CHEBI:472805"(display_long)|intact:"3-(alpha-L-rhamnopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(synonym)|intact:G-Strophanthin(synonym)|intact:Ouabagenin L-Rhamnoside(synonym)|intact:Ouabagenin-L-rhamnosid(synonym)|intact:Ouabain(synonym)|intact:Ouabain anhydrous(synonym)|intact:Ouabaine(synonym)|intact:Oubain(synonym)|intact:Strodival(synonym)|intact:"3-(6-deoxy-alpha-L-mannopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(iupac name)	psi-mi:at1b1_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:ATP1B(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Lanciotti et al. (2012)	imex:IM-23856|pubmed:22328087	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10095367|imex:IM-23856-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000143153(gene)|ensembl:ENST00000367815(transcript)|ensembl:ENST00000367816(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P05026|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001668.1	omim:604004(see-also)	inchi key:LPMXVESGRSUGHW-HBYQJFLCSA-N	-	figure legend:4; 1st left and S2|comment:syntrophin was shown to be copurifying but cannot be mapped to UniProt as the used antibody is not specific|comment:MLC1 and ATP1B1 copurified in isoosmotic and hypoosmotic conditions|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u251)|taxid:9606(Homo sapiens)	-	2015/01/23	2015/02/04	-	rogid:kE/mTDRgwTdf/AWUD0ZFpPN4FkE9606	intact-crc:B14DCAC7A873D93B	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:472805"	uniprotkb:P78508	intact:EBI-10103896|chebi:"CHEBI:44461"|chebi:"CHEBI:7805"	intact:EBI-9117877|uniprotkb:A3KME7|uniprotkb:Q5VUT9|uniprotkb:Q8N4I7|uniprotkb:Q92808|ensembl:ENSP00000491250|ensembl:ENSP00000492619|ensembl:ENSP00000495557	psi-mi:ouabain(display_short)|psi-mi:"CHEBI:472805"(display_long)|intact:"3-(alpha-L-rhamnopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(synonym)|intact:G-Strophanthin(synonym)|intact:Ouabagenin L-Rhamnoside(synonym)|intact:Ouabagenin-L-rhamnosid(synonym)|intact:Ouabain(synonym)|intact:Ouabain anhydrous(synonym)|intact:Ouabaine(synonym)|intact:Oubain(synonym)|intact:Strodival(synonym)|intact:"3-(6-deoxy-alpha-L-mannopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide"(iupac name)	psi-mi:kcj10_human(display_long)|uniprotkb:KCNJ10(gene name)|psi-mi:KCNJ10(display_short)|uniprotkb:ATP-dependent inwardly rectifying potassium channel Kir4.1(gene name synonym)|uniprotkb:"Inward rectifier K(+) channel Kir1.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 10(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Lanciotti et al. (2012)	imex:IM-23856|pubmed:22328087	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10095367|imex:IM-23856-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002232.2|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0044297"(cell body)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0051935"(glutamate reuptake)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097546"(ciliary base)|go:"GO:0098793"(presynapse)|go:"GO:1905515"(non-motile cilium assembly)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR003269(Potassium channel, inwardly rectifying, Kir1.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|interpro:IPR040445|interpro:IPR041647|reactome:R-HSA-1296041|reactome:R-HSA-1296067|reactome:R-HSA-997272|ensembl:ENSG00000177807(gene)|ensembl:ENST00000638728(transcript)|ensembl:ENST00000638868(transcript)|ensembl:ENST00000644903(transcript)|go:"GO:0005242"(inward rectifier potassium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007601"(visual perception)|go:"GO:0007628"(adult walking behavior)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)	omim:604004(see-also)	inchi key:LPMXVESGRSUGHW-HBYQJFLCSA-N	-	figure legend:4; 1st left and S2|comment:syntrophin was shown to be copurifying but cannot be mapped to UniProt as the used antibody is not specific|comment:MLC1 and ATP1B1 copurified in isoosmotic and hypoosmotic conditions|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u251)|taxid:9606(Homo sapiens)	-	2015/01/23	2015/02/04	-	rogid:4RhA3NWgH7eTMHQt0ovdxr/S5849606	intact-crc:B14DCAC7A873D93B	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15049	uniprotkb:P07340	intact:EBI-8475277|uniprotkb:Q9UGY8|intact:MINT-8417695|uniprotkb:Q8TAG4|uniprotkb:Q96RP5|uniprotkb:Q5JZ83|uniprotkb:B3KW61|uniprotkb:B7Z659|ensembl:ENSP00000310375|ensembl:ENSP00000379216	intact:EBI-2640714|uniprotkb:Q63062|ensembl:ENSRNOP00000003932	psi-mi:mlc1_human(display_long)|uniprotkb:MLC1(gene name)|psi-mi:MLC1(display_short)|uniprotkb:KIAA0027(gene name synonym)|uniprotkb:WKL1(gene name synonym)	psi-mi:at1b1_rat(display_long)|uniprotkb:Atp1b1(gene name)|psi-mi:Atp1b1(display_short)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lanciotti et al. (2012)	imex:IM-23856|pubmed:22328087	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10095479|imex:IM-23856-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_631941.1|refseq:NP_055981.1|refseq:XP_016884160.1|ensembl:ENSG00000100427(gene)|ensembl:ENST00000311597(transcript)|ensembl:ENST00000395876(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006811"(ion transport)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0072584"(caveolin-mediated endocytosis)|interpro:IPR033280|mint:Q15049	rgd:2170|refseq:NP_037245.2|ensembl:ENSRNOG00000002934(gene)|ensembl:ENSRNOT00000003932(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0001824"(blastocyst development)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030001"(metal ion transport)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:0030315"(T-tubule)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P07340|reactome:R-RNO-210991|reactome:R-RNO-5578775|reactome:R-RNO-936837|go:"GO:1990573"(potassium ion import across plasma membrane)	go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)	comment:mint|comment:homomint	-	figure legend:8|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/01/23	2015/01/23	rogid:iUNxhRAjiFIKlH5ymoTQghg3B3A9606	rogid:gJJ7PU6Tz3znT4wWy7GIPSV/x9w10116	intact-crc:6322C74D324733A5|rigid:6tSaliH1Hx6UYY6d46rZKCkpo5k	false	his tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15049	uniprotkb:Q9ERZ8	intact:EBI-8475277|uniprotkb:Q9UGY8|intact:MINT-8417695|uniprotkb:Q8TAG4|uniprotkb:Q96RP5|uniprotkb:Q5JZ83|uniprotkb:B3KW61|uniprotkb:B7Z659|ensembl:ENSP00000310375|ensembl:ENSP00000379216	intact:EBI-10095418|ensembl:ENSRNOP00000001586	psi-mi:mlc1_human(display_long)|uniprotkb:MLC1(gene name)|psi-mi:MLC1(display_short)|uniprotkb:KIAA0027(gene name synonym)|uniprotkb:WKL1(gene name synonym)	psi-mi:trpv4_rat(display_long)|uniprotkb:Trpv4(gene name)|psi-mi:Trpv4(display_short)|uniprotkb:Vroac(gene name synonym)|uniprotkb:Osm-9-like TRP channel 4(gene name synonym)|uniprotkb:Vanilloid receptor-related osmotically-activated channel(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lanciotti et al. (2012)	imex:IM-23856|pubmed:22328087	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10095479|imex:IM-23856-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_631941.1|refseq:NP_055981.1|refseq:XP_016884160.1|ensembl:ENSG00000100427(gene)|ensembl:ENST00000311597(transcript)|ensembl:ENST00000395876(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006811"(ion transport)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0072584"(caveolin-mediated endocytosis)|interpro:IPR033280|mint:Q15049	rgd:69337|refseq:NP_076460.1|refseq:XP_006249528.1|ensembl:ENSRNOG00000001195(gene)|ensembl:ENSRNOT00000001586(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005034"(osmosensor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006971"(hypotonic response)|go:"GO:0007015"(actin filament organization)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015275"(stretch-activated, cation-selective, calcium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030103"(vasopressin secretion)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032868"(response to insulin)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042538"(hyperosmotic salinity response)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0071477"(cellular hypotonic salinity response)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071642"(positive regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0097009"(energy homeostasis)|go:"GO:0097497"(blood vessel endothelial cell delamination)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:1902656"(calcium ion import into cytosol)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|interpro:IPR002110(Ankyrin)|interpro:IPR005821(Ion transport)|interpro:IPR008347(Vanilloid receptor)|interpro:IPR008348(Vanilloid receptor 2)|interpro:IPR024862|interpro:IPR036770|reactome:R-RNO-3295583|dip:DIP-59600N	go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)	comment:mint|comment:homomint	-	figure legend:8|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/01/23	2015/01/23	rogid:iUNxhRAjiFIKlH5ymoTQghg3B3A9606	rogid:K9C+gk06aTVdE0P7gtn/xrhej0I10116	intact-crc:6322C74D324733A5|rigid:6tSaliH1Hx6UYY6d46rZKCkpo5k	false	his tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15049	uniprotkb:P05026	intact:EBI-8475277|uniprotkb:Q9UGY8|intact:MINT-8417695|uniprotkb:Q8TAG4|uniprotkb:Q96RP5|uniprotkb:Q5JZ83|uniprotkb:B3KW61|uniprotkb:B7Z659|ensembl:ENSP00000310375|ensembl:ENSP00000379216	intact:EBI-714630|ensembl:ENSP00000356789|ensembl:ENSP00000356790|uniprotkb:Q5TGZ3	psi-mi:mlc1_human(display_long)|uniprotkb:MLC1(gene name)|psi-mi:MLC1(display_short)|uniprotkb:KIAA0027(gene name synonym)|uniprotkb:WKL1(gene name synonym)	psi-mi:at1b1_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:ATP1B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lanciotti et al. (2012)	imex:IM-23856|pubmed:22328087	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10095804|imex:IM-23856-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_631941.1|refseq:NP_055981.1|refseq:XP_016884160.1|ensembl:ENSG00000100427(gene)|ensembl:ENST00000311597(transcript)|ensembl:ENST00000395876(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006811"(ion transport)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0047484"(regulation of response to osmotic stress)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0072584"(caveolin-mediated endocytosis)|interpro:IPR033280|mint:Q15049	ensembl:ENSG00000143153(gene)|ensembl:ENST00000367815(transcript)|ensembl:ENST00000367816(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P05026|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001668.1	omim:604004(see-also)	comment:mint|comment:homomint	-	figure legend:S1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/01/23	2015/01/23	rogid:iUNxhRAjiFIKlH5ymoTQghg3B3A9606	rogid:kE/mTDRgwTdf/AWUD0ZFpPN4FkE9606	intact-crc:AF7572DD88D59241|rigid:diHi49s8zdpFN8+wUu8ok8li/cI	false	mutation decreasing interaction:280-280|mutation decreasing interaction:246-246|mutation disrupting interaction:125-125|his tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)