#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P23443 uniprotkb:O60346 intact:EBI-1775921|uniprotkb:B2R779|uniprotkb:B4DTG1|uniprotkb:F6UYM1|intact:EBI-11107861|uniprotkb:B4DLT4|uniprotkb:E7ESB8|uniprotkb:Q7Z721|ensembl:ENSP00000225577 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 psi-mi:ks6b1_human(display_long)|uniprotkb:RPS6KB1(gene name)|psi-mi:RPS6KB1(display_short)|uniprotkb:STK14A(gene name synonym)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 14A(gene name synonym) psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Liu et al. (2011) pubmed:21986499|imex:IM-24282 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10829921|imex:IM-24282-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003152.1|refseq:NP_001258989.1|refseq:NP_001258971.1|refseq:NP_001258972.1|refseq:NP_001258973.1|dip:DIP-29986N|ensembl:ENSG00000108443(gene)|ensembl:ENST00000225577(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:P23443|rcsb pdb:3A60|rcsb pdb:3A61|rcsb pdb:3A62|rcsb pdb:3WE4|rcsb pdb:3WF5|rcsb pdb:3WF6|rcsb pdb:3WF7|rcsb pdb:3WF8|rcsb pdb:3WF9|rcsb pdb:4L3J|rcsb pdb:4L3L|rcsb pdb:4L42|rcsb pdb:4L43|rcsb pdb:4L44|rcsb pdb:4L45|rcsb pdb:4L46|rcsb pdb:4RLO|rcsb pdb:4RLP|rcsb pdb:5WBH|rcsb pdb:5WBK|reactome:R-HSA-166208 ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 - - - figure legend:5A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ht_29)|taxid:9606(Homo sapiens HT-29 caucasian women with colon adenocarcinoma) - 2015/06/05 2015/06/15 rogid:rEFXLi6QTM8wdG7FNx1er6EzPFM9606 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 rigid:ceaqWGhaoyypi2ajoqHb8U4gz00 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P23443 uniprotkb:Q6ZVD8 intact:EBI-1775921|uniprotkb:B2R779|uniprotkb:B4DTG1|uniprotkb:F6UYM1|intact:EBI-11107861|uniprotkb:B4DLT4|uniprotkb:E7ESB8|uniprotkb:Q7Z721|ensembl:ENSP00000225577 intact:EBI-2511496|uniprotkb:Q9NV17|uniprotkb:Q9Y2E3|uniprotkb:A1L374|ensembl:ENSP00000457991 psi-mi:ks6b1_human(display_long)|uniprotkb:RPS6KB1(gene name)|psi-mi:RPS6KB1(display_short)|uniprotkb:STK14A(gene name synonym)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 14A(gene name synonym) psi-mi:phlp2_human(display_long)|uniprotkb:PHLPP2(gene name)|psi-mi:PHLPP2(display_short)|uniprotkb:KIAA0931(gene name synonym)|uniprotkb:PHLPPL(gene name synonym)|uniprotkb:PH domain leucine-rich repeat-containing protein phosphatase-like(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Liu et al. (2011) pubmed:21986499|imex:IM-24282 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10829921|imex:IM-24282-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003152.1|refseq:NP_001258989.1|refseq:NP_001258971.1|refseq:NP_001258972.1|refseq:NP_001258973.1|dip:DIP-29986N|ensembl:ENSG00000108443(gene)|ensembl:ENST00000225577(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:P23443|rcsb pdb:3A60|rcsb pdb:3A61|rcsb pdb:3A62|rcsb pdb:3WE4|rcsb pdb:3WF5|rcsb pdb:3WF6|rcsb pdb:3WF7|rcsb pdb:3WF8|rcsb pdb:3WF9|rcsb pdb:4L3J|rcsb pdb:4L3L|rcsb pdb:4L42|rcsb pdb:4L43|rcsb pdb:4L44|rcsb pdb:4L45|rcsb pdb:4L46|rcsb pdb:4RLO|rcsb pdb:4RLP|rcsb pdb:5WBH|rcsb pdb:5WBK|reactome:R-HSA-166208 refseq:NP_001275932.1|refseq:NP_055835.2|dip:DIP-53556N|ensembl:ENSG00000040199(gene)|ensembl:ENST00000568954(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0021766"(hippocampus development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036457|reactome:R-HSA-199418 - - - figure legend:5A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ht_29)|taxid:9606(Homo sapiens HT-29 caucasian women with colon adenocarcinoma) - 2015/06/05 2015/06/15 rogid:rEFXLi6QTM8wdG7FNx1er6EzPFM9606 rogid:Z6e8RRJ8TleJRWTlecN3DNu1Ums9606 rigid:ceaqWGhaoyypi2ajoqHb8U4gz00 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P23443 uniprotkb:P55884 intact:EBI-1775921|uniprotkb:B2R779|uniprotkb:B4DTG1|uniprotkb:F6UYM1|intact:EBI-11107861|uniprotkb:B4DLT4|uniprotkb:E7ESB8|uniprotkb:Q7Z721|ensembl:ENSP00000225577 intact:EBI-366696|uniprotkb:Q2NL77|uniprotkb:Q9UMF9|uniprotkb:A4D208|ensembl:ENSP00000354125|ensembl:ENSP00000380206 psi-mi:ks6b1_human(display_long)|uniprotkb:RPS6KB1(gene name)|psi-mi:RPS6KB1(display_short)|uniprotkb:STK14A(gene name synonym)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 14A(gene name synonym) psi-mi:eif3b_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 9(gene name synonym)|uniprotkb:eIF-3-eta(gene name synonym)|uniprotkb:eIF3 p116(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym)|uniprotkb:Prt1 homolog(gene name synonym)|uniprotkb:EIF3B(gene name)|psi-mi:EIF3B(display_short)|uniprotkb:EIF3S9(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Liu et al. (2011) pubmed:21986499|imex:IM-24282 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-10829963|imex:IM-24282-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003152.1|refseq:NP_001258989.1|refseq:NP_001258971.1|refseq:NP_001258972.1|refseq:NP_001258973.1|dip:DIP-29986N|ensembl:ENSG00000108443(gene)|ensembl:ENST00000225577(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:P23443|rcsb pdb:3A60|rcsb pdb:3A61|rcsb pdb:3A62|rcsb pdb:3WE4|rcsb pdb:3WF5|rcsb pdb:3WF6|rcsb pdb:3WF7|rcsb pdb:3WF8|rcsb pdb:3WF9|rcsb pdb:4L3J|rcsb pdb:4L3L|rcsb pdb:4L42|rcsb pdb:4L43|rcsb pdb:4L44|rcsb pdb:4L45|rcsb pdb:4L46|rcsb pdb:4RLO|rcsb pdb:4RLP|rcsb pdb:5WBH|rcsb pdb:5WBK|reactome:R-HSA-166208 refseq:NP_001032360.1|refseq:NP_003742.2|refseq:XP_011513901.1|refseq:XP_011513902.1|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|ensembl:ENSG00000106263(gene)|ensembl:ENST00000360876(transcript)|ensembl:ENST00000397011(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR011400(Translation initiation factor eIF-3b)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR034363|interpro:IPR035979|mint:P55884|rcsb pdb:2KRB|rcsb pdb:2NLW|rcsb pdb:5K1H|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:XP_016868241.1|dip:DIP-31113N - - - figure legend:6B|comment:Association decreased upon knockdown of PHLPP1 or PHLPP2.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ht_29)|taxid:9606(Homo sapiens HT-29 caucasian women with colon adenocarcinoma) - 2015/06/05 2015/06/05 rogid:rEFXLi6QTM8wdG7FNx1er6EzPFM9606 rogid:MxQFPvmuOcO/S+4NqzToozWr8K89606 rigid:Dtx8pXgN3nVWMDyns4D+O3KvDCg false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P23443 uniprotkb:O60346 intact:EBI-1775921|uniprotkb:B2R779|uniprotkb:B4DTG1|uniprotkb:F6UYM1|intact:EBI-11107861|uniprotkb:B4DLT4|uniprotkb:E7ESB8|uniprotkb:Q7Z721|ensembl:ENSP00000225577 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 psi-mi:ks6b1_human(display_long)|uniprotkb:RPS6KB1(gene name)|psi-mi:RPS6KB1(display_short)|uniprotkb:STK14A(gene name synonym)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 14A(gene name synonym) psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Liu et al. (2011) pubmed:21986499|imex:IM-24282 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10829931|imex:IM-24282-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003152.1|refseq:NP_001258989.1|refseq:NP_001258971.1|refseq:NP_001258972.1|refseq:NP_001258973.1|dip:DIP-29986N|ensembl:ENSG00000108443(gene)|ensembl:ENST00000225577(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:P23443|rcsb pdb:3A60|rcsb pdb:3A61|rcsb pdb:3A62|rcsb pdb:3WE4|rcsb pdb:3WF5|rcsb pdb:3WF6|rcsb pdb:3WF7|rcsb pdb:3WF8|rcsb pdb:3WF9|rcsb pdb:4L3J|rcsb pdb:4L3L|rcsb pdb:4L42|rcsb pdb:4L43|rcsb pdb:4L44|rcsb pdb:4L45|rcsb pdb:4L46|rcsb pdb:4RLO|rcsb pdb:4RLP|rcsb pdb:5WBH|rcsb pdb:5WBK|reactome:R-HSA-166208 ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 - - - figure legend:5A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293e)|taxid:9606(Human HEK293E or 293 c18 cell line) - 2015/06/05 2015/06/15 rogid:rEFXLi6QTM8wdG7FNx1er6EzPFM9606 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 rigid:ceaqWGhaoyypi2ajoqHb8U4gz00 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P23443 uniprotkb:Q6ZVD8 intact:EBI-1775921|uniprotkb:B2R779|uniprotkb:B4DTG1|uniprotkb:F6UYM1|intact:EBI-11107861|uniprotkb:B4DLT4|uniprotkb:E7ESB8|uniprotkb:Q7Z721|ensembl:ENSP00000225577 intact:EBI-2511496|uniprotkb:Q9NV17|uniprotkb:Q9Y2E3|uniprotkb:A1L374|ensembl:ENSP00000457991 psi-mi:ks6b1_human(display_long)|uniprotkb:RPS6KB1(gene name)|psi-mi:RPS6KB1(display_short)|uniprotkb:STK14A(gene name synonym)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 14A(gene name synonym) psi-mi:phlp2_human(display_long)|uniprotkb:PHLPP2(gene name)|psi-mi:PHLPP2(display_short)|uniprotkb:KIAA0931(gene name synonym)|uniprotkb:PHLPPL(gene name synonym)|uniprotkb:PH domain leucine-rich repeat-containing protein phosphatase-like(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Liu et al. (2011) pubmed:21986499|imex:IM-24282 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-10829931|imex:IM-24282-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003152.1|refseq:NP_001258989.1|refseq:NP_001258971.1|refseq:NP_001258972.1|refseq:NP_001258973.1|dip:DIP-29986N|ensembl:ENSG00000108443(gene)|ensembl:ENST00000225577(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:P23443|rcsb pdb:3A60|rcsb pdb:3A61|rcsb pdb:3A62|rcsb pdb:3WE4|rcsb pdb:3WF5|rcsb pdb:3WF6|rcsb pdb:3WF7|rcsb pdb:3WF8|rcsb pdb:3WF9|rcsb pdb:4L3J|rcsb pdb:4L3L|rcsb pdb:4L42|rcsb pdb:4L43|rcsb pdb:4L44|rcsb pdb:4L45|rcsb pdb:4L46|rcsb pdb:4RLO|rcsb pdb:4RLP|rcsb pdb:5WBH|rcsb pdb:5WBK|reactome:R-HSA-166208 refseq:NP_001275932.1|refseq:NP_055835.2|dip:DIP-53556N|ensembl:ENSG00000040199(gene)|ensembl:ENST00000568954(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0021766"(hippocampus development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036457|reactome:R-HSA-199418 - - - figure legend:5A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293e)|taxid:9606(Human HEK293E or 293 c18 cell line) - 2015/06/05 2015/06/15 rogid:rEFXLi6QTM8wdG7FNx1er6EzPFM9606 rogid:Z6e8RRJ8TleJRWTlecN3DNu1Ums9606 rigid:ceaqWGhaoyypi2ajoqHb8U4gz00 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P67999 uniprotkb:O60346 intact:EBI-2639458|uniprotkb:P21425|ensembl:ENSRNOP00000005226 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 psi-mi:ks6b1_rat(display_long)|uniprotkb:Rps6kb1(gene name)|psi-mi:Rps6kb1(display_short)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym) psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:"MI:0434"(phosphatase assay) Liu et al. (2011) pubmed:21986499|imex:IM-24282 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0203"(dephosphorylation reaction) psi-mi:"MI:0486"(UniProt) intact:EBI-10829953|imex:IM-24282-3 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:620683|refseq:NP_114191.1|ensembl:ENSRNOG00000003919(gene)|ensembl:ENSRNOT00000005226(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0009408"(response to heat)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009749"(response to glucose)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0033762"(response to glucagon)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043201"(response to leucine)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0106311"|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:P67999|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|reactome:R-RNO-166208|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0106310"(protein serine kinase activity) ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 go:"GO:0006470"(protein dephosphorylation)|go:"GO:0004721"(phosphoprotein phosphatase activity) - - figure legend:5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/06/05 2015/06/05 rogid:hBuNefgCfqyO/LhEhClgcQrTjlM10116 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 rigid:hikn0ceQjFRM3LYLudvCZgCDFp0 false O-phospho-L-threonine:252-252|O-phospho-L-threonine:412-412 sufficient binding region:1165..1165-1422..1422 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8BSK8 uniprotkb:Q8JZQ9 intact:EBI-646423|uniprotkb:Q5SWG1|uniprotkb:Q8CHX0|ensembl:ENSMUSP00000119715 intact:EBI-4286513|uniprotkb:Q922K2|ensembl:ENSMUSP00000098076 psi-mi:ks6b1_mouse(display_long)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:Rps6kb1(gene name)|psi-mi:Rps6kb1(display_short) psi-mi:eif3b_mouse(display_long)|uniprotkb:Eif3b(gene name)|psi-mi:Eif3b(display_short)|uniprotkb:eIF3 p116(gene name synonym)|uniprotkb:Eif3s9(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 9(gene name synonym)|uniprotkb:eIF-3-eta(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Liu et al. (2011) pubmed:21986499|imex:IM-24282 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-10829976|imex:IM-24282-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001107806.1|ensembl:ENSMUSG00000020516(gene)|ensembl:ENSMUST00000154617(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0009408"(response to heat)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009749"(response to glucose)|go:"GO:0009986"(cell surface)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0033762"(response to glucagon)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043201"(response to leucine)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|reactome:R-MMU-166208 refseq:NP_598677.1|ensembl:ENSMUSG00000056076(gene)|ensembl:ENSMUST00000100507(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045202"(synapse)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR034363|interpro:IPR035979|mint:Q8JZQ9|reactome:R-MMU-156827|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR011400(Translation initiation factor eIF-3b)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait) - - - figure legend:6C|comment:The association is decreased upon knock down of Phlpp1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2015/06/05 2015/06/05 rogid:uJPo7NVO75oHLm1/ZRG3W8uF//s10090 rogid:Mi9GReY+V693P20QOUsHizsl5DY10090 rigid:5bMtEj/DEneUbMciULa/qwCMUE4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P67999 uniprotkb:P67999 intact:EBI-2639458|uniprotkb:P21425|ensembl:ENSRNOP00000005226 intact:EBI-2639458|uniprotkb:P21425|ensembl:ENSRNOP00000005226 psi-mi:ks6b1_rat(display_long)|uniprotkb:Rps6kb1(gene name)|psi-mi:Rps6kb1(display_short)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym) psi-mi:ks6b1_rat(display_long)|uniprotkb:Rps6kb1(gene name)|psi-mi:Rps6kb1(display_short)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Liu et al. (2011) pubmed:21986499|imex:IM-24282 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0486"(UniProt) intact:EBI-10889339|imex:IM-24282-6 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:620683|refseq:NP_114191.1|ensembl:ENSRNOG00000003919(gene)|ensembl:ENSRNOT00000005226(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0009408"(response to heat)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009749"(response to glucose)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0033762"(response to glucagon)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043201"(response to leucine)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0106311"|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:P67999|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|reactome:R-RNO-166208|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0106310"(protein serine kinase activity) rgd:620683|refseq:NP_114191.1|ensembl:ENSRNOG00000003919(gene)|ensembl:ENSRNOT00000005226(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0009408"(response to heat)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009749"(response to glucose)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0033762"(response to glucagon)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043201"(response to leucine)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0106311"|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:P67999|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|reactome:R-RNO-166208|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0106310"(protein serine kinase activity) go:"GO:0004672"(protein kinase activity)|go:"GO:0046777"(protein autophosphorylation) - - figure legend:5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/06/05 2015/06/25 rogid:hBuNefgCfqyO/LhEhClgcQrTjlM10116 rogid:hBuNefgCfqyO/LhEhClgcQrTjlM10116 rigid:fc0pe+eKxaV1OKBUuNnulqhjcls false - - - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P62754 uniprotkb:P67999 intact:EBI-2000022|uniprotkb:P08227|uniprotkb:P10660|ensembl:ENSMUSP00000099878 intact:EBI-2639458|uniprotkb:P21425|ensembl:ENSRNOP00000005226 psi-mi:rs6_mouse(display_long)|uniprotkb:Rps6(gene name)|psi-mi:Rps6(display_short)|uniprotkb:Phosphoprotein NP33(gene name synonym) psi-mi:ks6b1_rat(display_long)|uniprotkb:Rps6kb1(gene name)|psi-mi:Rps6kb1(display_short)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Liu et al. (2011) pubmed:21986499|imex:IM-24282 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0486"(UniProt) intact:EBI-10889351|imex:IM-24282-7 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033122.1|refseq:XP_011238179.1|ensembl:ENSMUSG00000028495(gene)|ensembl:ENSMUST00000102814(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001890"(placenta development)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005844"(polysome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0007369"(gastrulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015935"(small ribosomal subunit)|interpro:IPR018282|mint:P62754|reactome:R-MMU-156827|go:"GO:0019901"(protein kinase binding)|go:"GO:0022605"(mammalian oogenesis stage)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030425"(dendrite)|go:"GO:0031929"(TOR signaling)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048821"(erythrocyte development)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001377(Ribosomal protein S6e)|interpro:IPR014401(Ribosomal protein S6, eukaryotic)|dip:DIP-42772N|reactome:R-MMU-166208|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957 rgd:620683|refseq:NP_114191.1|ensembl:ENSRNOG00000003919(gene)|ensembl:ENSRNOT00000005226(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0009408"(response to heat)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009749"(response to glucose)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0033762"(response to glucagon)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043201"(response to leucine)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0106311"|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:P67999|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|reactome:R-RNO-166208|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0106310"(protein serine kinase activity) go:"GO:0004672"(protein kinase activity)|go:"GO:0046777"(protein autophosphorylation) - - figure legend:5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/06/05 2015/06/15 rogid:beDuXCIqL99V9JlVfpzx7MdpH6810090 rogid:hBuNefgCfqyO/LhEhClgcQrTjlM10116 rigid:C74qCTlgSHUcCi5ZGQkGtquki6c false glutathione s tranferase tag:?-? - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)