#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P37088	uniprotkb:P51170	intact:EBI-7845444|ensembl:ENSP00000228916|intact:MINT-198663|uniprotkb:O43271|uniprotkb:Q9UM64|uniprotkb:C5HTZ0|uniprotkb:B4E2Q5|uniprotkb:A5X2U9|uniprotkb:Q6GSQ6	intact:EBI-2547354|ensembl:ENSP00000300061|uniprotkb:P78437|uniprotkb:Q6PCC2|uniprotkb:Q93023|uniprotkb:Q93024|uniprotkb:Q93025|uniprotkb:Q93026|uniprotkb:Q93027|uniprotkb:Q96TD2	psi-mi:scnna_human(display_long)|uniprotkb:SCNN1A(gene name)|psi-mi:SCNN1A(display_short)|uniprotkb:SCNN1(gene name synonym)|uniprotkb:"Epithelial Na(+) channel subunit alpha"(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit alpha(gene name synonym)|uniprotkb:SCNEA(gene name synonym)|uniprotkb:Alpha-NaCH(gene name synonym)	psi-mi:scnng_human(display_long)|uniprotkb:SCNN1G(gene name)|psi-mi:SCNN1G(display_short)|uniprotkb:"Epithelial Na(+) channel subunit gamma"(gene name synonym)|uniprotkb:SCNEG(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit gamma(gene name synonym)|uniprotkb:Gamma-NaCH(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Stewart et al. (2011)	pubmed:21775436|imex:IM-24737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11422502|imex:IM-24737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111319(gene)|ensembl:ENST00000228916(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050896"(response to stimulus)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097228"(sperm principal piece)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|rcsb pdb:2M3O|rcsb pdb:6BQN|rcsb pdb:6WTH|reactome:R-HSA-2672351|refseq:NP_001153048.1|refseq:NP_001153047.1|refseq:NP_001029.1	ensembl:ENSG00000166828(gene)|ensembl:ENST00000300061(transcript)|go:"GO:0005272"(sodium channel activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007588"(excretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0005216"(ion channel activity)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|rcsb pdb:6BQN|rcsb pdb:6WTH|reactome:R-HSA-2672351|refseq:NP_001030.2	-	comment:mint|function:"Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception"|function:"Defects in SCNN1A are a cause of autosomal recessive pseudohypoaldosteronism type 1 (PHA1) [MIM:264350]. PHA1 is a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. There are 2 forms of PHA1: the autosomal recessive form that is severe, and the dominant form which is more milder and due to defects in mineralocorticoid receptor. Autosomal recessive PHA1 is characterized by an often fulminant presentation in the neonatal period with dehydration, hyponatraemia, hyperkalaemia, metabolic acidosis, failure to thrive and weight loss"	-	figure legend:Fig. 2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-tsa201)|taxid:9606(Homo sapiens subclone of human embryonic kidney 293 cell line that expresses simian virus 40 T antigen)	-	2015/11/24	2015/11/24	rogid:gVnl0rzupzTZyIbIL8BogbWXkAU9606	rogid:y3n1CDg1c7oj3ugrx9Kur21BmNk9606	rigid:fQfFv3A1Zn2oi3slA6ZAKsfkzbI	false	ha tag:n-n|flag tag:c-c	ha tag:n-n|v5 tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P37088	uniprotkb:P51168	intact:EBI-7845444|ensembl:ENSP00000228916|intact:MINT-198663|uniprotkb:O43271|uniprotkb:Q9UM64|uniprotkb:C5HTZ0|uniprotkb:B4E2Q5|uniprotkb:A5X2U9|uniprotkb:Q6GSQ6	intact:EBI-2547187|ensembl:ENSP00000345751|uniprotkb:C5HTZ2|uniprotkb:O60891|uniprotkb:Q96KG2|uniprotkb:Q9UJ32|uniprotkb:Q9UMU5	psi-mi:scnna_human(display_long)|uniprotkb:SCNN1A(gene name)|psi-mi:SCNN1A(display_short)|uniprotkb:SCNN1(gene name synonym)|uniprotkb:"Epithelial Na(+) channel subunit alpha"(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit alpha(gene name synonym)|uniprotkb:SCNEA(gene name synonym)|uniprotkb:Alpha-NaCH(gene name synonym)	psi-mi:scnnb_human(display_long)|uniprotkb:SCNN1B(gene name)|psi-mi:SCNN1B(display_short)|uniprotkb:"Epithelial Na(+) channel subunit beta"(gene name synonym)|uniprotkb:SCNEB(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit beta(gene name synonym)|uniprotkb:Beta-NaCH(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Stewart et al. (2011)	pubmed:21775436|imex:IM-24737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11422502|imex:IM-24737-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111319(gene)|ensembl:ENST00000228916(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050896"(response to stimulus)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097228"(sperm principal piece)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|rcsb pdb:2M3O|rcsb pdb:6BQN|rcsb pdb:6WTH|reactome:R-HSA-2672351|refseq:NP_001153048.1|refseq:NP_001153047.1|refseq:NP_001029.1	ensembl:ENSG00000168447(gene)|ensembl:ENST00000343070(transcript)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007588"(excretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010467"(gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032094"(response to food)|go:"GO:0032341"(aldosterone metabolic process)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042493"|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070254"(mucus secretion)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0097274"(urea homeostasis)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|rcsb pdb:6BQN|rcsb pdb:6WTH|reactome:R-HSA-2672351|refseq:NP_000327.2	-	comment:mint|function:"Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception"|function:"Defects in SCNN1A are a cause of autosomal recessive pseudohypoaldosteronism type 1 (PHA1) [MIM:264350]. PHA1 is a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. There are 2 forms of PHA1: the autosomal recessive form that is severe, and the dominant form which is more milder and due to defects in mineralocorticoid receptor. Autosomal recessive PHA1 is characterized by an often fulminant presentation in the neonatal period with dehydration, hyponatraemia, hyperkalaemia, metabolic acidosis, failure to thrive and weight loss"	-	figure legend:Fig. 2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-tsa201)|taxid:9606(Homo sapiens subclone of human embryonic kidney 293 cell line that expresses simian virus 40 T antigen)	-	2015/11/24	2015/11/24	rogid:gVnl0rzupzTZyIbIL8BogbWXkAU9606	rogid:0V4pnxmI6KdZ8GaIuuLdAbrfamQ9606	rigid:fQfFv3A1Zn2oi3slA6ZAKsfkzbI	false	ha tag:n-n|flag tag:c-c	ha tag:n-n|his tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P37088	uniprotkb:P37088	intact:EBI-7845444|ensembl:ENSP00000228916|intact:MINT-198663|uniprotkb:O43271|uniprotkb:Q9UM64|uniprotkb:C5HTZ0|uniprotkb:B4E2Q5|uniprotkb:A5X2U9|uniprotkb:Q6GSQ6	intact:EBI-7845444|ensembl:ENSP00000228916|intact:MINT-198663|uniprotkb:O43271|uniprotkb:Q9UM64|uniprotkb:C5HTZ0|uniprotkb:B4E2Q5|uniprotkb:A5X2U9|uniprotkb:Q6GSQ6	psi-mi:scnna_human(display_long)|uniprotkb:SCNN1A(gene name)|psi-mi:SCNN1A(display_short)|uniprotkb:SCNN1(gene name synonym)|uniprotkb:"Epithelial Na(+) channel subunit alpha"(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit alpha(gene name synonym)|uniprotkb:SCNEA(gene name synonym)|uniprotkb:Alpha-NaCH(gene name synonym)	psi-mi:scnna_human(display_long)|uniprotkb:SCNN1A(gene name)|psi-mi:SCNN1A(display_short)|uniprotkb:SCNN1(gene name synonym)|uniprotkb:"Epithelial Na(+) channel subunit alpha"(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit alpha(gene name synonym)|uniprotkb:SCNEA(gene name synonym)|uniprotkb:Alpha-NaCH(gene name synonym)	psi-mi:"MI:0872"(atomic force microscopy)	Stewart et al. (2011)	pubmed:21775436|imex:IM-24737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11423903|imex:IM-24737-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111319(gene)|ensembl:ENST00000228916(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050896"(response to stimulus)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097228"(sperm principal piece)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|rcsb pdb:2M3O|rcsb pdb:6BQN|rcsb pdb:6WTH|reactome:R-HSA-2672351|refseq:NP_001153048.1|refseq:NP_001153047.1|refseq:NP_001029.1	ensembl:ENSG00000111319(gene)|ensembl:ENST00000228916(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050896"(response to stimulus)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097228"(sperm principal piece)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|rcsb pdb:2M3O|rcsb pdb:6BQN|rcsb pdb:6WTH|reactome:R-HSA-2672351|refseq:NP_001153048.1|refseq:NP_001153047.1|refseq:NP_001029.1	-	comment:mint|function:"Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception"|function:"Defects in SCNN1A are a cause of autosomal recessive pseudohypoaldosteronism type 1 (PHA1) [MIM:264350]. PHA1 is a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. There are 2 forms of PHA1: the autosomal recessive form that is severe, and the dominant form which is more milder and due to defects in mineralocorticoid receptor. Autosomal recessive PHA1 is characterized by an often fulminant presentation in the neonatal period with dehydration, hyponatraemia, hyperkalaemia, metabolic acidosis, failure to thrive and weight loss"	comment:mint|function:"Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception"|function:"Defects in SCNN1A are a cause of autosomal recessive pseudohypoaldosteronism type 1 (PHA1) [MIM:264350]. PHA1 is a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. There are 2 forms of PHA1: the autosomal recessive form that is severe, and the dominant form which is more milder and due to defects in mineralocorticoid receptor. Autosomal recessive PHA1 is characterized by an often fulminant presentation in the neonatal period with dehydration, hyponatraemia, hyperkalaemia, metabolic acidosis, failure to thrive and weight loss"	figure legend:Fig. 3d|comment:Likely typologies are trimers, hexamers and nonamers.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/11/24	2015/11/24	rogid:gVnl0rzupzTZyIbIL8BogbWXkAU9606	rogid:gVnl0rzupzTZyIbIL8BogbWXkAU9606	rigid:yBTdyHakf5rU5WTtIJYbH95Nfj0	false	ha tag:n-n|v5 tag:c-c	ha tag:n-n|v5 tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P51168	uniprotkb:P51168	intact:EBI-2547187|ensembl:ENSP00000345751|uniprotkb:C5HTZ2|uniprotkb:O60891|uniprotkb:Q96KG2|uniprotkb:Q9UJ32|uniprotkb:Q9UMU5	intact:EBI-2547187|ensembl:ENSP00000345751|uniprotkb:C5HTZ2|uniprotkb:O60891|uniprotkb:Q96KG2|uniprotkb:Q9UJ32|uniprotkb:Q9UMU5	psi-mi:scnnb_human(display_long)|uniprotkb:SCNN1B(gene name)|psi-mi:SCNN1B(display_short)|uniprotkb:"Epithelial Na(+) channel subunit beta"(gene name synonym)|uniprotkb:SCNEB(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit beta(gene name synonym)|uniprotkb:Beta-NaCH(gene name synonym)	psi-mi:scnnb_human(display_long)|uniprotkb:SCNN1B(gene name)|psi-mi:SCNN1B(display_short)|uniprotkb:"Epithelial Na(+) channel subunit beta"(gene name synonym)|uniprotkb:SCNEB(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit beta(gene name synonym)|uniprotkb:Beta-NaCH(gene name synonym)	psi-mi:"MI:0872"(atomic force microscopy)	Stewart et al. (2011)	pubmed:21775436|imex:IM-24737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11423916|imex:IM-24737-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168447(gene)|ensembl:ENST00000343070(transcript)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007588"(excretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010467"(gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032094"(response to food)|go:"GO:0032341"(aldosterone metabolic process)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042493"|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070254"(mucus secretion)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0097274"(urea homeostasis)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|rcsb pdb:6BQN|rcsb pdb:6WTH|reactome:R-HSA-2672351|refseq:NP_000327.2	ensembl:ENSG00000168447(gene)|ensembl:ENST00000343070(transcript)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007588"(excretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010467"(gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032094"(response to food)|go:"GO:0032341"(aldosterone metabolic process)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042493"|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070254"(mucus secretion)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0097274"(urea homeostasis)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|rcsb pdb:6BQN|rcsb pdb:6WTH|reactome:R-HSA-2672351|refseq:NP_000327.2	-	-	-	figure legend:Fig. 3e|comment:Homomers of min trimers and max nonamers were found.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/11/24	2015/11/24	rogid:0V4pnxmI6KdZ8GaIuuLdAbrfamQ9606	rogid:0V4pnxmI6KdZ8GaIuuLdAbrfamQ9606	rigid:c610oqMWvYQxJu2QL2TcZLpr0ns	false	ha tag:n-n|v5 tag:c-c	ha tag:n-n|v5 tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P51170	uniprotkb:P51170	intact:EBI-2547354|ensembl:ENSP00000300061|uniprotkb:P78437|uniprotkb:Q6PCC2|uniprotkb:Q93023|uniprotkb:Q93024|uniprotkb:Q93025|uniprotkb:Q93026|uniprotkb:Q93027|uniprotkb:Q96TD2	intact:EBI-2547354|ensembl:ENSP00000300061|uniprotkb:P78437|uniprotkb:Q6PCC2|uniprotkb:Q93023|uniprotkb:Q93024|uniprotkb:Q93025|uniprotkb:Q93026|uniprotkb:Q93027|uniprotkb:Q96TD2	psi-mi:scnng_human(display_long)|uniprotkb:SCNN1G(gene name)|psi-mi:SCNN1G(display_short)|uniprotkb:"Epithelial Na(+) channel subunit gamma"(gene name synonym)|uniprotkb:SCNEG(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit gamma(gene name synonym)|uniprotkb:Gamma-NaCH(gene name synonym)	psi-mi:scnng_human(display_long)|uniprotkb:SCNN1G(gene name)|psi-mi:SCNN1G(display_short)|uniprotkb:"Epithelial Na(+) channel subunit gamma"(gene name synonym)|uniprotkb:SCNEG(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit gamma(gene name synonym)|uniprotkb:Gamma-NaCH(gene name synonym)	psi-mi:"MI:0872"(atomic force microscopy)	Stewart et al. (2011)	pubmed:21775436|imex:IM-24737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11423931|imex:IM-24737-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166828(gene)|ensembl:ENST00000300061(transcript)|go:"GO:0005272"(sodium channel activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007588"(excretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0005216"(ion channel activity)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|rcsb pdb:6BQN|rcsb pdb:6WTH|reactome:R-HSA-2672351|refseq:NP_001030.2	ensembl:ENSG00000166828(gene)|ensembl:ENST00000300061(transcript)|go:"GO:0005272"(sodium channel activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007588"(excretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0005216"(ion channel activity)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|rcsb pdb:6BQN|rcsb pdb:6WTH|reactome:R-HSA-2672351|refseq:NP_001030.2	-	-	-	figure legend:Fig. 3f|comment:Homomers of min trimers and max nonamers were found.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/11/24	2015/11/24	rogid:y3n1CDg1c7oj3ugrx9Kur21BmNk9606	rogid:y3n1CDg1c7oj3ugrx9Kur21BmNk9606	rigid:fg/uH82sPZvOdCOMpb4ivengsD0	false	ha tag:n-n|v5 tag:c-c	ha tag:n-n|v5 tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P37088	uniprotkb:P51168	intact:EBI-7845444|ensembl:ENSP00000228916|intact:MINT-198663|uniprotkb:O43271|uniprotkb:Q9UM64|uniprotkb:C5HTZ0|uniprotkb:B4E2Q5|uniprotkb:A5X2U9|uniprotkb:Q6GSQ6	intact:EBI-2547187|ensembl:ENSP00000345751|uniprotkb:C5HTZ2|uniprotkb:O60891|uniprotkb:Q96KG2|uniprotkb:Q9UJ32|uniprotkb:Q9UMU5	psi-mi:scnna_human(display_long)|uniprotkb:SCNN1A(gene name)|psi-mi:SCNN1A(display_short)|uniprotkb:SCNN1(gene name synonym)|uniprotkb:"Epithelial Na(+) channel subunit alpha"(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit alpha(gene name synonym)|uniprotkb:SCNEA(gene name synonym)|uniprotkb:Alpha-NaCH(gene name synonym)	psi-mi:scnnb_human(display_long)|uniprotkb:SCNN1B(gene name)|psi-mi:SCNN1B(display_short)|uniprotkb:"Epithelial Na(+) channel subunit beta"(gene name synonym)|uniprotkb:SCNEB(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit beta(gene name synonym)|uniprotkb:Beta-NaCH(gene name synonym)	psi-mi:"MI:0872"(atomic force microscopy)	Stewart et al. (2011)	pubmed:21775436|imex:IM-24737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11423951|imex:IM-24737-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111319(gene)|ensembl:ENST00000228916(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050896"(response to stimulus)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097228"(sperm principal piece)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|rcsb pdb:2M3O|rcsb pdb:6BQN|rcsb pdb:6WTH|reactome:R-HSA-2672351|refseq:NP_001153048.1|refseq:NP_001153047.1|refseq:NP_001029.1	ensembl:ENSG00000168447(gene)|ensembl:ENST00000343070(transcript)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007588"(excretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010467"(gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032094"(response to food)|go:"GO:0032341"(aldosterone metabolic process)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042493"|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070254"(mucus secretion)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0097274"(urea homeostasis)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|rcsb pdb:6BQN|rcsb pdb:6WTH|reactome:R-HSA-2672351|refseq:NP_000327.2	-	comment:mint|function:"Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception"|function:"Defects in SCNN1A are a cause of autosomal recessive pseudohypoaldosteronism type 1 (PHA1) [MIM:264350]. PHA1 is a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. There are 2 forms of PHA1: the autosomal recessive form that is severe, and the dominant form which is more milder and due to defects in mineralocorticoid receptor. Autosomal recessive PHA1 is characterized by an often fulminant presentation in the neonatal period with dehydration, hyponatraemia, hyperkalaemia, metabolic acidosis, failure to thrive and weight loss"	-	figure legend:Fig.s 4c, 53, 5f|comment:Likely typologies are trimers, hexamers and nonamers.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/11/24	2015/11/24	rogid:gVnl0rzupzTZyIbIL8BogbWXkAU9606	rogid:0V4pnxmI6KdZ8GaIuuLdAbrfamQ9606	rigid:fQfFv3A1Zn2oi3slA6ZAKsfkzbI	false	ha tag:n-n|flag tag:c-c	ha tag:n-n|his tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P37088	uniprotkb:P51170	intact:EBI-7845444|ensembl:ENSP00000228916|intact:MINT-198663|uniprotkb:O43271|uniprotkb:Q9UM64|uniprotkb:C5HTZ0|uniprotkb:B4E2Q5|uniprotkb:A5X2U9|uniprotkb:Q6GSQ6	intact:EBI-2547354|ensembl:ENSP00000300061|uniprotkb:P78437|uniprotkb:Q6PCC2|uniprotkb:Q93023|uniprotkb:Q93024|uniprotkb:Q93025|uniprotkb:Q93026|uniprotkb:Q93027|uniprotkb:Q96TD2	psi-mi:scnna_human(display_long)|uniprotkb:SCNN1A(gene name)|psi-mi:SCNN1A(display_short)|uniprotkb:SCNN1(gene name synonym)|uniprotkb:"Epithelial Na(+) channel subunit alpha"(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit alpha(gene name synonym)|uniprotkb:SCNEA(gene name synonym)|uniprotkb:Alpha-NaCH(gene name synonym)	psi-mi:scnng_human(display_long)|uniprotkb:SCNN1G(gene name)|psi-mi:SCNN1G(display_short)|uniprotkb:"Epithelial Na(+) channel subunit gamma"(gene name synonym)|uniprotkb:SCNEG(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit gamma(gene name synonym)|uniprotkb:Gamma-NaCH(gene name synonym)	psi-mi:"MI:0872"(atomic force microscopy)	Stewart et al. (2011)	pubmed:21775436|imex:IM-24737	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11423951|imex:IM-24737-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111319(gene)|ensembl:ENST00000228916(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050896"(response to stimulus)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097228"(sperm principal piece)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|rcsb pdb:2M3O|rcsb pdb:6BQN|rcsb pdb:6WTH|reactome:R-HSA-2672351|refseq:NP_001153048.1|refseq:NP_001153047.1|refseq:NP_001029.1	ensembl:ENSG00000166828(gene)|ensembl:ENST00000300061(transcript)|go:"GO:0005272"(sodium channel activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007588"(excretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0005216"(ion channel activity)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|rcsb pdb:6BQN|rcsb pdb:6WTH|reactome:R-HSA-2672351|refseq:NP_001030.2	-	comment:mint|function:"Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception"|function:"Defects in SCNN1A are a cause of autosomal recessive pseudohypoaldosteronism type 1 (PHA1) [MIM:264350]. PHA1 is a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. There are 2 forms of PHA1: the autosomal recessive form that is severe, and the dominant form which is more milder and due to defects in mineralocorticoid receptor. Autosomal recessive PHA1 is characterized by an often fulminant presentation in the neonatal period with dehydration, hyponatraemia, hyperkalaemia, metabolic acidosis, failure to thrive and weight loss"	-	figure legend:Fig.s 4c, 53, 5f|comment:Likely typologies are trimers, hexamers and nonamers.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/11/24	2015/11/24	rogid:gVnl0rzupzTZyIbIL8BogbWXkAU9606	rogid:y3n1CDg1c7oj3ugrx9Kur21BmNk9606	rigid:fQfFv3A1Zn2oi3slA6ZAKsfkzbI	false	ha tag:n-n|flag tag:c-c	ha tag:n-n|v5 tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)