#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q14896 uniprotkb:Q5VU43-11 intact:EBI-704176|uniprotkb:Q16410|uniprotkb:Q6R2F7|uniprotkb:Q9UE27|uniprotkb:A5PL00|uniprotkb:Q9UM53|ensembl:ENSP00000442795 intact:EBI-10769071|ensembl:ENSP00000358353 psi-mi:mypc3_human(display_long)|uniprotkb:C-protein, cardiac muscle isoform(gene name synonym)|uniprotkb:MYBPC3(gene name)|psi-mi:MYBPC3(display_short) psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:"MI:0018"(two hybrid) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10769068|imex:IM-24136-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000247.2|ensembl:ENSG00000134571(gene)|ensembl:ENST00000545968(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005863"(striated muscle myosin thick filament)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014705"(C zone)|go:"GO:0017022"(myosin binding)|go:"GO:0030017"(sarcomere)|go:"GO:0031432"(titin binding)|go:"GO:0031672"(A band)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032971"(regulation of muscle filament sliding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q14896|rcsb pdb:1GXE|rcsb pdb:1PD6|rcsb pdb:2AVG|rcsb pdb:2K1M|rcsb pdb:2MQ0|rcsb pdb:2MQ3|rcsb pdb:2V6H|rcsb pdb:3CX2|rcsb pdb:5K6P|rcsb pdb:6CXI|rcsb pdb:6CXJ|rcsb pdb:6G2T|reactome:R-HSA-390522 ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) - - - figure legend:Table1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2015/04/24 2015/04/28 rogid:JYH9WxTpibBvj4Z6y0ZNgQEW2zE9606 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rigid:E3uNObfDZ+HPACt+IfkYN7VZr6s false sufficient binding region:153..153-452..452(IPR013098)|mutation:275-275,284-284,304-304 - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q14896 uniprotkb:P68032 intact:EBI-704176|uniprotkb:Q16410|uniprotkb:Q6R2F7|uniprotkb:Q9UE27|uniprotkb:A5PL00|uniprotkb:Q9UM53|ensembl:ENSP00000442795 intact:EBI-352273|uniprotkb:P04270|ensembl:ENSP00000290378 psi-mi:mypc3_human(display_long)|uniprotkb:C-protein, cardiac muscle isoform(gene name synonym)|uniprotkb:MYBPC3(gene name)|psi-mi:MYBPC3(display_short) psi-mi:actc_human(display_long)|uniprotkb:ACTC1(gene name)|psi-mi:ACTC1(display_short)|uniprotkb:ACTC(gene name synonym)|uniprotkb:Alpha-cardiac actin(gene name synonym) psi-mi:"MI:0018"(two hybrid) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10769097|imex:IM-24136-81 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000247.2|ensembl:ENSG00000134571(gene)|ensembl:ENST00000545968(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005863"(striated muscle myosin thick filament)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014705"(C zone)|go:"GO:0017022"(myosin binding)|go:"GO:0030017"(sarcomere)|go:"GO:0031432"(titin binding)|go:"GO:0031672"(A band)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032971"(regulation of muscle filament sliding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q14896|rcsb pdb:1GXE|rcsb pdb:1PD6|rcsb pdb:2AVG|rcsb pdb:2K1M|rcsb pdb:2MQ0|rcsb pdb:2MQ3|rcsb pdb:2V6H|rcsb pdb:3CX2|rcsb pdb:5K6P|rcsb pdb:6CXI|rcsb pdb:6CXJ|rcsb pdb:6G2T|reactome:R-HSA-390522 refseq:NP_005150.1|ensembl:ENSG00000159251(gene)|ensembl:ENST00000290378(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005869"(dynactin complex)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0017022"(myosin binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030175"(filopodium)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031674"(I band)|go:"GO:0033275"(actin-myosin filament sliding)|go:"GO:0042493"|go:"GO:0044297"(cell body)|go:"GO:0045471"(response to ethanol)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060047"(heart contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0090131"(mesenchyme migration)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P68032|reactome:R-HSA-390522|reactome:R-HSA-8980692|reactome:R-HSA-9013026 - - - figure legend:Table1-2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2015/04/24 2015/04/28 rogid:JYH9WxTpibBvj4Z6y0ZNgQEW2zE9606 rogid:U/lKYqWUWMSC3fBHFaAcgzfk+3w9606 rigid:xRyjWjHrErL7aQ7EOVVr7htZafE false sufficient binding region:153..153-452..452(IPR013098)|mutation:275-275,284-284,304-304 - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q14896 uniprotkb:P60709 intact:EBI-704176|uniprotkb:Q16410|uniprotkb:Q6R2F7|uniprotkb:Q9UE27|uniprotkb:A5PL00|uniprotkb:Q9UM53|ensembl:ENSP00000442795 intact:EBI-353944|uniprotkb:P02570|uniprotkb:P70514|uniprotkb:P99021|uniprotkb:Q11211|uniprotkb:Q64316|uniprotkb:Q75MN2|uniprotkb:Q96B34|uniprotkb:Q96HG5|ensembl:ENSP00000494269|ensembl:ENSP00000494750|ensembl:ENSP00000495995|ensembl:ENSP00000501862|ensembl:ENSP00000502821 psi-mi:mypc3_human(display_long)|uniprotkb:C-protein, cardiac muscle isoform(gene name synonym)|uniprotkb:MYBPC3(gene name)|psi-mi:MYBPC3(display_short) psi-mi:actb_human(display_long)|uniprotkb:ACTB(gene name)|psi-mi:ACTB(display_short)|uniprotkb:Beta-actin(gene name synonym) psi-mi:"MI:0018"(two hybrid) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10769109|imex:IM-24136-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000247.2|ensembl:ENSG00000134571(gene)|ensembl:ENST00000545968(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005863"(striated muscle myosin thick filament)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014705"(C zone)|go:"GO:0017022"(myosin binding)|go:"GO:0030017"(sarcomere)|go:"GO:0031432"(titin binding)|go:"GO:0031672"(A band)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032971"(regulation of muscle filament sliding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q14896|rcsb pdb:1GXE|rcsb pdb:1PD6|rcsb pdb:2AVG|rcsb pdb:2K1M|rcsb pdb:2MQ0|rcsb pdb:2MQ3|rcsb pdb:2V6H|rcsb pdb:3CX2|rcsb pdb:5K6P|rcsb pdb:6CXI|rcsb pdb:6CXJ|rcsb pdb:6G2T|reactome:R-HSA-390522 refseq:NP_001092.1|ensembl:ENSG00000075624(gene)|ensembl:ENST00000493945(transcript)|ensembl:ENST00000642480(transcript)|ensembl:ENST00000646664(transcript)|ensembl:ENST00000674681(transcript)|ensembl:ENST00000675515(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000785"(chromatin)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007409"(axonogenesis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031982"(vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043044"|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051623"(positive regulation of norepinephrine uptake)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070160"(tight junction)|go:"GO:0070527"(platelet aggregation)|reactome:R-HSA-4420097|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072562"(blood microparticle)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P60709|rcsb pdb:3BYH|rcsb pdb:3D2U|rcsb pdb:3J82|rcsb pdb:3LUE|rcsb pdb:6ANU|rcsb pdb:6ICT|rcsb pdb:6ICV|rcsb pdb:6LTJ|rcsb pdb:6MBJ|rcsb pdb:6MBK|rcsb pdb:6MBL|rcsb pdb:6NBW|rcsb pdb:6OX0|rcsb pdb:6OX1|rcsb pdb:6OX2|rcsb pdb:6OX3|rcsb pdb:6OX4|rcsb pdb:6OX5|rcsb pdb:6V62|rcsb pdb:6V63|rcsb pdb:6WK1|rcsb pdb:6WK2|rcsb pdb:7AS4|reactome:R-HSA-1445148|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2029482|reactome:R-HSA-3214847|reactome:R-HSA-389957|reactome:R-HSA-390450|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-418990|reactome:R-HSA-437239|reactome:R-HSA-446353|reactome:R-HSA-5250924|reactome:R-HSA-5626467|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5674135|reactome:R-HSA-5689603|reactome:R-HSA-5696394|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856828|reactome:R-HSA-9035034|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9664422|reactome:R-HSA-983231|reactome:R-HSA-445095|dip:DIP-29686N - - - figure legend:Table1-3|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2015/04/24 2015/04/28 rogid:JYH9WxTpibBvj4Z6y0ZNgQEW2zE9606 rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc9606 rigid:8UBXY1cjCcPouv3enMKuCSfB5jM false mutation:275-275,284-284,304-304|sufficient binding region:153..153-452..452(IPR013098) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0CAP1 uniprotkb:Q14896 intact:EBI-7929343|uniprotkb:Q8NC58|uniprotkb:Q96JB7|uniprotkb:Q6K046|uniprotkb:Q6K051|uniprotkb:Q6EF01|uniprotkb:Q6EER8|uniprotkb:Q6EF00|uniprotkb:Q6EES2|uniprotkb:Q6EF46|uniprotkb:Q6K050|uniprotkb:Q6EFN8|uniprotkb:Q6EM48|uniprotkb:Q96NF5|uniprotkb:Q6EF02|uniprotkb:Q6ZQZ3|uniprotkb:Q6EEV3|uniprotkb:D2E9U7|uniprotkb:Q8NCF3|intact:MINT-1370040|uniprotkb:Q96DI5|ensembl:ENSP00000267853 intact:EBI-704176|uniprotkb:Q16410|uniprotkb:Q6R2F7|uniprotkb:Q9UE27|uniprotkb:A5PL00|uniprotkb:Q9UM53|ensembl:ENSP00000442795 psi-mi:myzap_human(display_long)|uniprotkb:MYZAP(gene name)|psi-mi:MYZAP(display_short)|uniprotkb:GRINL1A upstream protein(gene name synonym)|uniprotkb:MYOZAP(gene name synonym) psi-mi:mypc3_human(display_long)|uniprotkb:C-protein, cardiac muscle isoform(gene name synonym)|uniprotkb:MYBPC3(gene name)|psi-mi:MYBPC3(display_short) psi-mi:"MI:0018"(two hybrid) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10769120|imex:IM-24136-61 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018110.1|refseq:NP_689664.3|refseq:NP_001018100.1|refseq:NP_001018101.1|ensembl:ENSG00000263155(gene)|ensembl:ENST00000267853(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031674"(I band)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR028273|rcsb pdb:2KXS|refseq:NP_001018112.1 refseq:NP_000247.2|ensembl:ENSG00000134571(gene)|ensembl:ENST00000545968(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005863"(striated muscle myosin thick filament)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014705"(C zone)|go:"GO:0017022"(myosin binding)|go:"GO:0030017"(sarcomere)|go:"GO:0031432"(titin binding)|go:"GO:0031672"(A band)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032971"(regulation of muscle filament sliding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q14896|rcsb pdb:1GXE|rcsb pdb:1PD6|rcsb pdb:2AVG|rcsb pdb:2K1M|rcsb pdb:2MQ0|rcsb pdb:2MQ3|rcsb pdb:2V6H|rcsb pdb:3CX2|rcsb pdb:5K6P|rcsb pdb:6CXI|rcsb pdb:6CXJ|rcsb pdb:6G2T|reactome:R-HSA-390522 - comment:mint|comment:homomint - figure legend:Table1-4|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2015/04/24 2015/04/28 rogid:AU7Lj2Q3eNiTbVod6aQbU2faxOg9606 rogid:JYH9WxTpibBvj4Z6y0ZNgQEW2zE9606 rigid:inZTzq1prWPjy1he9C2Cm5hbTfo false - mutation:275-275,284-284,304-304|sufficient binding region:153..153-452..452(IPR013098) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q14896 uniprotkb:Q14315 intact:EBI-704176|uniprotkb:Q16410|uniprotkb:Q6R2F7|uniprotkb:Q9UE27|uniprotkb:A5PL00|uniprotkb:Q9UM53|ensembl:ENSP00000442795 intact:EBI-489954|uniprotkb:O95303|uniprotkb:Q07985|uniprotkb:Q9NS12|uniprotkb:Q9NYE5|uniprotkb:Q9UMR8|uniprotkb:Q9Y503|uniprotkb:B2ZZ88|ensembl:ENSP00000327145 psi-mi:mypc3_human(display_long)|uniprotkb:C-protein, cardiac muscle isoform(gene name synonym)|uniprotkb:MYBPC3(gene name)|psi-mi:MYBPC3(display_short) psi-mi:flnc_human(display_long)|uniprotkb:Filamin-2(gene name synonym)|uniprotkb:Actin-binding-like protein(gene name synonym)|uniprotkb:ABP-L(gene name synonym)|uniprotkb:ABP-280-like protein(gene name synonym)|uniprotkb:Gamma-filamin(gene name synonym)|uniprotkb:FLNC(gene name)|psi-mi:FLNC(display_short)|uniprotkb:ABPL(gene name synonym)|uniprotkb:FLN2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10769131|imex:IM-24136-63 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000247.2|ensembl:ENSG00000134571(gene)|ensembl:ENST00000545968(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005863"(striated muscle myosin thick filament)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014705"(C zone)|go:"GO:0017022"(myosin binding)|go:"GO:0030017"(sarcomere)|go:"GO:0031432"(titin binding)|go:"GO:0031672"(A band)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032971"(regulation of muscle filament sliding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q14896|rcsb pdb:1GXE|rcsb pdb:1PD6|rcsb pdb:2AVG|rcsb pdb:2K1M|rcsb pdb:2MQ0|rcsb pdb:2MQ3|rcsb pdb:2V6H|rcsb pdb:3CX2|rcsb pdb:5K6P|rcsb pdb:6CXI|rcsb pdb:6CXJ|rcsb pdb:6G2T|reactome:R-HSA-390522 refseq:NP_001120959.1|refseq:NP_001449.3|ensembl:ENSG00000128591(gene)|ensembl:ENST00000325888(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0051015"(actin filament binding)|go:"GO:0055001"(muscle cell development)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:Q14315|rcsb pdb:1V05|rcsb pdb:2D7M|rcsb pdb:2D7N|rcsb pdb:2D7O|rcsb pdb:2D7P|rcsb pdb:2D7Q|rcsb pdb:2K9U|rcsb pdb:2NQC|rcsb pdb:3V8O|rcsb pdb:4MGX|reactome:R-HSA-446353|dip:DIP-33398N - - - figure legend:Table1-5|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2015/04/24 2015/04/28 rogid:JYH9WxTpibBvj4Z6y0ZNgQEW2zE9606 rogid:sBGhjObBECicoAu/8T5lDIt1ToY9606 rigid:W9ZqGKBy/yPKfd+WVZjJG1G1Z0o false mutation:275-275,284-284,304-304|sufficient binding region:153..153-452..452(IPR013098) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q14896 uniprotkb:P51911 intact:EBI-704176|uniprotkb:Q16410|uniprotkb:Q6R2F7|uniprotkb:Q9UE27|uniprotkb:A5PL00|uniprotkb:Q9UM53|ensembl:ENSP00000442795 intact:EBI-2873130|ensembl:ENSP00000252456|uniprotkb:B4DUX6|uniprotkb:Q8IY93|uniprotkb:Q15416|uniprotkb:O00638|uniprotkb:Q99438|uniprotkb:B2R868 psi-mi:mypc3_human(display_long)|uniprotkb:C-protein, cardiac muscle isoform(gene name synonym)|uniprotkb:MYBPC3(gene name)|psi-mi:MYBPC3(display_short) psi-mi:cnn1_human(display_long)|uniprotkb:CNN1(gene name)|psi-mi:CNN1(display_short)|uniprotkb:Basic calponin(gene name synonym)|uniprotkb:Calponin H1, smooth muscle(gene name synonym) psi-mi:"MI:0018"(two hybrid) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10769142|imex:IM-24136-65 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000247.2|ensembl:ENSG00000134571(gene)|ensembl:ENST00000545968(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005863"(striated muscle myosin thick filament)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014705"(C zone)|go:"GO:0017022"(myosin binding)|go:"GO:0030017"(sarcomere)|go:"GO:0031432"(titin binding)|go:"GO:0031672"(A band)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032971"(regulation of muscle filament sliding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q14896|rcsb pdb:1GXE|rcsb pdb:1PD6|rcsb pdb:2AVG|rcsb pdb:2K1M|rcsb pdb:2MQ0|rcsb pdb:2MQ3|rcsb pdb:2V6H|rcsb pdb:3CX2|rcsb pdb:5K6P|rcsb pdb:6CXI|rcsb pdb:6CXJ|rcsb pdb:6G2T|reactome:R-HSA-390522 ensembl:ENSG00000130176(gene)|ensembl:ENST00000252456(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|interpro:IPR000557(Calponin repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001997(Calponin)|interpro:IPR003096(SM22/calponin)|interpro:IPR036872|rcsb pdb:1WYP|refseq:NP_001295270.1|refseq:NP_001290.2 - - - figure legend:Table1-6|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2015/04/24 2015/04/28 rogid:JYH9WxTpibBvj4Z6y0ZNgQEW2zE9606 rogid:blXz1RLzyvJ1QIZzI3knBEC2qoA9606 rigid:/tFzafSVZN5iixZ2dAR2qenDU9w false mutation:275-275,284-284,304-304|sufficient binding region:153..153-452..452(IPR013098) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q14896 uniprotkb:Q8TEW0 intact:EBI-704176|uniprotkb:Q16410|uniprotkb:Q6R2F7|uniprotkb:Q9UE27|uniprotkb:A5PL00|uniprotkb:Q9UM53|ensembl:ENSP00000442795 intact:EBI-81968|uniprotkb:Q5T2U1|uniprotkb:Q5VWV0|uniprotkb:Q5VWV4|uniprotkb:Q5VWV5|uniprotkb:Q8TEW1|uniprotkb:Q8TEW2|uniprotkb:Q8TEW3|uniprotkb:Q96K28|uniprotkb:Q96RM6|uniprotkb:Q96RM7|uniprotkb:Q9BY57|uniprotkb:Q9BY58|uniprotkb:Q9HC48|uniprotkb:Q9NWL4|uniprotkb:Q9NYE6|uniprotkb:Q5VWV3|uniprotkb:Q5VUA2|uniprotkb:Q5VUA3|uniprotkb:Q5VWV1|intact:EBI-1221123|uniprotkb:Q8TCZ9|ensembl:ENSP00000363921|intact:EBI-10975849|uniprotkb:F5H5T0|uniprotkb:Q6IQ47 psi-mi:mypc3_human(display_long)|uniprotkb:C-protein, cardiac muscle isoform(gene name synonym)|uniprotkb:MYBPC3(gene name)|psi-mi:MYBPC3(display_short) psi-mi:pard3_human(display_long)|uniprotkb:PARD3(gene name)|psi-mi:PARD3(display_short)|uniprotkb:PAR3(gene name synonym)|uniprotkb:PAR3A(gene name synonym)|uniprotkb:Atypical PKC isotype-specific-interacting protein(gene name synonym)|uniprotkb:CTCL tumor antigen se2-5(gene name synonym)|uniprotkb:PAR3-alpha(gene name synonym) psi-mi:"MI:0018"(two hybrid) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10769164|imex:IM-24136-67 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000247.2|ensembl:ENSG00000134571(gene)|ensembl:ENST00000545968(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005863"(striated muscle myosin thick filament)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014705"(C zone)|go:"GO:0017022"(myosin binding)|go:"GO:0030017"(sarcomere)|go:"GO:0031432"(titin binding)|go:"GO:0031672"(A band)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032971"(regulation of muscle filament sliding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q14896|rcsb pdb:1GXE|rcsb pdb:1PD6|rcsb pdb:2AVG|rcsb pdb:2K1M|rcsb pdb:2MQ0|rcsb pdb:2MQ3|rcsb pdb:2V6H|rcsb pdb:3CX2|rcsb pdb:5K6P|rcsb pdb:6CXI|rcsb pdb:6CXJ|rcsb pdb:6G2T|reactome:R-HSA-390522 interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|mint:Q8TEW0|rcsb pdb:2KOM|reactome:R-HSA-2173791|reactome:R-HSA-420029|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|ensembl:ENSG00000148498(gene)|go:"GO:0006612"(protein targeting to membrane)|ensembl:ENST00000374789(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0008104"(protein localization)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033269"(internode region of axon)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043296"(apical junction complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090162"(establishment of epithelial cell polarity)|refseq:NP_001171714.1|refseq:NP_001171716.1|refseq:NP_001171717.1|refseq:NP_001171718.1|refseq:NP_001171719.1|refseq:NP_001171720.1|refseq:NP_001171721.1|refseq:NP_001171722.1|refseq:NP_001171723.1|refseq:NP_062565.2|refseq:NP_001171715.1|dip:DIP-31315N - - - figure legend:Table1-8|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2015/04/24 2015/04/28 rogid:JYH9WxTpibBvj4Z6y0ZNgQEW2zE9606 rogid:FdOAcXyXE7jKSBJdlPcabwbnq5k9606 rigid:nnvvFTbIjlMeKjkcLQIoFs42CP0 false mutation:275-275,284-284,304-304|sufficient binding region:153..153-452..452(IPR013098) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q14896 uniprotkb:Q99832 intact:EBI-704176|uniprotkb:Q16410|uniprotkb:Q6R2F7|uniprotkb:Q9UE27|uniprotkb:A5PL00|uniprotkb:Q9UM53|ensembl:ENSP00000442795 intact:EBI-357046|uniprotkb:B7WNW9|uniprotkb:O14871|uniprotkb:Q6FI26|uniprotkb:A8K7E6|uniprotkb:A8MWI8|uniprotkb:B7Z4T9|uniprotkb:B7Z4Z7|ensembl:ENSP00000258091 psi-mi:mypc3_human(display_long)|uniprotkb:C-protein, cardiac muscle isoform(gene name synonym)|uniprotkb:MYBPC3(gene name)|psi-mi:MYBPC3(display_short) psi-mi:tcph_human(display_long)|uniprotkb:CCT7(gene name)|psi-mi:CCT7(display_short)|uniprotkb:CCTH(gene name synonym)|uniprotkb:NIP7-1(gene name synonym)|uniprotkb:CCT-eta(gene name synonym)|uniprotkb:HIV-1 Nef-interacting protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10769175|imex:IM-24136-69 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000247.2|ensembl:ENSG00000134571(gene)|ensembl:ENST00000545968(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005863"(striated muscle myosin thick filament)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014705"(C zone)|go:"GO:0017022"(myosin binding)|go:"GO:0030017"(sarcomere)|go:"GO:0031432"(titin binding)|go:"GO:0031672"(A band)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032971"(regulation of muscle filament sliding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q14896|rcsb pdb:1GXE|rcsb pdb:1PD6|rcsb pdb:2AVG|rcsb pdb:2K1M|rcsb pdb:2MQ0|rcsb pdb:2MQ3|rcsb pdb:2V6H|rcsb pdb:3CX2|rcsb pdb:5K6P|rcsb pdb:6CXI|rcsb pdb:6CXJ|rcsb pdb:6G2T|reactome:R-HSA-390522 dip:DIP-51608N|refseq:NP_006420.1|refseq:XP_011530780.1|refseq:XP_011530781.1|refseq:NP_001009570.1|refseq:NP_001159756.1|refseq:NP_001159757.1|ensembl:ENSG00000135624(gene)|ensembl:ENST00000258091(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012720(T-complex protein 1, eta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:Q99832|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422 - - - figure legend:Table1-9|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2015/04/24 2015/04/28 rogid:JYH9WxTpibBvj4Z6y0ZNgQEW2zE9606 rogid:buiW7iGdAbfcld/zMJOrkR2jxRo9606 rigid:DVJnDAHBntaUcRAY35MvPX0lkyU false mutation:275-275,284-284,304-304|sufficient binding region:153..153-452..452(IPR013098) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q14896 uniprotkb:O95425 intact:EBI-704176|uniprotkb:Q16410|uniprotkb:Q6R2F7|uniprotkb:Q9UE27|uniprotkb:A5PL00|uniprotkb:Q9UM53|ensembl:ENSP00000442795 intact:EBI-487145|uniprotkb:O60611|uniprotkb:O60612|uniprotkb:Q5VZK5|uniprotkb:Q5VZK6|uniprotkb:Q9H1R7|uniprotkb:D3DRW9|ensembl:ENSP00000348128|uniprotkb:M1J557 psi-mi:mypc3_human(display_long)|uniprotkb:C-protein, cardiac muscle isoform(gene name synonym)|uniprotkb:MYBPC3(gene name)|psi-mi:MYBPC3(display_short) psi-mi:svil_human(display_long)|uniprotkb:Archvillin(gene name synonym)|uniprotkb:p205/p250(gene name synonym)|uniprotkb:SVIL(gene name)|psi-mi:SVIL(display_short) psi-mi:"MI:0018"(two hybrid) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10769186|imex:IM-24136-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000247.2|ensembl:ENSG00000134571(gene)|ensembl:ENST00000545968(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005863"(striated muscle myosin thick filament)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014705"(C zone)|go:"GO:0017022"(myosin binding)|go:"GO:0030017"(sarcomere)|go:"GO:0031432"(titin binding)|go:"GO:0031672"(A band)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032971"(regulation of muscle filament sliding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q14896|rcsb pdb:1GXE|rcsb pdb:1PD6|rcsb pdb:2AVG|rcsb pdb:2K1M|rcsb pdb:2MQ0|rcsb pdb:2MQ3|rcsb pdb:2V6H|rcsb pdb:3CX2|rcsb pdb:5K6P|rcsb pdb:6CXI|rcsb pdb:6CXJ|rcsb pdb:6G2T|reactome:R-HSA-390522 go:"GO:0007519"(skeletal muscle tissue development)|refseq:NP_003165.2|refseq:NP_068506.2|ensembl:ENSG00000197321(gene)|ensembl:ENST00000355867(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|interpro:IPR007123(Gelsolin region)|interpro:IPR015628(Supervillin)|interpro:IPR029006|interpro:IPR036886|mint:O95425|rcsb pdb:2K6M|rcsb pdb:2K6N|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0042995"(cell projection)|go:"GO:0043034"(costamere)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|interpro:IPR003128(Villin headpiece)|interpro:IPR007122(Gelsolin) - - - figure legend:Table1-10|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2015/04/24 2015/04/28 rogid:JYH9WxTpibBvj4Z6y0ZNgQEW2zE9606 rogid:5FaBAFdOX+nPJzTwEdBt8e5Keng9606 rigid:k6FkYUCBN290h4jhZ49JIsshLnU false mutation:275-275,284-284,304-304|sufficient binding region:153..153-452..452(IPR013098) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q14896 uniprotkb:Q8TB22 intact:EBI-704176|uniprotkb:Q16410|uniprotkb:Q6R2F7|uniprotkb:Q9UE27|uniprotkb:A5PL00|uniprotkb:Q9UM53|ensembl:ENSP00000442795 intact:EBI-372221|uniprotkb:Q2TA99|uniprotkb:Q2XUZ6|uniprotkb:Q6P0P1|uniprotkb:Q8WVW3|uniprotkb:Q9H747|ensembl:ENSP00000348878 psi-mi:mypc3_human(display_long)|uniprotkb:C-protein, cardiac muscle isoform(gene name synonym)|uniprotkb:MYBPC3(gene name)|psi-mi:MYBPC3(display_short) psi-mi:spt20_human(display_long)|uniprotkb:Sperm-specific protein 411(gene name synonym)|uniprotkb:SPATA20(gene name)|psi-mi:SPATA20(display_short) psi-mi:"MI:0018"(two hybrid) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10769197|imex:IM-24136-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000247.2|ensembl:ENSG00000134571(gene)|ensembl:ENST00000545968(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005863"(striated muscle myosin thick filament)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014705"(C zone)|go:"GO:0017022"(myosin binding)|go:"GO:0030017"(sarcomere)|go:"GO:0031432"(titin binding)|go:"GO:0031672"(A band)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032971"(regulation of muscle filament sliding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q14896|rcsb pdb:1GXE|rcsb pdb:1PD6|rcsb pdb:2AVG|rcsb pdb:2K1M|rcsb pdb:2MQ0|rcsb pdb:2MQ3|rcsb pdb:2V6H|rcsb pdb:3CX2|rcsb pdb:5K6P|rcsb pdb:6CXI|rcsb pdb:6CXJ|rcsb pdb:6G2T|reactome:R-HSA-390522 refseq:NP_001245301.1|refseq:NP_073738.2|refseq:NP_001245302.1|ensembl:ENSG00000006282(gene)|ensembl:ENST00000356488(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|interpro:IPR004879(Protein of unknown function DUF255)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR012341(Six-hairpin glycosidase)|interpro:IPR024705|interpro:IPR036249 - - - figure legend:Table1-11|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2015/04/24 2015/04/28 rogid:JYH9WxTpibBvj4Z6y0ZNgQEW2zE9606 rogid:B+QOPQcxgoTSVdoAJsnabauFFFo9606 rigid:0ZD47BzlEYanFWifT0ea2ZIzHDs false mutation:275-275,284-284,304-304|sufficient binding region:153..153-452..452(IPR013098) - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q5VU43-11 uniprotkb:P20674 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-715032|uniprotkb:P30045|intact:EBI-1043629|uniprotkb:Q8TB65|ensembl:ENSP00000317780|ensembl:ENSP00000456386 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:cox5a_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Va(gene name synonym)|uniprotkb:COX5A(gene name)|psi-mi:COX5A(display_short) psi-mi:"MI:0018"(two hybrid) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10770495|imex:IM-24136-45 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) refseq:NP_004246.2|interpro:IPR003204(Cytochrome c oxidase, subunit Va)|interpro:IPR036545|mint:P20674|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0046872"(metal ion binding)|ensembl:ENSG00000178741(gene)|ensembl:ENST00000322347(transcript)|ensembl:ENST00000564811(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0009055"(electron transfer activity) - - - figure legend:Text near to Table2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2015/04/24 2015/04/29 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:dWvZKYawyJQwN29Mhkm44DXXqhg9606 rigid:vZPsC63SgKrDHHC7u2tBNYr66tc false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O60493 uniprotkb:Q5VU43-11 intact:EBI-727209|uniprotkb:Q4TT31|uniprotkb:O60718|uniprotkb:Q5JXJ7|uniprotkb:Q5JXJ8|uniprotkb:Q96AP9|uniprotkb:Q9C0J5|uniprotkb:Q9NU45|intact:EBI-1056609|uniprotkb:A8K0B1|uniprotkb:Q4TT29|uniprotkb:E1P5E4|uniprotkb:E1P5E5|ensembl:ENSP00000230085 intact:EBI-10769071|ensembl:ENSP00000358353 psi-mi:snx3_human(display_long)|uniprotkb:Protein SDP3(gene name synonym)|uniprotkb:SNX3(gene name)|psi-mi:SNX3(display_short) psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:"MI:0018"(two hybrid) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10770510|imex:IM-24136-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003786.1|refseq:NP_690040.1|refseq:NP_001287858.1|ensembl:ENSG00000112335(gene)|ensembl:ENST00000230085(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0009617"(response to bacterium)|go:"GO:0010008"(endosome membrane)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0010324"(membrane invagination)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022615"(protein to membrane docking)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034499"(late endosome to Golgi transport)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070676"(intralumenal vesicle formation)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1905394"(retromer complex binding)|go:"GO:2000642"(negative regulation of early endosome to late endosome transport)|interpro:IPR001683(Phox-like)|interpro:IPR036871|interpro:IPR042137|rcsb pdb:2MXC|rcsb pdb:2YPS|rcsb pdb:5F0J|rcsb pdb:5F0L|rcsb pdb:5F0M|rcsb pdb:5F0P|rcsb pdb:7BLO|reactome:R-HSA-3238698|reactome:R-HSA-5689880 ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) - - - figure legend:Text near to Table2 i|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2015/04/24 2015/04/29 rogid:M/QKs79zhWobkEdFuxrJTnrrUes9606 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rigid:u5J5V7/N7pGSID79C04pPTx74yU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P19429 uniprotkb:Q5VU43-11 intact:EBI-704146|ensembl:ENSP00000341838 intact:EBI-10769071|ensembl:ENSP00000358353 psi-mi:tnni3_human(display_long)|uniprotkb:Cardiac troponin I(gene name synonym)|uniprotkb:TNNI3(gene name)|psi-mi:TNNI3(display_short)|uniprotkb:TNNC1(gene name synonym) psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:"MI:0018"(two hybrid) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10770516|imex:IM-24136-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000354.4|dip:DIP-34065N|ensembl:ENSG00000129991(gene)|ensembl:ENST00000344887(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001980"(regulation of systemic arterial blood pressure by ischemic conditions)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005861"(troponin complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006936"(muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007507"(heart development)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030172"(troponin C binding)|go:"GO:0031014"(troponin T binding)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060047"(heart contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|go:"GO:1990584"(cardiac Troponin complex)|interpro:IPR001978(Troponin)|interpro:IPR021666|interpro:IPR038077|mint:P19429|rcsb pdb:1J1D|rcsb pdb:1J1E|rcsb pdb:1LXF|rcsb pdb:1MXL|rcsb pdb:1OZS|rcsb pdb:2KGB|rcsb pdb:2KRD|rcsb pdb:2L1R|rcsb pdb:2MZP|rcsb pdb:2N7L|rcsb pdb:4Y99|rcsb pdb:5VLN|rcsb pdb:5W88|rcsb pdb:5WCL|rcsb pdb:6KN7|rcsb pdb:6KN8|rcsb pdb:6MV3|rcsb pdb:7JGI|reactome:R-HSA-390522|reactome:R-HSA-5578775 ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) - - - figure legend:Table 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2015/04/24 2015/04/29 rogid:kLAHLvln+lIzJRQ8Dit1sSKw/6Y9606 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rigid:RTtZOwVx4OrGAefskdgzXGOMWZQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q15327 uniprotkb:Q5VU43-11 intact:EBI-5653378|uniprotkb:Q96LE7|ensembl:ENSP00000360762 intact:EBI-10769071|ensembl:ENSP00000358353 psi-mi:ankr1_human(display_long)|uniprotkb:C193(gene name synonym)|uniprotkb:CARP(gene name synonym)|uniprotkb:Cardiac ankyrin repeat protein(gene name synonym)|uniprotkb:Cytokine-inducible gene C-193 protein(gene name synonym)|uniprotkb:Cytokine-inducible nuclear protein(gene name synonym)|uniprotkb:HA1A2(gene name synonym)|uniprotkb:ANKRD1(gene name)|psi-mi:ANKRD1(display_short) psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:"MI:0018"(two hybrid) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10770526|imex:IM-24136-33 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055206.2|ensembl:ENSG00000148677(gene)|ensembl:ENST00000371697(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0031432"(titin binding)|go:"GO:0031674"(I band)|go:"GO:0035690"|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045214"(sarcomere organization)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|reactome:R-HSA-1989781 ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) - - - figure legend:Table 2-2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2015/04/24 2015/04/29 rogid:UQq7pp3hORsCvEVEvGXE7gq+4mk9606 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rigid:yqogXs7vkPkqC5J9vv74wI28OyA false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9H0A8 uniprotkb:Q5VU43-11 intact:EBI-1550064|uniprotkb:Q7L637|uniprotkb:Q9NX43|uniprotkb:B2RBN4|uniprotkb:H3BUL2|ensembl:ENSP00000267935|ensembl:ENSP00000433662 intact:EBI-10769071|ensembl:ENSP00000358353 psi-mi:comd4_human(display_long)|uniprotkb:COMMD4(gene name)|psi-mi:COMMD4(display_short) psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:"MI:0018"(two hybrid) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10770531|imex:IM-24136-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001271306.1|refseq:NP_060298.2|refseq:NP_001271307.1|ensembl:ENSG00000140365(gene)|ensembl:ENST00000267935(transcript)|ensembl:ENST00000480484(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017920|interpro:IPR037356|reactome:R-HSA-8951664 ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) - - - figure legend:Table 2-3|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2015/04/24 2015/04/29 rogid:v1pkDNc18f7sZM/89Gv0bho9GN89606 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rigid:l/1nwFGY4qDFfEJAz5PF4KpjIbs false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P06733 uniprotkb:Q5VU43-11 intact:EBI-353877|uniprotkb:P22712|uniprotkb:Q16704|uniprotkb:Q4TUS4|uniprotkb:Q658M5|uniprotkb:Q6GMP2|uniprotkb:Q71V37|uniprotkb:Q7Z3V6|uniprotkb:Q8WU71|uniprotkb:Q96GV1|uniprotkb:Q9BT62|uniprotkb:Q9UM55|ensembl:ENSP00000234590|uniprotkb:B2RD59|uniprotkb:Q53FT9|uniprotkb:Q53HR3|uniprotkb:Q9UCH6 intact:EBI-10769071|ensembl:ENSP00000358353 psi-mi:enoa_human(display_long)|uniprotkb:ENO1(gene name)|psi-mi:ENO1(display_short)|uniprotkb:ENO1L1(gene name synonym)|uniprotkb:MBPB1(gene name synonym)|uniprotkb:MPB1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)|uniprotkb:Phosphopyruvate hydratase(gene name synonym)|uniprotkb:C-myc promoter-binding protein(gene name synonym)|uniprotkb:MBP-1(gene name synonym)|uniprotkb:MPB-1(gene name synonym)|uniprotkb:Plasminogen-binding protein(gene name synonym) psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:"MI:0018"(two hybrid) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10770535|imex:IM-24136-47 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001188412.1|refseq:NP_001419.1|ensembl:ENSG00000074800(gene)|ensembl:ENST00000234590(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016020"(membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031430"(M band)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0051020"(GTPase binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P06733|rcsb pdb:2PSN|rcsb pdb:3B97|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5OCK|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-9636667 ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) - - - figure legend:Table 2-4|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2015/04/24 2015/04/29 rogid:RmP7cr55H8ylcgBOEyivwljIE+09606 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rigid:mJuR+V6T/mUeIesfCY0LAwQxXuc false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P13929 uniprotkb:Q5VU43-11 intact:EBI-4287222|uniprotkb:B4DUI6|uniprotkb:B4DUM6|uniprotkb:Q96AE2|uniprotkb:D3DTL2|uniprotkb:E7ENK8|ensembl:ENSP00000324105|ensembl:ENSP00000430055|ensembl:ENSP00000431087 intact:EBI-10769071|ensembl:ENSP00000358353 psi-mi:enob_human(display_long)|uniprotkb:ENO3(gene name)|psi-mi:ENO3(display_short)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Enolase 3(gene name synonym)|uniprotkb:Muscle-specific enolase(gene name synonym)|uniprotkb:Skeletal muscle enolase(gene name synonym) psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:"MI:0018"(two hybrid) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10770539|imex:IM-24136-85 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001180432.1|refseq:NP_001967.3|refseq:NP_443739.3|refseq:XP_011522031.1|refseq:XP_016879835.1|go:"GO:0016020"(membrane)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|rcsb pdb:2XSX|reactome:R-HSA-70171|reactome:R-HSA-70263|ensembl:ENSG00000108515(gene)|ensembl:ENST00000323997(transcript)|ensembl:ENST00000518175(transcript)|ensembl:ENST00000519602(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0007568"(aging) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) - - - figure legend:Table 2-5|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2015/04/24 2015/04/29 rogid:E25deDsQGp3y1HGuTqYwM1pUoD49606 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rigid:SMulSmoo0zsr8G5MWkGyOxvi0Ic false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q5VU43-11 uniprotkb:Q14896 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-704176|uniprotkb:Q16410|uniprotkb:Q6R2F7|uniprotkb:Q9UE27|uniprotkb:A5PL00|uniprotkb:Q9UM53|ensembl:ENSP00000442795 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:mypc3_human(display_long)|uniprotkb:C-protein, cardiac muscle isoform(gene name synonym)|uniprotkb:MYBPC3(gene name)|psi-mi:MYBPC3(display_short) psi-mi:"MI:0416"(fluorescence microscopy) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-10769218|imex:IM-24136-83 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) refseq:NP_000247.2|ensembl:ENSG00000134571(gene)|ensembl:ENST00000545968(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005863"(striated muscle myosin thick filament)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014705"(C zone)|go:"GO:0017022"(myosin binding)|go:"GO:0030017"(sarcomere)|go:"GO:0031432"(titin binding)|go:"GO:0031672"(A band)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032971"(regulation of muscle filament sliding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q14896|rcsb pdb:1GXE|rcsb pdb:1PD6|rcsb pdb:2AVG|rcsb pdb:2K1M|rcsb pdb:2MQ0|rcsb pdb:2MQ3|rcsb pdb:2V6H|rcsb pdb:3CX2|rcsb pdb:5K6P|rcsb pdb:6CXI|rcsb pdb:6CXJ|rcsb pdb:6G2T|reactome:R-HSA-390522 go:"GO:0030017"(sarcomere) - - figure legend:Figure 1|agonist:isoproterenol -an beta-adrenergic agonist|comment:It has been assumed the non-mutated form of cMyBPC was used here, as Isoproterenol was added to stimulate phosphorylation of the MyBPC-motif, which would not be possible if the serine residues were not present.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2015/04/28 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:JYH9WxTpibBvj4Z6y0ZNgQEW2zE9606 rigid:E3uNObfDZ+HPACt+IfkYN7VZr6s false red fluorescent protein tag:n-n sufficient binding region:153..153-452..452(IPR013098)|green fluorescent protein tag:n-n - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:Q5VU43-11 uniprotkb:P13861 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-2556122|intact:EBI-6116682|uniprotkb:Q9BUB1|uniprotkb:Q16823|ensembl:ENSP00000265563|ensembl:ENSP00000394041|intact:EBI-10961724 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:kap2_human(display_long)|uniprotkb:PKR2(gene name synonym)|uniprotkb:PRKAR2(gene name synonym)|uniprotkb:PRKAR2A(gene name)|psi-mi:PRKAR2A(display_short) psi-mi:"MI:0416"(fluorescence microscopy) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-10769652|imex:IM-24136-29 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) dip:DIP-552N|refseq:XP_011532244.1|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:P13861|rcsb pdb:2IZX|rcsb pdb:2KYG|rcsb pdb:4ZP3|rcsb pdb:5H78|rcsb pdb:5XBY|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-381676|reactome:R-HSA-432040|reactome:R-HSA-442720|reactome:R-HSA-5610787|reactome:R-HSA-9010642|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|ensembl:ENSG00000114302(gene)|ensembl:ENST00000265563(transcript)|ensembl:ENST00000454963(transcript)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097546"(ciliary base)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|refseq:NP_001308911.1|refseq:NP_001308912.1|refseq:NP_004148.1|refseq:XP_016862304.1 go:"GO:0005829"(cytosol) - - figure legend:Figure 3B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2015/04/28 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:9Jf7EDZ9CZjeRERWwLAR0NyqFGQ9606 rigid:Xgp1khZqpqKBEh2XmChcgnIZkbs false red fluorescent protein tag:n-n green fluorescent protein tag:n-n - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P10644 uniprotkb:Q5VU43-11 intact:EBI-476431|uniprotkb:Q567S7|uniprotkb:K7ER48|ensembl:ENSP00000351410|ensembl:ENSP00000376475|ensembl:ENSP00000445625|ensembl:ENSP00000464977|ensembl:ENSP00000466459 intact:EBI-10769071|ensembl:ENSP00000358353 psi-mi:kap0_human(display_long)|uniprotkb:Tissue-specific extinguisher 1(gene name synonym)|uniprotkb:PRKAR1A(gene name)|psi-mi:PRKAR1A(display_short)|uniprotkb:PKR1(gene name synonym)|uniprotkb:PRKAR1(gene name synonym)|uniprotkb:TSE1(gene name synonym) psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-10769691|imex:IM-24136-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002725.1|refseq:NP_997636.1|refseq:NP_997637.1|refseq:XP_011523285.1|refseq:XP_011523286.1|refseq:XP_011523287.1|refseq:NP_001263218.1|refseq:NP_001263219.1|refseq:NP_001265362.1|dip:DIP-34368N|ensembl:ENSG00000108946(gene)|ensembl:ENST00000358598(transcript)|ensembl:ENST00000392711(transcript)|ensembl:ENST00000536854(transcript)|ensembl:ENST00000586397(transcript)|ensembl:ENST00000589228(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0097546"(ciliary base)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|rcsb pdb:5KJZ|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-381676|reactome:R-HSA-432040|reactome:R-HSA-442720|reactome:R-HSA-5610787|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|interpro:IPR018490|mint:P10644|rcsb pdb:5KJX|rcsb pdb:5KJY ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) go:"GO:0005829"(cytosol) - - figure legend:Figure 3Bi|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2015/04/28 rogid:dUZaCJQnC0KZEG4pccIqoT066VY9606 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rigid:mN55RDqOcE2UYejWJKspeHH5F/o false green fluorescent protein tag:n-n red fluorescent protein tag:n-n - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:Q5VU43-11 uniprotkb:Q15327 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-5653378|uniprotkb:Q96LE7|ensembl:ENSP00000360762 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:ankr1_human(display_long)|uniprotkb:C193(gene name synonym)|uniprotkb:CARP(gene name synonym)|uniprotkb:Cardiac ankyrin repeat protein(gene name synonym)|uniprotkb:Cytokine-inducible gene C-193 protein(gene name synonym)|uniprotkb:Cytokine-inducible nuclear protein(gene name synonym)|uniprotkb:HA1A2(gene name synonym)|uniprotkb:ANKRD1(gene name)|psi-mi:ANKRD1(display_short) psi-mi:"MI:0416"(fluorescence microscopy) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-10770549|imex:IM-24136-87 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) refseq:NP_055206.2|ensembl:ENSG00000148677(gene)|ensembl:ENST00000371697(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0031432"(titin binding)|go:"GO:0031674"(I band)|go:"GO:0035690"|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045214"(sarcomere organization)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|reactome:R-HSA-1989781 go:"GO:0005829"(cytosol) - - figure legend:Figure 4|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2015/04/29 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:UQq7pp3hORsCvEVEvGXE7gq+4mk9606 rigid:yqogXs7vkPkqC5J9vv74wI28OyA false red fluorescent protein tag:n-n green fluorescent protein tag:n-n - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:Q5VU43-11 uniprotkb:Q9H0A8 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-1550064|uniprotkb:Q7L637|uniprotkb:Q9NX43|uniprotkb:B2RBN4|uniprotkb:H3BUL2|ensembl:ENSP00000267935|ensembl:ENSP00000433662 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:comd4_human(display_long)|uniprotkb:COMMD4(gene name)|psi-mi:COMMD4(display_short) psi-mi:"MI:0416"(fluorescence microscopy) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-10770559|imex:IM-24136-75 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) refseq:NP_001271306.1|refseq:NP_060298.2|refseq:NP_001271307.1|ensembl:ENSG00000140365(gene)|ensembl:ENST00000267935(transcript)|ensembl:ENST00000480484(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017920|interpro:IPR037356|reactome:R-HSA-8951664 go:"GO:0005829"(cytosol) - - figure legend:Figure 4-1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2015/04/29 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:v1pkDNc18f7sZM/89Gv0bho9GN89606 rigid:l/1nwFGY4qDFfEJAz5PF4KpjIbs false red fluorescent protein tag:n-n green fluorescent protein tag:n-n - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:Q5VU43-11 uniprotkb:P06733 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-353877|uniprotkb:P22712|uniprotkb:Q16704|uniprotkb:Q4TUS4|uniprotkb:Q658M5|uniprotkb:Q6GMP2|uniprotkb:Q71V37|uniprotkb:Q7Z3V6|uniprotkb:Q8WU71|uniprotkb:Q96GV1|uniprotkb:Q9BT62|uniprotkb:Q9UM55|ensembl:ENSP00000234590|uniprotkb:B2RD59|uniprotkb:Q53FT9|uniprotkb:Q53HR3|uniprotkb:Q9UCH6 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:enoa_human(display_long)|uniprotkb:ENO1(gene name)|psi-mi:ENO1(display_short)|uniprotkb:ENO1L1(gene name synonym)|uniprotkb:MBPB1(gene name synonym)|uniprotkb:MPB1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)|uniprotkb:Phosphopyruvate hydratase(gene name synonym)|uniprotkb:C-myc promoter-binding protein(gene name synonym)|uniprotkb:MBP-1(gene name synonym)|uniprotkb:MPB-1(gene name synonym)|uniprotkb:Plasminogen-binding protein(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-10770582|imex:IM-24136-35 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) refseq:NP_001188412.1|refseq:NP_001419.1|ensembl:ENSG00000074800(gene)|ensembl:ENST00000234590(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016020"(membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031430"(M band)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0051020"(GTPase binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P06733|rcsb pdb:2PSN|rcsb pdb:3B97|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5OCK|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-9636667 go:"GO:0005829"(cytosol) - - figure legend:Figure 4-2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2015/04/29 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:RmP7cr55H8ylcgBOEyivwljIE+09606 rigid:mJuR+V6T/mUeIesfCY0LAwQxXuc false red fluorescent protein tag:n-n green fluorescent protein tag:n-n - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:Q5VU43-11 uniprotkb:P13929 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-4287222|uniprotkb:B4DUI6|uniprotkb:B4DUM6|uniprotkb:Q96AE2|uniprotkb:D3DTL2|uniprotkb:E7ENK8|ensembl:ENSP00000324105|ensembl:ENSP00000430055|ensembl:ENSP00000431087 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:enob_human(display_long)|uniprotkb:ENO3(gene name)|psi-mi:ENO3(display_short)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Enolase 3(gene name synonym)|uniprotkb:Muscle-specific enolase(gene name synonym)|uniprotkb:Skeletal muscle enolase(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-10770600|imex:IM-24136-37 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) refseq:NP_001180432.1|refseq:NP_001967.3|refseq:NP_443739.3|refseq:XP_011522031.1|refseq:XP_016879835.1|go:"GO:0016020"(membrane)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|rcsb pdb:2XSX|reactome:R-HSA-70171|reactome:R-HSA-70263|ensembl:ENSG00000108515(gene)|ensembl:ENST00000323997(transcript)|ensembl:ENST00000518175(transcript)|ensembl:ENST00000519602(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0007568"(aging) go:"GO:0005829"(cytosol) - - figure legend:Figure 4-3|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2015/04/29 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:E25deDsQGp3y1HGuTqYwM1pUoD49606 rigid:SMulSmoo0zsr8G5MWkGyOxvi0Ic false red fluorescent protein tag:n-n green fluorescent protein tag:n-n - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:Q5VU43-11 uniprotkb:P19429 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-704146|ensembl:ENSP00000341838 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:tnni3_human(display_long)|uniprotkb:Cardiac troponin I(gene name synonym)|uniprotkb:TNNI3(gene name)|psi-mi:TNNI3(display_short)|uniprotkb:TNNC1(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-10770637|imex:IM-24136-89 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) refseq:NP_000354.4|dip:DIP-34065N|ensembl:ENSG00000129991(gene)|ensembl:ENST00000344887(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001980"(regulation of systemic arterial blood pressure by ischemic conditions)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005861"(troponin complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006936"(muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007507"(heart development)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030172"(troponin C binding)|go:"GO:0031014"(troponin T binding)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060047"(heart contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|go:"GO:1990584"(cardiac Troponin complex)|interpro:IPR001978(Troponin)|interpro:IPR021666|interpro:IPR038077|mint:P19429|rcsb pdb:1J1D|rcsb pdb:1J1E|rcsb pdb:1LXF|rcsb pdb:1MXL|rcsb pdb:1OZS|rcsb pdb:2KGB|rcsb pdb:2KRD|rcsb pdb:2L1R|rcsb pdb:2MZP|rcsb pdb:2N7L|rcsb pdb:4Y99|rcsb pdb:5VLN|rcsb pdb:5W88|rcsb pdb:5WCL|rcsb pdb:6KN7|rcsb pdb:6KN8|rcsb pdb:6MV3|rcsb pdb:7JGI|reactome:R-HSA-390522|reactome:R-HSA-5578775 go:"GO:0030017"(sarcomere) - - figure legend:Figure 5A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2015/04/29 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:kLAHLvln+lIzJRQ8Dit1sSKw/6Y9606 rigid:RTtZOwVx4OrGAefskdgzXGOMWZQ false yellow fluorescent protein tag:n-n red fluorescent protein tag:n-n - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P19429 uniprotkb:Q5VU43-11 intact:EBI-704146|ensembl:ENSP00000341838 intact:EBI-10769071|ensembl:ENSP00000358353 psi-mi:tnni3_human(display_long)|uniprotkb:Cardiac troponin I(gene name synonym)|uniprotkb:TNNI3(gene name)|psi-mi:TNNI3(display_short)|uniprotkb:TNNC1(gene name synonym) psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-10770651|imex:IM-24136-49 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000354.4|dip:DIP-34065N|ensembl:ENSG00000129991(gene)|ensembl:ENST00000344887(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001980"(regulation of systemic arterial blood pressure by ischemic conditions)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005861"(troponin complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006936"(muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007507"(heart development)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030172"(troponin C binding)|go:"GO:0031014"(troponin T binding)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060047"(heart contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|go:"GO:1990584"(cardiac Troponin complex)|interpro:IPR001978(Troponin)|interpro:IPR021666|interpro:IPR038077|mint:P19429|rcsb pdb:1J1D|rcsb pdb:1J1E|rcsb pdb:1LXF|rcsb pdb:1MXL|rcsb pdb:1OZS|rcsb pdb:2KGB|rcsb pdb:2KRD|rcsb pdb:2L1R|rcsb pdb:2MZP|rcsb pdb:2N7L|rcsb pdb:4Y99|rcsb pdb:5VLN|rcsb pdb:5W88|rcsb pdb:5WCL|rcsb pdb:6KN7|rcsb pdb:6KN8|rcsb pdb:6MV3|rcsb pdb:7JGI|reactome:R-HSA-390522|reactome:R-HSA-5578775 ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) go:"GO:0030017"(sarcomere) - - figure legend:Figure 5B|agonist:isoproterenol -an beta-adrenergic agonist|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2015/04/29 rogid:kLAHLvln+lIzJRQ8Dit1sSKw/6Y9606 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rigid:RTtZOwVx4OrGAefskdgzXGOMWZQ false green fluorescent protein tag:n-n red fluorescent protein tag:n-n - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:Q5VU43-11 uniprotkb:Q14896 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-704176|uniprotkb:Q16410|uniprotkb:Q6R2F7|uniprotkb:Q9UE27|uniprotkb:A5PL00|uniprotkb:Q9UM53|ensembl:ENSP00000442795 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:mypc3_human(display_long)|uniprotkb:C-protein, cardiac muscle isoform(gene name synonym)|uniprotkb:MYBPC3(gene name)|psi-mi:MYBPC3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10769502|imex:IM-24136-71 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) refseq:NP_000247.2|ensembl:ENSG00000134571(gene)|ensembl:ENST00000545968(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005863"(striated muscle myosin thick filament)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014705"(C zone)|go:"GO:0017022"(myosin binding)|go:"GO:0030017"(sarcomere)|go:"GO:0031432"(titin binding)|go:"GO:0031672"(A band)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032971"(regulation of muscle filament sliding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q14896|rcsb pdb:1GXE|rcsb pdb:1PD6|rcsb pdb:2AVG|rcsb pdb:2K1M|rcsb pdb:2MQ0|rcsb pdb:2MQ3|rcsb pdb:2V6H|rcsb pdb:3CX2|rcsb pdb:5K6P|rcsb pdb:6CXI|rcsb pdb:6CXJ|rcsb pdb:6G2T|reactome:R-HSA-390522 go:"GO:0030017"(sarcomere) - - figure legend:Figure 2A|comment:MMGL interacts with the native as well as the trisphospho-mimic form of cMyBPC.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/04/24 2015/04/28 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:JYH9WxTpibBvj4Z6y0ZNgQEW2zE9606 rigid:E3uNObfDZ+HPACt+IfkYN7VZr6s false ha tag:?-?|35s radiolabel:?-? sufficient binding region:153..153-452..452(IPR013098)|myc tag:?-?|35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q5VU43-11 uniprotkb:Q14896 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-704176|uniprotkb:Q16410|uniprotkb:Q6R2F7|uniprotkb:Q9UE27|uniprotkb:A5PL00|uniprotkb:Q9UM53|ensembl:ENSP00000442795 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:mypc3_human(display_long)|uniprotkb:C-protein, cardiac muscle isoform(gene name synonym)|uniprotkb:MYBPC3(gene name)|psi-mi:MYBPC3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10769536|imex:IM-24136-41 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) refseq:NP_000247.2|ensembl:ENSG00000134571(gene)|ensembl:ENST00000545968(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005863"(striated muscle myosin thick filament)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014705"(C zone)|go:"GO:0017022"(myosin binding)|go:"GO:0030017"(sarcomere)|go:"GO:0031432"(titin binding)|go:"GO:0031672"(A band)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032971"(regulation of muscle filament sliding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q14896|rcsb pdb:1GXE|rcsb pdb:1PD6|rcsb pdb:2AVG|rcsb pdb:2K1M|rcsb pdb:2MQ0|rcsb pdb:2MQ3|rcsb pdb:2V6H|rcsb pdb:3CX2|rcsb pdb:5K6P|rcsb pdb:6CXI|rcsb pdb:6CXJ|rcsb pdb:6G2T|reactome:R-HSA-390522 - - - figure legend:Figure 2B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2015/04/28 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:JYH9WxTpibBvj4Z6y0ZNgQEW2zE9606 rigid:E3uNObfDZ+HPACt+IfkYN7VZr6s false red fluorescent protein tag:n-n sufficient binding region:153..153-452..452(IPR013098)|green fluorescent protein tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q5VU43-11 uniprotkb:Q14896 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-704176|uniprotkb:Q16410|uniprotkb:Q6R2F7|uniprotkb:Q9UE27|uniprotkb:A5PL00|uniprotkb:Q9UM53|ensembl:ENSP00000442795 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:mypc3_human(display_long)|uniprotkb:C-protein, cardiac muscle isoform(gene name synonym)|uniprotkb:MYBPC3(gene name)|psi-mi:MYBPC3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10769553|imex:IM-24136-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) refseq:NP_000247.2|ensembl:ENSG00000134571(gene)|ensembl:ENST00000545968(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005863"(striated muscle myosin thick filament)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014705"(C zone)|go:"GO:0017022"(myosin binding)|go:"GO:0030017"(sarcomere)|go:"GO:0031432"(titin binding)|go:"GO:0031672"(A band)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032971"(regulation of muscle filament sliding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849|mint:Q14896|rcsb pdb:1GXE|rcsb pdb:1PD6|rcsb pdb:2AVG|rcsb pdb:2K1M|rcsb pdb:2MQ0|rcsb pdb:2MQ3|rcsb pdb:2V6H|rcsb pdb:3CX2|rcsb pdb:5K6P|rcsb pdb:6CXI|rcsb pdb:6CXJ|rcsb pdb:6G2T|reactome:R-HSA-390522 - - - figure legend:Figure 2B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2015/04/28 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:JYH9WxTpibBvj4Z6y0ZNgQEW2zE9606 rigid:E3uNObfDZ+HPACt+IfkYN7VZr6s false red fluorescent protein tag:n-n sufficient binding region:153..153-452..452(IPR013098)|green fluorescent protein tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q5VU43-11 uniprotkb:Q9H0A8 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-1550064|uniprotkb:Q7L637|uniprotkb:Q9NX43|uniprotkb:B2RBN4|uniprotkb:H3BUL2|ensembl:ENSP00000267935|ensembl:ENSP00000433662 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:comd4_human(display_long)|uniprotkb:COMMD4(gene name)|psi-mi:COMMD4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10770722|imex:IM-24136-39 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) refseq:NP_001271306.1|refseq:NP_060298.2|refseq:NP_001271307.1|ensembl:ENSG00000140365(gene)|ensembl:ENST00000267935(transcript)|ensembl:ENST00000480484(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017920|interpro:IPR037356|reactome:R-HSA-8951664 - - - figure legend:Figure 6v-B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2015/04/29 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:v1pkDNc18f7sZM/89Gv0bho9GN89606 rigid:l/1nwFGY4qDFfEJAz5PF4KpjIbs false red fluorescent protein tag:n-n green fluorescent protein tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q5VU43-11 uniprotkb:Q9H0A8 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-1550064|uniprotkb:Q7L637|uniprotkb:Q9NX43|uniprotkb:B2RBN4|uniprotkb:H3BUL2|ensembl:ENSP00000267935|ensembl:ENSP00000433662 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:comd4_human(display_long)|uniprotkb:COMMD4(gene name)|psi-mi:COMMD4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10770730|imex:IM-24136-91 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) refseq:NP_001271306.1|refseq:NP_060298.2|refseq:NP_001271307.1|ensembl:ENSG00000140365(gene)|ensembl:ENST00000267935(transcript)|ensembl:ENST00000480484(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017920|interpro:IPR037356|reactome:R-HSA-8951664 - - - figure legend:Figure 6v-A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2015/04/29 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:v1pkDNc18f7sZM/89Gv0bho9GN89606 rigid:l/1nwFGY4qDFfEJAz5PF4KpjIbs false red fluorescent protein tag:n-n green fluorescent protein tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P13861 uniprotkb:Q5VU43-11 intact:EBI-2556122|intact:EBI-6116682|uniprotkb:Q9BUB1|uniprotkb:Q16823|ensembl:ENSP00000265563|ensembl:ENSP00000394041|intact:EBI-10961724 intact:EBI-10769071|ensembl:ENSP00000358353 psi-mi:kap2_human(display_long)|uniprotkb:PKR2(gene name synonym)|uniprotkb:PRKAR2(gene name synonym)|uniprotkb:PRKAR2A(gene name)|psi-mi:PRKAR2A(display_short) psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:"MI:0018"(two hybrid) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10769608|imex:IM-24136-27 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-552N|refseq:XP_011532244.1|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:P13861|rcsb pdb:2IZX|rcsb pdb:2KYG|rcsb pdb:4ZP3|rcsb pdb:5H78|rcsb pdb:5XBY|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-381676|reactome:R-HSA-432040|reactome:R-HSA-442720|reactome:R-HSA-5610787|reactome:R-HSA-9010642|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|ensembl:ENSG00000114302(gene)|ensembl:ENST00000265563(transcript)|ensembl:ENST00000454963(transcript)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097546"(ciliary base)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|refseq:NP_001308911.1|refseq:NP_001308912.1|refseq:NP_004148.1|refseq:XP_016862304.1 ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) - - - figure legend:Figure 3A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2015/04/24 2015/04/28 rogid:9Jf7EDZ9CZjeRERWwLAR0NyqFGQ9606 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rigid:Xgp1khZqpqKBEh2XmChcgnIZkbs false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P10644 uniprotkb:Q5VU43-11 intact:EBI-476431|uniprotkb:Q567S7|uniprotkb:K7ER48|ensembl:ENSP00000351410|ensembl:ENSP00000376475|ensembl:ENSP00000445625|ensembl:ENSP00000464977|ensembl:ENSP00000466459 intact:EBI-10769071|ensembl:ENSP00000358353 psi-mi:kap0_human(display_long)|uniprotkb:Tissue-specific extinguisher 1(gene name synonym)|uniprotkb:PRKAR1A(gene name)|psi-mi:PRKAR1A(display_short)|uniprotkb:PKR1(gene name synonym)|uniprotkb:PRKAR1(gene name synonym)|uniprotkb:TSE1(gene name synonym) psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:"MI:0018"(two hybrid) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10769632|imex:IM-24136-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002725.1|refseq:NP_997636.1|refseq:NP_997637.1|refseq:XP_011523285.1|refseq:XP_011523286.1|refseq:XP_011523287.1|refseq:NP_001263218.1|refseq:NP_001263219.1|refseq:NP_001265362.1|dip:DIP-34368N|ensembl:ENSG00000108946(gene)|ensembl:ENST00000358598(transcript)|ensembl:ENST00000392711(transcript)|ensembl:ENST00000536854(transcript)|ensembl:ENST00000586397(transcript)|ensembl:ENST00000589228(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0097546"(ciliary base)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|rcsb pdb:5KJZ|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-381676|reactome:R-HSA-432040|reactome:R-HSA-442720|reactome:R-HSA-5610787|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|interpro:IPR018490|mint:P10644|rcsb pdb:5KJX|rcsb pdb:5KJY ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) - - - figure legend:Figure 3A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2015/04/24 2015/04/28 rogid:dUZaCJQnC0KZEG4pccIqoT066VY9606 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rigid:mN55RDqOcE2UYejWJKspeHH5F/o false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5VU43-11 uniprotkb:P19429 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-704146|ensembl:ENSP00000341838 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:tnni3_human(display_long)|uniprotkb:Cardiac troponin I(gene name synonym)|uniprotkb:TNNI3(gene name)|psi-mi:TNNI3(display_short)|uniprotkb:TNNC1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10769641|imex:IM-24136-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) refseq:NP_000354.4|dip:DIP-34065N|ensembl:ENSG00000129991(gene)|ensembl:ENST00000344887(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001980"(regulation of systemic arterial blood pressure by ischemic conditions)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005861"(troponin complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006936"(muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007507"(heart development)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030172"(troponin C binding)|go:"GO:0031014"(troponin T binding)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060047"(heart contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|go:"GO:1990584"(cardiac Troponin complex)|interpro:IPR001978(Troponin)|interpro:IPR021666|interpro:IPR038077|mint:P19429|rcsb pdb:1J1D|rcsb pdb:1J1E|rcsb pdb:1LXF|rcsb pdb:1MXL|rcsb pdb:1OZS|rcsb pdb:2KGB|rcsb pdb:2KRD|rcsb pdb:2L1R|rcsb pdb:2MZP|rcsb pdb:2N7L|rcsb pdb:4Y99|rcsb pdb:5VLN|rcsb pdb:5W88|rcsb pdb:5WCL|rcsb pdb:6KN7|rcsb pdb:6KN8|rcsb pdb:6MV3|rcsb pdb:7JGI|reactome:R-HSA-390522|reactome:R-HSA-5578775 - - - figure legend:Figure 3A|comment:Positive control|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2015/04/24 2015/04/28 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:kLAHLvln+lIzJRQ8Dit1sSKw/6Y9606 rigid:RTtZOwVx4OrGAefskdgzXGOMWZQ false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P09456 uniprotkb:Q5VU43-11 intact:EBI-916215|ensembl:ENSRNOP00000067771 intact:EBI-10769071|ensembl:ENSP00000358353 psi-mi:kap0_rat(display_long)|uniprotkb:Prkar1a(gene name)|psi-mi:Prkar1a(display_short) psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10769744|imex:IM-24136-31 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3391|refseq:NP_037313.1|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|reactome:R-RNO-163615|reactome:R-RNO-164378|reactome:R-RNO-180024|reactome:R-RNO-432040|reactome:R-RNO-442720|reactome:R-RNO-5610787|reactome:R-RNO-983231|ensembl:ENSRNOG00000049876(gene)|ensembl:ENSRNOT00000071153(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005813"(centrosome)|go:"GO:0005930"(axoneme)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0007507"(heart development)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|refseq:XP_008766533.1|refseq:XP_017452536.1 ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) - - - figure legend:Figure 3C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2015/05/08 rogid:nGBB094hlb7YlbgO+DYsOaikgjk10116 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rigid:O9FulRLMHB7iBB9ak8Xm02x+zSY false - red fluorescent protein tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5VU43-11 uniprotkb:P12368 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-919521|uniprotkb:Q8K1M2|uniprotkb:G3V8Q6|ensembl:ENSRNOP00000027552 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:kap2_rat(display_long)|uniprotkb:Prkar2a(gene name)|psi-mi:Prkar2a(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10769751|imex:IM-24136-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) rgd:3393|refseq:NP_062137.1|dip:DIP-555N|ensembl:ENSRNOG00000020284(gene)|ensembl:ENSRNOT00000027552(transcript)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0097338"(response to clozapine)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2DRN|rcsb pdb:2H9R|rcsb pdb:2HWN|rcsb pdb:3TMH|reactome:R-RNO-163615|reactome:R-RNO-164378|reactome:R-RNO-180024|reactome:R-RNO-432040|reactome:R-RNO-442720|reactome:R-RNO-5610787|reactome:R-RNO-983231 - - - figure legend:Figure 3Ci|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2017/10/20 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:ZPxd/oQFtg/sxxKaVa+N/yzkUhY10116 rigid:Msn/gDsL8V46Fzv03dd8SbBF5H4 false red fluorescent protein tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5VU43-11 uniprotkb:Q8R560 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-10817505|ensembl:ENSRNOP00000025258|uniprotkb:Q9Z1F0 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:ankr1_rat(display_long)|uniprotkb:Cardiac adriamycin-responsive protein(gene name synonym)|uniprotkb:Cardiac ankyrin repeat protein(gene name synonym)|uniprotkb:Ankrd1(gene name)|psi-mi:Ankrd1(display_short)|uniprotkb:Carp(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10770670|imex:IM-24136-77 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) rgd:61989|ensembl:ENSRNOG00000018598(gene)|ensembl:ENSRNOT00000025258(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030016"(myofibril)|go:"GO:0031432"(titin binding)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035690"|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|refseq:NP_037352.1 - - - figure legend:Figure 6i-B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2015/05/20 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:CyorjT9elu6xQM7B/e4Oh/1zjwg10116 rigid:UWEXBrjnBNeT80x3LE1Xzg6GQss false yellow fluorescent protein tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5VU43-11 uniprotkb:P04764 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-915852|uniprotkb:Q66HI3|uniprotkb:Q6AYV3|uniprotkb:Q6P504|ensembl:ENSRNOP00000024106|ensembl:ENSRNOP00000073191 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:enoa_rat(display_long)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)|uniprotkb:Eno1(gene name)|psi-mi:Eno1(display_short)|uniprotkb:Eno-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10770684|imex:IM-24136-51 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) rgd:2553|refseq:NP_001103378.1|refseq:NP_036686.2|ensembl:ENSRNOG00000017895(gene)|ensembl:ENSRNOT00000024106(transcript)|ensembl:ENSRNOT00000081579(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016020"(membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030426"(growth cone)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0051020"(GTPase binding)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0099738"(cell cortex region)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P04764|reactome:R-RNO-70171|reactome:R-RNO-70263 - - - figure legend:Figure 6ii-B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2015/05/08 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:JPjYBxy1gOmhfZso6+adhg5N8UM10116 rigid:q5U6D9nQYhh7jKG36h7fVGuXE60 false red fluorescent protein tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5VU43-11 uniprotkb:P15429 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-10817548|ensembl:ENSRNOP00000005612|uniprotkb:Q5XIV3 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:enob_rat(display_long)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Enolase 3(gene name synonym)|uniprotkb:Muscle-specific enolase(gene name synonym)|uniprotkb:Skeletal muscle enolase(gene name synonym)|uniprotkb:Eno3(gene name)|psi-mi:Eno3(display_short)|uniprotkb:Eno-3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10770697|imex:IM-24136-55 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) rgd:2555|ensembl:ENSRNOG00000004078(gene)|ensembl:ENSRNOT00000005612(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0007568"(aging)|go:"GO:0016020"(membrane)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|reactome:R-RNO-70171|reactome:R-RNO-70263|refseq:NP_037081.2|refseq:XP_006246661.1|refseq:XP_006246662.1 - - - figure legend:Figure 6iii-B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2015/05/08 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:1FQHyBT1Y7UyyDlu00uX/fDKpRI10116 rigid:7CiZm1zJ2K2a6HoLsmpDAeS6UhU false red fluorescent protein tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5VU43-11 uniprotkb:P23693 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-10817583|ensembl:ENSRNOP00000024640|uniprotkb:Q4PP23 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:tnni3_rat(display_long)|uniprotkb:Cardiac troponin I(gene name synonym)|uniprotkb:Tnni3(gene name)|psi-mi:Tnni3(display_short)|uniprotkb:Ctni(gene name synonym)|uniprotkb:Tni(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10770716|imex:IM-24136-59 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) rgd:62052|ensembl:ENSRNOG00000018250(gene)|ensembl:ENSRNOT00000024640(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001980"(regulation of systemic arterial blood pressure by ischemic conditions)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005861"(troponin complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007507"(heart development)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0030172"(troponin C binding)|go:"GO:0031014"(troponin T binding)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0043292"(contractile fiber)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060047"(heart contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|go:"GO:1990584"(cardiac Troponin complex)|interpro:IPR001978(Troponin)|interpro:IPR021666|interpro:IPR038077|reactome:R-RNO-390522|reactome:R-RNO-5578775|refseq:NP_058840.1 - - - figure legend:Figure 6iv-B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2015/05/08 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:bW+9M+3Rd5EybJg8SpjEQwo7sRA10116 rigid:PU8Kk/BdgohDTw0RPaAq+C3FoNQ false red fluorescent protein tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P09456 uniprotkb:Q5VU43-11 intact:EBI-916215|ensembl:ENSRNOP00000067771 intact:EBI-10769071|ensembl:ENSP00000358353 psi-mi:kap0_rat(display_long)|uniprotkb:Prkar1a(gene name)|psi-mi:Prkar1a(display_short) psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10769765|imex:IM-24136-73 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3391|refseq:NP_037313.1|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|reactome:R-RNO-163615|reactome:R-RNO-164378|reactome:R-RNO-180024|reactome:R-RNO-432040|reactome:R-RNO-442720|reactome:R-RNO-5610787|reactome:R-RNO-983231|ensembl:ENSRNOG00000049876(gene)|ensembl:ENSRNOT00000071153(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005813"(centrosome)|go:"GO:0005930"(axoneme)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0007507"(heart development)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|refseq:XP_008766533.1|refseq:XP_017452536.1 ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) - - - figure legend:Figure 3C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2015/05/08 rogid:nGBB094hlb7YlbgO+DYsOaikgjk10116 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rigid:O9FulRLMHB7iBB9ak8Xm02x+zSY false - red fluorescent protein tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q5VU43-11 uniprotkb:P12368 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-919521|uniprotkb:Q8K1M2|uniprotkb:G3V8Q6|ensembl:ENSRNOP00000027552 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:kap2_rat(display_long)|uniprotkb:Prkar2a(gene name)|psi-mi:Prkar2a(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10769771|imex:IM-24136-43 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) rgd:3393|refseq:NP_062137.1|dip:DIP-555N|ensembl:ENSRNOG00000020284(gene)|ensembl:ENSRNOT00000027552(transcript)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0097338"(response to clozapine)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2DRN|rcsb pdb:2H9R|rcsb pdb:2HWN|rcsb pdb:3TMH|reactome:R-RNO-163615|reactome:R-RNO-164378|reactome:R-RNO-180024|reactome:R-RNO-432040|reactome:R-RNO-442720|reactome:R-RNO-5610787|reactome:R-RNO-983231 - - - figure legend:Figure 3Ci|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2017/10/20 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:ZPxd/oQFtg/sxxKaVa+N/yzkUhY10116 rigid:Msn/gDsL8V46Fzv03dd8SbBF5H4 false red fluorescent protein tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q5VU43-11 uniprotkb:Q8R560 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-10817505|ensembl:ENSRNOP00000025258|uniprotkb:Q9Z1F0 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:ankr1_rat(display_long)|uniprotkb:Cardiac adriamycin-responsive protein(gene name synonym)|uniprotkb:Cardiac ankyrin repeat protein(gene name synonym)|uniprotkb:Ankrd1(gene name)|psi-mi:Ankrd1(display_short)|uniprotkb:Carp(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10770664|imex:IM-24136-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) rgd:61989|ensembl:ENSRNOG00000018598(gene)|ensembl:ENSRNOT00000025258(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030016"(myofibril)|go:"GO:0031432"(titin binding)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035690"|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|refseq:NP_037352.1 - - - figure legend:Figure 6i-A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2015/05/08 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:CyorjT9elu6xQM7B/e4Oh/1zjwg10116 rigid:UWEXBrjnBNeT80x3LE1Xzg6GQss false yellow fluorescent protein tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q5VU43-11 uniprotkb:P04764 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-915852|uniprotkb:Q66HI3|uniprotkb:Q6AYV3|uniprotkb:Q6P504|ensembl:ENSRNOP00000024106|ensembl:ENSRNOP00000073191 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:enoa_rat(display_long)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)|uniprotkb:Eno1(gene name)|psi-mi:Eno1(display_short)|uniprotkb:Eno-1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10770677|imex:IM-24136-79 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) rgd:2553|refseq:NP_001103378.1|refseq:NP_036686.2|ensembl:ENSRNOG00000017895(gene)|ensembl:ENSRNOT00000024106(transcript)|ensembl:ENSRNOT00000081579(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016020"(membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030426"(growth cone)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0051020"(GTPase binding)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0099738"(cell cortex region)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P04764|reactome:R-RNO-70171|reactome:R-RNO-70263 - - - figure legend:Figure 6ii-A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2015/05/08 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:JPjYBxy1gOmhfZso6+adhg5N8UM10116 rigid:q5U6D9nQYhh7jKG36h7fVGuXE60 false red fluorescent protein tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q5VU43-11 uniprotkb:P15429 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-10817548|ensembl:ENSRNOP00000005612|uniprotkb:Q5XIV3 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:enob_rat(display_long)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Enolase 3(gene name synonym)|uniprotkb:Muscle-specific enolase(gene name synonym)|uniprotkb:Skeletal muscle enolase(gene name synonym)|uniprotkb:Eno3(gene name)|psi-mi:Eno3(display_short)|uniprotkb:Eno-3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10770691|imex:IM-24136-53 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) rgd:2555|ensembl:ENSRNOG00000004078(gene)|ensembl:ENSRNOT00000005612(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0007568"(aging)|go:"GO:0016020"(membrane)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|reactome:R-RNO-70171|reactome:R-RNO-70263|refseq:NP_037081.2|refseq:XP_006246661.1|refseq:XP_006246662.1 - - - figure legend:Figure 6iii-A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2015/05/08 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:1FQHyBT1Y7UyyDlu00uX/fDKpRI10116 rigid:7CiZm1zJ2K2a6HoLsmpDAeS6UhU false red fluorescent protein tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q5VU43-11 uniprotkb:P23693 intact:EBI-10769071|ensembl:ENSP00000358353 intact:EBI-10817583|ensembl:ENSRNOP00000024640|uniprotkb:Q4PP23 psi-mi:q5vu43-11(display_long)|uniprotkb:Cardiomyopathy-associated protein 2(gene name synonym)|uniprotkb:Phosphodiesterase 4D-interacting protein(gene name synonym)|uniprotkb:PDE4DIP(gene name)|psi-mi:PDE4DIP(display_short)|uniprotkb:CMYA2(gene name synonym)|uniprotkb:KIAA0454(gene name synonym)|uniprotkb:KIAA0477(gene name synonym)|uniprotkb:MMGL(gene name synonym) psi-mi:tnni3_rat(display_long)|uniprotkb:Cardiac troponin I(gene name synonym)|uniprotkb:Tnni3(gene name)|psi-mi:Tnni3(display_short)|uniprotkb:Ctni(gene name synonym)|uniprotkb:Tni(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uys et al. (2010) pubmed:21569246|imex:IM-24136 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10770705|imex:IM-24136-57 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000178104(gene)|ensembl:ENST00000369347(transcript)|intact:EBI-1105124(isoform-parent) rgd:62052|ensembl:ENSRNOG00000018250(gene)|ensembl:ENSRNOT00000024640(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001980"(regulation of systemic arterial blood pressure by ischemic conditions)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005861"(troponin complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007507"(heart development)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0030172"(troponin C binding)|go:"GO:0031014"(troponin T binding)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0043292"(contractile fiber)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060047"(heart contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|go:"GO:1990584"(cardiac Troponin complex)|interpro:IPR001978(Troponin)|interpro:IPR021666|interpro:IPR038077|reactome:R-RNO-390522|reactome:R-RNO-5578775|refseq:NP_058840.1 - - - figure legend:Figure 6iv-A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-h9c2)|taxid:10116(h9c2 rat myoblasts) - 2015/04/24 2015/05/08 rogid:w5Avuhn01Gr1dKLNCqmXuC2USMw9606 rogid:bW+9M+3Rd5EybJg8SpjEQwo7sRA10116 rigid:PU8Kk/BdgohDTw0RPaAq+C3FoNQ false red fluorescent protein tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)