#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q6VVB1	uniprotkb:O95278	intact:EBI-6426628|ensembl:ENSP00000345464|uniprotkb:Q6IMH1|uniprotkb:Q5VUK7|uniprotkb:Q3SYB1	intact:EBI-2506661|uniprotkb:O95483|uniprotkb:Q5T3F5|uniprotkb:Q8IU96|uniprotkb:Q8IX24|uniprotkb:Q8IX25|uniprotkb:Q9BS66|uniprotkb:Q9UEN2|ensembl:ENSP00000356489|uniprotkb:B3KMU5|uniprotkb:B4DRZ2|uniprotkb:Q6IS15	psi-mi:nhlc1_human(display_long)|uniprotkb:NHLRC1(gene name)|psi-mi:NHLRC1(display_short)|uniprotkb:EPM2B(gene name synonym)|uniprotkb:Malin(gene name synonym)|uniprotkb:NHL repeat-containing protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NHLRC1(gene name synonym)	psi-mi:epm2a_human(display_long)|uniprotkb:EPM2A(gene name)|psi-mi:EPM2A(display_short)|uniprotkb:Lafora PTPase(gene name synonym)|uniprotkb:Glycogen phosphatase(gene name synonym)|uniprotkb:Glucan phosphatase(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Couarch et al. (2011)	imex:IM-23804|pubmed:21505799	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10100008|imex:IM-23804-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000187566(gene)|ensembl:ENST00000340650(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_940988.2	refseq:XP_011534418.1|ensembl:ENSG00000112425(gene)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019203"(carbohydrate phosphatase activity)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030425"(dendrite)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035305"(negative regulation of dephosphorylation)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046835"(carbohydrate phosphorylation)|go:"GO:0046838"(phosphorylated carbohydrate dephosphorylation)|go:"GO:0046959"(habituation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0098556"(cytoplasmic side of rough endoplasmic reticulum membrane)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904666"(regulation of ubiquitin protein ligase activity)|go:"GO:2000465"("regulation of glycogen (starch) synthase activity")|go:"GO:2001069"(glycogen binding)|go:"GO:2001070"(starch binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|ensembl:ENST00000367519(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004373"("glycogen (starch) synthase activity")|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0014009"(glial cell proliferation)|interpro:IPR002044(Glycoside hydrolase, carbohydrate-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013784(Carbohydrate-binding-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR034831|interpro:IPR042942|rcsb pdb:4R30|rcsb pdb:4RKK|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_001018051.1|refseq:NP_005661.1|refseq:XP_006715627.1|refseq:XP_016866789.1|refseq:XP_016866790.1|refseq:XP_016866791.1	go:"GO:0005737"(cytoplasm)|omim:254780(see-also)	comment:NHLRC1/EPM2B/malin EPM2 mutations cy46tyr pro69ala,asp146asn and leu261pro also colocalize	-	figure legend:5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2015/02/02	2015/02/02	rogid:jLFXF8B5yGb+VWcX1MkEFOm8hUU9606	rogid:SzLH6Z+48utiGISu59PgvgBzXD49606	intact-crc:7234508D105F4F04|rigid:E8FR0twVOuYoyIAMvCIh47stEi4	false	green fluorescent protein tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q6VVB1	uniprotkb:O95278	intact:EBI-6426628|ensembl:ENSP00000345464|uniprotkb:Q6IMH1|uniprotkb:Q5VUK7|uniprotkb:Q3SYB1	intact:EBI-2506661|uniprotkb:O95483|uniprotkb:Q5T3F5|uniprotkb:Q8IU96|uniprotkb:Q8IX24|uniprotkb:Q8IX25|uniprotkb:Q9BS66|uniprotkb:Q9UEN2|ensembl:ENSP00000356489|uniprotkb:B3KMU5|uniprotkb:B4DRZ2|uniprotkb:Q6IS15	psi-mi:nhlc1_human(display_long)|uniprotkb:NHLRC1(gene name)|psi-mi:NHLRC1(display_short)|uniprotkb:EPM2B(gene name synonym)|uniprotkb:Malin(gene name synonym)|uniprotkb:NHL repeat-containing protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NHLRC1(gene name synonym)	psi-mi:epm2a_human(display_long)|uniprotkb:EPM2A(gene name)|psi-mi:EPM2A(display_short)|uniprotkb:Lafora PTPase(gene name synonym)|uniprotkb:Glycogen phosphatase(gene name synonym)|uniprotkb:Glucan phosphatase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Couarch et al. (2011)	imex:IM-23804|pubmed:21505799	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10100088|imex:IM-23804-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000187566(gene)|ensembl:ENST00000340650(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_940988.2	refseq:XP_011534418.1|ensembl:ENSG00000112425(gene)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019203"(carbohydrate phosphatase activity)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030425"(dendrite)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035305"(negative regulation of dephosphorylation)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046835"(carbohydrate phosphorylation)|go:"GO:0046838"(phosphorylated carbohydrate dephosphorylation)|go:"GO:0046959"(habituation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0098556"(cytoplasmic side of rough endoplasmic reticulum membrane)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904666"(regulation of ubiquitin protein ligase activity)|go:"GO:2000465"("regulation of glycogen (starch) synthase activity")|go:"GO:2001069"(glycogen binding)|go:"GO:2001070"(starch binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|ensembl:ENST00000367519(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004373"("glycogen (starch) synthase activity")|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0014009"(glial cell proliferation)|interpro:IPR002044(Glycoside hydrolase, carbohydrate-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013784(Carbohydrate-binding-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR034831|interpro:IPR042942|rcsb pdb:4R30|rcsb pdb:4RKK|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_001018051.1|refseq:NP_005661.1|refseq:XP_006715627.1|refseq:XP_016866789.1|refseq:XP_016866790.1|refseq:XP_016866791.1	omim:254780(see-also)	-	-	figure legend:6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2015/02/02	2015/02/02	rogid:jLFXF8B5yGb+VWcX1MkEFOm8hUU9606	rogid:SzLH6Z+48utiGISu59PgvgBzXD49606	intact-crc:728D089903252CFB|rigid:E8FR0twVOuYoyIAMvCIh47stEi4	false	mutation decreasing interaction:69-69|mutation decreasing interaction:146-146|mutation disrupting interaction:46-46|mutation disrupting interaction:261-261	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)