#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9BQB4	uniprotkb:O75197	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-2466421|ensembl:ENSP00000294304|uniprotkb:Q96TD6|uniprotkb:Q9UP66|uniprotkb:Q9UES7	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:lrp5_human(display_long)|uniprotkb:LRP5(gene name)|psi-mi:LRP5(display_short)|uniprotkb:LRP7(gene name synonym)|uniprotkb:LR3(gene name synonym)|uniprotkb:Low-density lipoprotein receptor-related protein 7(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Leupin et al. (2011)	pubmed:21471202|imex:IM-23705	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10092103|imex:IM-23705-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	ensembl:ENSG00000162337(gene)|ensembl:ENST00000294304(transcript)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002076"(osteoblast development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006007"(glucose catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046849"(bone remodeling)|go:"GO:0048539"(bone marrow development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060612"(adipose tissue development)|go:"GO:0060764"(cell-cell signaling involved in mammary gland development)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR017049(Low density lipoprotein receptor-related protein, 5/6)|interpro:IPR023415|interpro:IPR036055|mint:O75197|reactome:R-HSA-201681|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5339717|reactome:R-HSA-5340588|go:"GO:0071936"(coreceptor activity involved in Wnt signaling pathway)|refseq:NP_002326.2|refseq:NP_001278831.1|dip:DIP-47265N	-	-	-	figure legend:1A, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2015/01/20	2015/01/20	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:5Or5NJwtSvZrk2kM2bBAQQOCW749606	intact-crc:46CA67E0907931B2|rigid:bVjBwOxny6SFUqqQJoMEYbpI1Q0	false	calmodulin binding peptide plus protein a tag:c-c|sufficient binding region:21-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:O75096	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-310873|uniprotkb:B2RN39|uniprotkb:Q4AC85|uniprotkb:Q5KTZ5|ensembl:ENSP00000367888	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:lrp4_human(display_long)|uniprotkb:LRP4(gene name)|psi-mi:LRP4(display_short)|uniprotkb:KIAA0816(gene name synonym)|uniprotkb:MEGF7(gene name synonym)|uniprotkb:Multiple epidermal growth factor-like domains 7(gene name synonym)|uniprotkb:LRP10(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Leupin et al. (2011)	pubmed:21471202|imex:IM-23705	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10092103|imex:IM-23705-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	refseq:NP_002325.2|ensembl:ENSG00000134569(gene)|ensembl:ENST00000378623(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001942"(hair follicle development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030425"(dendrite)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0060173"(limb development)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1901631"(positive regulation of presynaptic membrane organization)|go:"GO:1904395"(positive regulation of skeletal muscle acetylcholine-gated channel clustering)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|mint:O75096|reactome:R-HSA-3000178	-	-	-	figure legend:1A, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2015/01/20	2015/01/20	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:IbVlpu46vNtRqtZvYsySZ6go3kE9606	intact-crc:46CA67E0907931B2|rigid:bVjBwOxny6SFUqqQJoMEYbpI1Q0	false	calmodulin binding peptide plus protein a tag:c-c|sufficient binding region:21-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:O75581	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-910915|ensembl:ENSP00000261349|ensembl:ENSP00000486315|uniprotkb:Q17RZ2	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:lrp6_human(display_long)|uniprotkb:LRP6(gene name)|psi-mi:LRP6(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Leupin et al. (2011)	pubmed:21471202|imex:IM-23705	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10092103|imex:IM-23705-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0014029"(neural crest formation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|ensembl:ENSG00000070018(gene)|ensembl:ENSG00000281324(gene)|ensembl:ENST00000261349(transcript)|ensembl:ENST00000628182(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019534"(toxin transmembrane transporter activity)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021794"(thalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030901"(midbrain development)|go:"GO:0030917"(midbrain-hindbrain boundary development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060535"(trachea cartilage morphogenesis)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044335"(canonical Wnt signaling pathway involved in neural crest cell differentiation)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0071936"(coreceptor activity involved in Wnt signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046849"(bone remodeling)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060026"(convergent extension)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR017049(Low density lipoprotein receptor-related protein, 5/6)|interpro:IPR023415|interpro:IPR036055|mint:O75581|rcsb pdb:3S2K|rcsb pdb:3S8V|refseq:XP_006719141.1|refseq:NP_002327.2|dip:DIP-29884N|rcsb pdb:3S8Z|rcsb pdb:3S94|rcsb pdb:3SOB|rcsb pdb:3SOQ|rcsb pdb:3SOV|rcsb pdb:4A0P|rcsb pdb:4DG6|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:5AIR|rcsb pdb:5FWW|rcsb pdb:5GJE|rcsb pdb:6H15|rcsb pdb:6H16|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5340588	-	-	-	figure legend:1A, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2015/01/20	2015/01/20	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:MCGyqWGRjE0XbT9NW2U5OZGX2as9606	intact-crc:46CA67E0907931B2|rigid:bVjBwOxny6SFUqqQJoMEYbpI1Q0	false	calmodulin binding peptide plus protein a tag:c-c|sufficient binding region:21-213	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9BQB4	uniprotkb:O75096	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	intact:EBI-310873|uniprotkb:B2RN39|uniprotkb:Q4AC85|uniprotkb:Q5KTZ5|ensembl:ENSP00000367888	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:lrp4_human(display_long)|uniprotkb:LRP4(gene name)|psi-mi:LRP4(display_short)|uniprotkb:KIAA0816(gene name synonym)|uniprotkb:MEGF7(gene name synonym)|uniprotkb:Multiple epidermal growth factor-like domains 7(gene name synonym)|uniprotkb:LRP10(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Leupin et al. (2011)	pubmed:21471202|imex:IM-23705	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10092139|imex:IM-23705-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	refseq:NP_002325.2|ensembl:ENSG00000134569(gene)|ensembl:ENST00000378623(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001942"(hair follicle development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030425"(dendrite)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0060173"(limb development)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1901631"(positive regulation of presynaptic membrane organization)|go:"GO:1904395"(positive regulation of skeletal muscle acetylcholine-gated channel clustering)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|mint:O75096|reactome:R-HSA-3000178	omim:614305(see-also)	-	-	figure legend:1B and C|comment:Association is blocked by incubation with SOST/sclerostin antibody|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/01/20	2015/01/23	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	rogid:IbVlpu46vNtRqtZvYsySZ6go3kE9606	intact-crc:482DC4E0BA130AA7|rigid:l81eY0b862y2h7mqkoycHIY+pZs	false	sufficient binding region:24-213	sufficient binding region:21-1725..1725|mutation decreasing interaction:1170-1170|tag:?-?|fusion protein:n-n|mutation decreasing interaction:1186-1186	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O75096	uniprotkb:Q9BQB4	intact:EBI-310873|uniprotkb:B2RN39|uniprotkb:Q4AC85|uniprotkb:Q5KTZ5|ensembl:ENSP00000367888	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	psi-mi:lrp4_human(display_long)|uniprotkb:LRP4(gene name)|psi-mi:LRP4(display_short)|uniprotkb:KIAA0816(gene name synonym)|uniprotkb:MEGF7(gene name synonym)|uniprotkb:Multiple epidermal growth factor-like domains 7(gene name synonym)|uniprotkb:LRP10(gene name synonym)	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Leupin et al. (2011)	pubmed:21471202|imex:IM-23705	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10095170|imex:IM-23705-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002325.2|ensembl:ENSG00000134569(gene)|ensembl:ENST00000378623(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001942"(hair follicle development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030425"(dendrite)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0060173"(limb development)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1901631"(positive regulation of presynaptic membrane organization)|go:"GO:1904395"(positive regulation of skeletal muscle acetylcholine-gated channel clustering)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|mint:O75096|reactome:R-HSA-3000178	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	omim:614305(see-also)	-	-	figure legend:5 C and E|comment:Association is blocked by incubation with SOST/sclerostin antibody|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/01/20	2015/01/23	rogid:IbVlpu46vNtRqtZvYsySZ6go3kE9606	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	intact-crc:EF96CA1DDD84D8C6|rigid:l81eY0b862y2h7mqkoycHIY+pZs	false	mutation decreasing interaction:1186-1186|sufficient binding region:21-1725..1725|tag:?-?|mutation decreasing interaction:1170-1170|fusion protein:n-n	sufficient binding region:24-213	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O75096	uniprotkb:Q9BQB4	intact:EBI-310873|uniprotkb:B2RN39|uniprotkb:Q4AC85|uniprotkb:Q5KTZ5|ensembl:ENSP00000367888	intact:EBI-5746563|uniprotkb:Q495N9|ensembl:ENSP00000301691	psi-mi:lrp4_human(display_long)|uniprotkb:LRP4(gene name)|psi-mi:LRP4(display_short)|uniprotkb:KIAA0816(gene name synonym)|uniprotkb:MEGF7(gene name synonym)|uniprotkb:Multiple epidermal growth factor-like domains 7(gene name synonym)|uniprotkb:LRP10(gene name synonym)	psi-mi:sost_human(display_long)|uniprotkb:SOST(gene name)|psi-mi:SOST(display_short)|uniprotkb:UNQ2976/PRO7455/PRO7476(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Leupin et al. (2011)	pubmed:21471202|imex:IM-23705	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10092236|imex:IM-23705-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002325.2|ensembl:ENSG00000134569(gene)|ensembl:ENST00000378623(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001942"(hair follicle development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030425"(dendrite)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0060173"(limb development)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1901631"(positive regulation of presynaptic membrane organization)|go:"GO:1904395"(positive regulation of skeletal muscle acetylcholine-gated channel clustering)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|mint:O75096|reactome:R-HSA-3000178	refseq:NP_079513.1|dip:DIP-59407N|ensembl:ENSG00000167941(gene)|ensembl:ENST00000301691(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008201"(heparin binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036122"(BMP binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008835(Sclerostin)|interpro:IPR015665(Sclerostin precursor)|interpro:IPR029034|rcsb pdb:2K8P|rcsb pdb:3SOV|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470	-	-	-	figure legend:1D|comment:Association is blocked by incubation with SOST/sclerostin antibody|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:9.0x10^-9(molar)	2015/01/20	2015/01/23	rogid:IbVlpu46vNtRqtZvYsySZ6go3kE9606	rogid:/GYVuETUy1BJZ9w+/hHyUPrvkg49606	intact-crc:095A2F42992DF744|rigid:l81eY0b862y2h7mqkoycHIY+pZs	false	sufficient binding region:21-1725..1725|fusion protein:n-n|tag:?-?	sufficient binding region:24-213	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)