#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B ensembl:ENSMUSG00000039521 uniprotkb:P15806-2 intact:EBI-10899641 intact:EBI-413585|ensembl:ENSMUSP00000100982 uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|ensembl:foxp3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000039521(display_long) psi-mi:p15806-2(display_long)|uniprotkb:Tcf3(gene name)|psi-mi:Tcf3(display_short)|uniprotkb:Alf2(gene name synonym)|uniprotkb:Me2(gene name synonym)|uniprotkb:Tcfe2a(gene name synonym)|uniprotkb:Immunoglobulin enhancer-binding factor E12/E47(gene name synonym)|uniprotkb:Transcription factor 3(gene name synonym)|uniprotkb:Transcription factor A1(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Maruyama et al. (2011) imex:IM-24539|pubmed:21131965 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11291004|imex:IM-24539-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1 ensembl:ENSMUSG00000020167(gene)|ensembl:ENSMUST00000105345(transcript)|intact:EBI-81370(tfe2_mouse) - - isoform-comment:Contains a phosphothreonine at position 528. Contains a phosphoserine at position 533. figure legend:3B|comment:TGF-beta was present throughout|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell) - 2015/08/11 2015/09/25 - rogid:e4BH3vr/brPozXccOZby0yDXxYI10090 - false sufficient binding region:?-?|sufficient binding region:?-? - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) ensembl:ENSMUSG00000039521 uniprotkb:P15806-2 intact:EBI-10899641 intact:EBI-413585|ensembl:ENSMUSP00000100982 uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|ensembl:foxp3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000039521(display_long) psi-mi:p15806-2(display_long)|uniprotkb:Tcf3(gene name)|psi-mi:Tcf3(display_short)|uniprotkb:Alf2(gene name synonym)|uniprotkb:Me2(gene name synonym)|uniprotkb:Tcfe2a(gene name synonym)|uniprotkb:Immunoglobulin enhancer-binding factor E12/E47(gene name synonym)|uniprotkb:Transcription factor 3(gene name synonym)|uniprotkb:Transcription factor A1(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Maruyama et al. (2011) imex:IM-24539|pubmed:21131965 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11291026|imex:IM-24539-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1 ensembl:ENSMUSG00000020167(gene)|ensembl:ENSMUST00000105345(transcript)|intact:EBI-81370(tfe2_mouse) - - isoform-comment:Contains a phosphothreonine at position 528. Contains a phosphoserine at position 533. figure legend:3 C/D/E, 4F, 5G,Supp 6|agonist:P01137 -TGF-beta1|causality statement:P01137 increases the binding of P15806-2 to ENSMUSG00000039521|causality statement:P15806-2 is required for the P01137 induced expression at RNA level of ENSMUSG00000039521|causality statement:P41133 increases the binding of P15806-2 to ENSMUSG00000039521|causality statement:Q64729 is required for the binding of P15806-2 to ENSMUSG00000039521|comment:"Freshly isolated spleen CD4+CD25+ TReg cells showed increased binding as compared to CD4+CD25− T cells (not treated with TGF-beta). This effect is not seen in Id3–/– mice."|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell) - 2015/08/11 2015/09/25 - rogid:e4BH3vr/brPozXccOZby0yDXxYI10090 - false sufficient binding region:?-? - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) ensembl:ENSMUSG00000039521 uniprotkb:P29037 intact:EBI-10899641 intact:EBI-4399956|uniprotkb:O09169|uniprotkb:Q80UL8|uniprotkb:Q8C3S1|ensembl:ENSMUSP00000014911|ensembl:ENSMUSP00000112794|ensembl:ENSMUSP00000124317 uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|ensembl:foxp3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000039521(display_long) psi-mi:tbp_mouse(display_long)|uniprotkb:Tbp(gene name)|psi-mi:Tbp(display_short)|uniprotkb:Tfiid(gene name synonym)|uniprotkb:TATA sequence-binding protein(gene name synonym)|uniprotkb:TATA-binding factor(gene name synonym)|uniprotkb:TATA-box factor(gene name synonym)|uniprotkb:Transcription initiation factor TFIID TBP subunit(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Maruyama et al. (2011) imex:IM-24539|pubmed:21131965 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11291040|imex:IM-24539-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1 refseq:NP_038712.3|dip:DIP-24197N|ensembl:ENSMUSG00000014767(gene)|ensembl:ENSMUST00000014911(transcript)|ensembl:ENSMUST00000117593(transcript)|ensembl:ENSMUST00000162505(transcript)|go:"GO:0000120"(RNA polymerase I transcription regulator complex)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000995"(RNA polymerase III general transcription initiation factor activity)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045120"(pronucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140223"(general transcription initiation factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000814(TATA-box binding)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR030491|interpro:IPR033710|reactome:R-MMU-5250924|reactome:R-MMU-674695|reactome:R-MMU-6804756|reactome:R-MMU-6807505|reactome:R-MMU-73762|reactome:R-MMU-73772|reactome:R-MMU-73776|reactome:R-MMU-73779|reactome:R-MMU-73863|reactome:R-MMU-75953|reactome:R-MMU-76042|reactome:R-MMU-76061|reactome:R-MMU-76066|reactome:R-MMU-76071|reactome:R-MMU-9018519 - - - figure legend:3 D|agonist:P01137 -TGF-beta1|causality statement:P01137 increases the binding of P29037 to ENSMUSG00000039521|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell) - 2015/08/11 2015/09/25 - rogid:Rv5vNIOGEhlaWS1woZqBFiuf5pg10090 - false sufficient binding region:?-? - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) ensembl:ENSMUSG00000039521 uniprotkb:P23772 intact:EBI-10899641 intact:EBI-6664905|ensembl:ENSMUSP00000100041 uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|ensembl:foxp3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000039521(display_long) psi-mi:gata3_mouse(display_long)|uniprotkb:Gata3(gene name)|psi-mi:Gata3(display_short)|uniprotkb:Gata-3(gene name synonym)|uniprotkb:GATA-binding factor 3(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Maruyama et al. (2011) imex:IM-24539|pubmed:21131965 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11291185|imex:IM-24539-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1 go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060065"(uterus development)|go:"GO:0060231"(mesenchymal to epithelial transition)|go:"GO:0060374"(mast cell differentiation)|go:"GO:0060676"(ureteric bud formation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0061085"(regulation of histone H3-K27 methylation)|go:"GO:0061290"(canonical Wnt signaling pathway involved in metanephric kidney development)|go:"GO:0070888"(E-box binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071442"(positive regulation of histone H3-K14 acetylation)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0072107"(positive regulation of ureteric bud formation)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072179"(nephric duct formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0072676"(lymphocyte migration)|go:"GO:0090102"(cochlea development)|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000607"(negative regulation of cell proliferation involved in mesonephros development)|go:"GO:2000611"(positive regulation of thyroid hormone generation)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000683"(regulation of cellular response to X-ray)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:2000703"(negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation)|go:"GO:2000734"(negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR016374(Transcription factor, GATA-1/2/3)|interpro:IPR029521|go:"GO:0048469"(cell maturation)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050728"(negative regulation of inflammatory response)|rcsb pdb:3DFV|rcsb pdb:3DFX|reactome:R-MMU-5689880|reactome:R-MMU-8939236|reactome:R-MMU-9018519|reactome:R-MMU-983231|interpro:IPR039355|ensembl:ENSMUSG00000015619(gene)|ensembl:ENSMUST00000102976(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001764"(neuron migration)|go:"GO:0001775"(cell activation)|go:"GO:0001806"(type IV hypersensitivity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001822"(kidney development)|go:"GO:0001823"(mesonephros development)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002520"(immune system development)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005134"(interleukin-2 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0031929"(TOR signaling)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0035799"(ureter maturation)|go:"GO:0035898"(parathyroid hormone secretion)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043583"(ear development)|go:"GO:0043627"(response to estrogen)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045471"(response to ethanol)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0003281"(ventricular septum development)|refseq:XP_006497417.1|refseq:NP_032117.1|dip:DIP-29712N - - - figure legend:5F|causality statement:P01137 decreases the binding of P23772 to ENSMUSG00000039521.|causality statement:P41133 decreases the binding of P23772 to ENSMUSG00000039521.|causality statement:P01137 decreases the expression at RNA level of P23772.|causality statement:P41133 decreases the expression at RNA level of P23772.|causality statement:P41133 decreases the expression at protein level of P23772.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell) - 2015/08/11 2015/09/25 - rogid:DW2mskj2jgiJdOYO6yJxNbBd0Ng10090 - false sufficient binding region:?-? - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) ensembl:ENSMUSG00000028150 uniprotkb:P15806-2 intact:EBI-4422030 intact:EBI-413585|ensembl:ENSMUSP00000100982 psi-mi:rorg_mouse_gene(display_short)|psi-mi:ENSMUSG00000028150(display_long) psi-mi:p15806-2(display_long)|uniprotkb:Tcf3(gene name)|psi-mi:Tcf3(display_short)|uniprotkb:Alf2(gene name synonym)|uniprotkb:Me2(gene name synonym)|uniprotkb:Tcfe2a(gene name synonym)|uniprotkb:Immunoglobulin enhancer-binding factor E12/E47(gene name synonym)|uniprotkb:Transcription factor 3(gene name synonym)|uniprotkb:Transcription factor A1(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Maruyama et al. (2011) imex:IM-24539|pubmed:21131965 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11291312|imex:IM-24539-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) - ensembl:ENSMUSG00000020167(gene)|ensembl:ENSMUST00000105345(transcript)|intact:EBI-81370(tfe2_mouse) - - isoform-comment:Contains a phosphothreonine at position 528. Contains a phosphoserine at position 533. figure legend:Supp 8A|causality statement:P01137 increases the binding of P15806-2 to ENSMUSG00000028150|agonist:P01137 -TGF-beta|causality statement:P15806-2 increases expression at RNA level of ENSMUSG00000028150|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell) - 2015/08/11 2015/09/25 - rogid:e4BH3vr/brPozXccOZby0yDXxYI10090 - false sufficient binding region:?-? - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr)