#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q06287	uniprotkb:Q06287	intact:EBI-11979|ensemblfungi:YLR186W|uniprotkb:E9P8U2|uniprotkb:D6VYI9	intact:EBI-11979|ensemblfungi:YLR186W|uniprotkb:E9P8U2|uniprotkb:D6VYI9	psi-mi:nep1_yeast(display_long)|uniprotkb:EMG1(gene name)|psi-mi:EMG1(display_short)|uniprotkb:NEP1(gene name synonym)|uniprotkb:YLR186W(locus name)|uniprotkb:L9470.5(orf name)|uniprotkb:Nucleolar essential protein 1(gene name synonym)|uniprotkb:"18S rRNA (pseudouridine(1189)-N1)-methyltransferase"(gene name synonym)|uniprotkb:Essential for mitotic growth protein 1(gene name synonym)	psi-mi:nep1_yeast(display_long)|uniprotkb:EMG1(gene name)|psi-mi:EMG1(display_short)|uniprotkb:NEP1(gene name synonym)|uniprotkb:YLR186W(locus name)|uniprotkb:L9470.5(orf name)|uniprotkb:Nucleolar essential protein 1(gene name synonym)|uniprotkb:"18S rRNA (pseudouridine(1189)-N1)-methyltransferase"(gene name synonym)|uniprotkb:Essential for mitotic growth protein 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Meyer et al. (2011)	imex:IM-24471|pubmed:20972225	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10903893|imex:IM-24471-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005880"(nuclear microtubule)|go:"GO:0006364"(rRNA processing)|go:"GO:0019843"(rRNA binding)|go:"GO:0030686"(90S preribosome)|go:"GO:0031167"(rRNA methylation)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0070037"("rRNA (pseudouridine) methyltransferase activity")|go:"GO:0070475"(rRNA base methylation)|interpro:IPR005304(Suppressor Mra1)|ensemblfungi:YLR186W(gene)|interpro:IPR029026|interpro:IPR029028|rcsb pdb:2V3J|rcsb pdb:2V3K|ensemblfungi:YLR186W_mRNA(transcript)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000472"("endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000480"("endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0005634"(nucleus)|rcsb pdb:3OIJ|rcsb pdb:3OIN|rcsb pdb:5JPQ|rcsb pdb:5TZS|rcsb pdb:5WLC|rcsb pdb:5WYJ|rcsb pdb:5WYK|rcsb pdb:6KE6|rcsb pdb:6LQP|rcsb pdb:6LQQ|rcsb pdb:6LQR|rcsb pdb:6LQS|rcsb pdb:6LQT|rcsb pdb:6LQU|rcsb pdb:3OII|rcsb pdb:6LQV|rcsb pdb:6ZQA|rcsb pdb:6ZQB|rcsb pdb:6ZQC|rcsb pdb:6ZQD|rcsb pdb:6ZQE|rcsb pdb:6ZQF|rcsb pdb:6ZQG|rcsb pdb:7AJT|rcsb pdb:7AJU|sgd:S000004176|refseq:NP_013287.1|reactome:R-SCE-6791226|dip:DIP-6504N	go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005880"(nuclear microtubule)|go:"GO:0006364"(rRNA processing)|go:"GO:0019843"(rRNA binding)|go:"GO:0030686"(90S preribosome)|go:"GO:0031167"(rRNA methylation)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0070037"("rRNA (pseudouridine) methyltransferase activity")|go:"GO:0070475"(rRNA base methylation)|interpro:IPR005304(Suppressor Mra1)|ensemblfungi:YLR186W(gene)|interpro:IPR029026|interpro:IPR029028|rcsb pdb:2V3J|rcsb pdb:2V3K|ensemblfungi:YLR186W_mRNA(transcript)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000472"("endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000480"("endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0005634"(nucleus)|rcsb pdb:3OIJ|rcsb pdb:3OIN|rcsb pdb:5JPQ|rcsb pdb:5TZS|rcsb pdb:5WLC|rcsb pdb:5WYJ|rcsb pdb:5WYK|rcsb pdb:6KE6|rcsb pdb:6LQP|rcsb pdb:6LQQ|rcsb pdb:6LQR|rcsb pdb:6LQS|rcsb pdb:6LQT|rcsb pdb:6LQU|rcsb pdb:3OII|rcsb pdb:6LQV|rcsb pdb:6ZQA|rcsb pdb:6ZQB|rcsb pdb:6ZQC|rcsb pdb:6ZQD|rcsb pdb:6ZQE|rcsb pdb:6ZQF|rcsb pdb:6ZQG|rcsb pdb:7AJT|rcsb pdb:7AJU|sgd:S000004176|refseq:NP_013287.1|reactome:R-SCE-6791226|dip:DIP-6504N	-	crc64:4A8FCDA812051AD1	crc64:4A8FCDA812051AD1	figure legend:Fig5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:134.0x10^-6(molar)	2015/07/16	2015/07/23	rogid:z62Fg9aJ4kKGgU5NIlAND2yHGrQ559292	rogid:z62Fg9aJ4kKGgU5NIlAND2yHGrQ559292	rigid:0fT4WZHgikzwCKhxOX8545/PG5w	false	mutation increasing interaction:90-90|his tag:n-n	mutation increasing interaction:90-90|his tag:n-n	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-10821373	uniprotkb:Q06287	rnacentral:URS00005F2C2D_559292	intact:EBI-11979|ensemblfungi:YLR186W|uniprotkb:E9P8U2|uniprotkb:D6VYI9	psi-mi:rrna 18s yeast(display_short)|psi-mi:EBI-10821373(display_long)	psi-mi:nep1_yeast(display_long)|uniprotkb:EMG1(gene name)|psi-mi:EMG1(display_short)|uniprotkb:NEP1(gene name synonym)|uniprotkb:YLR186W(locus name)|uniprotkb:L9470.5(orf name)|uniprotkb:Nucleolar essential protein 1(gene name synonym)|uniprotkb:"18S rRNA (pseudouridine(1189)-N1)-methyltransferase"(gene name synonym)|uniprotkb:Essential for mitotic growth protein 1(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Meyer et al. (2011)	imex:IM-24471|pubmed:20972225	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10903990|imex:IM-24471-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0608"(ribosomal rna)	psi-mi:"MI:0326"(protein)	-	go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005880"(nuclear microtubule)|go:"GO:0006364"(rRNA processing)|go:"GO:0019843"(rRNA binding)|go:"GO:0030686"(90S preribosome)|go:"GO:0031167"(rRNA methylation)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0070037"("rRNA (pseudouridine) methyltransferase activity")|go:"GO:0070475"(rRNA base methylation)|interpro:IPR005304(Suppressor Mra1)|ensemblfungi:YLR186W(gene)|interpro:IPR029026|interpro:IPR029028|rcsb pdb:2V3J|rcsb pdb:2V3K|ensemblfungi:YLR186W_mRNA(transcript)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000472"("endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000480"("endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0005634"(nucleus)|rcsb pdb:3OIJ|rcsb pdb:3OIN|rcsb pdb:5JPQ|rcsb pdb:5TZS|rcsb pdb:5WLC|rcsb pdb:5WYJ|rcsb pdb:5WYK|rcsb pdb:6KE6|rcsb pdb:6LQP|rcsb pdb:6LQQ|rcsb pdb:6LQR|rcsb pdb:6LQS|rcsb pdb:6LQT|rcsb pdb:6LQU|rcsb pdb:3OII|rcsb pdb:6LQV|rcsb pdb:6ZQA|rcsb pdb:6ZQB|rcsb pdb:6ZQC|rcsb pdb:6ZQD|rcsb pdb:6ZQE|rcsb pdb:6ZQF|rcsb pdb:6ZQG|rcsb pdb:7AJT|rcsb pdb:7AJU|sgd:S000004176|refseq:NP_013287.1|reactome:R-SCE-6791226|dip:DIP-6504N	-	-	crc64:4A8FCDA812051AD1	figure legend:Fig5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:629.0x10^-6(molar)	2015/07/16	2015/07/16	-	rogid:z62Fg9aJ4kKGgU5NIlAND2yHGrQ559292	-	false	sufficient binding region:1188-1198|fluorescein label:1188-1188	mutation increasing interaction:90-90	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
intact:EBI-10821373	uniprotkb:Q06287	rnacentral:URS00005F2C2D_559292	intact:EBI-11979|ensemblfungi:YLR186W|uniprotkb:E9P8U2|uniprotkb:D6VYI9	psi-mi:rrna 18s yeast(display_short)|psi-mi:EBI-10821373(display_long)	psi-mi:nep1_yeast(display_long)|uniprotkb:EMG1(gene name)|psi-mi:EMG1(display_short)|uniprotkb:NEP1(gene name synonym)|uniprotkb:YLR186W(locus name)|uniprotkb:L9470.5(orf name)|uniprotkb:Nucleolar essential protein 1(gene name synonym)|uniprotkb:"18S rRNA (pseudouridine(1189)-N1)-methyltransferase"(gene name synonym)|uniprotkb:Essential for mitotic growth protein 1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Meyer et al. (2011)	imex:IM-24471|pubmed:20972225	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0213"(methylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10916010|imex:IM-24471-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0608"(ribosomal rna)	psi-mi:"MI:0326"(protein)	-	go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005880"(nuclear microtubule)|go:"GO:0006364"(rRNA processing)|go:"GO:0019843"(rRNA binding)|go:"GO:0030686"(90S preribosome)|go:"GO:0031167"(rRNA methylation)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0070037"("rRNA (pseudouridine) methyltransferase activity")|go:"GO:0070475"(rRNA base methylation)|interpro:IPR005304(Suppressor Mra1)|ensemblfungi:YLR186W(gene)|interpro:IPR029026|interpro:IPR029028|rcsb pdb:2V3J|rcsb pdb:2V3K|ensemblfungi:YLR186W_mRNA(transcript)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000472"("endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000480"("endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0005634"(nucleus)|rcsb pdb:3OIJ|rcsb pdb:3OIN|rcsb pdb:5JPQ|rcsb pdb:5TZS|rcsb pdb:5WLC|rcsb pdb:5WYJ|rcsb pdb:5WYK|rcsb pdb:6KE6|rcsb pdb:6LQP|rcsb pdb:6LQQ|rcsb pdb:6LQR|rcsb pdb:6LQS|rcsb pdb:6LQT|rcsb pdb:6LQU|rcsb pdb:3OII|rcsb pdb:6LQV|rcsb pdb:6ZQA|rcsb pdb:6ZQB|rcsb pdb:6ZQC|rcsb pdb:6ZQD|rcsb pdb:6ZQE|rcsb pdb:6ZQF|rcsb pdb:6ZQG|rcsb pdb:7AJT|rcsb pdb:7AJU|sgd:S000004176|refseq:NP_013287.1|reactome:R-SCE-6791226|dip:DIP-6504N	-	-	crc64:4A8FCDA812051AD1	figure legend:Fig6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/16	2015/07/20	-	rogid:z62Fg9aJ4kKGgU5NIlAND2yHGrQ559292	-	false	sufficient binding region:1188-1198|RNA chemical modification:1191-1191("CHEBI:19068")	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)