#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P09483	uniprotkb:P12390	intact:EBI-7842410|uniprotkb:O35769|intact:MINT-198047	intact:EBI-9008812|uniprotkb:Q53YK1|ensembl:ENSRNOP00000028200	psi-mi:acha4_rat(display_long)|uniprotkb:Chrna4(gene name)|psi-mi:Chrna4(display_short)|uniprotkb:Acra4(gene name synonym)	psi-mi:achb2_rat(display_long)|uniprotkb:Chrnb2(gene name)|psi-mi:Chrnb2(display_short)|uniprotkb:Acrb2(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-1 chain(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gahring et al. (2010)	pubmed:20566638|imex:IM-24267	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10828364|imex:IM-24267-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0001508"(action potential)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005216"(ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035640"(exploration behavior)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042113"(B cell activation)|interpro:IPR018000|refseq:NP_077330.1|rgd:2346|rcsb pdb:1OLE|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	refseq:NP_062170.1|rgd:2350|ensembl:ENSRNOG00000020778(gene)|ensembl:ENSRNOT00000028200(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021562"(vestibulocochlear nerve development)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021771"(lateral geniculate nucleus development)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032225"(regulation of synaptic transmission, dopaminergic)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035176"(social behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042113"(B cell activation)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042320"(regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045188"(regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1905144"(response to acetylcholine)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR032932|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLE|rcsb pdb:1OLF|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	-	comment:mint|function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane	-	figure legend:"Fig.s 2a (upper left gel), 5a (left gel)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/06/03	2015/06/03	rogid:X/Fy7r31J41STO/uzlWjkbD2E6g10116	rogid:V5uVKdZkq4z+1m4A/AIp9wgQglg10116	rigid:wAinV/3zMm24uuQFHQAp5hufv8U	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P09483	uniprotkb:P20420	intact:EBI-7842410|uniprotkb:O35769|intact:MINT-198047	intact:EBI-10828372	psi-mi:acha4_rat(display_long)|uniprotkb:Chrna4(gene name)|psi-mi:Chrna4(display_short)|uniprotkb:Acra4(gene name synonym)	psi-mi:acha5_rat(display_long)|uniprotkb:Chrna5(gene name)|psi-mi:Chrna5(display_short)|uniprotkb:Acra5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gahring et al. (2010)	pubmed:20566638|imex:IM-24267	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10828368|imex:IM-24267-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0001508"(action potential)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005216"(ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035640"(exploration behavior)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042113"(B cell activation)|interpro:IPR018000|refseq:NP_077330.1|rgd:2346|rcsb pdb:1OLE|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	reactome:R-RNO-629594|reactome:R-RNO-629597|rgd:2347|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR018000|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR036719|interpro:IPR036734	-	comment:mint|function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane	-	figure legend:"Fig. 2a (lower gels)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/06/03	2015/06/03	rogid:X/Fy7r31J41STO/uzlWjkbD2E6g10116	rogid:NZ+9X28yNEd7JU3dfSWMU/0J6c010116	rigid:l7E1FUkiadooAKqtpYNB/KEApZ4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P09483	uniprotkb:P12392	intact:EBI-7842410|uniprotkb:O35769|intact:MINT-198047	intact:EBI-9008856|ensembl:ENSRNOP00000019458|uniprotkb:Q63361	psi-mi:acha4_rat(display_long)|uniprotkb:Chrna4(gene name)|psi-mi:Chrna4(display_short)|uniprotkb:Acra4(gene name synonym)	psi-mi:achb4_rat(display_long)|uniprotkb:Chrnb4(gene name)|psi-mi:Chrnb4(display_short)|uniprotkb:Acrb4(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-2 chain(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gahring et al. (2010)	pubmed:20566638|imex:IM-24267	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10828494|imex:IM-24267-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0001508"(action potential)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005216"(ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035640"(exploration behavior)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042113"(B cell activation)|interpro:IPR018000|refseq:NP_077330.1|rgd:2346|rcsb pdb:1OLE|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0098981"(cholinergic synapse)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLJ|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597|reactome:R-RNO-6798695|ensembl:ENSRNOG00000014427(gene)|ensembl:ENSRNOT00000019458(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|refseq:NP_434693.1|rgd:2351	-	comment:mint|function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane	-	figure legend:"Fig.s 2a (upper right gel), 5a (right gel)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/06/03	2015/06/03	rogid:X/Fy7r31J41STO/uzlWjkbD2E6g10116	rogid:5dJnJuHTUCfgfuOzNn5YfdKFCOs10116	rigid:k+OGWW/VjO9ZFOfn2um0AHFCibM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P12390	uniprotkb:P09483	intact:EBI-9008812|uniprotkb:Q53YK1|ensembl:ENSRNOP00000028200	intact:EBI-7842410|uniprotkb:O35769|intact:MINT-198047	psi-mi:achb2_rat(display_long)|uniprotkb:Chrnb2(gene name)|psi-mi:Chrnb2(display_short)|uniprotkb:Acrb2(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-1 chain(gene name synonym)	psi-mi:acha4_rat(display_long)|uniprotkb:Chrna4(gene name)|psi-mi:Chrna4(display_short)|uniprotkb:Acra4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gahring et al. (2010)	pubmed:20566638|imex:IM-24267	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10828402|imex:IM-24267-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062170.1|rgd:2350|ensembl:ENSRNOG00000020778(gene)|ensembl:ENSRNOT00000028200(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021562"(vestibulocochlear nerve development)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021771"(lateral geniculate nucleus development)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032225"(regulation of synaptic transmission, dopaminergic)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035176"(social behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042113"(B cell activation)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042320"(regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045188"(regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1905144"(response to acetylcholine)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR032932|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLE|rcsb pdb:1OLF|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0001508"(action potential)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005216"(ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035640"(exploration behavior)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042113"(B cell activation)|interpro:IPR018000|refseq:NP_077330.1|rgd:2346|rcsb pdb:1OLE|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	-	-	comment:mint|function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane	figure legend:"Fig. 3a (left gel)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/06/03	2015/06/03	rogid:V5uVKdZkq4z+1m4A/AIp9wgQglg10116	rogid:X/Fy7r31J41STO/uzlWjkbD2E6g10116	rigid:DZhuvyUEfRgg44ihUsNk31CvROg	false	-	tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P12390	uniprotkb:P20420	intact:EBI-9008812|uniprotkb:Q53YK1|ensembl:ENSRNOP00000028200	intact:EBI-10828372	psi-mi:achb2_rat(display_long)|uniprotkb:Chrnb2(gene name)|psi-mi:Chrnb2(display_short)|uniprotkb:Acrb2(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-1 chain(gene name synonym)	psi-mi:acha5_rat(display_long)|uniprotkb:Chrna5(gene name)|psi-mi:Chrna5(display_short)|uniprotkb:Acra5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gahring et al. (2010)	pubmed:20566638|imex:IM-24267	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10828402|imex:IM-24267-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062170.1|rgd:2350|ensembl:ENSRNOG00000020778(gene)|ensembl:ENSRNOT00000028200(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021562"(vestibulocochlear nerve development)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021771"(lateral geniculate nucleus development)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032225"(regulation of synaptic transmission, dopaminergic)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035176"(social behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042113"(B cell activation)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042320"(regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045188"(regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1905144"(response to acetylcholine)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR032932|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLE|rcsb pdb:1OLF|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	reactome:R-RNO-629594|reactome:R-RNO-629597|rgd:2347|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR018000|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR036719|interpro:IPR036734	-	-	-	figure legend:"Fig. 3a (left gel)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/06/03	2015/06/03	rogid:V5uVKdZkq4z+1m4A/AIp9wgQglg10116	rogid:NZ+9X28yNEd7JU3dfSWMU/0J6c010116	rigid:DZhuvyUEfRgg44ihUsNk31CvROg	false	-	tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P12392	uniprotkb:P09483	intact:EBI-9008856|ensembl:ENSRNOP00000019458|uniprotkb:Q63361	intact:EBI-7842410|uniprotkb:O35769|intact:MINT-198047	psi-mi:achb4_rat(display_long)|uniprotkb:Chrnb4(gene name)|psi-mi:Chrnb4(display_short)|uniprotkb:Acrb4(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-2 chain(gene name synonym)	psi-mi:acha4_rat(display_long)|uniprotkb:Chrna4(gene name)|psi-mi:Chrna4(display_short)|uniprotkb:Acra4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gahring et al. (2010)	pubmed:20566638|imex:IM-24267	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10828406|imex:IM-24267-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0098981"(cholinergic synapse)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLJ|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597|reactome:R-RNO-6798695|ensembl:ENSRNOG00000014427(gene)|ensembl:ENSRNOT00000019458(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|refseq:NP_434693.1|rgd:2351	interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0001508"(action potential)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005216"(ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035640"(exploration behavior)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042113"(B cell activation)|interpro:IPR018000|refseq:NP_077330.1|rgd:2346|rcsb pdb:1OLE|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	-	-	comment:mint|function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane	figure legend:"Fig. 3a (right gel)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/06/03	2015/06/03	rogid:5dJnJuHTUCfgfuOzNn5YfdKFCOs10116	rogid:X/Fy7r31J41STO/uzlWjkbD2E6g10116	rigid:4Pms72KTh8KlyvXRneRJwLHsKY8	false	-	tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P12392	uniprotkb:P20420	intact:EBI-9008856|ensembl:ENSRNOP00000019458|uniprotkb:Q63361	intact:EBI-10828372	psi-mi:achb4_rat(display_long)|uniprotkb:Chrnb4(gene name)|psi-mi:Chrnb4(display_short)|uniprotkb:Acrb4(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-2 chain(gene name synonym)	psi-mi:acha5_rat(display_long)|uniprotkb:Chrna5(gene name)|psi-mi:Chrna5(display_short)|uniprotkb:Acra5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gahring et al. (2010)	pubmed:20566638|imex:IM-24267	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10828406|imex:IM-24267-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0098981"(cholinergic synapse)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLJ|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597|reactome:R-RNO-6798695|ensembl:ENSRNOG00000014427(gene)|ensembl:ENSRNOT00000019458(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|refseq:NP_434693.1|rgd:2351	reactome:R-RNO-629594|reactome:R-RNO-629597|rgd:2347|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR018000|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR036719|interpro:IPR036734	-	-	-	figure legend:"Fig. 3a (right gel)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/06/03	2015/06/03	rogid:5dJnJuHTUCfgfuOzNn5YfdKFCOs10116	rogid:NZ+9X28yNEd7JU3dfSWMU/0J6c010116	rigid:4Pms72KTh8KlyvXRneRJwLHsKY8	false	-	tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P12392	uniprotkb:P12390	intact:EBI-9008856|ensembl:ENSRNOP00000019458|uniprotkb:Q63361	intact:EBI-9008812|uniprotkb:Q53YK1|ensembl:ENSRNOP00000028200	psi-mi:achb4_rat(display_long)|uniprotkb:Chrnb4(gene name)|psi-mi:Chrnb4(display_short)|uniprotkb:Acrb4(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-2 chain(gene name synonym)	psi-mi:achb2_rat(display_long)|uniprotkb:Chrnb2(gene name)|psi-mi:Chrnb2(display_short)|uniprotkb:Acrb2(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-1 chain(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gahring et al. (2010)	pubmed:20566638|imex:IM-24267	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10828406|imex:IM-24267-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0098981"(cholinergic synapse)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLJ|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597|reactome:R-RNO-6798695|ensembl:ENSRNOG00000014427(gene)|ensembl:ENSRNOT00000019458(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|refseq:NP_434693.1|rgd:2351	refseq:NP_062170.1|rgd:2350|ensembl:ENSRNOG00000020778(gene)|ensembl:ENSRNOT00000028200(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021562"(vestibulocochlear nerve development)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021771"(lateral geniculate nucleus development)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032225"(regulation of synaptic transmission, dopaminergic)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035176"(social behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042113"(B cell activation)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042320"(regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045188"(regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1905144"(response to acetylcholine)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR032932|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLE|rcsb pdb:1OLF|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	-	-	-	figure legend:"Fig. 3a (right gel)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/06/03	2015/06/03	rogid:5dJnJuHTUCfgfuOzNn5YfdKFCOs10116	rogid:V5uVKdZkq4z+1m4A/AIp9wgQglg10116	rigid:4Pms72KTh8KlyvXRneRJwLHsKY8	false	-	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P09483	uniprotkb:P20420	intact:EBI-7842410|uniprotkb:O35769|intact:MINT-198047	intact:EBI-10828372	psi-mi:acha4_rat(display_long)|uniprotkb:Chrna4(gene name)|psi-mi:Chrna4(display_short)|uniprotkb:Acra4(gene name synonym)	psi-mi:acha5_rat(display_long)|uniprotkb:Chrna5(gene name)|psi-mi:Chrna5(display_short)|uniprotkb:Acra5(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Gahring et al. (2010)	pubmed:20566638|imex:IM-24267	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10828431|imex:IM-24267-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0001508"(action potential)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005216"(ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035640"(exploration behavior)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042113"(B cell activation)|interpro:IPR018000|refseq:NP_077330.1|rgd:2346|rcsb pdb:1OLE|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	reactome:R-RNO-629594|reactome:R-RNO-629597|rgd:2347|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR018000|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR036719|interpro:IPR036734	-	comment:mint|function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane	-	figure legend:Fig. 4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/06/03	2015/06/03	rogid:X/Fy7r31J41STO/uzlWjkbD2E6g10116	rogid:NZ+9X28yNEd7JU3dfSWMU/0J6c010116	rigid:l7E1FUkiadooAKqtpYNB/KEApZ4	false	tag:?-?	tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P09483	uniprotkb:P20420	intact:EBI-7842410|uniprotkb:O35769|intact:MINT-198047	intact:EBI-10828372	psi-mi:acha4_rat(display_long)|uniprotkb:Chrna4(gene name)|psi-mi:Chrna4(display_short)|uniprotkb:Acra4(gene name synonym)	psi-mi:acha5_rat(display_long)|uniprotkb:Chrna5(gene name)|psi-mi:Chrna5(display_short)|uniprotkb:Acra5(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Gahring et al. (2010)	pubmed:20566638|imex:IM-24267	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10828482|imex:IM-24267-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0001508"(action potential)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005216"(ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035640"(exploration behavior)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042113"(B cell activation)|interpro:IPR018000|refseq:NP_077330.1|rgd:2346|rcsb pdb:1OLE|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	reactome:R-RNO-629594|reactome:R-RNO-629597|rgd:2347|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR018000|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR036719|interpro:IPR036734	-	comment:mint|function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane	-	figure legend:Fig. 4d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/06/03	2015/06/03	rogid:X/Fy7r31J41STO/uzlWjkbD2E6g10116	rogid:NZ+9X28yNEd7JU3dfSWMU/0J6c010116	rigid:DZhuvyUEfRgg44ihUsNk31CvROg	false	tag:?-?	tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P09483	uniprotkb:P12390	intact:EBI-7842410|uniprotkb:O35769|intact:MINT-198047	intact:EBI-9008812|uniprotkb:Q53YK1|ensembl:ENSRNOP00000028200	psi-mi:acha4_rat(display_long)|uniprotkb:Chrna4(gene name)|psi-mi:Chrna4(display_short)|uniprotkb:Acra4(gene name synonym)	psi-mi:achb2_rat(display_long)|uniprotkb:Chrnb2(gene name)|psi-mi:Chrnb2(display_short)|uniprotkb:Acrb2(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-1 chain(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Gahring et al. (2010)	pubmed:20566638|imex:IM-24267	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10828482|imex:IM-24267-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0001508"(action potential)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005216"(ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035640"(exploration behavior)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042113"(B cell activation)|interpro:IPR018000|refseq:NP_077330.1|rgd:2346|rcsb pdb:1OLE|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	refseq:NP_062170.1|rgd:2350|ensembl:ENSRNOG00000020778(gene)|ensembl:ENSRNOT00000028200(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021562"(vestibulocochlear nerve development)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021771"(lateral geniculate nucleus development)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032225"(regulation of synaptic transmission, dopaminergic)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035176"(social behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042113"(B cell activation)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042320"(regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045188"(regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1905144"(response to acetylcholine)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR032932|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLE|rcsb pdb:1OLF|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	-	comment:mint|function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane	-	figure legend:Fig. 4d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/06/03	2015/06/03	rogid:X/Fy7r31J41STO/uzlWjkbD2E6g10116	rogid:V5uVKdZkq4z+1m4A/AIp9wgQglg10116	rigid:DZhuvyUEfRgg44ihUsNk31CvROg	false	tag:?-?	tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P09483	uniprotkb:P20420	intact:EBI-7842410|uniprotkb:O35769|intact:MINT-198047	intact:EBI-10828372	psi-mi:acha4_rat(display_long)|uniprotkb:Chrna4(gene name)|psi-mi:Chrna4(display_short)|uniprotkb:Acra4(gene name synonym)	psi-mi:acha5_rat(display_long)|uniprotkb:Chrna5(gene name)|psi-mi:Chrna5(display_short)|uniprotkb:Acra5(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Gahring et al. (2010)	pubmed:20566638|imex:IM-24267	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10828512|imex:IM-24267-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0001508"(action potential)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005216"(ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035640"(exploration behavior)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042113"(B cell activation)|interpro:IPR018000|refseq:NP_077330.1|rgd:2346|rcsb pdb:1OLE|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	reactome:R-RNO-629594|reactome:R-RNO-629597|rgd:2347|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR018000|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR036719|interpro:IPR036734	-	comment:mint|function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane	-	figure legend:"Fig. 5b (bottom panels)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/06/03	2015/06/03	rogid:X/Fy7r31J41STO/uzlWjkbD2E6g10116	rogid:NZ+9X28yNEd7JU3dfSWMU/0J6c010116	rigid:l7E1FUkiadooAKqtpYNB/KEApZ4	false	tag:?-?	tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P09483	uniprotkb:P20420	intact:EBI-7842410|uniprotkb:O35769|intact:MINT-198047	intact:EBI-10828372	psi-mi:acha4_rat(display_long)|uniprotkb:Chrna4(gene name)|psi-mi:Chrna4(display_short)|uniprotkb:Acra4(gene name synonym)	psi-mi:acha5_rat(display_long)|uniprotkb:Chrna5(gene name)|psi-mi:Chrna5(display_short)|uniprotkb:Acra5(gene name synonym)	psi-mi:"MI:0276"(blue native page)	Gahring et al. (2010)	pubmed:20566638|imex:IM-24267	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10828449|imex:IM-24267-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0001508"(action potential)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005216"(ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035640"(exploration behavior)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042113"(B cell activation)|interpro:IPR018000|refseq:NP_077330.1|rgd:2346|rcsb pdb:1OLE|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	reactome:R-RNO-629594|reactome:R-RNO-629597|rgd:2347|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR018000|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR036719|interpro:IPR036734	-	comment:mint|function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane	-	figure legend:"Fig.s 4c, 5b (top right)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/06/03	2015/06/03	rogid:X/Fy7r31J41STO/uzlWjkbD2E6g10116	rogid:NZ+9X28yNEd7JU3dfSWMU/0J6c010116	rigid:4Pms72KTh8KlyvXRneRJwLHsKY8	false	tag:?-?	tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P09483	uniprotkb:P12390	intact:EBI-7842410|uniprotkb:O35769|intact:MINT-198047	intact:EBI-9008812|uniprotkb:Q53YK1|ensembl:ENSRNOP00000028200	psi-mi:acha4_rat(display_long)|uniprotkb:Chrna4(gene name)|psi-mi:Chrna4(display_short)|uniprotkb:Acra4(gene name synonym)	psi-mi:achb2_rat(display_long)|uniprotkb:Chrnb2(gene name)|psi-mi:Chrnb2(display_short)|uniprotkb:Acrb2(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-1 chain(gene name synonym)	psi-mi:"MI:0276"(blue native page)	Gahring et al. (2010)	pubmed:20566638|imex:IM-24267	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10828449|imex:IM-24267-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0001508"(action potential)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005216"(ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035640"(exploration behavior)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042113"(B cell activation)|interpro:IPR018000|refseq:NP_077330.1|rgd:2346|rcsb pdb:1OLE|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	refseq:NP_062170.1|rgd:2350|ensembl:ENSRNOG00000020778(gene)|ensembl:ENSRNOT00000028200(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021562"(vestibulocochlear nerve development)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021771"(lateral geniculate nucleus development)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032225"(regulation of synaptic transmission, dopaminergic)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035176"(social behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042113"(B cell activation)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042320"(regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045188"(regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1905144"(response to acetylcholine)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR032932|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLE|rcsb pdb:1OLF|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	-	comment:mint|function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane	-	figure legend:"Fig.s 4c, 5b (top right)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/06/03	2015/06/03	rogid:X/Fy7r31J41STO/uzlWjkbD2E6g10116	rogid:V5uVKdZkq4z+1m4A/AIp9wgQglg10116	rigid:4Pms72KTh8KlyvXRneRJwLHsKY8	false	tag:?-?	tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P09483	uniprotkb:P12392	intact:EBI-7842410|uniprotkb:O35769|intact:MINT-198047	intact:EBI-9008856|ensembl:ENSRNOP00000019458|uniprotkb:Q63361	psi-mi:acha4_rat(display_long)|uniprotkb:Chrna4(gene name)|psi-mi:Chrna4(display_short)|uniprotkb:Acra4(gene name synonym)	psi-mi:achb4_rat(display_long)|uniprotkb:Chrnb4(gene name)|psi-mi:Chrnb4(display_short)|uniprotkb:Acrb4(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-2 chain(gene name synonym)	psi-mi:"MI:0276"(blue native page)	Gahring et al. (2010)	pubmed:20566638|imex:IM-24267	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10828449|imex:IM-24267-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0001508"(action potential)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005216"(ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035640"(exploration behavior)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042113"(B cell activation)|interpro:IPR018000|refseq:NP_077330.1|rgd:2346|rcsb pdb:1OLE|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0098981"(cholinergic synapse)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLJ|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597|reactome:R-RNO-6798695|ensembl:ENSRNOG00000014427(gene)|ensembl:ENSRNOT00000019458(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|refseq:NP_434693.1|rgd:2351	-	comment:mint|function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane	-	figure legend:"Fig.s 4c, 5b (top right)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/06/03	2015/06/03	rogid:X/Fy7r31J41STO/uzlWjkbD2E6g10116	rogid:5dJnJuHTUCfgfuOzNn5YfdKFCOs10116	rigid:4Pms72KTh8KlyvXRneRJwLHsKY8	false	tag:?-?	tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P09483	uniprotkb:P20420	intact:EBI-7842410|uniprotkb:O35769|intact:MINT-198047	intact:EBI-10828372	psi-mi:acha4_rat(display_long)|uniprotkb:Chrna4(gene name)|psi-mi:Chrna4(display_short)|uniprotkb:Acra4(gene name synonym)	psi-mi:acha5_rat(display_long)|uniprotkb:Chrna5(gene name)|psi-mi:Chrna5(display_short)|uniprotkb:Acra5(gene name synonym)	psi-mi:"MI:0276"(blue native page)	Gahring et al. (2010)	pubmed:20566638|imex:IM-24267	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10828463|imex:IM-24267-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0001508"(action potential)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005216"(ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035640"(exploration behavior)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042113"(B cell activation)|interpro:IPR018000|refseq:NP_077330.1|rgd:2346|rcsb pdb:1OLE|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	reactome:R-RNO-629594|reactome:R-RNO-629597|rgd:2347|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR018000|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR036719|interpro:IPR036734	-	comment:mint|function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane	-	figure legend:"Fig.s 4c, 5b (top right)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/06/03	2015/06/03	rogid:X/Fy7r31J41STO/uzlWjkbD2E6g10116	rogid:NZ+9X28yNEd7JU3dfSWMU/0J6c010116	rigid:DZhuvyUEfRgg44ihUsNk31CvROg	false	tag:?-?	tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P09483	uniprotkb:P12390	intact:EBI-7842410|uniprotkb:O35769|intact:MINT-198047	intact:EBI-9008812|uniprotkb:Q53YK1|ensembl:ENSRNOP00000028200	psi-mi:acha4_rat(display_long)|uniprotkb:Chrna4(gene name)|psi-mi:Chrna4(display_short)|uniprotkb:Acra4(gene name synonym)	psi-mi:achb2_rat(display_long)|uniprotkb:Chrnb2(gene name)|psi-mi:Chrnb2(display_short)|uniprotkb:Acrb2(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-1 chain(gene name synonym)	psi-mi:"MI:0276"(blue native page)	Gahring et al. (2010)	pubmed:20566638|imex:IM-24267	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10828463|imex:IM-24267-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0001508"(action potential)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005216"(ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035640"(exploration behavior)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042113"(B cell activation)|interpro:IPR018000|refseq:NP_077330.1|rgd:2346|rcsb pdb:1OLE|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	refseq:NP_062170.1|rgd:2350|ensembl:ENSRNOG00000020778(gene)|ensembl:ENSRNOT00000028200(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021562"(vestibulocochlear nerve development)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021771"(lateral geniculate nucleus development)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032225"(regulation of synaptic transmission, dopaminergic)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035176"(social behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042113"(B cell activation)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042320"(regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045188"(regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1905144"(response to acetylcholine)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR032932|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLE|rcsb pdb:1OLF|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	-	comment:mint|function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane	-	figure legend:"Fig.s 4c, 5b (top right)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/06/03	2015/06/03	rogid:X/Fy7r31J41STO/uzlWjkbD2E6g10116	rogid:V5uVKdZkq4z+1m4A/AIp9wgQglg10116	rigid:DZhuvyUEfRgg44ihUsNk31CvROg	false	tag:?-?	tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P12392	uniprotkb:P12392	intact:EBI-9008856|ensembl:ENSRNOP00000019458|uniprotkb:Q63361	intact:EBI-9008856|ensembl:ENSRNOP00000019458|uniprotkb:Q63361	psi-mi:achb4_rat(display_long)|uniprotkb:Chrnb4(gene name)|psi-mi:Chrnb4(display_short)|uniprotkb:Acrb4(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-2 chain(gene name synonym)	psi-mi:achb4_rat(display_long)|uniprotkb:Chrnb4(gene name)|psi-mi:Chrnb4(display_short)|uniprotkb:Acrb4(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-2 chain(gene name synonym)	psi-mi:"MI:0276"(blue native page)	Gahring et al. (2010)	pubmed:20566638|imex:IM-24267	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10828477|imex:IM-24267-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0098981"(cholinergic synapse)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLJ|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597|reactome:R-RNO-6798695|ensembl:ENSRNOG00000014427(gene)|ensembl:ENSRNOT00000019458(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|refseq:NP_434693.1|rgd:2351	go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0098981"(cholinergic synapse)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLJ|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597|reactome:R-RNO-6798695|ensembl:ENSRNOG00000014427(gene)|ensembl:ENSRNOT00000019458(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|refseq:NP_434693.1|rgd:2351	-	-	-	figure legend:"Fig.s 4c, 5b (top right)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/06/03	2015/06/03	rogid:5dJnJuHTUCfgfuOzNn5YfdKFCOs10116	rogid:5dJnJuHTUCfgfuOzNn5YfdKFCOs10116	rigid:t81HW5LU9SciL1L5R4+t/yrC08E	false	tag:?-?	tag:?-?	2	0	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P09483	uniprotkb:P12390	intact:EBI-7842410|uniprotkb:O35769|intact:MINT-198047	intact:EBI-9008812|uniprotkb:Q53YK1|ensembl:ENSRNOP00000028200	psi-mi:acha4_rat(display_long)|uniprotkb:Chrna4(gene name)|psi-mi:Chrna4(display_short)|uniprotkb:Acra4(gene name synonym)	psi-mi:achb2_rat(display_long)|uniprotkb:Chrnb2(gene name)|psi-mi:Chrnb2(display_short)|uniprotkb:Acrb2(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-1 chain(gene name synonym)	psi-mi:"MI:0276"(blue native page)	Gahring et al. (2010)	pubmed:20566638|imex:IM-24267	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10828498|imex:IM-24267-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0001508"(action potential)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005216"(ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035640"(exploration behavior)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042113"(B cell activation)|interpro:IPR018000|refseq:NP_077330.1|rgd:2346|rcsb pdb:1OLE|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	refseq:NP_062170.1|rgd:2350|ensembl:ENSRNOG00000020778(gene)|ensembl:ENSRNOT00000028200(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021562"(vestibulocochlear nerve development)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021771"(lateral geniculate nucleus development)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032225"(regulation of synaptic transmission, dopaminergic)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035176"(social behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042113"(B cell activation)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042320"(regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045188"(regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1905144"(response to acetylcholine)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR032932|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLE|rcsb pdb:1OLF|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	-	comment:mint|function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane	-	figure legend:"Fig. 5b (top left)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/06/03	2015/06/03	rogid:X/Fy7r31J41STO/uzlWjkbD2E6g10116	rogid:V5uVKdZkq4z+1m4A/AIp9wgQglg10116	rigid:s2FeGRbwCxp5t6LhuBfy4QU0MfA	false	tag:?-?	tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P09483	uniprotkb:P12392	intact:EBI-7842410|uniprotkb:O35769|intact:MINT-198047	intact:EBI-9008856|ensembl:ENSRNOP00000019458|uniprotkb:Q63361	psi-mi:acha4_rat(display_long)|uniprotkb:Chrna4(gene name)|psi-mi:Chrna4(display_short)|uniprotkb:Acra4(gene name synonym)	psi-mi:achb4_rat(display_long)|uniprotkb:Chrnb4(gene name)|psi-mi:Chrnb4(display_short)|uniprotkb:Acrb4(gene name synonym)|uniprotkb:Neuronal acetylcholine receptor non-alpha-2 chain(gene name synonym)	psi-mi:"MI:0276"(blue native page)	Gahring et al. (2010)	pubmed:20566638|imex:IM-24267	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10828498|imex:IM-24267-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0001508"(action potential)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005216"(ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007626"(locomotory behavior)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035640"(exploration behavior)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0042113"(B cell activation)|interpro:IPR018000|refseq:NP_077330.1|rgd:2346|rcsb pdb:1OLE|interpro:IPR036719|interpro:IPR036734|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597	go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0098981"(cholinergic synapse)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:1OLJ|reactome:R-RNO-629587|reactome:R-RNO-629594|reactome:R-RNO-629597|reactome:R-RNO-6798695|ensembl:ENSRNOG00000014427(gene)|ensembl:ENSRNOT00000019458(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|refseq:NP_434693.1|rgd:2351	-	comment:mint|function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane	-	figure legend:"Fig. 5b (top left)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/06/03	2015/06/03	rogid:X/Fy7r31J41STO/uzlWjkbD2E6g10116	rogid:5dJnJuHTUCfgfuOzNn5YfdKFCOs10116	rigid:s2FeGRbwCxp5t6LhuBfy4QU0MfA	false	tag:?-?	tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)