#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-10889363	uniprotkb:P41819	-	intact:EBI-5884|uniprotkb:D6W3A4|ensemblfungi:YPL266W	psi-mi:rrna 20s(display_short)|psi-mi:EBI-10889363(display_long)	psi-mi:dim1_yeast(display_long)|uniprotkb:YPL266W(locus name)|uniprotkb:DIM1(gene name)|psi-mi:DIM1(display_short)|uniprotkb:"S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase"(gene name synonym)|uniprotkb:18S rRNA dimethylase(gene name synonym)|uniprotkb:"18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase"(gene name synonym)	psi-mi:"MI:2194"(crac)	Granneman et al. (2010)	pubmed:20453830|imex:IM-26559	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10889371|imex:IM-26559-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0608"(ribosomal rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_015057.1|sgd:S000006187|dip:DIP-3924N|ensemblfungi:YPL266W(gene)|ensemblfungi:YPL266W_mRNA(transcript)|go:"GO:0000154"(rRNA modification)|go:"GO:0000179"("rRNA (adenine-N6,N6-)-dimethyltransferase activity")|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0030686"(90S preribosome)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0031167"(rRNA methylation)|go:"GO:0052909"("18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity")|interpro:IPR001737(Ribosomal RNA adenine methylase transferase)|interpro:IPR011530(rRNA adenine dimethylase)|interpro:IPR020596|interpro:IPR020598|interpro:IPR029063|rcsb pdb:6RBD|rcsb pdb:6ZQD|rcsb pdb:6ZQE|rcsb pdb:6ZQF|rcsb pdb:6ZQG|rcsb pdb:7AJU	-	-	crc64:EE77C9DF574A042A	figure legend:Fig1A, suppl tab S4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/06/15	2015/06/15	-	rogid:Nw+Q3lw0yvfq3/+tJDq7uXTOeZo559292	-	false	binding-associated region:1137-1156,1753-1794	tandem tag:c-c	-	-	psi-mi:"MI:1193"(partial RNA sequence identification)	psi-mi:"MI:1193"(partial RNA sequence identification)
intact:EBI-10889363	uniprotkb:Q07381	-	intact:EBI-35023|uniprotkb:Q03128|uniprotkb:D6VRT6|ensemblfungi:YDL060W	psi-mi:rrna 20s(display_short)|psi-mi:EBI-10889363(display_long)	psi-mi:tsr1_yeast(display_long)|uniprotkb:TSR1(gene name)|psi-mi:TSR1(display_short)|uniprotkb:20S rRNA accumulation protein 1(gene name synonym)|uniprotkb:YDL060W(locus name)	psi-mi:"MI:2194"(crac)	Granneman et al. (2010)	pubmed:20453830|imex:IM-26559	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10889377|imex:IM-26559-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0608"(ribosomal rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_010223.1|sgd:S000002218|mint:Q07381|dip:DIP-6294N|ensemblfungi:YDL060W(gene)|ensemblfungi:YDL060W_mRNA(transcript)|go:"GO:0000461"("endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000479"("endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030686"(90S preribosome)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|interpro:IPR007034(Protein of unknown function DUF663)|interpro:IPR012948(AARP2CN)|interpro:IPR030387|interpro:IPR039761|rcsb pdb:5IW7|rcsb pdb:5WWN|rcsb pdb:6EML|rcsb pdb:6FAI|rcsb pdb:6RBD|rcsb pdb:6WDR|rcsb pdb:6Y7C|reactome:R-SCE-6791226	-	-	crc64:71BA5461E8A858C7	figure legend:Fig1, suppl tab 9|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/06/15	2015/06/15	-	rogid:Kq/+eUGYUKlNeGEy4cf/uuOrXQs559292	-	false	binding-associated region:1771-1780,1060-1200,1445-1460	tandem tag:c-c	-	-	psi-mi:"MI:1193"(partial RNA sequence identification)	psi-mi:"MI:1193"(partial RNA sequence identification)
intact:EBI-10889363	uniprotkb:Q08444	-	intact:EBI-29777|uniprotkb:O00021|uniprotkb:D6W2B9|ensemblfungi:YOR056C	psi-mi:rrna 20s(display_short)|psi-mi:EBI-10889363(display_long)	psi-mi:nob1_yeast(display_long)|uniprotkb:Pre-rRNA-processing endonuclease NOB1(gene name synonym)|uniprotkb:NIN1-binding protein(gene name synonym)|uniprotkb:NOB1(gene name)|psi-mi:NOB1(display_short)|uniprotkb:YOR29-07(orf name)|uniprotkb:YOR056C(locus name)	psi-mi:"MI:2194"(crac)	Granneman et al. (2010)	pubmed:20453830|imex:IM-26559	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10889752|imex:IM-26559-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0608"(ribosomal rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_014699.1|sgd:S000005582|dip:DIP-6440N|mint:Q08444|ensemblfungi:YOR056C(gene)|ensemblfungi:YOR056C_mRNA(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000469"(cleavage involved in rRNA processing)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0043248"(proteasome assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR002716(PilT protein, N-terminal)|interpro:IPR014881("Nin one binding (NOB1) Zn-ribbon like")|interpro:IPR017117(D-site 20S pre-rRNA nuclease)|interpro:IPR033411|interpro:IPR036283|interpro:IPR039907|reactome:R-SCE-6791226	-	-	crc64:96DEB818BB490A98	figure legend:Fig1A, suppl tab 7, suppl fig 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/06/15	2015/06/16	-	rogid:qrgJ9wPGJB07VDMdjSLr5Gw674o559292	-	false	binding-associated region:1380-1442	tandem tag:c-c|mutation:15-15	-	-	psi-mi:"MI:1193"(partial RNA sequence identification)	psi-mi:"MI:1193"(partial RNA sequence identification)
intact:EBI-10889363	uniprotkb:P34078	-	intact:EBI-10248|uniprotkb:D6VX53|ensemblfungi:YKL143W	psi-mi:rrna 20s(display_short)|psi-mi:EBI-10889363(display_long)	psi-mi:ltv1_yeast(display_long)|uniprotkb:LTV1(gene name)|psi-mi:LTV1(display_short)|uniprotkb:YKL143W(locus name)|uniprotkb:YKL2(orf name)|uniprotkb:Low-temperature viability protein 1(gene name synonym)	psi-mi:"MI:2194"(crac)	Granneman et al. (2010)	pubmed:20453830|imex:IM-26559	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10893062|imex:IM-26559-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0608"(ribosomal rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_012779.1|sgd:S000001626|ensemblfungi:YKL143W_mRNA(transcript)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0015031"(protein transport)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0031902"(late endosome membrane)|go:"GO:0034599"(cellular response to oxidative stress)|ensemblfungi:YKL143W(gene)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904669"(ATP export)|interpro:IPR007307(Low temperature viability protein)|rcsb pdb:5WWO|rcsb pdb:6FAI|rcsb pdb:6Y7C|reactome:R-SCE-6791226|dip:DIP-2801N|mint:P34078	-	-	crc64:F432C239B3B0A68A	figure legend:Fig1, suppl tab 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/06/15	2015/06/22	-	rogid:mJ8DnoypAtCiH25AR8AtXvRGi/0559292	-	false	binding-associated region:451-530,630-690,1382-1422,1460-1550	tandem tag:c-c	-	-	psi-mi:"MI:1193"(partial RNA sequence identification)	psi-mi:"MI:1193"(partial RNA sequence identification)
intact:EBI-10889363	uniprotkb:P38333	-	intact:EBI-6482|uniprotkb:D6VQP3|ensemblfungi:YBR247C	psi-mi:rrna 20s(display_short)|psi-mi:EBI-10889363(display_long)	psi-mi:enp1_yeast(display_long)|uniprotkb:ENP1(gene name)|psi-mi:ENP1(display_short)|uniprotkb:MEG1(gene name synonym)|uniprotkb:YBR247C(locus name)|uniprotkb:YBR1635(orf name)	psi-mi:"MI:2194"(crac)	Granneman et al. (2010)	pubmed:20453830|imex:IM-26559	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10893111|imex:IM-26559-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0608"(ribosomal rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009806.3|sgd:S000000451|mint:P38333|dip:DIP-6612N|ensemblfungi:YBR247C(gene)|ensemblfungi:YBR247C_mRNA(transcript)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0030515"(snoRNA binding)|go:"GO:0030686"(90S preribosome)|go:"GO:0030688"(preribosome, small subunit precursor)|interpro:IPR007955(Bystin)|rcsb pdb:5WLC|rcsb pdb:5WWO|rcsb pdb:5WYJ|rcsb pdb:6EML|rcsb pdb:6FAI|rcsb pdb:6KE6|rcsb pdb:6LQP|rcsb pdb:6LQQ|rcsb pdb:6LQR|rcsb pdb:6LQS|rcsb pdb:6LQU|rcsb pdb:6LQV|rcsb pdb:6RBD|rcsb pdb:6Y7C|rcsb pdb:6ZQA|rcsb pdb:6ZQB|rcsb pdb:6ZQC|rcsb pdb:6ZQD|rcsb pdb:6ZQE|rcsb pdb:6ZQF|rcsb pdb:6ZQG|rcsb pdb:7AJT|rcsb pdb:7AJU|reactome:R-SCE-6791226	-	-	crc64:399A415131294637	figure legend:Fig1 S5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/06/15	2015/06/22	-	rogid:hRWEGOAGLPtihuRsJqQDpZyNtcE559292	-	false	binding-associated region:1241-1274,1427-1443	tandem tag:c-c	-	-	psi-mi:"MI:1193"(partial RNA sequence identification)	psi-mi:"MI:1193"(partial RNA sequence identification)
intact:EBI-10889363	uniprotkb:P40160	-	intact:EBI-29124|uniprotkb:D6W0Y3|ensemblfungi:YNL207W	psi-mi:rrna 20s(display_short)|psi-mi:EBI-10889363(display_long)	psi-mi:rio2_yeast(display_long)|uniprotkb:N1342(orf name)|uniprotkb:YNL207W(locus name)|uniprotkb:RIO2(gene name)|psi-mi:RIO2(display_short)	psi-mi:"MI:2194"(crac)	Granneman et al. (2010)	pubmed:20453830|imex:IM-26559	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10893137|imex:IM-26559-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0608"(ribosomal rna)	psi-mi:"MI:0326"(protein)	-	refseq:NP_014192.1|sgd:S000005151|dip:DIP-4894N|mint:P40160|ensemblfungi:YNL207W(gene)|ensemblfungi:YNL207W_mRNA(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0046830"(positive regulation of RNA import into nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000687(RIO kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015285(RIO2 kinase, winged helix, N-terminal)|interpro:IPR030484|interpro:IPR036388|interpro:IPR036390|rcsb pdb:6EML|rcsb pdb:6FAI|rcsb pdb:6RBD|rcsb pdb:6Y7C|reactome:R-SCE-6791226	-	-	crc64:02117D0328118E8D	figure legend:fig1, suppl. tab 8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/06/15	2015/06/22	-	rogid:6KYaKieXMwrTGLueZEH2C9SpTR4559292	-	false	binding-associated region:1160-1207	tandem tag:c-c	-	-	psi-mi:"MI:1193"(partial RNA sequence identification)	psi-mi:"MI:1193"(partial RNA sequence identification)
uniprotkb:Q08444	intact:EBI-10889363	intact:EBI-29777|uniprotkb:O00021|uniprotkb:D6W2B9|ensemblfungi:YOR056C	-	psi-mi:nob1_yeast(display_long)|uniprotkb:Pre-rRNA-processing endonuclease NOB1(gene name synonym)|uniprotkb:NIN1-binding protein(gene name synonym)|uniprotkb:NOB1(gene name)|psi-mi:NOB1(display_short)|uniprotkb:YOR29-07(orf name)|uniprotkb:YOR056C(locus name)	psi-mi:rrna 20s(display_short)|psi-mi:EBI-10889363(display_long)	psi-mi:"MI:0004"(affinity chromatography technology)	Granneman et al. (2010)	pubmed:20453830|imex:IM-26559	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10893246|imex:IM-26559-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0608"(ribosomal rna)	refseq:NP_014699.1|sgd:S000005582|dip:DIP-6440N|mint:Q08444|ensemblfungi:YOR056C(gene)|ensemblfungi:YOR056C_mRNA(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000469"(cleavage involved in rRNA processing)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0043248"(proteasome assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR002716(PilT protein, N-terminal)|interpro:IPR014881("Nin one binding (NOB1) Zn-ribbon like")|interpro:IPR017117(D-site 20S pre-rRNA nuclease)|interpro:IPR033411|interpro:IPR036283|interpro:IPR039907|reactome:R-SCE-6791226	-	-	crc64:96DEB818BB490A98	-	figure legend:Fig4 B,C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/06/15	2015/06/22	rogid:qrgJ9wPGJB07VDMdjSLr5Gw674o559292	-	-	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:1194"(reverse transcription pcr)	psi-mi:"MI:1194"(reverse transcription pcr)