#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q13291 uniprotkb:Q92918 intact:EBI-4315002|uniprotkb:Q5W172|uniprotkb:Q9HBE8|uniprotkb:W0HKK7|ensembl:ENSP00000306190 intact:EBI-881|intact:EBI-28975476|ensembl:ENSP00000465039|ensembl:ENSP00000489001 psi-mi:slaf1_human(display_long)|uniprotkb:SLAMF1(gene name)|psi-mi:SLAMF1(display_short)|uniprotkb:SLAM family member 1(gene name synonym)|uniprotkb:SLAM(gene name synonym)|uniprotkb:CDw150(gene name synonym)|uniprotkb:IPO-3(gene name synonym) psi-mi:m4k1_human(display_long)|uniprotkb:HPK1(gene name synonym)|uniprotkb:MAP4K1(gene name)|psi-mi:MAP4K1(display_short)|uniprotkb:MAPK/ERK kinase kinase kinase 1(gene name synonym)|uniprotkb:Hematopoietic progenitor kinase(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Yurchenko et al. (2010) pubmed:20231852|imex:IM-24997 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-11327414|imex:IM-24997-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005245513.1|refseq:NP_003028.1|refseq:NP_001317683.1|ensembl:ENSG00000117090(gene)|ensembl:ENST00000302035(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001779"(natural killer cell differentiation)|interpro:IPR036179|rcsb pdb:1D4T|rcsb pdb:1D4W|rcsb pdb:1I3Z|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|rcsb pdb:2DZF|rcsb pdb:2IE9|rcsb pdb:2IFL|rcsb pdb:2IG5|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0003823"(antigen binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031338"(regulation of vesicle fusion)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000349"(negative regulation of CD40 signaling pathway)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010407(Signaling lymphocytic activation molecule, N-terminal)|go:"GO:0001787"(natural killer cell proliferation)|dip:DIP-40767N refseq:NP_009112.1|refseq:NP_001036065.1|ensembl:ENST00000396857|ensembl:ENSP00000380066|ensembl:ENSP00000465039|ensembl:ENSP00000489001|ensembl:ENST00000634494|ensembl:ENSP00000489158|dip:DIP-31019N|ensembl:ENSG00000104814(gene)|ensembl:ENSG00000282928(gene)|ensembl:ENST00000591517(transcript)|ensembl:ENST00000634395(transcript)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|mint:Q92918|rcsb pdb:6CQD|rcsb pdb:6CQE|rcsb pdb:6CQF|rcsb pdb:6NFY|rcsb pdb:6NFZ|rcsb pdb:6NG0|rcsb pdb:7KAC|rcsb pdb:7L24|rcsb pdb:7L25|rcsb pdb:7L26|rcsb pdb:7M0K|rcsb pdb:7M0L|rcsb pdb:7M0M - - - figure legend:5a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mp-1)|taxid:9606(human B lymphoblastoid cell line MP-1) - 2015/10/22 2015/10/22 rogid:DduZeT4BxhSno9xA/om9mkV1rpI9606 rogid:XAnNUBaT7pFyJMbz5gbC1ahCono9606 rigid:6wTzgpFgpBvnJty2tRxbbIGf2Hc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13291 uniprotkb:O60880 intact:EBI-4315002|uniprotkb:Q5W172|uniprotkb:Q9HBE8|uniprotkb:W0HKK7|ensembl:ENSP00000306190 intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0 psi-mi:slaf1_human(display_long)|uniprotkb:SLAMF1(gene name)|psi-mi:SLAMF1(display_short)|uniprotkb:SLAM family member 1(gene name synonym)|uniprotkb:SLAM(gene name synonym)|uniprotkb:CDw150(gene name synonym)|uniprotkb:IPO-3(gene name synonym) psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym) psi-mi:"MI:0096"(pull down) Yurchenko et al. (2010) pubmed:20231852|imex:IM-24997 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-11327425|imex:IM-24997-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005245513.1|refseq:NP_003028.1|refseq:NP_001317683.1|ensembl:ENSG00000117090(gene)|ensembl:ENST00000302035(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001779"(natural killer cell differentiation)|interpro:IPR036179|rcsb pdb:1D4T|rcsb pdb:1D4W|rcsb pdb:1I3Z|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|rcsb pdb:2DZF|rcsb pdb:2IE9|rcsb pdb:2IFL|rcsb pdb:2IG5|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0003823"(antigen binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031338"(regulation of vesicle fusion)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000349"(negative regulation of CD40 signaling pathway)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010407(Signaling lymphocytic activation molecule, N-terminal)|go:"GO:0001787"(natural killer cell proliferation)|dip:DIP-40767N rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N - - comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma" figure legend:5b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/10/22 2015/10/22 rogid:DduZeT4BxhSno9xA/om9mkV1rpI9606 rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606 rigid:C91pzTc4qnKroc5Qs4Bt3MRA8ys false sufficient binding region:259..259-335|glutathione s tranferase tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13291 uniprotkb:Q92918 intact:EBI-4315002|uniprotkb:Q5W172|uniprotkb:Q9HBE8|uniprotkb:W0HKK7|ensembl:ENSP00000306190 intact:EBI-881|intact:EBI-28975476|ensembl:ENSP00000465039|ensembl:ENSP00000489001 psi-mi:slaf1_human(display_long)|uniprotkb:SLAMF1(gene name)|psi-mi:SLAMF1(display_short)|uniprotkb:SLAM family member 1(gene name synonym)|uniprotkb:SLAM(gene name synonym)|uniprotkb:CDw150(gene name synonym)|uniprotkb:IPO-3(gene name synonym) psi-mi:m4k1_human(display_long)|uniprotkb:HPK1(gene name synonym)|uniprotkb:MAP4K1(gene name)|psi-mi:MAP4K1(display_short)|uniprotkb:MAPK/ERK kinase kinase kinase 1(gene name synonym)|uniprotkb:Hematopoietic progenitor kinase(gene name synonym) psi-mi:"MI:0096"(pull down) Yurchenko et al. (2010) pubmed:20231852|imex:IM-24997 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-11327425|imex:IM-24997-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005245513.1|refseq:NP_003028.1|refseq:NP_001317683.1|ensembl:ENSG00000117090(gene)|ensembl:ENST00000302035(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001779"(natural killer cell differentiation)|interpro:IPR036179|rcsb pdb:1D4T|rcsb pdb:1D4W|rcsb pdb:1I3Z|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|rcsb pdb:2DZF|rcsb pdb:2IE9|rcsb pdb:2IFL|rcsb pdb:2IG5|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0003823"(antigen binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031338"(regulation of vesicle fusion)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000349"(negative regulation of CD40 signaling pathway)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010407(Signaling lymphocytic activation molecule, N-terminal)|go:"GO:0001787"(natural killer cell proliferation)|dip:DIP-40767N refseq:NP_009112.1|refseq:NP_001036065.1|ensembl:ENST00000396857|ensembl:ENSP00000380066|ensembl:ENSP00000465039|ensembl:ENSP00000489001|ensembl:ENST00000634494|ensembl:ENSP00000489158|dip:DIP-31019N|ensembl:ENSG00000104814(gene)|ensembl:ENSG00000282928(gene)|ensembl:ENST00000591517(transcript)|ensembl:ENST00000634395(transcript)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|mint:Q92918|rcsb pdb:6CQD|rcsb pdb:6CQE|rcsb pdb:6CQF|rcsb pdb:6NFY|rcsb pdb:6NFZ|rcsb pdb:6NG0|rcsb pdb:7KAC|rcsb pdb:7L24|rcsb pdb:7L25|rcsb pdb:7L26|rcsb pdb:7M0K|rcsb pdb:7M0L|rcsb pdb:7M0M - - - figure legend:5b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/10/22 2015/10/22 rogid:DduZeT4BxhSno9xA/om9mkV1rpI9606 rogid:XAnNUBaT7pFyJMbz5gbC1ahCono9606 rigid:C91pzTc4qnKroc5Qs4Bt3MRA8ys false sufficient binding region:259..259-335|glutathione s tranferase tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13291 uniprotkb:Q92918 intact:EBI-4315002|uniprotkb:Q5W172|uniprotkb:Q9HBE8|uniprotkb:W0HKK7|ensembl:ENSP00000306190 intact:EBI-881|intact:EBI-28975476|ensembl:ENSP00000465039|ensembl:ENSP00000489001 psi-mi:slaf1_human(display_long)|uniprotkb:SLAMF1(gene name)|psi-mi:SLAMF1(display_short)|uniprotkb:SLAM family member 1(gene name synonym)|uniprotkb:SLAM(gene name synonym)|uniprotkb:CDw150(gene name synonym)|uniprotkb:IPO-3(gene name synonym) psi-mi:m4k1_human(display_long)|uniprotkb:HPK1(gene name synonym)|uniprotkb:MAP4K1(gene name)|psi-mi:MAP4K1(display_short)|uniprotkb:MAPK/ERK kinase kinase kinase 1(gene name synonym)|uniprotkb:Hematopoietic progenitor kinase(gene name synonym) psi-mi:"MI:0096"(pull down) Yurchenko et al. (2010) pubmed:20231852|imex:IM-24997 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-11327435|imex:IM-24997-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005245513.1|refseq:NP_003028.1|refseq:NP_001317683.1|ensembl:ENSG00000117090(gene)|ensembl:ENST00000302035(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001779"(natural killer cell differentiation)|interpro:IPR036179|rcsb pdb:1D4T|rcsb pdb:1D4W|rcsb pdb:1I3Z|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|rcsb pdb:2DZF|rcsb pdb:2IE9|rcsb pdb:2IFL|rcsb pdb:2IG5|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0003823"(antigen binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031338"(regulation of vesicle fusion)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000349"(negative regulation of CD40 signaling pathway)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010407(Signaling lymphocytic activation molecule, N-terminal)|go:"GO:0001787"(natural killer cell proliferation)|dip:DIP-40767N refseq:NP_009112.1|refseq:NP_001036065.1|ensembl:ENST00000396857|ensembl:ENSP00000380066|ensembl:ENSP00000465039|ensembl:ENSP00000489001|ensembl:ENST00000634494|ensembl:ENSP00000489158|dip:DIP-31019N|ensembl:ENSG00000104814(gene)|ensembl:ENSG00000282928(gene)|ensembl:ENST00000591517(transcript)|ensembl:ENST00000634395(transcript)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|mint:Q92918|rcsb pdb:6CQD|rcsb pdb:6CQE|rcsb pdb:6CQF|rcsb pdb:6NFY|rcsb pdb:6NFZ|rcsb pdb:6NG0|rcsb pdb:7KAC|rcsb pdb:7L24|rcsb pdb:7L25|rcsb pdb:7L26|rcsb pdb:7M0K|rcsb pdb:7M0L|rcsb pdb:7M0M - - - figure legend:5b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/10/22 2015/10/22 rogid:DduZeT4BxhSno9xA/om9mkV1rpI9606 rogid:XAnNUBaT7pFyJMbz5gbC1ahCono9606 rigid:6wTzgpFgpBvnJty2tRxbbIGf2Hc false sufficient binding region:259..259-335|glutathione s tranferase tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)