#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9ET78 uniprotkb:Q9QZC1 intact:EBI-8350389|intact:MINT-4099221|uniprotkb:Q9ET79|uniprotkb:Q3U077|ensembl:ENSMUSP00000017961|ensembl:ENSMUSP00000105052 intact:EBI-10051366|uniprotkb:Q61058 psi-mi:jph2_mouse(display_long)|uniprotkb:Jph2(gene name)|psi-mi:Jph2(display_short)|uniprotkb:Jp2(gene name synonym)|uniprotkb:Junctophilin type 2(gene name synonym) psi-mi:trpc3_mouse(display_long)|uniprotkb:Trp3(gene name synonym)|uniprotkb:Trrp3(gene name synonym)|uniprotkb:Trpc3(gene name)|psi-mi:Trpc3(display_short)|uniprotkb:Receptor-activated cation channel TRP3(gene name synonym)|uniprotkb:Transient receptor protein 3(gene name synonym)|uniprotkb:Trp-related protein 3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Woo et al. (2010) pubmed:20095964|imex:IM-23688 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-10051385|imex:IM-23688-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067541.1|refseq:NP_001192005.1|refseq:XP_006500035.1|ensembl:ENSMUSG00000017817(gene)|ensembl:ENSMUST00000017961(transcript)|ensembl:ENSMUST00000109425(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0055024"(regulation of cardiac muscle tissue development)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|interpro:IPR003409(MORN motif)|interpro:IPR017191(Junctophilin)|mint:Q9ET78 reactome:R-MMU-114508|reactome:R-MMU-139853|reactome:R-MMU-3295583|go:"GO:0005227"(calcium activated cation channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0007338"(single fertilization)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0033198"(response to ATP)|go:"GO:0034703"(cation channel complex)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005459(Transient receptor potential channel 3)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR020683|interpro:IPR036770|dip:DIP-61309N - comment:mint|function:Contributes to the stabilization of the junctional membrane complexes, which are common to excitable cells and mediate cross-talk between cell surface and intracellular ion channels. Probably acts by anchoring the plasma membrane and endoplasmic/sarcoplasmic reticulum. Contributes to the construction of skeletal muscle triad junctions, and plays an essential role in heart development - figure legend:6C|antagonist:"GF-109203X ( selective protein kinase C inhibitor)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-skeletal-muscle)|taxid:10090(Mus musculus skeletal muscle.) - 2015/01/05 2015/01/05 rogid:vs5IFdM0JlfwvmUcraIjKfxlfY810090 rogid:eln40WH92qwpmdmJ+mbGYRHOnDc10090 intact-crc:9C8DF4EDE751BDC1|rigid:HGVkcBtAL3F/tnCvzU/PNBB5IoA false mutation decreasing interaction:165-165 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)