#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-11167512	uniprotkb:P15307	-	intact:EBI-5323778	psi-mi:foxp3_enhancer/cns3_probe_wt(display_short)|psi-mi:EBI-11167512(display_long)	psi-mi:rel_mouse(display_long)|uniprotkb:Rel(gene name)|psi-mi:Rel(display_short)	psi-mi:"MI:0096"(pull down)	Zheng et al. (2010)	imex:IM-24477|pubmed:20072126	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11167509|imex:IM-24477-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0681"(double stranded deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	dip:DIP-59241N|reactome:R-MMU-1169091|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR030505|interpro:IPR032397|interpro:IPR033926|interpro:IPR037059|interpro:IPR042845	-	-	-	figure legend:1H|agonist:"CD3/C28 antibodies + TGF-beta:NO Rel binding was seen in the absence of this stimulation."|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/17	2015/08/20	-	rogid:nBmYOU9oy70IMqXtGgSd4rTB5Vk10090	-	false	biotin tag:?-?|necessary binding region:162..163-175..176	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-11167536	uniprotkb:P15307	-	intact:EBI-5323778	psi-mi:il-2 cd28re_probe(display_short)|psi-mi:EBI-11167536(display_long)	psi-mi:rel_mouse(display_long)|uniprotkb:Rel(gene name)|psi-mi:Rel(display_short)	psi-mi:"MI:0096"(pull down)	Zheng et al. (2010)	imex:IM-24477|pubmed:20072126	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11167523|imex:IM-24477-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0681"(double stranded deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	dip:DIP-59241N|reactome:R-MMU-1169091|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR030505|interpro:IPR032397|interpro:IPR033926|interpro:IPR037059|interpro:IPR042845	-	-	-	figure legend:1Hi|agonist:CD3/C28 antibodies + TGF-beta;interaction was seen in the presence AND absence of stimulation.|comment:Positive control|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/17	2015/08/20	-	rogid:nBmYOU9oy70IMqXtGgSd4rTB5Vk10090	-	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-11167690	uniprotkb:Q08024	-	intact:EBI-475586|uniprotkb:Q08025|uniprotkb:Q62050|uniprotkb:Q62051|uniprotkb:Q8C282|uniprotkb:Q8CGD5|ensembl:ENSMUSP00000059382	psi-mi:demethylated_foxp3_enhancer/cns2_probe_wt(display_short)|psi-mi:EBI-11167690(display_long)	psi-mi:pebb_mouse(display_long)|uniprotkb:Polyomavirus enhancer-binding protein 2 beta subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 subunit beta(gene name synonym)|uniprotkb:SL3/AKV core-binding factor beta subunit(gene name synonym)|uniprotkb:Cbfb(gene name)|psi-mi:Cbfb(display_short)|uniprotkb:Pebp2b(gene name synonym)|uniprotkb:Pebpb2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zheng et al. (2010)	imex:IM-24477|pubmed:20072126	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11167683|imex:IM-24477-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0681"(double stranded deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSMUSG00000031885(gene)|ensembl:ENSMUST00000052209(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR003417(Core binding factor, beta subunit)|refseq:NP_001154928.1|refseq:NP_001154929.1|refseq:NP_001154930.1|refseq:NP_071704.3|rcsb pdb:1ILF|interpro:IPR036552|rcsb pdb:1IO4|rcsb pdb:2JHB|rcsb pdb:3WTS|rcsb pdb:3WTT|rcsb pdb:3WTU|rcsb pdb:3WTV|rcsb pdb:3WTW|rcsb pdb:3WTX|rcsb pdb:3WTY|reactome:R-MMU-8877330|reactome:R-MMU-8878166|reactome:R-MMU-8931987|reactome:R-MMU-8934593|reactome:R-MMU-8936459|reactome:R-MMU-8939236|reactome:R-MMU-8939243|reactome:R-MMU-8939245|reactome:R-MMU-8939246|reactome:R-MMU-8939247|reactome:R-MMU-8941326|reactome:R-MMU-8941858|reactome:R-MMU-8951936|reactome:R-MMU-9018519	-	-	-	figure legend:4H|comment:"Binding of the demethylated CNS2 probe to Cbf-beta/Pebb was seen using both  naive (CD4+CD25-) and TReg (CD4+CD25+) T cells."|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/17	2015/08/20	-	rogid:rLI+FjXTPj8Z/0+MNAdcOhjHpMg10090	-	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-11167571	uniprotkb:Q9WVH4	-	intact:EBI-6127038|uniprotkb:D3Z6Y6|uniprotkb:Q05CZ4|ensembl:ENSMUSP00000050683|ensembl:ENSMUSP00000101141|ensembl:ENSMUSP00000135380	psi-mi:foxp3_enhancer/cns2_probe_wt(display_short)|psi-mi:EBI-11167571(display_long)	psi-mi:foxo3_mouse(display_long)|uniprotkb:Foxo3(gene name)|psi-mi:Foxo3(display_short)|uniprotkb:Fkhr2(gene name synonym)|uniprotkb:Foxo3a(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zheng et al. (2010)	imex:IM-24477|pubmed:20072126	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11167560|imex:IM-24477-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0681"(double stranded deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_062714.1|refseq:XP_006512869.1|ensembl:ENSMUSG00000048756(gene)|ensembl:ENSMUST00000056974(transcript)|ensembl:ENSMUST00000105502(transcript)|ensembl:ENSMUST00000175881(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001544"(initiation of primordial ovarian follicle growth)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006417"(regulation of translation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990785"(response to water-immersion restraint stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032067|interpro:IPR032068|interpro:IPR036388|interpro:IPR036390|reactome:R-MMU-1181150|reactome:R-MMU-198693|reactome:R-MMU-5687128|reactome:R-MMU-9607240|reactome:R-MMU-9614399|reactome:R-MMU-9617629|reactome:R-MMU-9617828|reactome:R-MMU-9634638	-	-	-	figure legend:4D|comment:"No binding of the CNS2 probe was seen using naive (CD4+CD25-) T cells."|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/17	2015/08/20	-	rogid:HKBiozf3he1MKOGEW5e6aCZ4gsw10090	-	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-11167690	uniprotkb:Q03347	-	intact:EBI-3863873|uniprotkb:O08598|uniprotkb:Q62049|uniprotkb:Q9ESB9|uniprotkb:Q9ET65	psi-mi:demethylated_foxp3_enhancer/cns2_probe_wt(display_short)|psi-mi:EBI-11167690(display_long)	psi-mi:runx1_mouse(display_long)|uniprotkb:Runx1(gene name)|psi-mi:Runx1(display_short)|uniprotkb:Aml1(gene name synonym)|uniprotkb:Cbfa2(gene name synonym)|uniprotkb:Pebp2ab(gene name synonym)|uniprotkb:Acute myeloid leukemia 1 protein(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-2(gene name synonym)|uniprotkb:Oncogene AML-1(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha B subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha B subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha B subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zheng et al. (2010)	imex:IM-24477|pubmed:20072126	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11167708|imex:IM-24477-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0681"(double stranded deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048666"(neuron development)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0071336"(regulation of hair follicle cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903431"(positive regulation of cell maturation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000872"(positive regulation of progesterone secretion)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|interpro:IPR027384|rcsb pdb:1EAN|rcsb pdb:1EAO|rcsb pdb:1EAQ|rcsb pdb:1HJB|rcsb pdb:1HJC|rcsb pdb:1IO4|rcsb pdb:2J6W|rcsb pdb:3WTS|rcsb pdb:3WTT|rcsb pdb:3WTU|rcsb pdb:3WTV|rcsb pdb:3WTW|rcsb pdb:3WTX|rcsb pdb:3WTY|rcsb pdb:3WU1|rcsb pdb:4L0Y|rcsb pdb:4L0Z|rcsb pdb:4L18|dip:DIP-40723N|reactome:R-MMU-549127|reactome:R-MMU-8877330|reactome:R-MMU-8931987|reactome:R-MMU-8934593|reactome:R-MMU-8936459|reactome:R-MMU-8939236|reactome:R-MMU-8939243|reactome:R-MMU-8939245|reactome:R-MMU-8939246|reactome:R-MMU-8939247|reactome:R-MMU-9018519	-	-	-	figure legend:4Hi|comment:Binding of Cbf-beta/Pebb was seen using  methylated and demethylated probes.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/17	2015/09/14	-	rogid:1rh6vkqvcnroruSaiTl+xBjDpms10090	-	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-11167690	uniprotkb:Q9WVH4	-	intact:EBI-6127038|uniprotkb:D3Z6Y6|uniprotkb:Q05CZ4|ensembl:ENSMUSP00000050683|ensembl:ENSMUSP00000101141|ensembl:ENSMUSP00000135380	psi-mi:demethylated_foxp3_enhancer/cns2_probe_wt(display_short)|psi-mi:EBI-11167690(display_long)	psi-mi:foxo3_mouse(display_long)|uniprotkb:Foxo3(gene name)|psi-mi:Foxo3(display_short)|uniprotkb:Fkhr2(gene name synonym)|uniprotkb:Foxo3a(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zheng et al. (2010)	imex:IM-24477|pubmed:20072126	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11167708|imex:IM-24477-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0681"(double stranded deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_062714.1|refseq:XP_006512869.1|ensembl:ENSMUSG00000048756(gene)|ensembl:ENSMUST00000056974(transcript)|ensembl:ENSMUST00000105502(transcript)|ensembl:ENSMUST00000175881(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001544"(initiation of primordial ovarian follicle growth)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006417"(regulation of translation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990785"(response to water-immersion restraint stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032067|interpro:IPR032068|interpro:IPR036388|interpro:IPR036390|reactome:R-MMU-1181150|reactome:R-MMU-198693|reactome:R-MMU-5687128|reactome:R-MMU-9607240|reactome:R-MMU-9614399|reactome:R-MMU-9617629|reactome:R-MMU-9617828|reactome:R-MMU-9634638	-	-	-	figure legend:4Hi|comment:Binding of Cbf-beta/Pebb was seen using  methylated and demethylated probes.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/17	2015/09/14	-	rogid:HKBiozf3he1MKOGEW5e6aCZ4gsw10090	-	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-11167690	uniprotkb:Q08024	-	intact:EBI-475586|uniprotkb:Q08025|uniprotkb:Q62050|uniprotkb:Q62051|uniprotkb:Q8C282|uniprotkb:Q8CGD5|ensembl:ENSMUSP00000059382	psi-mi:demethylated_foxp3_enhancer/cns2_probe_wt(display_short)|psi-mi:EBI-11167690(display_long)	psi-mi:pebb_mouse(display_long)|uniprotkb:Polyomavirus enhancer-binding protein 2 beta subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 subunit beta(gene name synonym)|uniprotkb:SL3/AKV core-binding factor beta subunit(gene name synonym)|uniprotkb:Cbfb(gene name)|psi-mi:Cbfb(display_short)|uniprotkb:Pebp2b(gene name synonym)|uniprotkb:Pebpb2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zheng et al. (2010)	imex:IM-24477|pubmed:20072126	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11167708|imex:IM-24477-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0681"(double stranded deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSMUSG00000031885(gene)|ensembl:ENSMUST00000052209(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR003417(Core binding factor, beta subunit)|refseq:NP_001154928.1|refseq:NP_001154929.1|refseq:NP_001154930.1|refseq:NP_071704.3|rcsb pdb:1ILF|interpro:IPR036552|rcsb pdb:1IO4|rcsb pdb:2JHB|rcsb pdb:3WTS|rcsb pdb:3WTT|rcsb pdb:3WTU|rcsb pdb:3WTV|rcsb pdb:3WTW|rcsb pdb:3WTX|rcsb pdb:3WTY|reactome:R-MMU-8877330|reactome:R-MMU-8878166|reactome:R-MMU-8931987|reactome:R-MMU-8934593|reactome:R-MMU-8936459|reactome:R-MMU-8939236|reactome:R-MMU-8939243|reactome:R-MMU-8939245|reactome:R-MMU-8939246|reactome:R-MMU-8939247|reactome:R-MMU-8941326|reactome:R-MMU-8941858|reactome:R-MMU-8951936|reactome:R-MMU-9018519	-	-	-	figure legend:4Hi|comment:Binding of Cbf-beta/Pebb was seen using  methylated and demethylated probes.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/17	2015/09/14	-	rogid:rLI+FjXTPj8Z/0+MNAdcOhjHpMg10090	-	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
ensembl:ENSMUSG00000048756	uniprotkb:Q9WVH4	intact:EBI-11167619	intact:EBI-6127038|uniprotkb:D3Z6Y6|uniprotkb:Q05CZ4|ensembl:ENSMUSP00000050683|ensembl:ENSMUSP00000101141|ensembl:ENSMUSP00000135380	uniprotkb:Foxo3(gene name)|psi-mi:Foxo3(display_short)|uniprotkb:Fkhr2(gene name synonym)|uniprotkb:Foxo3a(gene name synonym)|ensembl:foxo3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000048756(display_long)	psi-mi:foxo3_mouse(display_long)|uniprotkb:Foxo3(gene name)|psi-mi:Foxo3(display_short)|uniprotkb:Fkhr2(gene name synonym)|uniprotkb:Foxo3a(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Zheng et al. (2010)	imex:IM-24477|pubmed:20072126	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11167611|imex:IM-24477-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	refseq:NP_062714.1|refseq:XP_006512869.1	refseq:NP_062714.1|refseq:XP_006512869.1|ensembl:ENSMUSG00000048756(gene)|ensembl:ENSMUST00000056974(transcript)|ensembl:ENSMUST00000105502(transcript)|ensembl:ENSMUST00000175881(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001544"(initiation of primordial ovarian follicle growth)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006417"(regulation of translation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990785"(response to water-immersion restraint stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032067|interpro:IPR032068|interpro:IPR036388|interpro:IPR036390|reactome:R-MMU-1181150|reactome:R-MMU-198693|reactome:R-MMU-5687128|reactome:R-MMU-9607240|reactome:R-MMU-9614399|reactome:R-MMU-9617629|reactome:R-MMU-9617828|reactome:R-MMU-9634638	-	-	-	figure legend:4E, G, I|comment:"Induced TRegs (stimulated with anti-CD3/28+TGF-beta) did not demonstrate this interaction."|causality statement:Q08024 increased the binding of Q9WVH4 to ENSMUSG00000048756|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2015/07/17	2015/08/20	-	rogid:HKBiozf3he1MKOGEW5e6aCZ4gsw10090	-	false	sufficient binding region:?-?	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
ensembl:ENSMUSG00000025997	uniprotkb:Q9WVH4	intact:EBI-11167644	intact:EBI-6127038|uniprotkb:D3Z6Y6|uniprotkb:Q05CZ4|ensembl:ENSMUSP00000050683|ensembl:ENSMUSP00000101141|ensembl:ENSMUSP00000135380	uniprotkb:Ikzf2(gene name)|psi-mi:Ikzf2(display_short)|uniprotkb:Helios(gene name synonym)|uniprotkb:Zfpn1a2(gene name synonym)|uniprotkb:Znfn1a2(gene name synonym)|ensembl:ikzf2_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000025997(display_long)	psi-mi:foxo3_mouse(display_long)|uniprotkb:Foxo3(gene name)|psi-mi:Foxo3(display_short)|uniprotkb:Fkhr2(gene name synonym)|uniprotkb:Foxo3a(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Zheng et al. (2010)	imex:IM-24477|pubmed:20072126	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11167638|imex:IM-24477-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	refseq:NP_035900.2|refseq:XP_006496029.1|refseq:XP_006496030.1	refseq:NP_062714.1|refseq:XP_006512869.1|ensembl:ENSMUSG00000048756(gene)|ensembl:ENSMUST00000056974(transcript)|ensembl:ENSMUST00000105502(transcript)|ensembl:ENSMUST00000175881(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001544"(initiation of primordial ovarian follicle growth)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006417"(regulation of translation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990785"(response to water-immersion restraint stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032067|interpro:IPR032068|interpro:IPR036388|interpro:IPR036390|reactome:R-MMU-1181150|reactome:R-MMU-198693|reactome:R-MMU-5687128|reactome:R-MMU-9607240|reactome:R-MMU-9614399|reactome:R-MMU-9617629|reactome:R-MMU-9617828|reactome:R-MMU-9634638	-	-	-	figure legend:4Ei,4I|comment:Positive control|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2015/07/17	2015/08/20	-	rogid:HKBiozf3he1MKOGEW5e6aCZ4gsw10090	-	false	-	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
ensembl:ENSMUSG00000030671	uniprotkb:Q9WVH4	intact:EBI-11167663	intact:EBI-6127038|uniprotkb:D3Z6Y6|uniprotkb:Q05CZ4|ensembl:ENSMUSP00000050683|ensembl:ENSMUSP00000101141|ensembl:ENSMUSP00000135380	uniprotkb:Pde3b(gene name)|psi-mi:Pde3b(display_short)|ensembl:pde3b_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000030671(display_long)	psi-mi:foxo3_mouse(display_long)|uniprotkb:Foxo3(gene name)|psi-mi:Foxo3(display_short)|uniprotkb:Fkhr2(gene name synonym)|uniprotkb:Foxo3a(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Zheng et al. (2010)	imex:IM-24477|pubmed:20072126	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11167658|imex:IM-24477-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	refseq:NP_035185.2	refseq:NP_062714.1|refseq:XP_006512869.1|ensembl:ENSMUSG00000048756(gene)|ensembl:ENSMUST00000056974(transcript)|ensembl:ENSMUST00000105502(transcript)|ensembl:ENSMUST00000175881(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001544"(initiation of primordial ovarian follicle growth)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006417"(regulation of translation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990785"(response to water-immersion restraint stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032067|interpro:IPR032068|interpro:IPR036388|interpro:IPR036390|reactome:R-MMU-1181150|reactome:R-MMU-198693|reactome:R-MMU-5687128|reactome:R-MMU-9607240|reactome:R-MMU-9614399|reactome:R-MMU-9617629|reactome:R-MMU-9617828|reactome:R-MMU-9634638	-	-	-	figure legend:4G|comment:"Positive control;both naturally occurring and Induced TRegs (stimulated with anti-CD3/28+TGF-beta)  demonstrated this interaction."|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2015/07/17	2015/08/20	-	rogid:HKBiozf3he1MKOGEW5e6aCZ4gsw10090	-	false	-	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
ensembl:ENSMUSG00000032420	uniprotkb:Q9WVH4	intact:EBI-11167728	intact:EBI-6127038|uniprotkb:D3Z6Y6|uniprotkb:Q05CZ4|ensembl:ENSMUSP00000050683|ensembl:ENSMUSP00000101141|ensembl:ENSMUSP00000135380	uniprotkb:Nt5e(gene name)|psi-mi:Nt5e(display_short)|uniprotkb:Nt5(gene name synonym)|uniprotkb:Nte(gene name synonym)|ensembl:5ntd_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000032420(display_long)	psi-mi:foxo3_mouse(display_long)|uniprotkb:Foxo3(gene name)|psi-mi:Foxo3(display_short)|uniprotkb:Fkhr2(gene name synonym)|uniprotkb:Foxo3a(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Zheng et al. (2010)	imex:IM-24477|pubmed:20072126	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11167723|imex:IM-24477-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	refseq:NP_035981.1	refseq:NP_062714.1|refseq:XP_006512869.1|ensembl:ENSMUSG00000048756(gene)|ensembl:ENSMUST00000056974(transcript)|ensembl:ENSMUST00000105502(transcript)|ensembl:ENSMUST00000175881(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001544"(initiation of primordial ovarian follicle growth)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0001556"(oocyte maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006417"(regulation of translation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034246"(mitochondrial transcription factor activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990785"(response to water-immersion restraint stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032067|interpro:IPR032068|interpro:IPR036388|interpro:IPR036390|reactome:R-MMU-1181150|reactome:R-MMU-198693|reactome:R-MMU-5687128|reactome:R-MMU-9607240|reactome:R-MMU-9614399|reactome:R-MMU-9617629|reactome:R-MMU-9617828|reactome:R-MMU-9634638	-	-	-	figure legend:4I|comment:Positive control|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2015/07/17	2015/08/20	-	rogid:HKBiozf3he1MKOGEW5e6aCZ4gsw10090	-	false	-	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)