#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B intact:EBI-11413660 uniprotkb:Q64287 - intact:EBI-6398485|ensembl:ENSMUSP00000021784|uniprotkb:Q60802 psi-mi:irf4_consensus_binding_site_il10_promoter(display_short)|psi-mi:EBI-11413660(display_long) psi-mi:irf4_mouse(display_long)|uniprotkb:Irf4(gene name)|psi-mi:Irf4(display_short)|uniprotkb:Spip(gene name synonym)|uniprotkb:Lymphocyte-specific interferon regulatory factor(gene name synonym)|uniprotkb:NF-EM5(gene name synonym)|uniprotkb:PU.1 interaction partner(gene name synonym)|uniprotkb:Transcriptional activator PIP(gene name synonym) psi-mi:"MI:0096"(pull down) Ahyi et al. (2009) pubmed:19592658|imex:IM-24718 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11413644|imex:IM-24718-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5BVI|ensembl:ENSMUSG00000021356(gene)|ensembl:ENSMUST00000021784(transcript)|go:"GO:0000786"(nucleosome)|refseq:NP_001334437.1|refseq:NP_038702.1|dip:DIP-59740N - - - figure legend:4B|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/10/01 2015/11/11 - rogid:SQVoOKSlOxQYpoOhHowmFvknfgU10090 - false biotin tag:1-1 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) intact:EBI-11413660 uniprotkb:Q64287 - intact:EBI-6398485|ensembl:ENSMUSP00000021784|uniprotkb:Q60802 psi-mi:irf4_consensus_binding_site_il10_promoter(display_short)|psi-mi:EBI-11413660(display_long) psi-mi:irf4_mouse(display_long)|uniprotkb:Irf4(gene name)|psi-mi:Irf4(display_short)|uniprotkb:Spip(gene name synonym)|uniprotkb:Lymphocyte-specific interferon regulatory factor(gene name synonym)|uniprotkb:NF-EM5(gene name synonym)|uniprotkb:PU.1 interaction partner(gene name synonym)|uniprotkb:Transcriptional activator PIP(gene name synonym) psi-mi:"MI:0096"(pull down) Ahyi et al. (2009) pubmed:19592658|imex:IM-24718 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11413673|imex:IM-24718-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5BVI|ensembl:ENSMUSG00000021356(gene)|ensembl:ENSMUST00000021784(transcript)|go:"GO:0000786"(nucleosome)|refseq:NP_001334437.1|refseq:NP_038702.1|dip:DIP-59740N - - - figure legend:4Bi|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/10/01 2015/12/04 - rogid:SQVoOKSlOxQYpoOhHowmFvknfgU10090 - false biotin tag:1-1 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) intact:EBI-11413660 intact:EBI-11413686 - - psi-mi:irf4_consensus_binding_site_il10_promoter(display_short)|psi-mi:EBI-11413660(display_long) psi-mi:"ig_light_chain_lambda_(iglc2)_enhancer"(display_short)|psi-mi:EBI-11413686(display_long) psi-mi:"MI:0096"(pull down) Ahyi et al. (2009) pubmed:19592658|imex:IM-24718 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11413673|imex:IM-24718-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) psi-mi:"MI:0319"(deoxyribonucleic acid) - - - - - figure legend:4Bi|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/10/01 2015/12/04 - - - false biotin tag:1-1 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) intact:EBI-11413660 uniprotkb:Q64287 - intact:EBI-6398485|ensembl:ENSMUSP00000021784|uniprotkb:Q60802 psi-mi:irf4_consensus_binding_site_il10_promoter(display_short)|psi-mi:EBI-11413660(display_long) psi-mi:irf4_mouse(display_long)|uniprotkb:Irf4(gene name)|psi-mi:Irf4(display_short)|uniprotkb:Spip(gene name synonym)|uniprotkb:Lymphocyte-specific interferon regulatory factor(gene name synonym)|uniprotkb:NF-EM5(gene name synonym)|uniprotkb:PU.1 interaction partner(gene name synonym)|uniprotkb:Transcriptional activator PIP(gene name synonym) psi-mi:"MI:0096"(pull down) Ahyi et al. (2009) pubmed:19592658|imex:IM-24718 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11413690|imex:IM-24718-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5BVI|ensembl:ENSMUSG00000021356(gene)|ensembl:ENSMUST00000021784(transcript)|go:"GO:0000786"(nucleosome)|refseq:NP_001334437.1|refseq:NP_038702.1|dip:DIP-59740N - - - figure legend:4Bii|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/10/01 2015/11/11 - rogid:SQVoOKSlOxQYpoOhHowmFvknfgU10090 - false biotin tag:1-1 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) intact:EBI-11413660 intact:EBI-11413660 - - psi-mi:irf4_consensus_binding_site_il10_promoter(display_short)|psi-mi:EBI-11413660(display_long) psi-mi:irf4_consensus_binding_site_il10_promoter(display_short)|psi-mi:EBI-11413660(display_long) psi-mi:"MI:0096"(pull down) Ahyi et al. (2009) pubmed:19592658|imex:IM-24718 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11413690|imex:IM-24718-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) psi-mi:"MI:0681"(double stranded deoxyribonucleic acid) - - - - - figure legend:4Bii|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/10/01 2015/11/11 - - - false biotin tag:1-1 mutation disrupting interaction strength:9-23 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) ensembl:ENSMUSG00000016529 uniprotkb:Q64287 intact:EBI-6398833 intact:EBI-6398485|ensembl:ENSMUSP00000021784|uniprotkb:Q60802 psi-mi:il10_mouse_gene(display_short)|psi-mi:ENSMUSG00000016529(display_long) psi-mi:irf4_mouse(display_long)|uniprotkb:Irf4(gene name)|psi-mi:Irf4(display_short)|uniprotkb:Spip(gene name synonym)|uniprotkb:Lymphocyte-specific interferon regulatory factor(gene name synonym)|uniprotkb:NF-EM5(gene name synonym)|uniprotkb:PU.1 interaction partner(gene name synonym)|uniprotkb:Transcriptional activator PIP(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Ahyi et al. (2009) pubmed:19592658|imex:IM-24718 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11419721|imex:IM-24718-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) - go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5BVI|ensembl:ENSMUSG00000021356(gene)|ensembl:ENSMUST00000021784(transcript)|go:"GO:0000786"(nucleosome)|refseq:NP_001334437.1|refseq:NP_038702.1|dip:DIP-59740N - - - figure legend:4C, 5C|causality statement:P17433 decreases the binding of Q64287 to ENSMUSG00000016529|causality statement:Q64287 increases at protein level the expression of ENSMUSG00000016529|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_th2)|taxid:10090(mouse helper T-lymphocyte Th2) - 2015/10/01 2015/11/12 - rogid:SQVoOKSlOxQYpoOhHowmFvknfgU10090 - false sufficient binding region:?-?|sufficient binding region:?-? - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) ensembl:ENSMUSG00000000869 uniprotkb:Q64287 intact:EBI-11413561 intact:EBI-6398485|ensembl:ENSMUSP00000021784|uniprotkb:Q60802 uniprotkb:Il4(gene name)|psi-mi:Il4(display_short)|uniprotkb:Il-4(gene name synonym)|ensembl:il4_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000000869(display_long) psi-mi:irf4_mouse(display_long)|uniprotkb:Irf4(gene name)|psi-mi:Irf4(display_short)|uniprotkb:Spip(gene name synonym)|uniprotkb:Lymphocyte-specific interferon regulatory factor(gene name synonym)|uniprotkb:NF-EM5(gene name synonym)|uniprotkb:PU.1 interaction partner(gene name synonym)|uniprotkb:Transcriptional activator PIP(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Ahyi et al. (2009) pubmed:19592658|imex:IM-24718 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11419729|imex:IM-24718-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) refseq:NP_067258.1 go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5BVI|ensembl:ENSMUSG00000021356(gene)|ensembl:ENSMUST00000021784(transcript)|go:"GO:0000786"(nucleosome)|refseq:NP_001334437.1|refseq:NP_038702.1|dip:DIP-59740N - - - figure legend:4C, 5C|causality statement:P17433 decreases the binding of Q64287 to ENSMUSG00000000869|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_th2)|taxid:10090(mouse helper T-lymphocyte Th2) - 2015/10/01 2015/11/12 - rogid:SQVoOKSlOxQYpoOhHowmFvknfgU10090 - false sufficient binding region:?-?|sufficient binding region:?-? - - - psi-mi:"MI:1195"(quantitative pcr) psi-mi:"MI:1195"(quantitative pcr) uniprotkb:P17433 uniprotkb:P23772 intact:EBI-607588|ensembl:ENSMUSP00000002180|uniprotkb:Q99L57 intact:EBI-6664905|ensembl:ENSMUSP00000100041 psi-mi:spi1_mouse(display_long)|uniprotkb:Spi1(gene name)|psi-mi:Spi1(display_short)|uniprotkb:Sfpi1(gene name synonym)|uniprotkb:Sfpi-1(gene name synonym)|uniprotkb:31 kDa-transforming protein(gene name synonym)|uniprotkb:SFFV proviral integration 1 protein(gene name synonym) psi-mi:gata3_mouse(display_long)|uniprotkb:Gata3(gene name)|psi-mi:Gata3(display_short)|uniprotkb:Gata-3(gene name synonym)|uniprotkb:GATA-binding factor 3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ahyi et al. (2009) pubmed:19592658|imex:IM-24718 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11419745|imex:IM-24718-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002111(gene)|ensembl:ENSMUST00000002180(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001944"(vasculature development)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response)|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|rcsb pdb:1PUE|rcsb pdb:5W3G|interpro:IPR036390|refseq:NP_035485.1 go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060065"(uterus development)|go:"GO:0060231"(mesenchymal to epithelial transition)|go:"GO:0060374"(mast cell differentiation)|go:"GO:0060676"(ureteric bud formation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0061085"(regulation of histone H3-K27 methylation)|go:"GO:0061290"(canonical Wnt signaling pathway involved in metanephric kidney development)|go:"GO:0070888"(E-box binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071442"(positive regulation of histone H3-K14 acetylation)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0072107"(positive regulation of ureteric bud formation)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072179"(nephric duct formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0072676"(lymphocyte migration)|go:"GO:0090102"(cochlea development)|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000607"(negative regulation of cell proliferation involved in mesonephros development)|go:"GO:2000611"(positive regulation of thyroid hormone generation)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000683"(regulation of cellular response to X-ray)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:2000703"(negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation)|go:"GO:2000734"(negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR016374(Transcription factor, GATA-1/2/3)|interpro:IPR029521|go:"GO:0048469"(cell maturation)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050728"(negative regulation of inflammatory response)|rcsb pdb:3DFV|rcsb pdb:3DFX|reactome:R-MMU-5689880|reactome:R-MMU-8939236|reactome:R-MMU-9018519|reactome:R-MMU-983231|interpro:IPR039355|ensembl:ENSMUSG00000015619(gene)|ensembl:ENSMUST00000102976(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001764"(neuron migration)|go:"GO:0001775"(cell activation)|go:"GO:0001806"(type IV hypersensitivity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001822"(kidney development)|go:"GO:0001823"(mesonephros development)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002520"(immune system development)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005134"(interleukin-2 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0031929"(TOR signaling)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0035799"(ureter maturation)|go:"GO:0035898"(parathyroid hormone secretion)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043583"(ear development)|go:"GO:0043627"(response to estrogen)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045471"(response to ethanol)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0003281"(ventricular septum development)|refseq:XP_006497417.1|refseq:NP_032117.1|dip:DIP-29712N - - - figure legend:5A|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_th2)|taxid:10090(mouse helper T-lymphocyte Th2) - 2015/10/01 2015/11/12 rogid:oX+T3U9B+gJ3Aao0rDVm4CHqSR410090 rogid:DW2mskj2jgiJdOYO6yJxNbBd0Ng10090 rigid:XJxLq39TDJw2duHmL5+Z79I362Y false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P17433 uniprotkb:Q64287 intact:EBI-607588|ensembl:ENSMUSP00000002180|uniprotkb:Q99L57 intact:EBI-6398485|ensembl:ENSMUSP00000021784|uniprotkb:Q60802 psi-mi:spi1_mouse(display_long)|uniprotkb:Spi1(gene name)|psi-mi:Spi1(display_short)|uniprotkb:Sfpi1(gene name synonym)|uniprotkb:Sfpi-1(gene name synonym)|uniprotkb:31 kDa-transforming protein(gene name synonym)|uniprotkb:SFFV proviral integration 1 protein(gene name synonym) psi-mi:irf4_mouse(display_long)|uniprotkb:Irf4(gene name)|psi-mi:Irf4(display_short)|uniprotkb:Spip(gene name synonym)|uniprotkb:Lymphocyte-specific interferon regulatory factor(gene name synonym)|uniprotkb:NF-EM5(gene name synonym)|uniprotkb:PU.1 interaction partner(gene name synonym)|uniprotkb:Transcriptional activator PIP(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ahyi et al. (2009) pubmed:19592658|imex:IM-24718 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11419745|imex:IM-24718-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000002111(gene)|ensembl:ENSMUST00000002180(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001944"(vasculature development)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response)|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|rcsb pdb:1PUE|rcsb pdb:5W3G|interpro:IPR036390|refseq:NP_035485.1 go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5BVI|ensembl:ENSMUSG00000021356(gene)|ensembl:ENSMUST00000021784(transcript)|go:"GO:0000786"(nucleosome)|refseq:NP_001334437.1|refseq:NP_038702.1|dip:DIP-59740N - - - figure legend:5A|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_th2)|taxid:10090(mouse helper T-lymphocyte Th2) - 2015/10/01 2015/11/12 rogid:oX+T3U9B+gJ3Aao0rDVm4CHqSR410090 rogid:SQVoOKSlOxQYpoOhHowmFvknfgU10090 rigid:XJxLq39TDJw2duHmL5+Z79I362Y false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P23772 uniprotkb:P17433 intact:EBI-6664905|ensembl:ENSMUSP00000100041 intact:EBI-607588|ensembl:ENSMUSP00000002180|uniprotkb:Q99L57 psi-mi:gata3_mouse(display_long)|uniprotkb:Gata3(gene name)|psi-mi:Gata3(display_short)|uniprotkb:Gata-3(gene name synonym)|uniprotkb:GATA-binding factor 3(gene name synonym) psi-mi:spi1_mouse(display_long)|uniprotkb:Spi1(gene name)|psi-mi:Spi1(display_short)|uniprotkb:Sfpi1(gene name synonym)|uniprotkb:Sfpi-1(gene name synonym)|uniprotkb:31 kDa-transforming protein(gene name synonym)|uniprotkb:SFFV proviral integration 1 protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ahyi et al. (2009) pubmed:19592658|imex:IM-24718 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11419750|imex:IM-24718-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060065"(uterus development)|go:"GO:0060231"(mesenchymal to epithelial transition)|go:"GO:0060374"(mast cell differentiation)|go:"GO:0060676"(ureteric bud formation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0061085"(regulation of histone H3-K27 methylation)|go:"GO:0061290"(canonical Wnt signaling pathway involved in metanephric kidney development)|go:"GO:0070888"(E-box binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071442"(positive regulation of histone H3-K14 acetylation)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0072107"(positive regulation of ureteric bud formation)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072179"(nephric duct formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0072676"(lymphocyte migration)|go:"GO:0090102"(cochlea development)|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000607"(negative regulation of cell proliferation involved in mesonephros development)|go:"GO:2000611"(positive regulation of thyroid hormone generation)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000683"(regulation of cellular response to X-ray)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:2000703"(negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation)|go:"GO:2000734"(negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR016374(Transcription factor, GATA-1/2/3)|interpro:IPR029521|go:"GO:0048469"(cell maturation)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050728"(negative regulation of inflammatory response)|rcsb pdb:3DFV|rcsb pdb:3DFX|reactome:R-MMU-5689880|reactome:R-MMU-8939236|reactome:R-MMU-9018519|reactome:R-MMU-983231|interpro:IPR039355|ensembl:ENSMUSG00000015619(gene)|ensembl:ENSMUST00000102976(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001764"(neuron migration)|go:"GO:0001775"(cell activation)|go:"GO:0001806"(type IV hypersensitivity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001822"(kidney development)|go:"GO:0001823"(mesonephros development)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002520"(immune system development)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005134"(interleukin-2 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0031929"(TOR signaling)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0035799"(ureter maturation)|go:"GO:0035898"(parathyroid hormone secretion)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043583"(ear development)|go:"GO:0043627"(response to estrogen)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045471"(response to ethanol)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0003281"(ventricular septum development)|refseq:XP_006497417.1|refseq:NP_032117.1|dip:DIP-29712N ensembl:ENSMUSG00000002111(gene)|ensembl:ENSMUST00000002180(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001944"(vasculature development)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response)|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|rcsb pdb:1PUE|rcsb pdb:5W3G|interpro:IPR036390|refseq:NP_035485.1 - - - figure legend:5Ai|comment:Not much IRF4 was precipitated with this complex.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_th2)|taxid:10090(mouse helper T-lymphocyte Th2) - 2015/10/01 2015/11/12 rogid:DW2mskj2jgiJdOYO6yJxNbBd0Ng10090 rogid:oX+T3U9B+gJ3Aao0rDVm4CHqSR410090 rigid:XJxLq39TDJw2duHmL5+Z79I362Y false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P23772 uniprotkb:Q64287 intact:EBI-6664905|ensembl:ENSMUSP00000100041 intact:EBI-6398485|ensembl:ENSMUSP00000021784|uniprotkb:Q60802 psi-mi:gata3_mouse(display_long)|uniprotkb:Gata3(gene name)|psi-mi:Gata3(display_short)|uniprotkb:Gata-3(gene name synonym)|uniprotkb:GATA-binding factor 3(gene name synonym) psi-mi:irf4_mouse(display_long)|uniprotkb:Irf4(gene name)|psi-mi:Irf4(display_short)|uniprotkb:Spip(gene name synonym)|uniprotkb:Lymphocyte-specific interferon regulatory factor(gene name synonym)|uniprotkb:NF-EM5(gene name synonym)|uniprotkb:PU.1 interaction partner(gene name synonym)|uniprotkb:Transcriptional activator PIP(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ahyi et al. (2009) pubmed:19592658|imex:IM-24718 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11419750|imex:IM-24718-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060065"(uterus development)|go:"GO:0060231"(mesenchymal to epithelial transition)|go:"GO:0060374"(mast cell differentiation)|go:"GO:0060676"(ureteric bud formation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0061085"(regulation of histone H3-K27 methylation)|go:"GO:0061290"(canonical Wnt signaling pathway involved in metanephric kidney development)|go:"GO:0070888"(E-box binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071442"(positive regulation of histone H3-K14 acetylation)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0072107"(positive regulation of ureteric bud formation)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072179"(nephric duct formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0072676"(lymphocyte migration)|go:"GO:0090102"(cochlea development)|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000607"(negative regulation of cell proliferation involved in mesonephros development)|go:"GO:2000611"(positive regulation of thyroid hormone generation)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000683"(regulation of cellular response to X-ray)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:2000703"(negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation)|go:"GO:2000734"(negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR016374(Transcription factor, GATA-1/2/3)|interpro:IPR029521|go:"GO:0048469"(cell maturation)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050728"(negative regulation of inflammatory response)|rcsb pdb:3DFV|rcsb pdb:3DFX|reactome:R-MMU-5689880|reactome:R-MMU-8939236|reactome:R-MMU-9018519|reactome:R-MMU-983231|interpro:IPR039355|ensembl:ENSMUSG00000015619(gene)|ensembl:ENSMUST00000102976(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001764"(neuron migration)|go:"GO:0001775"(cell activation)|go:"GO:0001806"(type IV hypersensitivity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001822"(kidney development)|go:"GO:0001823"(mesonephros development)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002520"(immune system development)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005134"(interleukin-2 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0031929"(TOR signaling)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0035799"(ureter maturation)|go:"GO:0035898"(parathyroid hormone secretion)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043583"(ear development)|go:"GO:0043627"(response to estrogen)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045471"(response to ethanol)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0003281"(ventricular septum development)|refseq:XP_006497417.1|refseq:NP_032117.1|dip:DIP-29712N go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5BVI|ensembl:ENSMUSG00000021356(gene)|ensembl:ENSMUST00000021784(transcript)|go:"GO:0000786"(nucleosome)|refseq:NP_001334437.1|refseq:NP_038702.1|dip:DIP-59740N - - - figure legend:5Ai|comment:Not much IRF4 was precipitated with this complex.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_th2)|taxid:10090(mouse helper T-lymphocyte Th2) - 2015/10/01 2015/11/12 rogid:DW2mskj2jgiJdOYO6yJxNbBd0Ng10090 rogid:SQVoOKSlOxQYpoOhHowmFvknfgU10090 rigid:XJxLq39TDJw2duHmL5+Z79I362Y false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q64287 uniprotkb:P17433 intact:EBI-6398485|ensembl:ENSMUSP00000021784|uniprotkb:Q60802 intact:EBI-607588|ensembl:ENSMUSP00000002180|uniprotkb:Q99L57 psi-mi:irf4_mouse(display_long)|uniprotkb:Irf4(gene name)|psi-mi:Irf4(display_short)|uniprotkb:Spip(gene name synonym)|uniprotkb:Lymphocyte-specific interferon regulatory factor(gene name synonym)|uniprotkb:NF-EM5(gene name synonym)|uniprotkb:PU.1 interaction partner(gene name synonym)|uniprotkb:Transcriptional activator PIP(gene name synonym) psi-mi:spi1_mouse(display_long)|uniprotkb:Spi1(gene name)|psi-mi:Spi1(display_short)|uniprotkb:Sfpi1(gene name synonym)|uniprotkb:Sfpi-1(gene name synonym)|uniprotkb:31 kDa-transforming protein(gene name synonym)|uniprotkb:SFFV proviral integration 1 protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ahyi et al. (2009) pubmed:19592658|imex:IM-24718 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11419755|imex:IM-24718-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5BVI|ensembl:ENSMUSG00000021356(gene)|ensembl:ENSMUST00000021784(transcript)|go:"GO:0000786"(nucleosome)|refseq:NP_001334437.1|refseq:NP_038702.1|dip:DIP-59740N ensembl:ENSMUSG00000002111(gene)|ensembl:ENSMUST00000002180(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001944"(vasculature development)|go:"GO:0002314"(germinal center B cell differentiation)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002357"(defense response to tumor cell)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034401"(obsolete chromatin organization involved in regulation of transcription)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043314"(negative regulation of neutrophil degranulation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060033"(anatomical structure regression)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0090402"(oncogene-induced cell senescence)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098508"(endothelial to hematopoietic transition)|go:"GO:0120186"(negative regulation of protein localization to chromatin)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901674"(regulation of histone H3-K27 acetylation)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1904238"(pericyte cell differentiation)|go:"GO:1905036"(positive regulation of antifungal innate immune response)|go:"GO:1905453"(regulation of myeloid progenitor cell differentiation)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|interpro:IPR000418(Ets)|interpro:IPR036388|rcsb pdb:1PUE|rcsb pdb:5W3G|interpro:IPR036390|refseq:NP_035485.1 - - - figure legend:5Aii|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_th2)|taxid:10090(mouse helper T-lymphocyte Th2) - 2015/10/01 2015/11/12 rogid:SQVoOKSlOxQYpoOhHowmFvknfgU10090 rogid:oX+T3U9B+gJ3Aao0rDVm4CHqSR410090 rigid:XJxLq39TDJw2duHmL5+Z79I362Y false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q64287 uniprotkb:P23772 intact:EBI-6398485|ensembl:ENSMUSP00000021784|uniprotkb:Q60802 intact:EBI-6664905|ensembl:ENSMUSP00000100041 psi-mi:irf4_mouse(display_long)|uniprotkb:Irf4(gene name)|psi-mi:Irf4(display_short)|uniprotkb:Spip(gene name synonym)|uniprotkb:Lymphocyte-specific interferon regulatory factor(gene name synonym)|uniprotkb:NF-EM5(gene name synonym)|uniprotkb:PU.1 interaction partner(gene name synonym)|uniprotkb:Transcriptional activator PIP(gene name synonym) psi-mi:gata3_mouse(display_long)|uniprotkb:Gata3(gene name)|psi-mi:Gata3(display_short)|uniprotkb:Gata-3(gene name synonym)|uniprotkb:GATA-binding factor 3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ahyi et al. (2009) pubmed:19592658|imex:IM-24718 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-11419755|imex:IM-24718-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5BVI|ensembl:ENSMUSG00000021356(gene)|ensembl:ENSMUST00000021784(transcript)|go:"GO:0000786"(nucleosome)|refseq:NP_001334437.1|refseq:NP_038702.1|dip:DIP-59740N go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060065"(uterus development)|go:"GO:0060231"(mesenchymal to epithelial transition)|go:"GO:0060374"(mast cell differentiation)|go:"GO:0060676"(ureteric bud formation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0061085"(regulation of histone H3-K27 methylation)|go:"GO:0061290"(canonical Wnt signaling pathway involved in metanephric kidney development)|go:"GO:0070888"(E-box binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071442"(positive regulation of histone H3-K14 acetylation)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0072107"(positive regulation of ureteric bud formation)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072179"(nephric duct formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0072676"(lymphocyte migration)|go:"GO:0090102"(cochlea development)|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000607"(negative regulation of cell proliferation involved in mesonephros development)|go:"GO:2000611"(positive regulation of thyroid hormone generation)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000683"(regulation of cellular response to X-ray)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:2000703"(negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation)|go:"GO:2000734"(negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR016374(Transcription factor, GATA-1/2/3)|interpro:IPR029521|go:"GO:0048469"(cell maturation)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050728"(negative regulation of inflammatory response)|rcsb pdb:3DFV|rcsb pdb:3DFX|reactome:R-MMU-5689880|reactome:R-MMU-8939236|reactome:R-MMU-9018519|reactome:R-MMU-983231|interpro:IPR039355|ensembl:ENSMUSG00000015619(gene)|ensembl:ENSMUST00000102976(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001764"(neuron migration)|go:"GO:0001775"(cell activation)|go:"GO:0001806"(type IV hypersensitivity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001822"(kidney development)|go:"GO:0001823"(mesonephros development)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002520"(immune system development)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005134"(interleukin-2 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0031929"(TOR signaling)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0035799"(ureter maturation)|go:"GO:0035898"(parathyroid hormone secretion)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043583"(ear development)|go:"GO:0043627"(response to estrogen)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045471"(response to ethanol)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0003281"(ventricular septum development)|refseq:XP_006497417.1|refseq:NP_032117.1|dip:DIP-29712N - - - figure legend:5Aii|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_th2)|taxid:10090(mouse helper T-lymphocyte Th2) - 2015/10/01 2015/11/12 rogid:SQVoOKSlOxQYpoOhHowmFvknfgU10090 rogid:DW2mskj2jgiJdOYO6yJxNbBd0Ng10090 rigid:XJxLq39TDJw2duHmL5+Z79I362Y false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)