#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O00167	uniprotkb:Q15475	intact:EBI-750211|uniprotkb:Q86U84|uniprotkb:Q5JSW8|uniprotkb:Q96CV6|uniprotkb:Q96H97|uniprotkb:Q99503|uniprotkb:Q99812|uniprotkb:Q9BWF6|uniprotkb:Q9H4S3|uniprotkb:Q9H4S9|uniprotkb:Q9NPZ4|uniprotkb:Q9UIX7|intact:EBI-28973816|ensembl:ENSP00000333640	intact:EBI-743675|uniprotkb:Q96H64|uniprotkb:Q53Y16|ensembl:ENSP00000494686	psi-mi:eya2_human(display_long)|uniprotkb:EYA2(gene name)|psi-mi:EYA2(display_short)|uniprotkb:EAB1(gene name synonym)	psi-mi:six1_human(display_long)|uniprotkb:Sine oculis homeobox homolog 1(gene name synonym)|uniprotkb:SIX1(gene name)|psi-mi:SIX1(display_short)	psi-mi:"MI:0071"(molecular sieving)	Patrick et al. (2009)	imex:IM-24853|pubmed:19497856	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11421200|imex:IM-24853-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000333640|ensembl:ENST00000357410|ensembl:ENSP00000349986|ensembl:ENST00000497062|ensembl:ENSP00000417105|refseq:NP_005235.3|refseq:NP_742108.2|dip:DIP-40707N|ensembl:ENSG00000064655(gene)|ensembl:ENST00000327619(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0048856"(anatomical structure development)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR006545(EYA)|interpro:IPR028472|interpro:IPR028473|interpro:IPR036412|interpro:IPR038102|interpro:IPR042577|mint:O00167|rcsb pdb:3GEB|rcsb pdb:3HB0|rcsb pdb:3HB1|rcsb pdb:4EGC|rcsb pdb:5ZMA|reactome:R-HSA-5693565	refseq:NP_005973.1|ensembl:ENSG00000126778(gene)|ensembl:ENST00000645694(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001822"(kidney development)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007389"(pattern specification process)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0014857"(regulation of skeletal muscle cell proliferation)|go:"GO:0021610"(facial nerve morphogenesis)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048538"(thymus development)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048699"(generation of neurons)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048839"(inner ear development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0051451"(myoblast migration)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0061055"(myotome development)|go:"GO:0061197"(fungiform papilla morphogenesis)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0071599"(otic vesicle development)|go:"GO:0072075"(metanephric mesenchyme development)|interpro:IPR031278|interpro:IPR031701|go:"GO:0072095"(regulation of branch elongation involved in ureteric bud branching)|mint:Q15475|rcsb pdb:4EGC|go:"GO:0072107"(positive regulation of ureteric bud formation)|go:"GO:0072172"(mesonephric tubule formation)|go:"GO:0072193"(ureter smooth muscle cell differentiation)|go:"GO:0072513"(positive regulation of secondary heart field cardioblast proliferation)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:1905243"(cellular response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|dip:DIP-34448N	omim:608389(see-also)	-	comment:"Following SIX1 variants linked to BOS3 shown to interact: val106gly, arg112cys, tyr129cys. Further del133 linked to DFNA23 and arg110trp"	figure legend:4A and C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/11/19	2015/11/19	rogid:GzEF57gMLHQVYIXIpdcf3XffCS49606	rogid:CDsvqBP4KDSbYoxt3Qi/sdP9ivo9606	rigid:Lf5CTq5OtZmBoIhmmfzcmNXbpLw	false	sufficient binding region:267..267-538(IPR006545)	mutation decreasing interaction strength:17-17	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)