#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q92985	uniprotkb:P29128	intact:EBI-968267|intact:EBI-28973647|ensembl:ENSP00000434009|ensembl:ENSP00000480358|uniprotkb:O00331|uniprotkb:O00332|uniprotkb:O00333|uniprotkb:O75924|uniprotkb:Q9UE79|intact:EBI-2339383|uniprotkb:B9EGL3	intact:EBI-11292028	psi-mi:irf7_human(display_long)|uniprotkb:IRF7(gene name)|psi-mi:IRF7(display_short)	psi-mi:icp0_bhv1j(display_long)|uniprotkb:BICP0(gene name)|psi-mi:BICP0(display_short)|uniprotkb:IER 2.9/ER2.6(gene name synonym)|uniprotkb:P135 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ICP0(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Saira et al. (2009)	pubmed:19176627|imex:IM-25915	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:31518(BoHV-1)|taxid:31518("Bovine herpesvirus 1.1 (strain Jura)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11296042|imex:IM-25915-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000185507(gene)|ensembl:ENSG00000276561(gene)|ensembl:ENST00000525445(transcript)|ensembl:ENST00000621391(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|reactome:R-HSA-3134963|go:"GO:0006974"(cellular response to DNA damage stimulus)|reactome:R-HSA-877300|reactome:R-HSA-9013973|go:"GO:0009615"(response to virus)|go:"GO:0010008"(endosome membrane)|reactome:R-HSA-909733|go:"GO:0016064"(immunoglobulin mediated immune response)|reactome:R-HSA-918233|reactome:R-HSA-933541|go:"GO:0019043"(establishment of viral latency)|reactome:R-HSA-936964|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|reactome:R-HSA-975110|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0034124"(regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0034127"(regulation of MyD88-independent toll-like receptor signaling pathway)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045655"(regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050776"(regulation of immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000110"(negative regulation of macrophage apoptotic process)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|mint:Q92985|rcsb pdb:2O61|ensembl:ENST00000330243|ensembl:ENSP00000329411|ensembl:ENSP00000331803|ensembl:ENST00000397566|ensembl:ENSP00000380697|ensembl:ENST00000469048|ensembl:ENSP00000434607|ensembl:ENSP00000434009|ensembl:ENST00000533182|ensembl:ENSP00000433903|ensembl:ENST00000612534|ensembl:ENSP00000479615|ensembl:ENSP00000480358|ensembl:ENST00000632827|ensembl:ENSP00000488039|ensembl:ENST00000633274|ensembl:ENSP00000488591|ensembl:ENST00000633943|ensembl:ENSP00000488666|ensembl:ENST00000634105|ensembl:ENSP00000488581|ensembl:ENST00000348655|refseq:NP_001563.2|refseq:NP_004020.1|refseq:NP_004022.2|refseq:XP_005252963.1|refseq:XP_016873163.1|dip:DIP-34895N	refseq:NP_045363.1|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|go:"GO:0003677"(DNA binding)|go:"GO:0016740"(transferase activity)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046774"(suppression by virus of host intracellular interferon activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0075341"(host cell PML body)|go:"GO:0075342"(disruption by symbiont of host cell PML body)	go:"GO:0005634"(nucleus)	-	-	figure legend:2A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-p19)|taxid:10090(Mus musculus embryonic teratocarcinoma cell line,  epithelial-like, induced by retinoic acid)	-	2015/10/02	2015/10/02	rogid:Wjak+z4pcHAXB3W9k+eqP4V8SuI9606	rogid:jEYz5rQfiT7aZtZlL0ks9XzRMRo31518	rigid:u9ueYGzP5TyvoGtHqKuhx/Sxm/k	false	-	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92985	uniprotkb:P29128	intact:EBI-968267|intact:EBI-28973647|ensembl:ENSP00000434009|ensembl:ENSP00000480358|uniprotkb:O00331|uniprotkb:O00332|uniprotkb:O00333|uniprotkb:O75924|uniprotkb:Q9UE79|intact:EBI-2339383|uniprotkb:B9EGL3	intact:EBI-11292028	psi-mi:irf7_human(display_long)|uniprotkb:IRF7(gene name)|psi-mi:IRF7(display_short)	psi-mi:icp0_bhv1j(display_long)|uniprotkb:BICP0(gene name)|psi-mi:BICP0(display_short)|uniprotkb:IER 2.9/ER2.6(gene name synonym)|uniprotkb:P135 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ICP0(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Saira et al. (2009)	pubmed:19176627|imex:IM-25915	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:31518(BoHV-1)|taxid:31518("Bovine herpesvirus 1.1 (strain Jura)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11296064|imex:IM-25915-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000185507(gene)|ensembl:ENSG00000276561(gene)|ensembl:ENST00000525445(transcript)|ensembl:ENST00000621391(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|reactome:R-HSA-3134963|go:"GO:0006974"(cellular response to DNA damage stimulus)|reactome:R-HSA-877300|reactome:R-HSA-9013973|go:"GO:0009615"(response to virus)|go:"GO:0010008"(endosome membrane)|reactome:R-HSA-909733|go:"GO:0016064"(immunoglobulin mediated immune response)|reactome:R-HSA-918233|reactome:R-HSA-933541|go:"GO:0019043"(establishment of viral latency)|reactome:R-HSA-936964|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|reactome:R-HSA-975110|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0034124"(regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0034127"(regulation of MyD88-independent toll-like receptor signaling pathway)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045655"(regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050776"(regulation of immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000110"(negative regulation of macrophage apoptotic process)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|mint:Q92985|rcsb pdb:2O61|ensembl:ENST00000330243|ensembl:ENSP00000329411|ensembl:ENSP00000331803|ensembl:ENST00000397566|ensembl:ENSP00000380697|ensembl:ENST00000469048|ensembl:ENSP00000434607|ensembl:ENSP00000434009|ensembl:ENST00000533182|ensembl:ENSP00000433903|ensembl:ENST00000612534|ensembl:ENSP00000479615|ensembl:ENSP00000480358|ensembl:ENST00000632827|ensembl:ENSP00000488039|ensembl:ENST00000633274|ensembl:ENSP00000488591|ensembl:ENST00000633943|ensembl:ENSP00000488666|ensembl:ENST00000634105|ensembl:ENSP00000488581|ensembl:ENST00000348655|refseq:NP_001563.2|refseq:NP_004020.1|refseq:NP_004022.2|refseq:XP_005252963.1|refseq:XP_016873163.1|dip:DIP-34895N	refseq:NP_045363.1|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|go:"GO:0003677"(DNA binding)|go:"GO:0016740"(transferase activity)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046774"(suppression by virus of host intracellular interferon activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0075341"(host cell PML body)|go:"GO:0075342"(disruption by symbiont of host cell PML body)	go:"GO:0005634"(nucleus)	-	-	figure legend:2B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-p19)|taxid:10090(Mus musculus embryonic teratocarcinoma cell line,  epithelial-like, induced by retinoic acid)	-	2015/10/02	2015/10/02	rogid:Wjak+z4pcHAXB3W9k+eqP4V8SuI9606	rogid:jEYz5rQfiT7aZtZlL0ks9XzRMRo31518	rigid:u9ueYGzP5TyvoGtHqKuhx/Sxm/k	false	-	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92985	uniprotkb:P29128	intact:EBI-968267|intact:EBI-28973647|ensembl:ENSP00000434009|ensembl:ENSP00000480358|uniprotkb:O00331|uniprotkb:O00332|uniprotkb:O00333|uniprotkb:O75924|uniprotkb:Q9UE79|intact:EBI-2339383|uniprotkb:B9EGL3	intact:EBI-11292028	psi-mi:irf7_human(display_long)|uniprotkb:IRF7(gene name)|psi-mi:IRF7(display_short)	psi-mi:icp0_bhv1j(display_long)|uniprotkb:BICP0(gene name)|psi-mi:BICP0(display_short)|uniprotkb:IER 2.9/ER2.6(gene name synonym)|uniprotkb:P135 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ICP0(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Saira et al. (2009)	pubmed:19176627|imex:IM-25915	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:31518(BoHV-1)|taxid:31518("Bovine herpesvirus 1.1 (strain Jura)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11296079|imex:IM-25915-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000185507(gene)|ensembl:ENSG00000276561(gene)|ensembl:ENST00000525445(transcript)|ensembl:ENST00000621391(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|reactome:R-HSA-3134963|go:"GO:0006974"(cellular response to DNA damage stimulus)|reactome:R-HSA-877300|reactome:R-HSA-9013973|go:"GO:0009615"(response to virus)|go:"GO:0010008"(endosome membrane)|reactome:R-HSA-909733|go:"GO:0016064"(immunoglobulin mediated immune response)|reactome:R-HSA-918233|reactome:R-HSA-933541|go:"GO:0019043"(establishment of viral latency)|reactome:R-HSA-936964|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|reactome:R-HSA-975110|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0034124"(regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0034127"(regulation of MyD88-independent toll-like receptor signaling pathway)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045655"(regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050776"(regulation of immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000110"(negative regulation of macrophage apoptotic process)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|mint:Q92985|rcsb pdb:2O61|ensembl:ENST00000330243|ensembl:ENSP00000329411|ensembl:ENSP00000331803|ensembl:ENST00000397566|ensembl:ENSP00000380697|ensembl:ENST00000469048|ensembl:ENSP00000434607|ensembl:ENSP00000434009|ensembl:ENST00000533182|ensembl:ENSP00000433903|ensembl:ENST00000612534|ensembl:ENSP00000479615|ensembl:ENSP00000480358|ensembl:ENST00000632827|ensembl:ENSP00000488039|ensembl:ENST00000633274|ensembl:ENSP00000488591|ensembl:ENST00000633943|ensembl:ENSP00000488666|ensembl:ENST00000634105|ensembl:ENSP00000488581|ensembl:ENST00000348655|refseq:NP_001563.2|refseq:NP_004020.1|refseq:NP_004022.2|refseq:XP_005252963.1|refseq:XP_016873163.1|dip:DIP-34895N|go:"GO:0005737"(cytoplasm)	refseq:NP_045363.1|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|go:"GO:0003677"(DNA binding)|go:"GO:0016740"(transferase activity)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046774"(suppression by virus of host intracellular interferon activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0075341"(host cell PML body)|go:"GO:0075342"(disruption by symbiont of host cell PML body)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075341"(host cell PML body)	go:"GO:0005634"(nucleus)|go:"GO:0016605"(PML body)	-	-	figure legend:3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-p19)|taxid:10090(Mus musculus embryonic teratocarcinoma cell line,  epithelial-like, induced by retinoic acid)	-	2015/10/02	2015/10/02	rogid:Wjak+z4pcHAXB3W9k+eqP4V8SuI9606	rogid:jEYz5rQfiT7aZtZlL0ks9XzRMRo31518	rigid:u9ueYGzP5TyvoGtHqKuhx/Sxm/k	false	-	flag tag:n-n	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q92985	uniprotkb:P29128	intact:EBI-968267|intact:EBI-28973647|ensembl:ENSP00000434009|ensembl:ENSP00000480358|uniprotkb:O00331|uniprotkb:O00332|uniprotkb:O00333|uniprotkb:O75924|uniprotkb:Q9UE79|intact:EBI-2339383|uniprotkb:B9EGL3	intact:EBI-11292028	psi-mi:irf7_human(display_long)|uniprotkb:IRF7(gene name)|psi-mi:IRF7(display_short)	psi-mi:icp0_bhv1j(display_long)|uniprotkb:BICP0(gene name)|psi-mi:BICP0(display_short)|uniprotkb:IER 2.9/ER2.6(gene name synonym)|uniprotkb:P135 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ICP0(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Saira et al. (2009)	pubmed:19176627|imex:IM-25915	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:31518(BoHV-1)|taxid:31518("Bovine herpesvirus 1.1 (strain Jura)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11296108|imex:IM-25915-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000185507(gene)|ensembl:ENSG00000276561(gene)|ensembl:ENST00000525445(transcript)|ensembl:ENST00000621391(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|reactome:R-HSA-3134963|go:"GO:0006974"(cellular response to DNA damage stimulus)|reactome:R-HSA-877300|reactome:R-HSA-9013973|go:"GO:0009615"(response to virus)|go:"GO:0010008"(endosome membrane)|reactome:R-HSA-909733|go:"GO:0016064"(immunoglobulin mediated immune response)|reactome:R-HSA-918233|reactome:R-HSA-933541|go:"GO:0019043"(establishment of viral latency)|reactome:R-HSA-936964|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|reactome:R-HSA-975110|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0034124"(regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0034127"(regulation of MyD88-independent toll-like receptor signaling pathway)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045655"(regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050776"(regulation of immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000110"(negative regulation of macrophage apoptotic process)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|mint:Q92985|rcsb pdb:2O61|ensembl:ENST00000330243|ensembl:ENSP00000329411|ensembl:ENSP00000331803|ensembl:ENST00000397566|ensembl:ENSP00000380697|ensembl:ENST00000469048|ensembl:ENSP00000434607|ensembl:ENSP00000434009|ensembl:ENST00000533182|ensembl:ENSP00000433903|ensembl:ENST00000612534|ensembl:ENSP00000479615|ensembl:ENSP00000480358|ensembl:ENST00000632827|ensembl:ENSP00000488039|ensembl:ENST00000633274|ensembl:ENSP00000488591|ensembl:ENST00000633943|ensembl:ENSP00000488666|ensembl:ENST00000634105|ensembl:ENSP00000488581|ensembl:ENST00000348655|refseq:NP_001563.2|refseq:NP_004020.1|refseq:NP_004022.2|refseq:XP_005252963.1|refseq:XP_016873163.1|dip:DIP-34895N|go:"GO:0005737"(cytoplasm)	refseq:NP_045363.1|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|go:"GO:0003677"(DNA binding)|go:"GO:0016740"(transferase activity)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046774"(suppression by virus of host intracellular interferon activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0075341"(host cell PML body)|go:"GO:0075342"(disruption by symbiont of host cell PML body)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075341"(host cell PML body)	go:"GO:0005634"(nucleus)|go:"GO:0016605"(PML body)	-	-	figure legend:3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9913(bovin-testis)|taxid:9913(Bos taurus)	-	2015/10/02	2015/10/02	rogid:Wjak+z4pcHAXB3W9k+eqP4V8SuI9606	rogid:jEYz5rQfiT7aZtZlL0ks9XzRMRo31518	rigid:u9ueYGzP5TyvoGtHqKuhx/Sxm/k	false	-	flag tag:n-n	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q92985	uniprotkb:P29128	intact:EBI-968267|intact:EBI-28973647|ensembl:ENSP00000434009|ensembl:ENSP00000480358|uniprotkb:O00331|uniprotkb:O00332|uniprotkb:O00333|uniprotkb:O75924|uniprotkb:Q9UE79|intact:EBI-2339383|uniprotkb:B9EGL3	intact:EBI-11292028	psi-mi:irf7_human(display_long)|uniprotkb:IRF7(gene name)|psi-mi:IRF7(display_short)	psi-mi:icp0_bhv1j(display_long)|uniprotkb:BICP0(gene name)|psi-mi:BICP0(display_short)|uniprotkb:IER 2.9/ER2.6(gene name synonym)|uniprotkb:P135 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ICP0(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Saira et al. (2009)	pubmed:19176627|imex:IM-25915	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:31518(BoHV-1)|taxid:31518("Bovine herpesvirus 1.1 (strain Jura)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11296134|imex:IM-25915-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000185507(gene)|ensembl:ENSG00000276561(gene)|ensembl:ENST00000525445(transcript)|ensembl:ENST00000621391(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|reactome:R-HSA-3134963|go:"GO:0006974"(cellular response to DNA damage stimulus)|reactome:R-HSA-877300|reactome:R-HSA-9013973|go:"GO:0009615"(response to virus)|go:"GO:0010008"(endosome membrane)|reactome:R-HSA-909733|go:"GO:0016064"(immunoglobulin mediated immune response)|reactome:R-HSA-918233|reactome:R-HSA-933541|go:"GO:0019043"(establishment of viral latency)|reactome:R-HSA-936964|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|reactome:R-HSA-975110|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0034124"(regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0034127"(regulation of MyD88-independent toll-like receptor signaling pathway)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045655"(regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050776"(regulation of immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000110"(negative regulation of macrophage apoptotic process)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|mint:Q92985|rcsb pdb:2O61|ensembl:ENST00000330243|ensembl:ENSP00000329411|ensembl:ENSP00000331803|ensembl:ENST00000397566|ensembl:ENSP00000380697|ensembl:ENST00000469048|ensembl:ENSP00000434607|ensembl:ENSP00000434009|ensembl:ENST00000533182|ensembl:ENSP00000433903|ensembl:ENST00000612534|ensembl:ENSP00000479615|ensembl:ENSP00000480358|ensembl:ENST00000632827|ensembl:ENSP00000488039|ensembl:ENST00000633274|ensembl:ENSP00000488591|ensembl:ENST00000633943|ensembl:ENSP00000488666|ensembl:ENST00000634105|ensembl:ENSP00000488581|ensembl:ENST00000348655|refseq:NP_001563.2|refseq:NP_004020.1|refseq:NP_004022.2|refseq:XP_005252963.1|refseq:XP_016873163.1|dip:DIP-34895N|go:"GO:0005737"(cytoplasm)	refseq:NP_045363.1|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|go:"GO:0003677"(DNA binding)|go:"GO:0016740"(transferase activity)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046774"(suppression by virus of host intracellular interferon activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0075341"(host cell PML body)|go:"GO:0075342"(disruption by symbiont of host cell PML body)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075341"(host cell PML body)	go:"GO:0005634"(nucleus)|go:"GO:0016605"(PML body)	-	-	figure legend:3 and 4B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2015/10/02	2015/10/02	rogid:Wjak+z4pcHAXB3W9k+eqP4V8SuI9606	rogid:jEYz5rQfiT7aZtZlL0ks9XzRMRo31518	rigid:u9ueYGzP5TyvoGtHqKuhx/Sxm/k	false	-	necessary binding region:607-676|flag tag:n-n	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:A8E4Q6	uniprotkb:P29128	intact:EBI-11302757	intact:EBI-11292028	psi-mi:a8e4q6_bovin(display_long)|uniprotkb:IRF7(gene name)|psi-mi:IRF7(display_short)	psi-mi:icp0_bhv1j(display_long)|uniprotkb:BICP0(gene name)|psi-mi:BICP0(display_short)|uniprotkb:IER 2.9/ER2.6(gene name synonym)|uniprotkb:P135 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ICP0(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Saira et al. (2009)	pubmed:19176627|imex:IM-25915	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:31518(BoHV-1)|taxid:31518("Bovine herpesvirus 1.1 (strain Jura)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11302743|imex:IM-25915-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001098510.1|interpro:IPR019817|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR019471|interpro:IPR017855(SMAD domain-like)|interpro:IPR008984(SMAD/FHA domain)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|interpro:IPR036388|interpro:IPR036390|go:"GO:0005737"(cytoplasm)	refseq:NP_045363.1|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|go:"GO:0003677"(DNA binding)|go:"GO:0016740"(transferase activity)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046774"(suppression by virus of host intracellular interferon activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0075341"(host cell PML body)|go:"GO:0075342"(disruption by symbiont of host cell PML body)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075341"(host cell PML body)	go:"GO:0005634"(nucleus)|go:"GO:0016605"(PML body)	-	-	figure legend:4D|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9913(bovin-mdbk)|taxid:9913(Bos taurus)	-	2015/10/02	2015/10/12	rogid:uUxA+AWvNOQ6epSMilcL22S4UtA9913	rogid:jEYz5rQfiT7aZtZlL0ks9XzRMRo31518	rigid:SdE1ewaPfzhN3lrorP42o5Mmj+0	false	-	flag tag:n-n	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)