#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O88509	ensembl:ENSMUSG00000039521	intact:EBI-7987547|intact:MINT-2523761|uniprotkb:O88510|uniprotkb:O88511|ensembl:ENSMUSP00000072761|ensembl:ENSMUSP00000105396	intact:EBI-10899641	psi-mi:dnm3b_mouse(display_long)|uniprotkb:Dnmt3b(gene name)|psi-mi:Dnmt3b(display_short)|uniprotkb:DNA methyltransferase MmuIIIB(gene name synonym)	uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|ensembl:foxp3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000039521(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Lal et al. (2009)	pubmed:19109157|imex:IM-24540	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11291360|imex:IM-24540-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_001258676.1|refseq:NP_001003961.2|refseq:NP_001258674.1|refseq:NP_001003960.2|refseq:NP_034198.3|refseq:NP_001258673.1|dip:DIP-43736N|ensembl:ENSMUSG00000027478(gene)|ensembl:ENSMUST00000072997(transcript)|ensembl:ENSMUST00000109774(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051718"("DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates")|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0060821"(obsolete inactivation of X chromosome by DNA methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090116"(C-5 methylation of cytosine)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030488|interpro:IPR040552|mint:O88509|rcsb pdb:1KHC|reactome:R-MMU-212300|reactome:R-MMU-4655427	refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1	-	comment:mint|function:Required for genome wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones	-	figure legend:3Ai|antagonist:"CHEBI:50131;5-aza-2′-deoxycytidine (Aza); a DNA methyltransferase inhibitor, causing DNA demethylation."|comment:DNMT1 and DNM3B bound much more to the upstream Foxp3 enhancer CpG island of naive cells rather than N-TReg cells. TGFbeta-induced Treg cells had much greater binding of DNMT1 and DNMT3b compared with N-Treg, or Aza plus TGFbeta-induced Treg cells.|causality statement:"CHEBI:50131 decreases the binding of O88509 to ENSMUSG00000039521."|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2015/08/11	2015/09/25	rogid:kyLQKXAetZyuwqBYP3+08/cb5JU10090	-	-	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:P13864	ensembl:ENSMUSG00000039521	intact:EBI-301927|uniprotkb:Q80ZU3|uniprotkb:Q9CSC6|uniprotkb:P97413|uniprotkb:Q9QXX6|ensembl:ENSMUSP00000004202	intact:EBI-10899641	psi-mi:dnmt1_mouse(display_long)|uniprotkb:Dnmt1(gene name)|psi-mi:Dnmt1(display_short)|uniprotkb:Dnmt(gene name synonym)|uniprotkb:Met1(gene name synonym)|uniprotkb:Uim(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase MmuI(gene name synonym)	uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|ensembl:foxp3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000039521(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Lal et al. (2009)	pubmed:19109157|imex:IM-24540	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11291388|imex:IM-24540-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_001186360.2|refseq:NP_001186361.1|refseq:NP_001186362.1|refseq:NP_034196.5|interpro:IPR031303|interpro:IPR043151|mint:P13864|rcsb pdb:3AV4|rcsb pdb:3AV5|rcsb pdb:3AV6|rcsb pdb:3PT6|rcsb pdb:3PT9|rcsb pdb:4DA4|rcsb pdb:5GUT|rcsb pdb:5GUV|rcsb pdb:5WY1|rcsb pdb:6W8V|rcsb pdb:6W8W|reactome:R-MMU-212300|reactome:R-MMU-4655427|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|ensembl:ENSMUST00000004202(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010424"(DNA methylation on cytosine within a CG sequence)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0044026"(DNA hypermethylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046500"(S-adenosylmethionine metabolic process)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051718"("DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates")|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:0016458"(obsolete gene silencing)|ensembl:ENSMUSG00000004099(gene)|refseq:NP_001300940.1	refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1	-	-	-	figure legend:3A, 5D|antagonist:"CHEBI:50131;5-aza-2′-deoxycytidine (Aza); a DNA methyltransferase inhibitor, causing DNA demethylation."|causality statement:"CHEBI:50131 decreases the binding of P13864 to ENSMUSG00000039521"|comment:DNMT1 and DNM3B bound much more to the upstream Foxp3 enhancer CpG island of naive cells rather than N-TReg cells. TGFbeta-induced Treg cells had much greater binding of DNMT1 and DNMT3b compared with N-Treg, or Aza plus TGFbeta-induced Treg cells.|agonist:P01137 -TFG-beta1|causality statement:P01137  increased the binding of P13864 to ENSMUSG00000039521|causality statement:P13864 decreases expression at RNA level of  ENSMUSG00000039521|causality statement:P13864 increases methylation  of  ENSMUSG00000039521|causality statement:P08505 decreases expression at RNA level of  ENSMUSG00000039521|causality statement:P42227 is required  for the  P08505 induced decrease in expression at RNA level of  ENSMUSG00000039521|causality statement:"CHEBI:50131  increases expression at RNA level of  ENSMUSG00000039521"|causality statement:"CHEBI:50131  increases expression at protein level of  ENSMUSG00000039521."|causality statement:"P01137 and  CHEBI:50131  increases expression at protein level of  ENSMUSG00000039521."|causality statement:P01137   increases expression at protein level of  ENSMUSG00000039521.|causality statement:"P01137 and  CHEBI:50131 indirectly demethylates   ENSMUSG00000039521."|causality statement:"CHEBI:50131  indirectly demethylates   ENSMUSG00000039521."|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2015/08/11	2015/09/25	rogid:JgHTnDhDn4nuU6ww3jXfDPq01xY10090	-	-	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:Q9Z2E1	ensembl:ENSMUSG00000039521	intact:EBI-5716946|uniprotkb:E9QMV9|uniprotkb:Q811D9|uniprotkb:Q9Z2D9|ensembl:ENSMUSP00000073701	intact:EBI-10899641	psi-mi:mbd2_mouse(display_long)|uniprotkb:Mbd2(gene name)|psi-mi:Mbd2(display_short)|uniprotkb:Methyl-CpG-binding protein MBD2(gene name synonym)	uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|ensembl:foxp3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000039521(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Lal et al. (2009)	pubmed:19109157|imex:IM-24540	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11291410|imex:IM-24540-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_034903.2|refseq:NP_001298000.1|ensembl:ENSMUSG00000024513(gene)|ensembl:ENSMUST00000074058(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0034622"|go:"GO:0035197"(siRNA binding)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042711"(maternal behavior)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0048568"(embryonic organ development)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR025884|interpro:IPR032343|mint:Q9Z2E1|reactome:R-MMU-427413|reactome:R-MMU-73728	refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1	-	-	-	figure legend:3B|antagonist:"CHEBI:50131;5-aza-2′-deoxycytidine (Aza); a DNA methyltransferase inhibitor, causing DNA demethylation."|agonist:P01137 -TFG-beta1|causality statement:P01137  increased the binding of  Q9Z2E1  to ENSMUSG00000039521|causality statement:"CHEBI:50131 decreases the binding of Q9Z2E1 to ENSMUSG00000039521"|comment:MBD2 and MeCP2 bound much more to the upstream Foxp3 enhancer CpG island of naive cells rather than N-TReg cells. TGFbeta-induced Treg cells had much greater binding of  MBD2 and MeCP2 compared with N-Treg, or Aza plus TGFbeta-induced Treg cells.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2015/08/11	2015/09/25	rogid:WxzH0gNkMXwFmBK/RWr2/RqWjXM10090	-	-	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:Q9Z2D6	ensembl:ENSMUSG00000039521	intact:EBI-1188816|uniprotkb:Q3TYG1|uniprotkb:B1AUZ2|uniprotkb:B1AUZ3|ensembl:ENSMUSP00000098314|ensembl:ENSMUSP00000127115	intact:EBI-10899641	psi-mi:mecp2_mouse(display_long)|uniprotkb:Mecp2(gene name)|psi-mi:Mecp2(display_short)	uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|ensembl:foxp3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000039521(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Lal et al. (2009)	pubmed:19109157|imex:IM-24540	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11291425|imex:IM-24540-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_001075448.1|refseq:NP_034918.1|ensembl:ENSMUSG00000031393(gene)|ensembl:ENSMUST00000100750(transcript)|ensembl:ENSMUST00000170481(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042220"(response to cocaine)|go:"GO:0042551"(neuron maturation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071317"(cellular response to isoquinoline alkaloid)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1901956"(positive regulation of retrograde dense core granule transport)|go:"GO:1903860"(negative regulation of dendrite extension)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905492"(positive regulation of branching morphogenesis of a nerve)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:Q9Z2D6|rcsb pdb:5NAF|reactome:R-MMU-9022692|go:"GO:0010385"(double-stranded methylated DNA binding)|dip:DIP-39984N	refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1	-	-	-	figure legend:3C|antagonist:"CHEBI:50131;5-aza-2′-deoxycytidine (Aza); a DNA methyltransferase inhibitor, causing DNA demethylation."|comment:MBD2 and MeCP2 bound much more to the upstream Foxp3 enhancer CpG island of naive cells rather than N-TReg cells. TGFbeta-induced Treg cells had much greater binding of  MBD2 and MeCP2 compared with N-Treg, or Aza plus TGFbeta-induced Treg cells.|causality statement:"CHEBI:50131 decreases the binding of Q9Z2D6 to ENSMUSG00000039521"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2015/08/11	2015/09/25	rogid:+kDY0EPkyG+tTLMlP0zZFOS1R3E10090	-	-	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:O89090	ensembl:ENSMUSG00000039521	intact:EBI-645192|uniprotkb:O89087|uniprotkb:Q62251|uniprotkb:Q64167	intact:EBI-10899641	psi-mi:sp1_mouse(display_long)|uniprotkb:Sp1(gene name)|psi-mi:Sp1(display_short)|uniprotkb:Specificity protein 1(gene name synonym)	uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|ensembl:foxp3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000039521(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Lal et al. (2009)	pubmed:19109157|imex:IM-24540	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11291462|imex:IM-24540-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_038700.2|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0060136"(embryonic process involved in female pregnancy)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1904828"(positive regulation of hydrogen sulfide biosynthetic process)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-MMU-2173796|reactome:R-MMU-6807505|reactome:R-MMU-9018519|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|dip:DIP-35276N|mint:O89090	refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1	-	-	-	figure legend:4A|comment:Sp1 binding was seen  using  nTreg and Aza plus TGF-beta Treg cells, but not in naive CD4+CD25− T cells, activated CD4+ T cells, or TGF-beta induced Treg cells .|agonist:"CHEBI:50131;5-aza-2′-deoxycytidine (Aza); a DNA methyltransferase inhibitor, causing DNA demethylation."|causality statement:"CHEBI:50131 increases the binding of O89090 to ENSMUSG00000039521"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2015/08/11	2015/09/28	rogid:yl6xflCilQfKGmNQ0vKKnbMhvIs10090	-	-	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:O89091	ensembl:ENSMUSG00000039521	intact:EBI-10949150|ensembl:ENSMUSP00000073690	intact:EBI-10899641	psi-mi:klf10_mouse(display_long)|uniprotkb:Gdnfif(gene name synonym)|uniprotkb:Tieg(gene name synonym)|uniprotkb:Tieg1(gene name synonym)|uniprotkb:Klf10(gene name)|psi-mi:Klf10(display_short)|uniprotkb:GDNF-inducible factor(gene name synonym)|uniprotkb:Transcription factor GIF(gene name synonym)|uniprotkb:Transforming growth factor-beta-inducible early growth response protein 1(gene name synonym)	uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|ensembl:foxp3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000039521(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Lal et al. (2009)	pubmed:19109157|imex:IM-24540	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11291477|imex:IM-24540-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	ensembl:ENSMUSG00000037465(gene)|ensembl:ENSMUST00000074043(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0030282"(bone mineralization)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|refseq:NP_038720.1	refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1	-	-	-	figure legend:4D|agonist:"CHEBI:50131;5-aza-2′-deoxycytidine (Aza); a DNA methyltransferase inhibitor, causing DNA demethylation."|causality statement:"CHEBI:50131 increases the binding of O89091 to ENSMUSG00000039521 O89091"|comment:Tieg1 binding was seen  using  nTreg and Aza plus TGF-beta Treg cells, but not in naive CD4+CD25− T cells, activated CD4+ T cells, or TGF-beta induced Treg cells .|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2015/08/11	2015/09/28	rogid:Om/5G27Tqsik8qYmwjBpDDxokPA10090	-	-	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:O88508	ensembl:ENSMUSG00000039521	intact:EBI-995154|uniprotkb:Q3UH24|uniprotkb:Q8CJ60|uniprotkb:Q922J0|uniprotkb:Q9CSE1|uniprotkb:Q3TZK8|ensembl:ENSMUSP00000020991|ensembl:ENSMUSP00000134009	intact:EBI-10899641	psi-mi:dnm3a_mouse(display_long)|uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)|uniprotkb:Dnmt3a(gene name)|psi-mi:Dnmt3a(display_short)	uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|ensembl:foxp3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000039521(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Lal et al. (2009)	pubmed:19109157|imex:IM-24540	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11291503|imex:IM-24540-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010288"(response to lead ion)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030182"(neuron differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0033189"(response to vitamin A)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0046872"(metal ion binding)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030487|interpro:IPR040552|interpro:IPR044108|mint:O88508|rcsb pdb:3SW9|rcsb pdb:3SWC|reactome:R-MMU-212300|reactome:R-MMU-3214858|ensembl:ENSMUSG00000020661(gene)|ensembl:ENSMUST00000020991(transcript)|ensembl:ENSMUST00000174817(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_031898.1|refseq:NP_714965.1|refseq:XP_006515016.1|refseq:XP_006515019.1|refseq:NP_001258682.1|dip:DIP-38005N	refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1	-	-	-	figure legend:Supp 3A|comment:There was no significant difference in DNMT3a binding  between  nTReg and naive cells.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2015/08/11	2015/09/28	rogid:ZLqyo0sbBdWAlvbJ25rm+p58o5810090	-	-	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:P34056	ensembl:ENSMUSG00000039521	intact:EBI-11291520|uniprotkb:Q60740|uniprotkb:Q60741|uniprotkb:Q60742|uniprotkb:Q60743|uniprotkb:Q62067|uniprotkb:Q62068|uniprotkb:Q62069|uniprotkb:Q91VX0|uniprotkb:Q9CRY4	intact:EBI-10899641	psi-mi:ap2a_mouse(display_long)|uniprotkb:AP-2 transcription factor(gene name synonym)|uniprotkb:Activating enhancer-binding protein 2-alpha(gene name synonym)|uniprotkb:Activator protein 2(gene name synonym)|uniprotkb:Tfap2a(gene name)|psi-mi:Tfap2a(display_short)|uniprotkb:Ap2tf(gene name synonym)|uniprotkb:Tcfap2a(gene name synonym)	uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|ensembl:foxp3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000039521(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Lal et al. (2009)	pubmed:19109157|imex:IM-24540	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11291513|imex:IM-24540-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	interpro:IPR004979(Transcription factor AP-2)|interpro:IPR008121(Transcription factor AP-2 alpha, N-terminal)|interpro:IPR013854(Transcription factor AP-2, C-terminal)|refseq:NP_001288603.1|refseq:NP_035677.2|reactome:R-MMU-8864260|reactome:R-MMU-8866904|reactome:R-MMU-8866907|reactome:R-MMU-8869496|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003334"(keratinocyte development)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0003409"(optic cup structural organization)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0007423"(sensory organ development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0014032"(neural crest cell development)|go:"GO:0021506"(anterior neuropore closure)|go:"GO:0021559"(trigeminal nerve development)|go:"GO:0021623"(oculomotor nerve formation)|go:"GO:0021884"(forebrain neuron development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043588"(skin development)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061303"(cornea development in camera-type eye)|go:"GO:0070172"(positive regulation of tooth mineralization)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0071711"(basement membrane organization)|go:"GO:0072210"(metanephric nephron development)|go:"GO:0140536"(nuclear receptor corepressor activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:0060235"(lens induction in camera-type eye)	refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1	-	-	-	figure legend:Supp 3B|comment:There was no significant difference in binding  between  nTReg and naive cells.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2015/08/11	2015/09/28	rogid:wtUWkjAbUkwg6v86hs6AT0Lcjhs10090	-	-	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:P08046	ensembl:ENSMUSG00000039521	intact:EBI-11291629|uniprotkb:Q61777|ensembl:ENSMUSP00000069616|ensembl:ENSMUSP00000126931	intact:EBI-10899641	psi-mi:egr1_mouse(display_long)|uniprotkb:Egr1(gene name)|psi-mi:Egr1(display_short)|uniprotkb:Egr-1(gene name synonym)|uniprotkb:Krox-24(gene name synonym)|uniprotkb:Nerve growth factor-induced protein A(gene name synonym)|uniprotkb:Transcription factor Zif268(gene name synonym)|uniprotkb:Zinc finger protein Krox-24(gene name synonym)	uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|ensembl:foxp3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000039521(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Lal et al. (2009)	pubmed:19109157|imex:IM-24540	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11291622|imex:IM-24540-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_031939.1|ensembl:ENSMUSG00000038418(gene)|ensembl:ENSMUST00000064795(transcript)|ensembl:ENSMUST00000165033(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007611"(learning or memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009749"(response to glucose)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033233"(regulation of protein sumoylation)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044729"(hemi-methylated DNA-binding)|go:"GO:0044849"(estrous cycle)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0061418"(regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071504"(cellular response to heparin)|go:"GO:0071506"(cellular response to mycophenolic acid)|go:"GO:0072110"(glomerular mesangial cell proliferation)|go:"GO:0072303"(positive regulation of glomerular metanephric mesangial cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0098759"(cellular response to interleukin-8)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000182"(regulation of progesterone biosynthetic process)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR021839|interpro:IPR021849|interpro:IPR036236|rcsb pdb:1A1F|rcsb pdb:1A1G|rcsb pdb:1A1H|rcsb pdb:1A1I|rcsb pdb:1A1J|rcsb pdb:1A1K|rcsb pdb:1A1L|rcsb pdb:1AAY|rcsb pdb:1F2I|rcsb pdb:1G2D|rcsb pdb:1G2F|rcsb pdb:1JK1|rcsb pdb:1JK2|rcsb pdb:1LLM|rcsb pdb:1P47|rcsb pdb:1ZAA	refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1	-	-	-	figure legend:Supp 3C|comment:"The text states that:- \"were not differentially bound in these subsets\" - referring to  nTReg and naive cells."|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2015/08/11	2015/09/28	rogid:Zzqbrs/khNbZMa+jrrJmFevL3Ec10090	-	-	false	-	sufficient binding region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)