#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B ensembl:ENSG00000109471 uniprotkb:Q13469 intact:EBI-1566859 intact:EBI-716258|uniprotkb:B5B2N9|uniprotkb:Q13468|uniprotkb:Q5TFW7|uniprotkb:Q5TFW8|uniprotkb:Q9NPX6|uniprotkb:Q9NQH3|uniprotkb:Q9UJR2|uniprotkb:B5B2P0|uniprotkb:B5B2N8|ensembl:ENSP00000379330|uniprotkb:B5B2P2|uniprotkb:B5B2P3 uniprotkb:IL2(gene name)|psi-mi:IL2(display_short)|ensembl:il2_human_gene(shortlabel)|psi-mi:ENSG00000109471(display_long) psi-mi:nfac2_human(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:NFATC2(gene name)|psi-mi:NFATC2(display_short)|uniprotkb:NFAT1(gene name synonym)|uniprotkb:NFATP(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Lesniewski et al. (2008) imex:IM-23697|pubmed:18769450 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-10092157|imex:IM-23697-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) refseq:NP_000577.2 refseq:NP_001245221.1|refseq:NP_036472.2|refseq:NP_775114.1|refseq:NP_001245223.1|refseq:NP_001245225.1|refseq:NP_001129493.1|ensembl:ENSG00000101096(gene)|ensembl:ENST00000396009(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0042493"|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR037059|rcsb pdb:1A02|rcsb pdb:1OWR|rcsb pdb:1P7H|go:"GO:1990904"(ribonucleoprotein complex)|rcsb pdb:1PZU|rcsb pdb:1S9K|rcsb pdb:2AS5|rcsb pdb:2O93|interpro:IPR002909(Cell surface receptor IPT/TIG)|rcsb pdb:3QRF|reactome:R-HSA-2025928|reactome:R-HSA-2871809|reactome:R-HSA-5607763|reactome:R-HSA-8877330|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|dip:DIP-27630N - - - figure legend:Fig. 4b|comment:IL-2 promoter DNA co-precipitated with anti-NFAT1/NFATc2 antibody in CD4+ T cells from adult peripheral blood but not from umbilical cord blood.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-pb_t-cell_cd4+)|taxid:9606(Homo sapiens peripheral blood cd4 positive T cell) - 2015/01/20 2015/01/20 - rogid:SNvCfCooUb7MH1xO0prmM4jv+o49606 intact-crc:2DB3EBA2601F841E false binding-associated region:?-? - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) ensembl:ENSG00000109471 uniprotkb:Q9BYV9 intact:EBI-1566859 intact:EBI-1642333|uniprotkb:E1P518|uniprotkb:Q59H70|uniprotkb:Q5T793|uniprotkb:Q9NTS5|ensembl:ENSP00000257749|ensembl:ENSP00000345642|ensembl:ENSP00000437473 uniprotkb:IL2(gene name)|psi-mi:IL2(display_short)|ensembl:il2_human_gene(shortlabel)|psi-mi:ENSG00000109471(display_long) psi-mi:bach2_human(display_long)|uniprotkb:BACH2(gene name)|psi-mi:BACH2(display_short)|uniprotkb:BTB and CNC homolog 2(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Lesniewski et al. (2008) imex:IM-23697|pubmed:18769450 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-10092176|imex:IM-23697-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) refseq:NP_000577.2 refseq:XP_011534341.1|refseq:XP_011534342.1|refseq:NP_001164265.1|refseq:NP_068585.1|refseq:XP_005248816.1|refseq:XP_016866654.1|refseq:XP_016866655.1|ensembl:ENSG00000112182(gene)|ensembl:ENST00000257749(transcript)|ensembl:ENST00000343122(transcript)|ensembl:ENST00000537989(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051170"(import into nucleus)|go:"GO:0090721"(primary adaptive immune response involving T cells and B cells)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR043321|rcsb pdb:3OHU|rcsb pdb:3OHV - - - figure legend:Fig. 4a, 4b|comment:IL-2 promoter DNA co-precipitated with anti-BACH2 antibody in CD4+ T cells from umbilical cord blood but not from adult peripheral blood.|causality statement:Q9BYV9 increases expression at RNA level of ENSG00000109471|causality statement:Q9BYV9 increases expression at protein level of ENSG00000109471|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ucb_t-cell_cd4+)|taxid:9606(Homo sapiens umbilical cord blood cd4 positive T cell) - 2015/01/20 2019/01/30 - rogid:yITQfsup6YNNo06tqFvTMqybh8w9606 intact-crc:93F4AEEA79EA1222 false binding-associated region:?-? - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:P17275 ensembl:ENSG00000109471 intact:EBI-748062|uniprotkb:Q96GH3|ensembl:ENSP00000303315 intact:EBI-1566859 psi-mi:junb_human(display_long)|uniprotkb:JUNB(gene name)|psi-mi:JUNB(display_short) uniprotkb:IL2(gene name)|psi-mi:IL2(display_short)|ensembl:il2_human_gene(shortlabel)|psi-mi:ENSG00000109471(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Lesniewski et al. (2008) imex:IM-23697|pubmed:18769450 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-10092183|imex:IM-23697-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_002220.1|ensembl:ENSG00000171223(gene)|ensembl:ENST00000302754(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0033687"(osteoblast proliferation)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046697"(decidualization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060136"(embryonic process involved in female pregnancy)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002112(Transcription factor Jun)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR005643(Jun-like transcription factor)|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029822|mint:P17275|reactome:R-HSA-2173796|reactome:R-HSA-6785807|reactome:R-HSA-9031628|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|dip:DIP-1052N refseq:NP_000577.2 - - - figure legend:Fig. 4b|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ucb_t-cell_cd4+)|taxid:9606(Homo sapiens umbilical cord blood cd4 positive T cell) - 2015/01/20 2019/01/30 rogid:p2UBpMzVG+A8AV7UCH4jYTsoPF89606 - intact-crc:C30C9523B9CD5EEC false - binding-associated region:?-? - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr)