#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P10914	intact:EBI-10952275	intact:EBI-1055781|uniprotkb:Q96GG7|ensembl:ENSP00000245414|ensembl:ENSP00000384406	-	psi-mi:irf1_human(display_long)|uniprotkb:IRF1(gene name)|psi-mi:IRF1(display_short)	psi-mi:conserved-region_foxp3_promoter_irf-e/isre(display_short)|psi-mi:EBI-10952275(display_long)	psi-mi:"MI:0096"(pull down)	Fragale et al. (2008)	imex:IM-24395|pubmed:18641303	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10952273|imex:IM-24395-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_002189.1|ensembl:ENSG00000125347(gene)|ensembl:ENST00000245414(transcript)|ensembl:ENST00000405885(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0034124"(regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0043374"(CD8-positive, alpha-beta T cell differentiation)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR017431(Interferon regulatory factor, 1/2)|interpro:IPR019817|interpro:IPR031215|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-5620971|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983231|dip:DIP-40988N|go:"GO:0005634"(nucleus)	-	-	-	-	figure legend:5B|agonist:"Interferon - gamma (P01579) increases  binding."|causality statement:P10914 decreases expression at RNA level  of  ENSMUSG00000039521|causality statement:P01579  decreases expression at RNA level  of  ENSMUSG00000039521|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/13	2015/07/31	rogid:ToPrN31Dt6/EQuaX8gkxFBDJp5Q9606	-	-	false	-	mutation disrupting interaction strength:22-22,16-16,20-20|biotin tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P10914	intact:EBI-10952320	intact:EBI-1055781|uniprotkb:Q96GG7|ensembl:ENSP00000245414|ensembl:ENSP00000384406	-	psi-mi:irf1_human(display_long)|uniprotkb:IRF1(gene name)|psi-mi:IRF1(display_short)	psi-mi:c13_canonical irf-1 consensus sequence(display_short)|psi-mi:EBI-10952320(display_long)	psi-mi:"MI:0096"(pull down)	Fragale et al. (2008)	imex:IM-24395|pubmed:18641303	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10952305|imex:IM-24395-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_002189.1|ensembl:ENSG00000125347(gene)|ensembl:ENST00000245414(transcript)|ensembl:ENST00000405885(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0034124"(regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0043374"(CD8-positive, alpha-beta T cell differentiation)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR017431(Interferon regulatory factor, 1/2)|interpro:IPR019817|interpro:IPR031215|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-5620971|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983231|dip:DIP-40988N|go:"GO:0005634"(nucleus)	-	-	-	-	figure legend:5B-2|agonist:"Interferon - gamma (P01579) increases  binding."|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/13	2015/07/31	rogid:ToPrN31Dt6/EQuaX8gkxFBDJp5Q9606	-	-	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15314	intact:EBI-10952275	intact:EBI-6115486|ensembl:ENSMUSP00000019043|ensembl:ENSMUSP00000104548	-	psi-mi:irf1_mouse(display_long)|uniprotkb:Irf1(gene name)|psi-mi:Irf1(display_short)	psi-mi:conserved-region_foxp3_promoter_irf-e/isre(display_short)|psi-mi:EBI-10952275(display_long)	psi-mi:"MI:0096"(pull down)	Fragale et al. (2008)	imex:IM-24395|pubmed:18641303	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10952334|imex:IM-24395-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_001152868.1|refseq:NP_032416.1|dip:DIP-61281N|ensembl:ENSMUSG00000018899(gene)|ensembl:ENSMUST00000019043(transcript)|ensembl:ENSMUST00000108920(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0034124"(regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043374"(CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045629"(negative regulation of T-helper 2 cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060416"(response to growth hormone)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR017431(Interferon regulatory factor, 1/2)|interpro:IPR019817|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|interpro:IPR031215|interpro:IPR036388|interpro:IPR036390|rcsb pdb:1IF1|go:"GO:0005634"(nucleus)	-	-	-	-	figure legend:6A|comment:Less IRF1 was bound when using CD4+CD25+   T- Reg cells as compared with CD4+CD25− T cells.|antagonist:"TGFB1  (P01137)"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/13	2015/07/31	rogid:4w9FNtN+6ov3Xj/KWEgeqlZmkHU10090	-	-	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P10914	intact:EBI-10952275	intact:EBI-1055781|uniprotkb:Q96GG7|ensembl:ENSP00000245414|ensembl:ENSP00000384406	-	psi-mi:irf1_human(display_long)|uniprotkb:IRF1(gene name)|psi-mi:IRF1(display_short)	psi-mi:conserved-region_foxp3_promoter_irf-e/isre(display_short)|psi-mi:EBI-10952275(display_long)	psi-mi:"MI:0096"(pull down)	Fragale et al. (2008)	imex:IM-24395|pubmed:18641303	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10952349|imex:IM-24395-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_002189.1|ensembl:ENSG00000125347(gene)|ensembl:ENST00000245414(transcript)|ensembl:ENST00000405885(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0034124"(regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0043374"(CD8-positive, alpha-beta T cell differentiation)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR017431(Interferon regulatory factor, 1/2)|interpro:IPR019817|interpro:IPR031215|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-5620971|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983231|dip:DIP-40988N|go:"GO:0005634"(nucleus)	-	-	-	-	figure legend:6A-2|comment:Less IRF1 was bound when using CD4+CD25+   T- Reg cells as compared with CD4+CD25− T cells.|antagonist:"TGFB1  (P01137)"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/13	2015/07/31	rogid:ToPrN31Dt6/EQuaX8gkxFBDJp5Q9606	-	-	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
ensembl:ENSG00000049768	uniprotkb:P10914	intact:EBI-10097414	intact:EBI-1055781|uniprotkb:Q96GG7|ensembl:ENSP00000245414|ensembl:ENSP00000384406	psi-mi:foxp3_human_gene(display_short)|psi-mi:ENSG00000049768(display_long)	psi-mi:irf1_human(display_long)|uniprotkb:IRF1(gene name)|psi-mi:IRF1(display_short)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Fragale et al. (2008)	imex:IM-24395|pubmed:18641303	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10952381|imex:IM-24395-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:NP_002189.1|ensembl:ENSG00000125347(gene)|ensembl:ENST00000245414(transcript)|ensembl:ENST00000405885(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0034124"(regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0043374"(CD8-positive, alpha-beta T cell differentiation)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR017431(Interferon regulatory factor, 1/2)|interpro:IPR019817|interpro:IPR031215|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-5620971|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983231|dip:DIP-40988N	-	-	-	figure legend:6C|causality statement:P60568 increases expression at protein level of  ENSMUSG00000039521|comment:Less IRF1 was bound when using CD4+CD25+ T- Reg cells as compared with CD4+CD25− T cells.|causality statement:P10914  decreases expression at RNA  level of   ENSG00000049768|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell)|taxid:9606(Homo sapiens)	-	2015/07/13	2015/07/31	-	rogid:ToPrN31Dt6/EQuaX8gkxFBDJp5Q9606	-	false	sufficient binding region:?-?	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
ensembl:ENSMUSG00000039521	uniprotkb:P15314	intact:EBI-10899641	intact:EBI-6115486|ensembl:ENSMUSP00000019043|ensembl:ENSMUSP00000104548	uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|ensembl:foxp3_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000039521(display_long)	psi-mi:irf1_mouse(display_long)|uniprotkb:Irf1(gene name)|psi-mi:Irf1(display_short)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Fragale et al. (2008)	imex:IM-24395|pubmed:18641303	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10952428|imex:IM-24395-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1	refseq:NP_001152868.1|refseq:NP_032416.1|dip:DIP-61281N|ensembl:ENSMUSG00000018899(gene)|ensembl:ENSMUST00000019043(transcript)|ensembl:ENSMUST00000108920(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0034124"(regulation of MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043374"(CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045629"(negative regulation of T-helper 2 cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060416"(response to growth hormone)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR017431(Interferon regulatory factor, 1/2)|interpro:IPR019817|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|interpro:IPR031215|interpro:IPR036388|interpro:IPR036390|rcsb pdb:1IF1	-	-	-	figure legend:6D|comment:Less IRF1 was bound when using CD4+CD25+ T- Reg cells as compared with CD4+CD25− T cells.|causality statement:P15314 decreases expression at RNA level of ENSMUSG00000039521|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2015/07/13	2015/07/31	-	rogid:4w9FNtN+6ov3Xj/KWEgeqlZmkHU10090	-	false	sufficient binding region:?-?	-	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)