#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P08246	uniprotkb:P03973	intact:EBI-986345|uniprotkb:P09649|uniprotkb:Q6B0D9|uniprotkb:Q6LDP5|ensembl:ENSP00000263621|ensembl:ENSP00000466090|ensembl:ENSP00000480128|ensembl:ENSP00000488075	intact:EBI-355293|uniprotkb:P07757|uniprotkb:B2R5H8|ensembl:ENSP00000342082	psi-mi:elne_human(display_long)|uniprotkb:Elastase-2(gene name synonym)|uniprotkb:ELANE(gene name)|psi-mi:ELANE(display_short)|uniprotkb:PMN elastase(gene name synonym)|uniprotkb:Bone marrow serine protease(gene name synonym)|uniprotkb:Medullasin(gene name synonym)|uniprotkb:Human leukocyte elastase(gene name synonym)|uniprotkb:ELA2(gene name synonym)	psi-mi:slpi_human(display_long)|uniprotkb:SLPI(gene name)|psi-mi:SLPI(display_short)|uniprotkb:WAP4(gene name synonym)|uniprotkb:WFDC4(gene name synonym)|uniprotkb:Secretory leukocyte protease inhibitor(gene name synonym)|uniprotkb:HUSI-1(gene name synonym)|uniprotkb:Seminal proteinase inhibitor(gene name synonym)|uniprotkb:BLPI(gene name synonym)|uniprotkb:Mucus proteinase inhibitor(gene name synonym)|uniprotkb:WAP four-disulfide core domain protein 4(gene name synonym)|uniprotkb:Protease inhibitor WAP4(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Koizumi et al. (2008)	pubmed:18421166|imex:IM-24449	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10949635|imex:IM-24449-1|pdbe:2z7f	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000197561(gene)|ensembl:ENSG00000277571(gene)|ensembl:ENST00000263621(transcript)|ensembl:ENST00000590230(transcript)|ensembl:ENST00000615489(transcript)|ensembl:ENST00000632488(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001878"(response to yeast)|go:"GO:0002020"(protease binding)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002812"(biosynthetic process of antibacterial peptides active against Gram-negative bacteria)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008201"(heparin binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0009986"(cell surface)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019955"(cytokine binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0030163"(protein catabolic process)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0050922"(negative regulation of chemotaxis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070269"(pyroptosis)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0070947"(neutrophil-mediated killing of fungus)|go:"GO:1903238"(positive regulation of leukocyte tethering or rolling)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|mint:P08246|rcsb pdb:1B0F|rcsb pdb:1H1B|rcsb pdb:1HNE|rcsb pdb:1PPF|rcsb pdb:1PPG|rcsb pdb:2RG3|rcsb pdb:2Z7F|rcsb pdb:3Q76|rcsb pdb:3Q77|rcsb pdb:4NZL|rcsb pdb:4WVP|rcsb pdb:5A09|rcsb pdb:5A0A|rcsb pdb:5A0B|rcsb pdb:5A0C|rcsb pdb:5A8X|rcsb pdb:5A8Y|rcsb pdb:5A8Z|rcsb pdb:5ABW|rcsb pdb:6E69|rcsb pdb:6F5M|rcsb pdb:6SMA|rcsb pdb:7CBK|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-5620971|reactome:R-HSA-6798695|reactome:R-HSA-6803157|reactome:R-HSA-977606|refseq:NP_001963.1|refseq:XP_011526078.1|refseq:XP_011526077.1	refseq:NP_003055.1|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008197(Whey acidic protein, 4-disulphide core)|interpro:IPR036645|rcsb pdb:2Z7F|rcsb pdb:4DOQ|reactome:R-HSA-6798695|ensembl:ENSG00000124107(gene)|ensembl:ENST00000338380(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006955"(immune response)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019899"(enzyme binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035821"(modulation of process of another organism)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)	-	-	-	figure legend:Fig 1a|3d-resolution:1.70 A|3d-r-factors:"R-working: 0.203 R-free: 0.231"|comment:"The sequence numbering  for HNE (Leucocyte Elastase) -amino acids 30-247 - was taken from PDBe web site; however this numbering is not given in the publication nor  on the Suppliers web site (Elastin Products Company)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/29	2015/07/29	rogid:0XCflWhF346d7Dy2+ENeMyDHPmA9606	rogid:R8NGKO6Dtq5Bxw2DC1RgEtLs7/w9606	rigid:aPUeT1tlLoSRQOPbWoSw9V7SNNI	false	sufficient binding region:30-247	sufficient binding region:83-132	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)