#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q92859	uniprotkb:Q6ZVN8	intact:EBI-2829116|uniprotkb:B7ZKM9|uniprotkb:Q17RX1|uniprotkb:O00340|intact:EBI-28985104|uniprotkb:B7ZKN0|ensembl:ENSP00000261908|ensembl:ENSP00000341198	intact:EBI-10900704|uniprotkb:B1ALI7|uniprotkb:Q2PQ63|uniprotkb:Q6IMF6|uniprotkb:Q8NAH2|uniprotkb:Q8WVJ5|ensembl:ENSP00000337014	psi-mi:neo1_human(display_long)|uniprotkb:NEO1(gene name)|psi-mi:NEO1(display_short)|uniprotkb:IGDCC2(gene name synonym)|uniprotkb:NGN(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 2(gene name synonym)	psi-mi:rgmc_human(display_long)|uniprotkb:HJV(gene name)|psi-mi:HJV(display_short)|uniprotkb:HFE2(gene name synonym)|uniprotkb:Hemochromatosis type 2 protein(gene name synonym)|uniprotkb:Hemojuvelin BMP coreceptor(gene name synonym)|uniprotkb:RGM domain family member C(gene name synonym)|uniprotkb:RGMC(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Yang et al. (2008)	pubmed:18335997|imex:IM-24352	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-10900702|imex:IM-24352-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002490.2|refseq:NP_001166095.1|ensembl:ENSP00000261908|ensembl:ENSP00000341198|ensembl:ENST00000558964|ensembl:ENSP00000453200|ensembl:ENST00000560262|ensembl:ENSP00000453317|refseq:NP_001166094.1|dip:DIP-46272N|ensembl:ENSG00000067141(gene)|ensembl:ENST00000261908(transcript)|ensembl:ENST00000339362(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0098797"(plasma membrane protein complex)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033024|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1X5F|rcsb pdb:1X5G|rcsb pdb:1X5H|rcsb pdb:1X5I|rcsb pdb:1X5J|rcsb pdb:1X5K|rcsb pdb:3P4L|reactome:R-HSA-373752|reactome:R-HSA-525793	refseq:NP_001303696.1|refseq:NP_660320.3|refseq:NP_973733.1|refseq:NP_998817.1|refseq:NP_998818.1|refseq:XP_005272989.1|ensembl:ENSG00000168509(gene)|ensembl:ENST00000336751(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0036122"(BMP binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990712"(HFE-transferrin receptor complex)|interpro:IPR009496(Repulsive guidance molecule, C-terminal)|interpro:IPR010536(Repulsive guidance molecule, N-terminal)|interpro:IPR033606|interpro:IPR040287|rcsb pdb:4UI1|rcsb pdb:6Z3L|reactome:R-HSA-373752|dip:DIP-61608N	-	-	-	figure legend:Table 1;Figure 2A, B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.1x10^-7(molar)	2015/07/13	2016/08/10	rogid:qfhSmuj+gTFt2FkBaL/aUUWeKrY9606	rogid:/AJNZs236A0oBXK8DPnb6jpixgs9606	rigid:91Ub5GOY+zeyJ8kGo0JYE2U5aMg	false	sufficient binding region:952-1103,1-33(IPR003961)|his tag:c-c	his tag:c-c|mutation decreasing interaction strength:172-172|sufficient binding region:1-401	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12643	uniprotkb:Q92859	intact:EBI-1029262|ensembl:ENSP00000368104	intact:EBI-2829116|uniprotkb:B7ZKM9|uniprotkb:Q17RX1|uniprotkb:O00340|intact:EBI-28985104|uniprotkb:B7ZKN0|ensembl:ENSP00000261908|ensembl:ENSP00000341198	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:neo1_human(display_long)|uniprotkb:NEO1(gene name)|psi-mi:NEO1(display_short)|uniprotkb:IGDCC2(gene name synonym)|uniprotkb:NGN(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Yang et al. (2008)	pubmed:18335997|imex:IM-24352	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-10900876|imex:IM-24352-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N	refseq:NP_002490.2|refseq:NP_001166095.1|ensembl:ENSP00000261908|ensembl:ENSP00000341198|ensembl:ENST00000558964|ensembl:ENSP00000453200|ensembl:ENST00000560262|ensembl:ENSP00000453317|refseq:NP_001166094.1|dip:DIP-46272N|ensembl:ENSG00000067141(gene)|ensembl:ENST00000261908(transcript)|ensembl:ENST00000339362(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0098797"(plasma membrane protein complex)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033024|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1X5F|rcsb pdb:1X5G|rcsb pdb:1X5H|rcsb pdb:1X5I|rcsb pdb:1X5J|rcsb pdb:1X5K|rcsb pdb:3P4L|reactome:R-HSA-373752|reactome:R-HSA-525793|interpro:IPR003961(Fibronectin, type III)	-	-	-	figure legend:Figure 4|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.9x10^-5(molar)	2015/07/13	2016/08/10	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rogid:qfhSmuj+gTFt2FkBaL/aUUWeKrY9606	rigid:qsYa5a+UwfaBzo6O0zaZgbtfaG4	false	-	sufficient binding region:851-1103|his tag:c-c	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12643	uniprotkb:Q6ZVN8	intact:EBI-1029262|ensembl:ENSP00000368104	intact:EBI-10900704|uniprotkb:B1ALI7|uniprotkb:Q2PQ63|uniprotkb:Q6IMF6|uniprotkb:Q8NAH2|uniprotkb:Q8WVJ5|ensembl:ENSP00000337014	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:rgmc_human(display_long)|uniprotkb:HJV(gene name)|psi-mi:HJV(display_short)|uniprotkb:HFE2(gene name synonym)|uniprotkb:Hemochromatosis type 2 protein(gene name synonym)|uniprotkb:Hemojuvelin BMP coreceptor(gene name synonym)|uniprotkb:RGM domain family member C(gene name synonym)|uniprotkb:RGMC(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Yang et al. (2008)	pubmed:18335997|imex:IM-24352	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-10900876|imex:IM-24352-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N	refseq:NP_001303696.1|refseq:NP_660320.3|refseq:NP_973733.1|refseq:NP_998817.1|refseq:NP_998818.1|refseq:XP_005272989.1|ensembl:ENSG00000168509(gene)|ensembl:ENST00000336751(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0036122"(BMP binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990712"(HFE-transferrin receptor complex)|interpro:IPR009496(Repulsive guidance molecule, C-terminal)|interpro:IPR010536(Repulsive guidance molecule, N-terminal)|interpro:IPR033606|interpro:IPR040287|rcsb pdb:4UI1|rcsb pdb:6Z3L|reactome:R-HSA-373752|dip:DIP-61608N	-	-	-	figure legend:Figure 4|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.9x10^-5(molar)	2015/07/13	2016/08/10	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rogid:/AJNZs236A0oBXK8DPnb6jpixgs9606	rigid:qsYa5a+UwfaBzo6O0zaZgbtfaG4	false	-	his tag:c-c|sufficient binding region:1-401	1	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12643	uniprotkb:Q6ZVN8	intact:EBI-1029262|ensembl:ENSP00000368104	intact:EBI-10900704|uniprotkb:B1ALI7|uniprotkb:Q2PQ63|uniprotkb:Q6IMF6|uniprotkb:Q8NAH2|uniprotkb:Q8WVJ5|ensembl:ENSP00000337014	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:rgmc_human(display_long)|uniprotkb:HJV(gene name)|psi-mi:HJV(display_short)|uniprotkb:HFE2(gene name synonym)|uniprotkb:Hemochromatosis type 2 protein(gene name synonym)|uniprotkb:Hemojuvelin BMP coreceptor(gene name synonym)|uniprotkb:RGM domain family member C(gene name synonym)|uniprotkb:RGMC(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Yang et al. (2008)	pubmed:18335997|imex:IM-24352	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-12504328|imex:IM-24352-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N	refseq:NP_001303696.1|refseq:NP_660320.3|refseq:NP_973733.1|refseq:NP_998817.1|refseq:NP_998818.1|refseq:XP_005272989.1|ensembl:ENSG00000168509(gene)|ensembl:ENST00000336751(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0036122"(BMP binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990712"(HFE-transferrin receptor complex)|interpro:IPR009496(Repulsive guidance molecule, C-terminal)|interpro:IPR010536(Repulsive guidance molecule, N-terminal)|interpro:IPR033606|interpro:IPR040287|rcsb pdb:4UI1|rcsb pdb:6Z3L|reactome:R-HSA-373752|dip:DIP-61608N	-	-	-	figure legend:Figure 4A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.4x10^-7(molar)	2015/07/13	2016/08/15	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rogid:/AJNZs236A0oBXK8DPnb6jpixgs9606	rigid:bmK4ChaEpDbBh65hE8bleNrbDuU	false	-	his tag:c-c|sufficient binding region:1-401	1	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92859	uniprotkb:Q6ZVN8	intact:EBI-2829116|uniprotkb:B7ZKM9|uniprotkb:Q17RX1|uniprotkb:O00340|intact:EBI-28985104|uniprotkb:B7ZKN0|ensembl:ENSP00000261908|ensembl:ENSP00000341198	intact:EBI-10900704|uniprotkb:B1ALI7|uniprotkb:Q2PQ63|uniprotkb:Q6IMF6|uniprotkb:Q8NAH2|uniprotkb:Q8WVJ5|ensembl:ENSP00000337014	psi-mi:neo1_human(display_long)|uniprotkb:NEO1(gene name)|psi-mi:NEO1(display_short)|uniprotkb:IGDCC2(gene name synonym)|uniprotkb:NGN(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 2(gene name synonym)	psi-mi:rgmc_human(display_long)|uniprotkb:HJV(gene name)|psi-mi:HJV(display_short)|uniprotkb:HFE2(gene name synonym)|uniprotkb:Hemochromatosis type 2 protein(gene name synonym)|uniprotkb:Hemojuvelin BMP coreceptor(gene name synonym)|uniprotkb:RGM domain family member C(gene name synonym)|uniprotkb:RGMC(gene name synonym)	psi-mi:"MI:0096"(pull down)	Yang et al. (2008)	pubmed:18335997|imex:IM-24352	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-10900938|imex:IM-24352-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002490.2|refseq:NP_001166095.1|ensembl:ENSP00000261908|ensembl:ENSP00000341198|ensembl:ENST00000558964|ensembl:ENSP00000453200|ensembl:ENST00000560262|ensembl:ENSP00000453317|refseq:NP_001166094.1|dip:DIP-46272N|ensembl:ENSG00000067141(gene)|ensembl:ENST00000261908(transcript)|ensembl:ENST00000339362(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0098797"(plasma membrane protein complex)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033024|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1X5F|rcsb pdb:1X5G|rcsb pdb:1X5H|rcsb pdb:1X5I|rcsb pdb:1X5J|rcsb pdb:1X5K|rcsb pdb:3P4L|reactome:R-HSA-373752|reactome:R-HSA-525793	refseq:NP_001303696.1|refseq:NP_660320.3|refseq:NP_973733.1|refseq:NP_998817.1|refseq:NP_998818.1|refseq:XP_005272989.1|ensembl:ENSG00000168509(gene)|ensembl:ENST00000336751(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0036122"(BMP binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990712"(HFE-transferrin receptor complex)|interpro:IPR009496(Repulsive guidance molecule, C-terminal)|interpro:IPR010536(Repulsive guidance molecule, N-terminal)|interpro:IPR033606|interpro:IPR040287|rcsb pdb:4UI1|rcsb pdb:6Z3L|reactome:R-HSA-373752|dip:DIP-61608N	-	-	-	figure legend:Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/13	2016/08/10	rogid:qfhSmuj+gTFt2FkBaL/aUUWeKrY9606	rogid:/AJNZs236A0oBXK8DPnb6jpixgs9606	rigid:91Ub5GOY+zeyJ8kGo0JYE2U5aMg	false	sufficient binding region:836-1103(IPR003961)|his tag:c-c	his tag:c-c|sufficient binding region:1-401	1	1	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q92859	uniprotkb:Q6ZVN8	intact:EBI-2829116|uniprotkb:B7ZKM9|uniprotkb:Q17RX1|uniprotkb:O00340|intact:EBI-28985104|uniprotkb:B7ZKN0|ensembl:ENSP00000261908|ensembl:ENSP00000341198	intact:EBI-10900704|uniprotkb:B1ALI7|uniprotkb:Q2PQ63|uniprotkb:Q6IMF6|uniprotkb:Q8NAH2|uniprotkb:Q8WVJ5|ensembl:ENSP00000337014	psi-mi:neo1_human(display_long)|uniprotkb:NEO1(gene name)|psi-mi:NEO1(display_short)|uniprotkb:IGDCC2(gene name synonym)|uniprotkb:NGN(gene name synonym)|uniprotkb:Immunoglobulin superfamily DCC subclass member 2(gene name synonym)	psi-mi:rgmc_human(display_long)|uniprotkb:HJV(gene name)|psi-mi:HJV(display_short)|uniprotkb:HFE2(gene name synonym)|uniprotkb:Hemochromatosis type 2 protein(gene name synonym)|uniprotkb:Hemojuvelin BMP coreceptor(gene name synonym)|uniprotkb:RGM domain family member C(gene name synonym)|uniprotkb:RGMC(gene name synonym)	psi-mi:"MI:0104"(static light scattering)	Yang et al. (2008)	pubmed:18335997|imex:IM-24352	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-12504355|imex:IM-24352-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002490.2|refseq:NP_001166095.1|ensembl:ENSP00000261908|ensembl:ENSP00000341198|ensembl:ENST00000558964|ensembl:ENSP00000453200|ensembl:ENST00000560262|ensembl:ENSP00000453317|refseq:NP_001166094.1|dip:DIP-46272N|ensembl:ENSG00000067141(gene)|ensembl:ENST00000261908(transcript)|ensembl:ENST00000339362(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0098797"(plasma membrane protein complex)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033024|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1X5F|rcsb pdb:1X5G|rcsb pdb:1X5H|rcsb pdb:1X5I|rcsb pdb:1X5J|rcsb pdb:1X5K|rcsb pdb:3P4L|reactome:R-HSA-373752|reactome:R-HSA-525793	refseq:NP_001303696.1|refseq:NP_660320.3|refseq:NP_973733.1|refseq:NP_998817.1|refseq:NP_998818.1|refseq:XP_005272989.1|ensembl:ENSG00000168509(gene)|ensembl:ENST00000336751(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0036122"(BMP binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990712"(HFE-transferrin receptor complex)|interpro:IPR009496(Repulsive guidance molecule, C-terminal)|interpro:IPR010536(Repulsive guidance molecule, N-terminal)|interpro:IPR033606|interpro:IPR040287|rcsb pdb:4UI1|rcsb pdb:6Z3L|reactome:R-HSA-373752|dip:DIP-61608N	-	-	-	figure legend:Figure 3|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/13	2016/08/10	rogid:qfhSmuj+gTFt2FkBaL/aUUWeKrY9606	rogid:/AJNZs236A0oBXK8DPnb6jpixgs9606	rigid:91Ub5GOY+zeyJ8kGo0JYE2U5aMg	false	sufficient binding region:836-1103(IPR003961)|his tag:c-c	his tag:c-c|sufficient binding region:1-401	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)