#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99JB6	ensembl:ENSMUSG00000027720	intact:EBI-10956246|ensembl:ENSMUSP00000041953|ensembl:ENSMUSP00000111403|ensembl:ENSMUSP00000111404|ensembl:ENSMUSP00000111405|ensembl:ENSMUSP00000157059|ensembl:ENSMUSP00000157093	intact:EBI-10960725	psi-mi:foxp3_mouse(display_long)|uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|uniprotkb:Scurfin(gene name synonym)	uniprotkb:Il2(gene name)|psi-mi:Il2(display_short)|uniprotkb:Il-2(gene name synonym)|ensembl:il2_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000027720(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Tao et al. (2007)	pubmed:17922010|imex:IM-24499	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11174358|imex:IM-24499-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1|ensembl:ENSMUSG00000039521(gene)|ensembl:ENSMUST00000045566(transcript)|ensembl:ENSMUST00000115738(transcript)|ensembl:ENSMUST00000115739(transcript)|ensembl:ENSMUST00000115740(transcript)|ensembl:ENSMUST00000234363(transcript)|ensembl:ENSMUST00000235116(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0002507"(tolerance induction)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002851"(positive regulation of peripheral T cell tolerance induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0050672"(negative regulation of lymphocyte proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051525"(NFAT protein binding)|go:"GO:1901355"(response to rapamycin)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|rcsb pdb:4I1L|reactome:R-MMU-8877330|dip:DIP-59739N	refseq:NP_032392.1	-	-	-	figure legend:4 C/H|agonist:"CHEBI:46024 ; TSA-trichostatin A - an HDAC inhibitor"|causality statement:"CHEBI:46024  increases binding of Q99JB6  to ENSMUSG00000027720"|comment:mutation mapping has been entered using the sequence given in Figure 4D rather than from the main body of the text, hence the K383 mutation is entered as K382.|causality statement:Q99JB6 decreases expression  at the protein level of ENSMUSG00000027720|causality statement:"CHEBI:46024  increases expression at the protein level of  Q99JB6"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2015/07/28	2015/09/04	rogid:KLiC5dIVXIMGQNgXoh6xzv2ozqE10090	-	-	false	mutation disrupting interaction strength:382-382,393-393|mutation decreasing interaction strength:415-415	sufficient binding region:?-?	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)