#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P01042 uniprotkb:P03952-PRO_0000028021 intact:EBI-6378713|ensembl:ENSP00000493985|uniprotkb:C9JEX1|uniprotkb:A8K474|uniprotkb:B2RCR2|uniprotkb:P01043|uniprotkb:Q53EQ0|uniprotkb:Q6PAU9|uniprotkb:Q7M4P1 intact:EBI-10097117 psi-mi:kng1_human(display_long)|uniprotkb:KNG1(gene name)|psi-mi:KNG1(display_short)|uniprotkb:BDK(gene name synonym)|uniprotkb:KNG(gene name synonym)|uniprotkb:Alpha-2-thiol proteinase inhibitor(gene name synonym)|uniprotkb:Fitzgerald factor(gene name synonym)|uniprotkb:High molecular weight kininogen(gene name synonym)|uniprotkb:Williams-Fitzgerald-Flaujeac factor(gene name synonym) psi-mi:p03952-pro_0000028021(display_long)|uniprotkb:KLKB1(gene name)|psi-mi:KLKB1(display_short)|uniprotkb:KLK3(gene name synonym)|uniprotkb:Fletcher factor(gene name synonym)|uniprotkb:Kininogenin(gene name synonym)|uniprotkb:Plasma prekallikrein(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Katsuda et al. (2007) imex:IM-23808|pubmed:17598838 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-10087151|imex:IM-23808-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113889(gene)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENST00000644859(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042311"(vasodilation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR002395(HMW kininogen)|interpro:IPR018073|interpro:IPR027358|mint:P01042|rcsb pdb:1NY2|rcsb pdb:2WOK|rcsb pdb:4ASQ|rcsb pdb:4ASR|rcsb pdb:4ECB|rcsb pdb:4ECC|rcsb pdb:5I25|rcsb pdb:6F27|rcsb pdb:6F3V|rcsb pdb:6F3W|rcsb pdb:6F3X|rcsb pdb:6F3Y|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-375276|reactome:R-HSA-381426|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-8957275|go:"GO:0005615"(extracellular space)|refseq:NP_000884.1|refseq:NP_001095886.1|refseq:NP_001159923.1 intact:EBI-10087153(chain-parent) omim:612423(see-also) - chain-seq-start:20|chain-seq-end:390 figure legend:4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/01/19 2015/01/27 rogid:Z/DOKINto4Ygn9lYUu6nuHA3soM9606 rogid:Hm2He60x+dcwQcMAWybIyzS91yc9606 intact-crc:C7DBA931E0E99DCD|rigid:rC63V5VIcXg9p/gnSEM3XRFfn+w false - maltose binding protein tag:n-n|sufficient binding region:93-180(IPR000177)|mutation decreasing interaction:124-124 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody)