#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8WXA8 uniprotkb:P46098 intact:EBI-9008753|uniprotkb:A2RRR5|ensembl:ENSP00000322617 intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 psi-mi:5ht3c_human(display_long)|uniprotkb:HTR3C(gene name)|psi-mi:HTR3C(display_short)|uniprotkb:Serotonin receptor 3C(gene name synonym) psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11163575|imex:IM-24467-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_570126.2|ensembl:ENSG00000178084(gene)|ensembl:ENST00000318351(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 - - - figure legend:Fig. 2a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/08/13 2015/09/04 rogid:S47Alp7IjIezhKmpsBJ+uMFGfZI9606 rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 rigid:MvubfhFsGQHN0Ska0mczpi8GEtw false ha tag:n-n ha tag:n-n|myc tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q70Z44 uniprotkb:P46098 intact:EBI-9008717|uniprotkb:Q7Z6B3|uniprotkb:Q495N6|uniprotkb:Q495N5|uniprotkb:C9J2I6|uniprotkb:J3QT78|ensembl:ENSP00000371929 intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 psi-mi:5ht3d_human(display_long)|uniprotkb:HTR3D(gene name)|psi-mi:HTR3D(display_short)|uniprotkb:Serotonin receptor 3D(gene name synonym) psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11163666|imex:IM-24467-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016861343.1|refseq:NP_001138615.1|refseq:NP_001157118.1|refseq:NP_872343.2|ensembl:ENSG00000186090(gene)|ensembl:ENST00000382489(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 - - - figure legend:Fig. 2b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/08/13 2015/09/04 rogid:htnUSJx97WHW9PEuU1hky/uqDv89606 rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 rigid:/qjz0PCcZHhKWpl3JkQKWfjrInc false ha tag:n-n myc tag:n-n|ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:A5X5Y0-3 uniprotkb:P46098 intact:EBI-11163690|ensembl:ENSP00000335511 intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 psi-mi:a5x5y0-3(display_long)|uniprotkb:HTR3E(gene name)|psi-mi:HTR3E(display_short)|uniprotkb:Serotonin receptor 3E(gene name synonym) psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11163674|imex:IM-24467-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-9008732(isoform-parent)|ensembl:ENSG00000186038(gene)|ensembl:ENST00000335304(transcript) refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 - - - figure legend:Fig. 2c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/08/13 2015/09/04 rogid:pi/NJYjTOKFzDnNLuZdrDUAjxEM9606 rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 rigid:SMHVLfYpoSAzRTaNYME2PDV1czE false myc tag:n-n myc tag:n-n|ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:A5X5Y0-1 uniprotkb:P46098 intact:EBI-11174612|ensembl:ENSP00000401444 intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 psi-mi:a5x5y0-1(display_long)|uniprotkb:HTR3E(gene name)|psi-mi:HTR3E(display_short)|uniprotkb:Serotonin receptor 3E(gene name synonym) psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11163682|imex:IM-24467-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-9008732(isoform-parent)|ensembl:ENSG00000186038(gene)|ensembl:ENST00000415389(transcript) refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 - - - figure legend:Fig. 2d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/08/13 2015/09/04 rogid:Uo1iE7Z9pBKylCnwV2MqVKdG1Ho9606 rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 rigid:8pm1v+fb2pRCbuVuFGcxfGu2mdY false myc tag:n-n ha tag:n-n|myc tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8WXA8 uniprotkb:P46098 intact:EBI-9008753|uniprotkb:A2RRR5|ensembl:ENSP00000322617 intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 psi-mi:5ht3c_human(display_long)|uniprotkb:HTR3C(gene name)|psi-mi:HTR3C(display_short)|uniprotkb:Serotonin receptor 3C(gene name synonym) psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:"MI:0096"(pull down) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11167823|imex:IM-24467-18 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_570126.2|ensembl:ENSG00000178084(gene)|ensembl:ENST00000318351(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 - - - figure legend:Suppl. Fig. 4a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/08/13 2015/09/04 rogid:S47Alp7IjIezhKmpsBJ+uMFGfZI9606 rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 rigid:MvubfhFsGQHN0Ska0mczpi8GEtw false ha tag:n-n|35s radiolabel:?-? myc tag:n-n|35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q70Z44 uniprotkb:P46098 intact:EBI-9008717|uniprotkb:Q7Z6B3|uniprotkb:Q495N6|uniprotkb:Q495N5|uniprotkb:C9J2I6|uniprotkb:J3QT78|ensembl:ENSP00000371929 intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 psi-mi:5ht3d_human(display_long)|uniprotkb:HTR3D(gene name)|psi-mi:HTR3D(display_short)|uniprotkb:Serotonin receptor 3D(gene name synonym) psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:"MI:0096"(pull down) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11167834|imex:IM-24467-20 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016861343.1|refseq:NP_001138615.1|refseq:NP_001157118.1|refseq:NP_872343.2|ensembl:ENSG00000186090(gene)|ensembl:ENST00000382489(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 - - - figure legend:Suppl. Fig. 4b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/08/13 2015/09/04 rogid:htnUSJx97WHW9PEuU1hky/uqDv89606 rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 rigid:/qjz0PCcZHhKWpl3JkQKWfjrInc false ha tag:n-n|35s radiolabel:?-? myc tag:n-n|35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:A5X5Y0-1 uniprotkb:P46098 intact:EBI-11174612|ensembl:ENSP00000401444 intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 psi-mi:a5x5y0-1(display_long)|uniprotkb:HTR3E(gene name)|psi-mi:HTR3E(display_short)|uniprotkb:Serotonin receptor 3E(gene name synonym) psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:"MI:0096"(pull down) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11167844|imex:IM-24467-22 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-9008732(isoform-parent)|ensembl:ENSG00000186038(gene)|ensembl:ENST00000415389(transcript) refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 - - - figure legend:Suppl. Fig. 4c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/08/13 2015/09/04 rogid:Uo1iE7Z9pBKylCnwV2MqVKdG1Ho9606 rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 rigid:8pm1v+fb2pRCbuVuFGcxfGu2mdY false myc tag:n-n|35s radiolabel:?-? ha tag:n-n|35s radiolabel:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q8WXA8 uniprotkb:P46098 intact:EBI-9008753|uniprotkb:A2RRR5|ensembl:ENSP00000322617 intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 psi-mi:5ht3c_human(display_long)|uniprotkb:HTR3C(gene name)|psi-mi:HTR3C(display_short)|uniprotkb:Serotonin receptor 3C(gene name synonym) psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:"MI:0096"(pull down) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11174543|imex:IM-24467-24 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_570126.2|ensembl:ENSG00000178084(gene)|ensembl:ENST00000318351(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 - - - figure legend:Suppl. Fig. 4a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/08/13 2015/09/04 rogid:S47Alp7IjIezhKmpsBJ+uMFGfZI9606 rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 rigid:MvubfhFsGQHN0Ska0mczpi8GEtw false ha tag:n-n|35s radiolabel:?-? myc tag:n-n|35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q70Z44 uniprotkb:P46098 intact:EBI-9008717|uniprotkb:Q7Z6B3|uniprotkb:Q495N6|uniprotkb:Q495N5|uniprotkb:C9J2I6|uniprotkb:J3QT78|ensembl:ENSP00000371929 intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 psi-mi:5ht3d_human(display_long)|uniprotkb:HTR3D(gene name)|psi-mi:HTR3D(display_short)|uniprotkb:Serotonin receptor 3D(gene name synonym) psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:"MI:0096"(pull down) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11174561|imex:IM-24467-26 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016861343.1|refseq:NP_001138615.1|refseq:NP_001157118.1|refseq:NP_872343.2|ensembl:ENSG00000186090(gene)|ensembl:ENST00000382489(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 - - - figure legend:Suppl. Fig. 4b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/08/13 2015/09/04 rogid:htnUSJx97WHW9PEuU1hky/uqDv89606 rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 rigid:/qjz0PCcZHhKWpl3JkQKWfjrInc false ha tag:n-n|35s radiolabel:?-? myc tag:n-n|35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:A5X5Y0-1 uniprotkb:P46098 intact:EBI-11174612|ensembl:ENSP00000401444 intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 psi-mi:a5x5y0-1(display_long)|uniprotkb:HTR3E(gene name)|psi-mi:HTR3E(display_short)|uniprotkb:Serotonin receptor 3E(gene name synonym) psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:"MI:0096"(pull down) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11174579|imex:IM-24467-28 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-9008732(isoform-parent)|ensembl:ENSG00000186038(gene)|ensembl:ENST00000415389(transcript) refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 - - - figure legend:Suppl. Fig. 4c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/08/13 2015/09/04 rogid:Uo1iE7Z9pBKylCnwV2MqVKdG1Ho9606 rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 rigid:8pm1v+fb2pRCbuVuFGcxfGu2mdY false myc tag:n-n|35s radiolabel:?-? ha tag:n-n|35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q8WXA8 uniprotkb:P46098 intact:EBI-9008753|uniprotkb:A2RRR5|ensembl:ENSP00000322617 intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 psi-mi:5ht3c_human(display_long)|uniprotkb:HTR3C(gene name)|psi-mi:HTR3C(display_short)|uniprotkb:Serotonin receptor 3C(gene name synonym) psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-11167871|imex:IM-24467-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_570126.2|ensembl:ENSG00000178084(gene)|ensembl:ENST00000318351(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 - - - figure legend:Fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/08/13 2015/08/20 rogid:S47Alp7IjIezhKmpsBJ+uMFGfZI9606 rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 rigid:MvubfhFsGQHN0Ska0mczpi8GEtw false tag:n-n mutation disrupting interaction:178-178|tag:n-n - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0707"(anti tag immunostaining) uniprotkb:Q70Z44 uniprotkb:P46098 intact:EBI-9008717|uniprotkb:Q7Z6B3|uniprotkb:Q495N6|uniprotkb:Q495N5|uniprotkb:C9J2I6|uniprotkb:J3QT78|ensembl:ENSP00000371929 intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 psi-mi:5ht3d_human(display_long)|uniprotkb:HTR3D(gene name)|psi-mi:HTR3D(display_short)|uniprotkb:Serotonin receptor 3D(gene name synonym) psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-11167882|imex:IM-24467-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016861343.1|refseq:NP_001138615.1|refseq:NP_001157118.1|refseq:NP_872343.2|ensembl:ENSG00000186090(gene)|ensembl:ENST00000382489(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 - - - figure legend:Fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/08/13 2015/08/20 rogid:htnUSJx97WHW9PEuU1hky/uqDv89606 rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 rigid:/qjz0PCcZHhKWpl3JkQKWfjrInc false tag:n-n mutation disrupting interaction:178-178|tag:n-n - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0707"(anti tag immunostaining) uniprotkb:A5X5Y0-3 uniprotkb:P46098 intact:EBI-11163690|ensembl:ENSP00000335511 intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 psi-mi:a5x5y0-3(display_long)|uniprotkb:HTR3E(gene name)|psi-mi:HTR3E(display_short)|uniprotkb:Serotonin receptor 3E(gene name synonym) psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-11167892|imex:IM-24467-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-9008732(isoform-parent)|ensembl:ENSG00000186038(gene)|ensembl:ENST00000335304(transcript) refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 - - - figure legend:Fig. 1, Suppl. Fig. 5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/08/13 2015/08/20 rogid:pi/NJYjTOKFzDnNLuZdrDUAjxEM9606 rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 rigid:SMHVLfYpoSAzRTaNYME2PDV1czE false tag:n-n tag:n-n - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0707"(anti tag immunostaining) uniprotkb:A5X5Y0-1 uniprotkb:P46098 intact:EBI-11174612|ensembl:ENSP00000401444 intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 psi-mi:a5x5y0-1(display_long)|uniprotkb:HTR3E(gene name)|psi-mi:HTR3E(display_short)|uniprotkb:Serotonin receptor 3E(gene name synonym) psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-11167901|imex:IM-24467-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-9008732(isoform-parent)|ensembl:ENSG00000186038(gene)|ensembl:ENST00000415389(transcript) refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 - - - figure legend:Fig. 1, Suppl. Fig. 5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/08/13 2015/09/04 rogid:Uo1iE7Z9pBKylCnwV2MqVKdG1Ho9606 rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 rigid:8pm1v+fb2pRCbuVuFGcxfGu2mdY false tag:n-n tag:n-n - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0707"(anti tag immunostaining) uniprotkb:O95264 uniprotkb:P46098 intact:EBI-9008726|uniprotkb:B0YJ23|uniprotkb:Q0VJC3|ensembl:ENSP00000260191 intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 psi-mi:5ht3b_human(display_long)|uniprotkb:HTR3B(gene name)|psi-mi:HTR3B(display_short)|uniprotkb:Serotonin receptor 3B(gene name synonym) psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-11167909|imex:IM-24467-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011541365.1|refseq:NP_006019.1|ensembl:ENSG00000149305(gene)|ensembl:ENST00000260191(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0009986"(cell surface)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008134(5-hydroxytryptamine 3 receptor, B subunit)|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 - - - figure legend:Suppl. Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/08/13 2015/08/20 rogid:jtLQsB+qo6/8wmr0udigU7iuIeM9606 rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 rigid:7XqKcjoS4Xuwf/OrUeVR6xY/Yo0 false myc tag:n-n ha tag:n-n - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0707"(anti tag immunostaining) chebi:"CHEBI:87784" uniprotkb:P46098 intact:EBI-11167954 intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 psi-mi:gr65630(display_short)|psi-mi:"CHEBI:87784"(display_long) psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:"MI:0440"(saturation binding) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11167943|imex:IM-24467-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:1100"(bioactive entity) psi-mi:"MI:0326"(protein) pubmed:17392525(see-also) refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 - - - figure legend:Fig. 4, T1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) kd:0.39x10^-9(molar) 2015/08/13 2015/08/20 - rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 - false 3h radiolabel:?-? - - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P46098 uniprotkb:Q8WXA8 intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 intact:EBI-9008753|uniprotkb:A2RRR5|ensembl:ENSP00000322617 psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:5ht3c_human(display_long)|uniprotkb:HTR3C(gene name)|psi-mi:HTR3C(display_short)|uniprotkb:Serotonin receptor 3C(gene name synonym) psi-mi:"MI:0440"(saturation binding) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11167958|imex:IM-24467-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 refseq:NP_570126.2|ensembl:ENSG00000178084(gene)|ensembl:ENST00000318351(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 - - - figure legend:Fig. 4, T1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) kd:0.29x10^-9(molar) 2015/08/13 2015/08/20 rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 rogid:S47Alp7IjIezhKmpsBJ+uMFGfZI9606 - false - - - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P46098 chebi:"CHEBI:87784" intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 intact:EBI-11167954 psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:gr65630(display_short)|psi-mi:"CHEBI:87784"(display_long) psi-mi:"MI:0440"(saturation binding) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11167958|imex:IM-24467-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:1100"(bioactive entity) refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 pubmed:17392525(see-also) - - - figure legend:Fig. 4, T1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) kd:0.29x10^-9(molar) 2015/08/13 2015/08/20 rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 - - false - 3h radiolabel:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P46098 uniprotkb:Q70Z44 intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 intact:EBI-9008717|uniprotkb:Q7Z6B3|uniprotkb:Q495N6|uniprotkb:Q495N5|uniprotkb:C9J2I6|uniprotkb:J3QT78|ensembl:ENSP00000371929 psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:5ht3d_human(display_long)|uniprotkb:HTR3D(gene name)|psi-mi:HTR3D(display_short)|uniprotkb:Serotonin receptor 3D(gene name synonym) psi-mi:"MI:0440"(saturation binding) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11167964|imex:IM-24467-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 refseq:XP_016861343.1|refseq:NP_001138615.1|refseq:NP_001157118.1|refseq:NP_872343.2|ensembl:ENSG00000186090(gene)|ensembl:ENST00000382489(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050877"(nervous system process)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 - - - figure legend:Fig. 4, T1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) kd:0.29x10^-9(molar) 2015/08/13 2015/08/20 rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 rogid:htnUSJx97WHW9PEuU1hky/uqDv89606 - false - - - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P46098 chebi:"CHEBI:87784" intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 intact:EBI-11167954 psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:gr65630(display_short)|psi-mi:"CHEBI:87784"(display_long) psi-mi:"MI:0440"(saturation binding) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11167964|imex:IM-24467-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:1100"(bioactive entity) refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 pubmed:17392525(see-also) - - - figure legend:Fig. 4, T1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) kd:0.29x10^-9(molar) 2015/08/13 2015/08/20 rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 - - false - 3h radiolabel:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P46098 uniprotkb:A5X5Y0-3 intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 intact:EBI-11163690|ensembl:ENSP00000335511 psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:a5x5y0-3(display_long)|uniprotkb:HTR3E(gene name)|psi-mi:HTR3E(display_short)|uniprotkb:Serotonin receptor 3E(gene name synonym) psi-mi:"MI:0440"(saturation binding) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11167970|imex:IM-24467-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 intact:EBI-9008732(isoform-parent)|ensembl:ENSG00000186038(gene)|ensembl:ENST00000335304(transcript) - - - figure legend:Fig. 4, T1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) kd:0.29x10^-9(molar) 2015/08/13 2015/08/20 rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 rogid:pi/NJYjTOKFzDnNLuZdrDUAjxEM9606 - false - - - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P46098 chebi:"CHEBI:87784" intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 intact:EBI-11167954 psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:gr65630(display_short)|psi-mi:"CHEBI:87784"(display_long) psi-mi:"MI:0440"(saturation binding) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11167970|imex:IM-24467-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:1100"(bioactive entity) refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 pubmed:17392525(see-also) - - - figure legend:Fig. 4, T1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) kd:0.29x10^-9(molar) 2015/08/13 2015/08/20 rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 - - false - 3h radiolabel:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P46098 uniprotkb:A5X5Y0-1 intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 intact:EBI-11174612|ensembl:ENSP00000401444 psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:a5x5y0-1(display_long)|uniprotkb:HTR3E(gene name)|psi-mi:HTR3E(display_short)|uniprotkb:Serotonin receptor 3E(gene name synonym) psi-mi:"MI:0440"(saturation binding) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11167976|imex:IM-24467-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 intact:EBI-9008732(isoform-parent)|ensembl:ENSG00000186038(gene)|ensembl:ENST00000415389(transcript) - - - figure legend:Fig. 4, T1|comment:Kd for HT3A was 0.30 nM when tested against HT3Ea.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) kd:0.35x10^-9(molar) 2015/08/13 2015/09/04 rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 rogid:Uo1iE7Z9pBKylCnwV2MqVKdG1Ho9606 - false - - - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P46098 chebi:"CHEBI:87784" intact:EBI-9008743|uniprotkb:O60854|uniprotkb:Q7KZM7|uniprotkb:Q99918|uniprotkb:Q9BSZ9|uniprotkb:B4DSY6|uniprotkb:G5E986|ensembl:ENSP00000424189 intact:EBI-11167954 psi-mi:5ht3a_human(display_long)|uniprotkb:HTR3A(gene name)|psi-mi:HTR3A(display_short)|uniprotkb:5-hydroxytryptamine receptor 3(gene name synonym)|uniprotkb:5HT3R(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Serotonin receptor 3A(gene name synonym)|uniprotkb:Serotonin-gated ion channel receptor(gene name synonym) psi-mi:gr65630(display_short)|psi-mi:"CHEBI:87784"(display_long) psi-mi:"MI:0440"(saturation binding) Niesler et al. (2007) pubmed:17392525|imex:IM-24467 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-11167976|imex:IM-24467-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:1100"(bioactive entity) refseq:NP_001155244.1|refseq:NP_998786.2|refseq:NP_000860.2|ensembl:ENSG00000166736(gene)|ensembl:ENST00000504030(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0022850"(serotonin-gated cation-selective channel activity)|go:"GO:0030424"(axon)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032414"(positive regulation of ion transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042220"(response to cocaine)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0050877"(nervous system process)|go:"GO:0051378"(serotonin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904602"(serotonin-activated cation-selective channel complex)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|interpro:IPR008132(5-hydroxytryptamine 3 receptor)|interpro:IPR008133(5-hydroxytryptamine 3 receptor, A subunit)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-112314 pubmed:17392525(see-also) - - - figure legend:Fig. 4, T1|comment:Kd for HT3A was 0.30 nM when tested against HT3Ea.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) kd:0.35x10^-9(molar) 2015/08/13 2015/09/04 rogid:SqoCjKrZZe5otDgS5KIY1QjUoF89606 - - false - 3h radiolabel:?-? - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation)