#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q03347 ensembl:ENSMUSG00000027720 intact:EBI-3863873|uniprotkb:O08598|uniprotkb:Q62049|uniprotkb:Q9ESB9|uniprotkb:Q9ET65 intact:EBI-10960725 psi-mi:runx1_mouse(display_long)|uniprotkb:Runx1(gene name)|psi-mi:Runx1(display_short)|uniprotkb:Aml1(gene name synonym)|uniprotkb:Cbfa2(gene name synonym)|uniprotkb:Pebp2ab(gene name synonym)|uniprotkb:Acute myeloid leukemia 1 protein(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-2(gene name synonym)|uniprotkb:Oncogene AML-1(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha B subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha B subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha B subunit(gene name synonym) uniprotkb:Il2(gene name)|psi-mi:Il2(display_short)|uniprotkb:Il-2(gene name synonym)|ensembl:il2_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000027720(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Ono et al. (2007) imex:IM-21202|pubmed:17377532 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-11294332|imex:IM-21202-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048666"(neuron development)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0071336"(regulation of hair follicle cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903431"(positive regulation of cell maturation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000872"(positive regulation of progesterone secretion)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|interpro:IPR027384|rcsb pdb:1EAN|rcsb pdb:1EAO|rcsb pdb:1EAQ|rcsb pdb:1HJB|rcsb pdb:1HJC|rcsb pdb:1IO4|rcsb pdb:2J6W|rcsb pdb:3WTS|rcsb pdb:3WTT|rcsb pdb:3WTU|rcsb pdb:3WTV|rcsb pdb:3WTW|rcsb pdb:3WTX|rcsb pdb:3WTY|rcsb pdb:3WU1|rcsb pdb:4L0Y|rcsb pdb:4L0Z|rcsb pdb:4L18|dip:DIP-40723N|reactome:R-MMU-549127|reactome:R-MMU-8877330|reactome:R-MMU-8931987|reactome:R-MMU-8934593|reactome:R-MMU-8936459|reactome:R-MMU-8939236|reactome:R-MMU-8939243|reactome:R-MMU-8939245|reactome:R-MMU-8939246|reactome:R-MMU-8939247|reactome:R-MMU-9018519 refseq:NP_032392.1 - - - figure legend:1B|causality statement:Q03347 increases the expression at protein level of ENSMUSG00000027720|comment:"The construct \"AML1A\" decreased the expression of IL2."|causality statement:Q99JB6 reduces the expression at protein level of ENSMUSG00000027720|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2015/08/12 2017/06/30 rogid:1rh6vkqvcnroruSaiTl+xBjDpms10090 - intact-crc:68B3C143DAE6F44E false - sufficient binding region:?-? - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q99JB6 ensembl:ENSMUSG00000027720 intact:EBI-10956246|ensembl:ENSMUSP00000041953|ensembl:ENSMUSP00000111403|ensembl:ENSMUSP00000111404|ensembl:ENSMUSP00000111405|ensembl:ENSMUSP00000157059|ensembl:ENSMUSP00000157093 intact:EBI-10960725 psi-mi:foxp3_mouse(display_long)|uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|uniprotkb:Scurfin(gene name synonym) uniprotkb:Il2(gene name)|psi-mi:Il2(display_short)|uniprotkb:Il-2(gene name synonym)|ensembl:il2_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000027720(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Ono et al. (2007) imex:IM-21202|pubmed:17377532 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-11294865|imex:IM-21202-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1|ensembl:ENSMUSG00000039521(gene)|ensembl:ENSMUST00000045566(transcript)|ensembl:ENSMUST00000115738(transcript)|ensembl:ENSMUST00000115739(transcript)|ensembl:ENSMUST00000115740(transcript)|ensembl:ENSMUST00000234363(transcript)|ensembl:ENSMUST00000235116(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0002507"(tolerance induction)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002851"(positive regulation of peripheral T cell tolerance induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0050672"(negative regulation of lymphocyte proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051525"(NFAT protein binding)|go:"GO:1901355"(response to rapamycin)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|rcsb pdb:4I1L|reactome:R-MMU-8877330|dip:DIP-59739N refseq:NP_032392.1 - - - figure legend:Supp 4|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2015/08/12 2017/06/30 rogid:KLiC5dIVXIMGQNgXoh6xzv2ozqE10090 - intact-crc:73AB799470A2F350 false - sufficient binding region:?-? - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q03347 ensembl:ENSMUSG00000026770 intact:EBI-3863873|uniprotkb:O08598|uniprotkb:Q62049|uniprotkb:Q9ESB9|uniprotkb:Q9ET65 intact:EBI-5259554 psi-mi:runx1_mouse(display_long)|uniprotkb:Runx1(gene name)|psi-mi:Runx1(display_short)|uniprotkb:Aml1(gene name synonym)|uniprotkb:Cbfa2(gene name synonym)|uniprotkb:Pebp2ab(gene name synonym)|uniprotkb:Acute myeloid leukemia 1 protein(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-2(gene name synonym)|uniprotkb:Oncogene AML-1(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha B subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha B subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha B subunit(gene name synonym) psi-mi:il2ra_mouse_gene(display_short)|psi-mi:ENSMUSG00000026770(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Ono et al. (2007) imex:IM-21202|pubmed:17377532 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-11295465|imex:IM-21202-16 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048666"(neuron development)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0071336"(regulation of hair follicle cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903431"(positive regulation of cell maturation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000872"(positive regulation of progesterone secretion)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|interpro:IPR027384|rcsb pdb:1EAN|rcsb pdb:1EAO|rcsb pdb:1EAQ|rcsb pdb:1HJB|rcsb pdb:1HJC|rcsb pdb:1IO4|rcsb pdb:2J6W|rcsb pdb:3WTS|rcsb pdb:3WTT|rcsb pdb:3WTU|rcsb pdb:3WTV|rcsb pdb:3WTW|rcsb pdb:3WTX|rcsb pdb:3WTY|rcsb pdb:3WU1|rcsb pdb:4L0Y|rcsb pdb:4L0Z|rcsb pdb:4L18|dip:DIP-40723N|reactome:R-MMU-549127|reactome:R-MMU-8877330|reactome:R-MMU-8931987|reactome:R-MMU-8934593|reactome:R-MMU-8936459|reactome:R-MMU-8939236|reactome:R-MMU-8939243|reactome:R-MMU-8939245|reactome:R-MMU-8939246|reactome:R-MMU-8939247|reactome:R-MMU-9018519 - - - - figure legend:Supp Fig 8|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2015/08/12 2017/06/30 rogid:1rh6vkqvcnroruSaiTl+xBjDpms10090 - intact-crc:34295E772D71411D false - sufficient binding region:?-? - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q03347 ensembl:ENSMUSG00000026011 intact:EBI-3863873|uniprotkb:O08598|uniprotkb:Q62049|uniprotkb:Q9ESB9|uniprotkb:Q9ET65 intact:EBI-10960795 psi-mi:runx1_mouse(display_long)|uniprotkb:Runx1(gene name)|psi-mi:Runx1(display_short)|uniprotkb:Aml1(gene name synonym)|uniprotkb:Cbfa2(gene name synonym)|uniprotkb:Pebp2ab(gene name synonym)|uniprotkb:Acute myeloid leukemia 1 protein(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-2(gene name synonym)|uniprotkb:Oncogene AML-1(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha B subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha B subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha B subunit(gene name synonym) uniprotkb:Ctla4(gene name)|psi-mi:Ctla4(display_short)|ensembl:ctla4_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000026011(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Ono et al. (2007) imex:IM-21202|pubmed:17377532 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-11295477|imex:IM-21202-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048666"(neuron development)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0071336"(regulation of hair follicle cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903431"(positive regulation of cell maturation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000872"(positive regulation of progesterone secretion)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|interpro:IPR027384|rcsb pdb:1EAN|rcsb pdb:1EAO|rcsb pdb:1EAQ|rcsb pdb:1HJB|rcsb pdb:1HJC|rcsb pdb:1IO4|rcsb pdb:2J6W|rcsb pdb:3WTS|rcsb pdb:3WTT|rcsb pdb:3WTU|rcsb pdb:3WTV|rcsb pdb:3WTW|rcsb pdb:3WTX|rcsb pdb:3WTY|rcsb pdb:3WU1|rcsb pdb:4L0Y|rcsb pdb:4L0Z|rcsb pdb:4L18|dip:DIP-40723N|reactome:R-MMU-549127|reactome:R-MMU-8877330|reactome:R-MMU-8931987|reactome:R-MMU-8934593|reactome:R-MMU-8936459|reactome:R-MMU-8939236|reactome:R-MMU-8939243|reactome:R-MMU-8939245|reactome:R-MMU-8939246|reactome:R-MMU-8939247|reactome:R-MMU-9018519 uniprotkb:Q6GTR6(see-also)|uniprotkb:P09793(see-also)|refseq:NP_033973.2 - - - figure legend:Supp Fig 8-1|causality statement:Q99JB6 increases the expression at protein level of ENSMUSG00000026011|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2015/08/12 2017/06/30 rogid:1rh6vkqvcnroruSaiTl+xBjDpms10090 - intact-crc:CC54749DE3AFC541 false - sufficient binding region:?-? - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q03347 ensembl:ENSMUSG00000041954 intact:EBI-3863873|uniprotkb:O08598|uniprotkb:Q62049|uniprotkb:Q9ESB9|uniprotkb:Q9ET65 intact:EBI-11295505 psi-mi:runx1_mouse(display_long)|uniprotkb:Runx1(gene name)|psi-mi:Runx1(display_short)|uniprotkb:Aml1(gene name synonym)|uniprotkb:Cbfa2(gene name synonym)|uniprotkb:Pebp2ab(gene name synonym)|uniprotkb:Acute myeloid leukemia 1 protein(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-2(gene name synonym)|uniprotkb:Oncogene AML-1(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha B subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha B subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha B subunit(gene name synonym) uniprotkb:Tnfrsf18(gene name)|psi-mi:Tnfrsf18(display_short)|uniprotkb:Gitr(gene name synonym)|ensembl:tnr18_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000041954(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Ono et al. (2007) imex:IM-21202|pubmed:17377532 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-11295494|imex:IM-21202-18 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048666"(neuron development)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0071336"(regulation of hair follicle cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903431"(positive regulation of cell maturation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000872"(positive regulation of progesterone secretion)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|interpro:IPR027384|rcsb pdb:1EAN|rcsb pdb:1EAO|rcsb pdb:1EAQ|rcsb pdb:1HJB|rcsb pdb:1HJC|rcsb pdb:1IO4|rcsb pdb:2J6W|rcsb pdb:3WTS|rcsb pdb:3WTT|rcsb pdb:3WTU|rcsb pdb:3WTV|rcsb pdb:3WTW|rcsb pdb:3WTX|rcsb pdb:3WTY|rcsb pdb:3WU1|rcsb pdb:4L0Y|rcsb pdb:4L0Z|rcsb pdb:4L18|dip:DIP-40723N|reactome:R-MMU-549127|reactome:R-MMU-8877330|reactome:R-MMU-8931987|reactome:R-MMU-8934593|reactome:R-MMU-8936459|reactome:R-MMU-8939236|reactome:R-MMU-8939243|reactome:R-MMU-8939245|reactome:R-MMU-8939246|reactome:R-MMU-8939247|reactome:R-MMU-9018519 refseq:NP_033426.1|refseq:NP_068820.1 - - - figure legend:Supp Fig 8-2|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2015/08/12 2017/06/30 rogid:1rh6vkqvcnroruSaiTl+xBjDpms10090 - intact-crc:74480EFA0365634D false - sufficient binding region:?-?|sufficient binding region:?-? - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q99JB6 ensembl:ENSMUSG00000041954 intact:EBI-10956246|ensembl:ENSMUSP00000041953|ensembl:ENSMUSP00000111403|ensembl:ENSMUSP00000111404|ensembl:ENSMUSP00000111405|ensembl:ENSMUSP00000157059|ensembl:ENSMUSP00000157093 intact:EBI-11295505 psi-mi:foxp3_mouse(display_long)|uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|uniprotkb:Scurfin(gene name synonym) uniprotkb:Tnfrsf18(gene name)|psi-mi:Tnfrsf18(display_short)|uniprotkb:Gitr(gene name synonym)|ensembl:tnr18_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000041954(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Ono et al. (2007) imex:IM-21202|pubmed:17377532 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-11295521|imex:IM-21202-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1|ensembl:ENSMUSG00000039521(gene)|ensembl:ENSMUST00000045566(transcript)|ensembl:ENSMUST00000115738(transcript)|ensembl:ENSMUST00000115739(transcript)|ensembl:ENSMUST00000115740(transcript)|ensembl:ENSMUST00000234363(transcript)|ensembl:ENSMUST00000235116(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0002507"(tolerance induction)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002851"(positive regulation of peripheral T cell tolerance induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0050672"(negative regulation of lymphocyte proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051525"(NFAT protein binding)|go:"GO:1901355"(response to rapamycin)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|rcsb pdb:4I1L|reactome:R-MMU-8877330|dip:DIP-59739N refseq:NP_033426.1|refseq:NP_068820.1 - - - figure legend:Supp Fig 9|causality statement:Q99JB6 increases the expression at protein level of ENSMUSG00000041954|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2015/08/12 2017/06/30 rogid:KLiC5dIVXIMGQNgXoh6xzv2ozqE10090 - intact-crc:0CDB7C48E119FF85 false - sufficient binding region:?-? - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q99JB6 ensembl:ENSMUSG00000026770 intact:EBI-10956246|ensembl:ENSMUSP00000041953|ensembl:ENSMUSP00000111403|ensembl:ENSMUSP00000111404|ensembl:ENSMUSP00000111405|ensembl:ENSMUSP00000157059|ensembl:ENSMUSP00000157093 intact:EBI-5259554 psi-mi:foxp3_mouse(display_long)|uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|uniprotkb:Scurfin(gene name synonym) psi-mi:il2ra_mouse_gene(display_short)|psi-mi:ENSMUSG00000026770(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Ono et al. (2007) imex:IM-21202|pubmed:17377532 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-11295530|imex:IM-21202-20 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1|ensembl:ENSMUSG00000039521(gene)|ensembl:ENSMUST00000045566(transcript)|ensembl:ENSMUST00000115738(transcript)|ensembl:ENSMUST00000115739(transcript)|ensembl:ENSMUST00000115740(transcript)|ensembl:ENSMUST00000234363(transcript)|ensembl:ENSMUST00000235116(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0002507"(tolerance induction)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002851"(positive regulation of peripheral T cell tolerance induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0050672"(negative regulation of lymphocyte proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051525"(NFAT protein binding)|go:"GO:1901355"(response to rapamycin)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|rcsb pdb:4I1L|reactome:R-MMU-8877330|dip:DIP-59739N - - - - figure legend:Supp Fig 9|causality statement:Q99JB6 increases the expression at protein level of ENSMUSG00000026770|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2015/08/12 2017/06/30 rogid:KLiC5dIVXIMGQNgXoh6xzv2ozqE10090 - intact-crc:30414AC09470E172 false - sufficient binding region:?-? - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q03347 ensembl:ENSMUSG00000055170 intact:EBI-3863873|uniprotkb:O08598|uniprotkb:Q62049|uniprotkb:Q9ESB9|uniprotkb:Q9ET65 intact:EBI-11174470 psi-mi:runx1_mouse(display_long)|uniprotkb:Runx1(gene name)|psi-mi:Runx1(display_short)|uniprotkb:Aml1(gene name synonym)|uniprotkb:Cbfa2(gene name synonym)|uniprotkb:Pebp2ab(gene name synonym)|uniprotkb:Acute myeloid leukemia 1 protein(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-2(gene name synonym)|uniprotkb:Oncogene AML-1(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha B subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha B subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha B subunit(gene name synonym) uniprotkb:Ifng(gene name)|psi-mi:Ifng(display_short)|ensembl:ifng_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000055170(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Ono et al. (2007) imex:IM-21202|pubmed:17377532 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-11295549|imex:IM-21202-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048666"(neuron development)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0071336"(regulation of hair follicle cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903431"(positive regulation of cell maturation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000872"(positive regulation of progesterone secretion)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|interpro:IPR027384|rcsb pdb:1EAN|rcsb pdb:1EAO|rcsb pdb:1EAQ|rcsb pdb:1HJB|rcsb pdb:1HJC|rcsb pdb:1IO4|rcsb pdb:2J6W|rcsb pdb:3WTS|rcsb pdb:3WTT|rcsb pdb:3WTU|rcsb pdb:3WTV|rcsb pdb:3WTW|rcsb pdb:3WTX|rcsb pdb:3WTY|rcsb pdb:3WU1|rcsb pdb:4L0Y|rcsb pdb:4L0Z|rcsb pdb:4L18|dip:DIP-40723N|reactome:R-MMU-549127|reactome:R-MMU-8877330|reactome:R-MMU-8931987|reactome:R-MMU-8934593|reactome:R-MMU-8936459|reactome:R-MMU-8939236|reactome:R-MMU-8939243|reactome:R-MMU-8939245|reactome:R-MMU-8939246|reactome:R-MMU-8939247|reactome:R-MMU-9018519 refseq:NP_032363.1 - - - figure legend:Supp Fig 11D|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2015/08/12 2017/06/30 rogid:1rh6vkqvcnroruSaiTl+xBjDpms10090 - intact-crc:FB13A2D83404B971 false - sufficient binding region:?-? - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q01196 ensembl:ENSG00000109471 intact:EBI-925904|uniprotkb:O60472|uniprotkb:O60473|uniprotkb:O76047|uniprotkb:O76089|uniprotkb:Q13081|uniprotkb:Q13755|uniprotkb:Q13756|uniprotkb:Q13757|uniprotkb:Q13758|uniprotkb:Q13759|uniprotkb:Q15341|uniprotkb:Q15343|uniprotkb:Q16122|uniprotkb:Q16284|uniprotkb:Q16285|uniprotkb:Q16286|uniprotkb:Q16346|uniprotkb:Q16347|uniprotkb:Q92479|uniprotkb:A8MV94|uniprotkb:B2RMS4|uniprotkb:D3DSG1|ensembl:ENSP00000340690 intact:EBI-1566859 psi-mi:runx1_human(display_long)|uniprotkb:RUNX1(gene name)|psi-mi:RUNX1(display_short)|uniprotkb:AML1(gene name synonym)|uniprotkb:CBFA2(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-2(gene name synonym)|uniprotkb:Acute myeloid leukemia 1 protein(gene name synonym)|uniprotkb:Oncogene AML-1(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha B subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha B subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha B subunit(gene name synonym) uniprotkb:IL2(gene name)|psi-mi:IL2(display_short)|ensembl:il2_human_gene(shortlabel)|psi-mi:ENSG00000109471(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Ono et al. (2007) imex:IM-21202|pubmed:17377532 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-11294346|imex:IM-21202-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:XP_011528068.1|refseq:NP_001001890.1|refseq:NP_001116079.1|refseq:NP_001745.2|refseq:XP_005261125.1|dip:DIP-36773N|ensembl:ENSG00000159216(gene)|ensembl:ENST00000344691(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010755"(regulation of plasminogen activation)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903055"(positive regulation of extracellular matrix organization)|go:"GO:1905203"(regulation of connective tissue replacement)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|interpro:IPR027384|mint:Q01196|rcsb pdb:1CMO|rcsb pdb:1CO1|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:1LJM|reactome:R-HSA-1912408|reactome:R-HSA-549127|reactome:R-HSA-8877330|reactome:R-HSA-8931987|reactome:R-HSA-8934593|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8941333|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222 refseq:NP_000577.2 - - - figure legend:1B|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2015/08/12 2017/06/30 rogid:8RknoK1Z7L/Ck94Nd1b9/k03C8k9606 - intact-crc:869EB6D66F27C34E false - sufficient binding region:?-? - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q01196 ensembl:ENSG00000111537 intact:EBI-925904|uniprotkb:O60472|uniprotkb:O60473|uniprotkb:O76047|uniprotkb:O76089|uniprotkb:Q13081|uniprotkb:Q13755|uniprotkb:Q13756|uniprotkb:Q13757|uniprotkb:Q13758|uniprotkb:Q13759|uniprotkb:Q15341|uniprotkb:Q15343|uniprotkb:Q16122|uniprotkb:Q16284|uniprotkb:Q16285|uniprotkb:Q16286|uniprotkb:Q16346|uniprotkb:Q16347|uniprotkb:Q92479|uniprotkb:A8MV94|uniprotkb:B2RMS4|uniprotkb:D3DSG1|ensembl:ENSP00000340690 intact:EBI-11174645 psi-mi:runx1_human(display_long)|uniprotkb:RUNX1(gene name)|psi-mi:RUNX1(display_short)|uniprotkb:AML1(gene name synonym)|uniprotkb:CBFA2(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-2(gene name synonym)|uniprotkb:Acute myeloid leukemia 1 protein(gene name synonym)|uniprotkb:Oncogene AML-1(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha B subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha B subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha B subunit(gene name synonym) uniprotkb:IFNG(gene name)|psi-mi:IFNG(display_short)|ensembl:ifng_human_gene(shortlabel)|psi-mi:ENSG00000111537(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Ono et al. (2007) imex:IM-21202|pubmed:17377532 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-11295557|imex:IM-21202-22 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:XP_011528068.1|refseq:NP_001001890.1|refseq:NP_001116079.1|refseq:NP_001745.2|refseq:XP_005261125.1|dip:DIP-36773N|ensembl:ENSG00000159216(gene)|ensembl:ENST00000344691(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010755"(regulation of plasminogen activation)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903055"(positive regulation of extracellular matrix organization)|go:"GO:1905203"(regulation of connective tissue replacement)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|interpro:IPR027384|mint:Q01196|rcsb pdb:1CMO|rcsb pdb:1CO1|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:1LJM|reactome:R-HSA-1912408|reactome:R-HSA-549127|reactome:R-HSA-8877330|reactome:R-HSA-8931987|reactome:R-HSA-8934593|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8941333|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222 refseq:NP_000610.2 - - - figure legend:Supp 11D|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2015/08/12 2017/06/30 rogid:8RknoK1Z7L/Ck94Nd1b9/k03C8k9606 - intact-crc:2F447569815F7A5A false - sufficient binding region:?-? - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) intact:EBI-11294374 uniprotkb:Q01196 - intact:EBI-925904|uniprotkb:O60472|uniprotkb:O60473|uniprotkb:O76047|uniprotkb:O76089|uniprotkb:Q13081|uniprotkb:Q13755|uniprotkb:Q13756|uniprotkb:Q13757|uniprotkb:Q13758|uniprotkb:Q13759|uniprotkb:Q15341|uniprotkb:Q15343|uniprotkb:Q16122|uniprotkb:Q16284|uniprotkb:Q16285|uniprotkb:Q16286|uniprotkb:Q16346|uniprotkb:Q16347|uniprotkb:Q92479|uniprotkb:A8MV94|uniprotkb:B2RMS4|uniprotkb:D3DSG1|ensembl:ENSP00000340690 psi-mi:re1_probe_il2_promoter(display_short)|psi-mi:EBI-11294374(display_long) psi-mi:runx1_human(display_long)|uniprotkb:RUNX1(gene name)|psi-mi:RUNX1(display_short)|uniprotkb:AML1(gene name synonym)|uniprotkb:CBFA2(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-2(gene name synonym)|uniprotkb:Acute myeloid leukemia 1 protein(gene name synonym)|uniprotkb:Oncogene AML-1(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha B subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha B subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha B subunit(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Ono et al. (2007) imex:IM-21202|pubmed:17377532 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-11294362|imex:IM-21202-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:XP_011528068.1|refseq:NP_001001890.1|refseq:NP_001116079.1|refseq:NP_001745.2|refseq:XP_005261125.1|dip:DIP-36773N|ensembl:ENSG00000159216(gene)|ensembl:ENST00000344691(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010755"(regulation of plasminogen activation)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903055"(positive regulation of extracellular matrix organization)|go:"GO:1905203"(regulation of connective tissue replacement)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|interpro:IPR027384|mint:Q01196|rcsb pdb:1CMO|rcsb pdb:1CO1|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:1LJM|reactome:R-HSA-1912408|reactome:R-HSA-549127|reactome:R-HSA-8877330|reactome:R-HSA-8931987|reactome:R-HSA-8934593|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8941333|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222 - - - figure legend:1C|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/08/12 2017/06/30 - rogid:8RknoK1Z7L/Ck94Nd1b9/k03C8k9606 intact-crc:29D510BCF2CC0E66 false 32p radiolabel:?-?|mutation disrupting interaction strength:15-16 flag tag:n-n|sufficient binding region:80..80-177..177 - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography) intact:EBI-11294400 uniprotkb:Q01196 - intact:EBI-925904|uniprotkb:O60472|uniprotkb:O60473|uniprotkb:O76047|uniprotkb:O76089|uniprotkb:Q13081|uniprotkb:Q13755|uniprotkb:Q13756|uniprotkb:Q13757|uniprotkb:Q13758|uniprotkb:Q13759|uniprotkb:Q15341|uniprotkb:Q15343|uniprotkb:Q16122|uniprotkb:Q16284|uniprotkb:Q16285|uniprotkb:Q16286|uniprotkb:Q16346|uniprotkb:Q16347|uniprotkb:Q92479|uniprotkb:A8MV94|uniprotkb:B2RMS4|uniprotkb:D3DSG1|ensembl:ENSP00000340690 psi-mi:re2_probe_il2_promoter(display_short)|psi-mi:EBI-11294400(display_long) psi-mi:runx1_human(display_long)|uniprotkb:RUNX1(gene name)|psi-mi:RUNX1(display_short)|uniprotkb:AML1(gene name synonym)|uniprotkb:CBFA2(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-2(gene name synonym)|uniprotkb:Acute myeloid leukemia 1 protein(gene name synonym)|uniprotkb:Oncogene AML-1(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha B subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha B subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha B subunit(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Ono et al. (2007) imex:IM-21202|pubmed:17377532 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-11294388|imex:IM-21202-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:XP_011528068.1|refseq:NP_001001890.1|refseq:NP_001116079.1|refseq:NP_001745.2|refseq:XP_005261125.1|dip:DIP-36773N|ensembl:ENSG00000159216(gene)|ensembl:ENST00000344691(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010755"(regulation of plasminogen activation)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903055"(positive regulation of extracellular matrix organization)|go:"GO:1905203"(regulation of connective tissue replacement)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|interpro:IPR027384|mint:Q01196|rcsb pdb:1CMO|rcsb pdb:1CO1|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:1LJM|reactome:R-HSA-1912408|reactome:R-HSA-549127|reactome:R-HSA-8877330|reactome:R-HSA-8931987|reactome:R-HSA-8934593|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8941333|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222 - - - figure legend:1C-2|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/08/12 2017/06/30 - rogid:8RknoK1Z7L/Ck94Nd1b9/k03C8k9606 intact-crc:2C897528CDA6A988 false 32p radiolabel:?-?|mutation disrupting interaction strength:16-17 flag tag:n-n|sufficient binding region:80..80-177..177 - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography) intact:EBI-11294416 uniprotkb:Q01196 - intact:EBI-925904|uniprotkb:O60472|uniprotkb:O60473|uniprotkb:O76047|uniprotkb:O76089|uniprotkb:Q13081|uniprotkb:Q13755|uniprotkb:Q13756|uniprotkb:Q13757|uniprotkb:Q13758|uniprotkb:Q13759|uniprotkb:Q15341|uniprotkb:Q15343|uniprotkb:Q16122|uniprotkb:Q16284|uniprotkb:Q16285|uniprotkb:Q16286|uniprotkb:Q16346|uniprotkb:Q16347|uniprotkb:Q92479|uniprotkb:A8MV94|uniprotkb:B2RMS4|uniprotkb:D3DSG1|ensembl:ENSP00000340690 psi-mi:re3_probe_il2_promoter(display_short)|psi-mi:EBI-11294416(display_long) psi-mi:runx1_human(display_long)|uniprotkb:RUNX1(gene name)|psi-mi:RUNX1(display_short)|uniprotkb:AML1(gene name synonym)|uniprotkb:CBFA2(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-2(gene name synonym)|uniprotkb:Acute myeloid leukemia 1 protein(gene name synonym)|uniprotkb:Oncogene AML-1(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha B subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha B subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha B subunit(gene name synonym) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Ono et al. (2007) imex:IM-21202|pubmed:17377532 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-11294403|imex:IM-21202-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0680"(single stranded deoxyribonucleic acid) psi-mi:"MI:0326"(protein) - refseq:XP_011528068.1|refseq:NP_001001890.1|refseq:NP_001116079.1|refseq:NP_001745.2|refseq:XP_005261125.1|dip:DIP-36773N|ensembl:ENSG00000159216(gene)|ensembl:ENST00000344691(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010755"(regulation of plasminogen activation)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903055"(positive regulation of extracellular matrix organization)|go:"GO:1905203"(regulation of connective tissue replacement)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|interpro:IPR027384|mint:Q01196|rcsb pdb:1CMO|rcsb pdb:1CO1|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:1LJM|reactome:R-HSA-1912408|reactome:R-HSA-549127|reactome:R-HSA-8877330|reactome:R-HSA-8931987|reactome:R-HSA-8934593|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8941333|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222 - - - figure legend:1C-3|comment:Binding to the Re-2 probe was weaker.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/08/12 2017/06/30 - rogid:8RknoK1Z7L/Ck94Nd1b9/k03C8k9606 intact-crc:26A76C15B10F4C8F false 32p radiolabel:?-?|mutation disrupting interaction strength:17-18 flag tag:n-n|sufficient binding region:80..80-177..177 - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography) uniprotkb:Q01196 uniprotkb:Q9BZS1 intact:EBI-925904|uniprotkb:O60472|uniprotkb:O60473|uniprotkb:O76047|uniprotkb:O76089|uniprotkb:Q13081|uniprotkb:Q13755|uniprotkb:Q13756|uniprotkb:Q13757|uniprotkb:Q13758|uniprotkb:Q13759|uniprotkb:Q15341|uniprotkb:Q15343|uniprotkb:Q16122|uniprotkb:Q16284|uniprotkb:Q16285|uniprotkb:Q16286|uniprotkb:Q16346|uniprotkb:Q16347|uniprotkb:Q92479|uniprotkb:A8MV94|uniprotkb:B2RMS4|uniprotkb:D3DSG1|ensembl:ENSP00000340690 intact:EBI-983719|uniprotkb:O60827|uniprotkb:Q14DD8|intact:EBI-28970697|ensembl:ENSP00000365380|uniprotkb:Q4ZH51|uniprotkb:A5HJT1|uniprotkb:B7ZLG0|uniprotkb:B9UN80 psi-mi:runx1_human(display_long)|uniprotkb:RUNX1(gene name)|psi-mi:RUNX1(display_short)|uniprotkb:AML1(gene name synonym)|uniprotkb:CBFA2(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-2(gene name synonym)|uniprotkb:Acute myeloid leukemia 1 protein(gene name synonym)|uniprotkb:Oncogene AML-1(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha B subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha B subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha B subunit(gene name synonym) psi-mi:foxp3_human(display_long)|uniprotkb:Scurfin(gene name synonym)|uniprotkb:FOXP3(gene name)|psi-mi:FOXP3(display_short)|uniprotkb:IPEX(gene name synonym)|uniprotkb:JM2(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ono et al. (2007) imex:IM-21202|pubmed:17377532 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-11294526|imex:IM-21202-1|dip:DIP-191100E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011528068.1|refseq:NP_001001890.1|refseq:NP_001116079.1|refseq:NP_001745.2|refseq:XP_005261125.1|dip:DIP-36773N|ensembl:ENSG00000159216(gene)|ensembl:ENST00000344691(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010755"(regulation of plasminogen activation)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903055"(positive regulation of extracellular matrix organization)|go:"GO:1905203"(regulation of connective tissue replacement)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|interpro:IPR027384|mint:Q01196|rcsb pdb:1CMO|rcsb pdb:1CO1|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:1LJM|reactome:R-HSA-1912408|reactome:R-HSA-549127|reactome:R-HSA-8877330|reactome:R-HSA-8931987|reactome:R-HSA-8934593|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8941333|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222 ensembl:ENST00000376199|ensembl:ENSP00000365372|ensembl:ENSP00000365380|ensembl:ENST00000518685|ensembl:ENSP00000428952|ensembl:ENST00000557224|ensembl:ENSP00000451208|ensembl:ENSG00000049768(gene)|ensembl:ENST00000376207(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002851"(positive regulation of peripheral T cell tolerance induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0010467"(gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051525"(NFAT protein binding)|go:"GO:1901355"(response to rapamycin)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030456|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|rcsb pdb:3QRF|rcsb pdb:4WK8|reactome:R-HSA-8877330|reactome:R-HSA-8939256|dip:DIP-36584N|refseq:NP_001107849.1|refseq:NP_054728.2 psi-mi:"MI:0465"(dip) - - figure legend:2A|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-pbmc)|taxid:9606(Human Peripheral Blood Mononuclear cell) - 2015/08/12 2017/06/30 rogid:8RknoK1Z7L/Ck94Nd1b9/k03C8k9606 rogid:ZDAplrVbraZ3/8zn8GPK/CPkGnA9606 intact-crc:58C9614280452889|rigid:6tnvI4JFIqr9fnEUSsrHsvGUjdY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q03347 uniprotkb:Q99JB6 intact:EBI-3863873|uniprotkb:O08598|uniprotkb:Q62049|uniprotkb:Q9ESB9|uniprotkb:Q9ET65 intact:EBI-10956246|ensembl:ENSMUSP00000041953|ensembl:ENSMUSP00000111403|ensembl:ENSMUSP00000111404|ensembl:ENSMUSP00000111405|ensembl:ENSMUSP00000157059|ensembl:ENSMUSP00000157093 psi-mi:runx1_mouse(display_long)|uniprotkb:Runx1(gene name)|psi-mi:Runx1(display_short)|uniprotkb:Aml1(gene name synonym)|uniprotkb:Cbfa2(gene name synonym)|uniprotkb:Pebp2ab(gene name synonym)|uniprotkb:Acute myeloid leukemia 1 protein(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-2(gene name synonym)|uniprotkb:Oncogene AML-1(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha B subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha B subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha B subunit(gene name synonym) psi-mi:foxp3_mouse(display_long)|uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|uniprotkb:Scurfin(gene name synonym) psi-mi:"MI:0096"(pull down) Ono et al. (2007) imex:IM-21202|pubmed:17377532 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-11294539|imex:IM-21202-5|dip:DIP-191101E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048666"(neuron development)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0071336"(regulation of hair follicle cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903431"(positive regulation of cell maturation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000872"(positive regulation of progesterone secretion)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|interpro:IPR027384|rcsb pdb:1EAN|rcsb pdb:1EAO|rcsb pdb:1EAQ|rcsb pdb:1HJB|rcsb pdb:1HJC|rcsb pdb:1IO4|rcsb pdb:2J6W|rcsb pdb:3WTS|rcsb pdb:3WTT|rcsb pdb:3WTU|rcsb pdb:3WTV|rcsb pdb:3WTW|rcsb pdb:3WTX|rcsb pdb:3WTY|rcsb pdb:3WU1|rcsb pdb:4L0Y|rcsb pdb:4L0Z|rcsb pdb:4L18|dip:DIP-40723N|reactome:R-MMU-549127|reactome:R-MMU-8877330|reactome:R-MMU-8931987|reactome:R-MMU-8934593|reactome:R-MMU-8936459|reactome:R-MMU-8939236|reactome:R-MMU-8939243|reactome:R-MMU-8939245|reactome:R-MMU-8939246|reactome:R-MMU-8939247|reactome:R-MMU-9018519 refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1|ensembl:ENSMUSG00000039521(gene)|ensembl:ENSMUST00000045566(transcript)|ensembl:ENSMUST00000115738(transcript)|ensembl:ENSMUST00000115739(transcript)|ensembl:ENSMUST00000115740(transcript)|ensembl:ENSMUST00000234363(transcript)|ensembl:ENSMUST00000235116(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0002507"(tolerance induction)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002851"(positive regulation of peripheral T cell tolerance induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0050672"(negative regulation of lymphocyte proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051525"(NFAT protein binding)|go:"GO:1901355"(response to rapamycin)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|rcsb pdb:4I1L|reactome:R-MMU-8877330|dip:DIP-59739N psi-mi:"MI:0465"(dip) - - figure legend:2B|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/08/12 2017/06/30 rogid:1rh6vkqvcnroruSaiTl+xBjDpms10090 rogid:KLiC5dIVXIMGQNgXoh6xzv2ozqE10090 intact-crc:075C15138914007D|rigid:WMmXQJibJcdhQ+uLrkzs24pK+SY false 35s radiolabel:?-? glutathione s tranferase tag:n-n - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography) uniprotkb:Q03347 uniprotkb:Q99JB6 intact:EBI-3863873|uniprotkb:O08598|uniprotkb:Q62049|uniprotkb:Q9ESB9|uniprotkb:Q9ET65 intact:EBI-10956246|ensembl:ENSMUSP00000041953|ensembl:ENSMUSP00000111403|ensembl:ENSMUSP00000111404|ensembl:ENSMUSP00000111405|ensembl:ENSMUSP00000157059|ensembl:ENSMUSP00000157093 psi-mi:runx1_mouse(display_long)|uniprotkb:Runx1(gene name)|psi-mi:Runx1(display_short)|uniprotkb:Aml1(gene name synonym)|uniprotkb:Cbfa2(gene name synonym)|uniprotkb:Pebp2ab(gene name synonym)|uniprotkb:Acute myeloid leukemia 1 protein(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-2(gene name synonym)|uniprotkb:Oncogene AML-1(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha B subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha B subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha B subunit(gene name synonym) psi-mi:foxp3_mouse(display_long)|uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|uniprotkb:Scurfin(gene name synonym) psi-mi:"MI:0096"(pull down) Ono et al. (2007) imex:IM-21202|pubmed:17377532 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-11294552|imex:IM-21202-8|dip:DIP-191101E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048666"(neuron development)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0071336"(regulation of hair follicle cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903431"(positive regulation of cell maturation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000872"(positive regulation of progesterone secretion)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|interpro:IPR027384|rcsb pdb:1EAN|rcsb pdb:1EAO|rcsb pdb:1EAQ|rcsb pdb:1HJB|rcsb pdb:1HJC|rcsb pdb:1IO4|rcsb pdb:2J6W|rcsb pdb:3WTS|rcsb pdb:3WTT|rcsb pdb:3WTU|rcsb pdb:3WTV|rcsb pdb:3WTW|rcsb pdb:3WTX|rcsb pdb:3WTY|rcsb pdb:3WU1|rcsb pdb:4L0Y|rcsb pdb:4L0Z|rcsb pdb:4L18|dip:DIP-40723N|reactome:R-MMU-549127|reactome:R-MMU-8877330|reactome:R-MMU-8931987|reactome:R-MMU-8934593|reactome:R-MMU-8936459|reactome:R-MMU-8939236|reactome:R-MMU-8939243|reactome:R-MMU-8939245|reactome:R-MMU-8939246|reactome:R-MMU-8939247|reactome:R-MMU-9018519 refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1|ensembl:ENSMUSG00000039521(gene)|ensembl:ENSMUST00000045566(transcript)|ensembl:ENSMUST00000115738(transcript)|ensembl:ENSMUST00000115739(transcript)|ensembl:ENSMUST00000115740(transcript)|ensembl:ENSMUST00000234363(transcript)|ensembl:ENSMUST00000235116(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0002507"(tolerance induction)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002851"(positive regulation of peripheral T cell tolerance induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0050672"(negative regulation of lymphocyte proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051525"(NFAT protein binding)|go:"GO:1901355"(response to rapamycin)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|rcsb pdb:4I1L|reactome:R-MMU-8877330|dip:DIP-59739N psi-mi:"MI:0465"(dip) - - figure legend:2Bi|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/08/12 2017/06/30 rogid:1rh6vkqvcnroruSaiTl+xBjDpms10090 rogid:KLiC5dIVXIMGQNgXoh6xzv2ozqE10090 intact-crc:62818518CE9A3D29|rigid:WMmXQJibJcdhQ+uLrkzs24pK+SY false glutathione s tranferase tag:n-n 35s radiolabel:?-? - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography) uniprotkb:Q03347 uniprotkb:Q99JB6 intact:EBI-3863873|uniprotkb:O08598|uniprotkb:Q62049|uniprotkb:Q9ESB9|uniprotkb:Q9ET65 intact:EBI-10956246|ensembl:ENSMUSP00000041953|ensembl:ENSMUSP00000111403|ensembl:ENSMUSP00000111404|ensembl:ENSMUSP00000111405|ensembl:ENSMUSP00000157059|ensembl:ENSMUSP00000157093 psi-mi:runx1_mouse(display_long)|uniprotkb:Runx1(gene name)|psi-mi:Runx1(display_short)|uniprotkb:Aml1(gene name synonym)|uniprotkb:Cbfa2(gene name synonym)|uniprotkb:Pebp2ab(gene name synonym)|uniprotkb:Acute myeloid leukemia 1 protein(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-2(gene name synonym)|uniprotkb:Oncogene AML-1(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha B subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha B subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha B subunit(gene name synonym) psi-mi:foxp3_mouse(display_long)|uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|uniprotkb:Scurfin(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Ono et al. (2007) imex:IM-21202|pubmed:17377532 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0465"(DIP) intact:EBI-11294569|imex:IM-21202-14 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048666"(neuron development)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0071336"(regulation of hair follicle cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903431"(positive regulation of cell maturation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000872"(positive regulation of progesterone secretion)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|interpro:IPR027384|rcsb pdb:1EAN|rcsb pdb:1EAO|rcsb pdb:1EAQ|rcsb pdb:1HJB|rcsb pdb:1HJC|rcsb pdb:1IO4|rcsb pdb:2J6W|rcsb pdb:3WTS|rcsb pdb:3WTT|rcsb pdb:3WTU|rcsb pdb:3WTV|rcsb pdb:3WTW|rcsb pdb:3WTX|rcsb pdb:3WTY|rcsb pdb:3WU1|rcsb pdb:4L0Y|rcsb pdb:4L0Z|rcsb pdb:4L18|dip:DIP-40723N|reactome:R-MMU-549127|reactome:R-MMU-8877330|reactome:R-MMU-8931987|reactome:R-MMU-8934593|reactome:R-MMU-8936459|reactome:R-MMU-8939236|reactome:R-MMU-8939243|reactome:R-MMU-8939245|reactome:R-MMU-8939246|reactome:R-MMU-8939247|reactome:R-MMU-9018519 refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1|ensembl:ENSMUSG00000039521(gene)|ensembl:ENSMUST00000045566(transcript)|ensembl:ENSMUST00000115738(transcript)|ensembl:ENSMUST00000115739(transcript)|ensembl:ENSMUST00000115740(transcript)|ensembl:ENSMUST00000234363(transcript)|ensembl:ENSMUST00000235116(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0002507"(tolerance induction)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002851"(positive regulation of peripheral T cell tolerance induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0050672"(negative regulation of lymphocyte proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051525"(NFAT protein binding)|go:"GO:1901355"(response to rapamycin)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|rcsb pdb:4I1L|reactome:R-MMU-8877330|dip:DIP-59739N go:"GO:0005634"(nucleus) - - figure legend:2C|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-t-cell_cd4+)|taxid:10090(Mouse CD4 positive T-cell) - 2015/08/12 2017/06/30 rogid:1rh6vkqvcnroruSaiTl+xBjDpms10090 rogid:KLiC5dIVXIMGQNgXoh6xzv2ozqE10090 intact-crc:99BB7B7BEDEE611A|rigid:WMmXQJibJcdhQ+uLrkzs24pK+SY false - - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q03347 uniprotkb:Q99JB6 intact:EBI-3863873|uniprotkb:O08598|uniprotkb:Q62049|uniprotkb:Q9ESB9|uniprotkb:Q9ET65 intact:EBI-10956246|ensembl:ENSMUSP00000041953|ensembl:ENSMUSP00000111403|ensembl:ENSMUSP00000111404|ensembl:ENSMUSP00000111405|ensembl:ENSMUSP00000157059|ensembl:ENSMUSP00000157093 psi-mi:runx1_mouse(display_long)|uniprotkb:Runx1(gene name)|psi-mi:Runx1(display_short)|uniprotkb:Aml1(gene name synonym)|uniprotkb:Cbfa2(gene name synonym)|uniprotkb:Pebp2ab(gene name synonym)|uniprotkb:Acute myeloid leukemia 1 protein(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-2(gene name synonym)|uniprotkb:Oncogene AML-1(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha B subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha B subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha B subunit(gene name synonym) psi-mi:foxp3_mouse(display_long)|uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|uniprotkb:Scurfin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ono et al. (2007) imex:IM-21202|pubmed:17377532 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-11294587|imex:IM-21202-3|dip:DIP-191101E|imex:IM-21202-7|dip:DIP-191104E|imex:IM-21202-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048666"(neuron development)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0071336"(regulation of hair follicle cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903431"(positive regulation of cell maturation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000872"(positive regulation of progesterone secretion)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|interpro:IPR027384|rcsb pdb:1EAN|rcsb pdb:1EAO|rcsb pdb:1EAQ|rcsb pdb:1HJB|rcsb pdb:1HJC|rcsb pdb:1IO4|rcsb pdb:2J6W|rcsb pdb:3WTS|rcsb pdb:3WTT|rcsb pdb:3WTU|rcsb pdb:3WTV|rcsb pdb:3WTW|rcsb pdb:3WTX|rcsb pdb:3WTY|rcsb pdb:3WU1|rcsb pdb:4L0Y|rcsb pdb:4L0Z|rcsb pdb:4L18|dip:DIP-40723N|reactome:R-MMU-549127|reactome:R-MMU-8877330|reactome:R-MMU-8931987|reactome:R-MMU-8934593|reactome:R-MMU-8936459|reactome:R-MMU-8939236|reactome:R-MMU-8939243|reactome:R-MMU-8939245|reactome:R-MMU-8939246|reactome:R-MMU-8939247|reactome:R-MMU-9018519 refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1|ensembl:ENSMUSG00000039521(gene)|ensembl:ENSMUST00000045566(transcript)|ensembl:ENSMUST00000115738(transcript)|ensembl:ENSMUST00000115739(transcript)|ensembl:ENSMUST00000115740(transcript)|ensembl:ENSMUST00000234363(transcript)|ensembl:ENSMUST00000235116(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0002507"(tolerance induction)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002851"(positive regulation of peripheral T cell tolerance induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0050672"(negative regulation of lymphocyte proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051525"(NFAT protein binding)|go:"GO:1901355"(response to rapamycin)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|rcsb pdb:4I1L|reactome:R-MMU-8877330|dip:DIP-59739N psi-mi:"MI:0465"(dip) - - figure legend:2E, Supp 12|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/08/12 2017/06/30 rogid:1rh6vkqvcnroruSaiTl+xBjDpms10090 rogid:KLiC5dIVXIMGQNgXoh6xzv2ozqE10090 intact-crc:65B1F483B16D5C7C|rigid:WMmXQJibJcdhQ+uLrkzs24pK+SY false necessary binding region:362-402|flag tag:?-? myc tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q03347 uniprotkb:Q99JB6 intact:EBI-3863873|uniprotkb:O08598|uniprotkb:Q62049|uniprotkb:Q9ESB9|uniprotkb:Q9ET65 intact:EBI-10956246|ensembl:ENSMUSP00000041953|ensembl:ENSMUSP00000111403|ensembl:ENSMUSP00000111404|ensembl:ENSMUSP00000111405|ensembl:ENSMUSP00000157059|ensembl:ENSMUSP00000157093 psi-mi:runx1_mouse(display_long)|uniprotkb:Runx1(gene name)|psi-mi:Runx1(display_short)|uniprotkb:Aml1(gene name synonym)|uniprotkb:Cbfa2(gene name synonym)|uniprotkb:Pebp2ab(gene name synonym)|uniprotkb:Acute myeloid leukemia 1 protein(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-2(gene name synonym)|uniprotkb:Oncogene AML-1(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha B subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha B subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha B subunit(gene name synonym) psi-mi:foxp3_mouse(display_long)|uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|uniprotkb:Scurfin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ono et al. (2007) imex:IM-21202|pubmed:17377532 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-11294591|imex:IM-21202-4|dip:DIP-191101E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007417"(central nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048666"(neuron development)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0071336"(regulation of hair follicle cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903431"(positive regulation of cell maturation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000872"(positive regulation of progesterone secretion)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|interpro:IPR027384|rcsb pdb:1EAN|rcsb pdb:1EAO|rcsb pdb:1EAQ|rcsb pdb:1HJB|rcsb pdb:1HJC|rcsb pdb:1IO4|rcsb pdb:2J6W|rcsb pdb:3WTS|rcsb pdb:3WTT|rcsb pdb:3WTU|rcsb pdb:3WTV|rcsb pdb:3WTW|rcsb pdb:3WTX|rcsb pdb:3WTY|rcsb pdb:3WU1|rcsb pdb:4L0Y|rcsb pdb:4L0Z|rcsb pdb:4L18|dip:DIP-40723N|reactome:R-MMU-549127|reactome:R-MMU-8877330|reactome:R-MMU-8931987|reactome:R-MMU-8934593|reactome:R-MMU-8936459|reactome:R-MMU-8939236|reactome:R-MMU-8939243|reactome:R-MMU-8939245|reactome:R-MMU-8939246|reactome:R-MMU-8939247|reactome:R-MMU-9018519 refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1|ensembl:ENSMUSG00000039521(gene)|ensembl:ENSMUST00000045566(transcript)|ensembl:ENSMUST00000115738(transcript)|ensembl:ENSMUST00000115739(transcript)|ensembl:ENSMUST00000115740(transcript)|ensembl:ENSMUST00000234363(transcript)|ensembl:ENSMUST00000235116(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0002507"(tolerance induction)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002851"(positive regulation of peripheral T cell tolerance induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0050672"(negative regulation of lymphocyte proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051525"(NFAT protein binding)|go:"GO:1901355"(response to rapamycin)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|rcsb pdb:4I1L|reactome:R-MMU-8877330|dip:DIP-59739N psi-mi:"MI:0465"(dip) - - figure legend:2G, 3G|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/08/12 2017/06/30 rogid:1rh6vkqvcnroruSaiTl+xBjDpms10090 rogid:KLiC5dIVXIMGQNgXoh6xzv2ozqE10090 intact-crc:BB9E361813F27FA6|rigid:WMmXQJibJcdhQ+uLrkzs24pK+SY false ha tag:n-n flag tag:n-n|necessary binding region:278-336|mutation decreasing interaction strength:329-330|mutation disrupting interaction strength:329-330,332-332 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q99JB6 uniprotkb:Q60591-3 intact:EBI-10956246|ensembl:ENSMUSP00000041953|ensembl:ENSMUSP00000111403|ensembl:ENSMUSP00000111404|ensembl:ENSMUSP00000111405|ensembl:ENSMUSP00000157059|ensembl:ENSMUSP00000157093 intact:EBI-11295123|ensembl:ENSMUSP00000074198 psi-mi:foxp3_mouse(display_long)|uniprotkb:Foxp3(gene name)|psi-mi:Foxp3(display_short)|uniprotkb:Scurfin(gene name synonym) psi-mi:q60591-3(display_long)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:Nfatc2(gene name)|psi-mi:Nfatc2(display_short)|uniprotkb:Nfat1(gene name synonym)|uniprotkb:Nfatp(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ono et al. (2007) imex:IM-21202|pubmed:17377532 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-11295121|imex:IM-21202-6|dip:DIP-191102E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186276.1|refseq:NP_001186277.1|refseq:NP_473380.1|ensembl:ENSMUSG00000039521(gene)|ensembl:ENSMUST00000045566(transcript)|ensembl:ENSMUST00000115738(transcript)|ensembl:ENSMUST00000115739(transcript)|ensembl:ENSMUST00000115740(transcript)|ensembl:ENSMUST00000234363(transcript)|ensembl:ENSMUST00000235116(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002362"(CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0002507"(tolerance induction)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002851"(positive regulation of peripheral T cell tolerance induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0010467"(gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0050672"(negative regulation of lymphocyte proliferation)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051525"(NFAT protein binding)|go:"GO:1901355"(response to rapamycin)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|rcsb pdb:4I1L|reactome:R-MMU-8877330|dip:DIP-59739N intact:EBI-643104(isoform-parent)|ensembl:ENSMUSG00000027544(gene)|ensembl:ENSMUST00000074618(transcript) psi-mi:"MI:0465"(dip) - - figure legend:Supp 6|comment:"From Supp Ref 1 + 2,, HA-tagged NFAT-CA is a constitutive active form of murine NFAT1 isoform C with twelve serine to alanine mutations. This mutant is probably the (ST2+5+8) mutant described."|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/08/12 2017/06/30 rogid:KLiC5dIVXIMGQNgXoh6xzv2ozqE10090 rogid:IKjLThZZ/+mxINbj5q5+R2GddJo10090 intact-crc:4E2D30F176D51666|rigid:XLar2ybiL3sMvLsOzLdwNhJhpyA false flag tag:n-n ha tag:?-?|mutation:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)