#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:39124"	uniprotkb:P05044	intact:EBI-10816878	intact:EBI-10816377	psi-mi:calcium ion(display_short)|psi-mi:"CHEBI:39124"(display_long)|intact:calcium ion(synonym)|intact:calcium ions(synonym)	psi-mi:sorcn_crigr(display_long)|uniprotkb:22 kDa protein(gene name synonym)|uniprotkb:CP-22(gene name synonym)|uniprotkb:V19(gene name synonym)|uniprotkb:SRI(gene name)|psi-mi:SRI(display_short)	psi-mi:"MI:0028"(cosedimentation in solution)	Colotti et al. (2006)	pubmed:17029407|imex:IM-24155	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10817030|imex:IM-24155-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:1GJY|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016020"(membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)	-	-	-	figure legend:Figure 3A|comment:When the level of calcium exceeds 2 equiv/monomer Sorcin formed  aggregates.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/04/27	2015/05/08	-	rogid:93Bpwy+ubS26SnjAwoQOK5w3LB010029	-	false	-	mutation:99-99	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:39124"	uniprotkb:P05044	intact:EBI-10816878	intact:EBI-10816377	psi-mi:calcium ion(display_short)|psi-mi:"CHEBI:39124"(display_long)|intact:calcium ion(synonym)|intact:calcium ions(synonym)	psi-mi:sorcn_crigr(display_long)|uniprotkb:22 kDa protein(gene name synonym)|uniprotkb:CP-22(gene name synonym)|uniprotkb:V19(gene name synonym)|uniprotkb:SRI(gene name)|psi-mi:SRI(display_short)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Colotti et al. (2006)	pubmed:17029407|imex:IM-24155	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10817068|imex:IM-24155-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:1GJY|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016020"(membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)	-	-	-	figure legend:Figure 3B|comment:"Ca2+ affinity of the mutants  is practically unaltered relative to that of wt sorcin and can be fitted with two Ca2+ binding constants in the micromolar range [K1 = (0.5 ± 0.2) × 10-6 M and K2 ∼ 10-5 M]."|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/04/27	2015/05/08	-	rogid:93Bpwy+ubS26SnjAwoQOK5w3LB010029	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07076	uniprotkb:P05044	intact:EBI-10824194|uniprotkb:Q3TT33|ensembl:ENSMUSP00000066035|ensembl:ENSMUSP00000153669	intact:EBI-10816377	psi-mi:anxa7_mouse(display_long)|uniprotkb:Anxa7(gene name)|psi-mi:Anxa7(display_short)|uniprotkb:Anx7(gene name synonym)|uniprotkb:Annexin VII(gene name synonym)|uniprotkb:Annexin-7(gene name synonym)|uniprotkb:Synexin(gene name synonym)	psi-mi:sorcn_crigr(display_long)|uniprotkb:22 kDa protein(gene name synonym)|uniprotkb:CP-22(gene name synonym)|uniprotkb:V19(gene name synonym)|uniprotkb:SRI(gene name)|psi-mi:SRI(display_short)	psi-mi:"MI:0047"(far western blotting)	Colotti et al. (2006)	pubmed:17029407|imex:IM-24155	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10817103|imex:IM-24155-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104264.1|refseq:NP_033804.2|interpro:IPR037104|ensembl:ENSMUSG00000021814(gene)|ensembl:ENSMUST00000065504(transcript)|ensembl:ENSMUST00000224975(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007599"(hemostasis)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009651"(response to salt stress)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0031982"(vesicle)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0061025"(membrane fusion)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001464(Annexin)|interpro:IPR018252|interpro:IPR018502	rcsb pdb:1GJY|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016020"(membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)	-	-	-	figure legend:Figure 4A|comment:Interaction is calcium-dependent.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/04/27	2015/05/26	rogid:RjXq3uZiAK+sw2XgZ7zZUkKoLn410090	rogid:93Bpwy+ubS26SnjAwoQOK5w3LB010029	rigid:sgnp1KDb7DjYGs3DiurJ6bkQtXY	false	-	mutation:99-99	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q07076	uniprotkb:P05044	intact:EBI-10824194|uniprotkb:Q3TT33|ensembl:ENSMUSP00000066035|ensembl:ENSMUSP00000153669	intact:EBI-10816377	psi-mi:anxa7_mouse(display_long)|uniprotkb:Anxa7(gene name)|psi-mi:Anxa7(display_short)|uniprotkb:Anx7(gene name synonym)|uniprotkb:Annexin VII(gene name synonym)|uniprotkb:Annexin-7(gene name synonym)|uniprotkb:Synexin(gene name synonym)	psi-mi:sorcn_crigr(display_long)|uniprotkb:22 kDa protein(gene name synonym)|uniprotkb:CP-22(gene name synonym)|uniprotkb:V19(gene name synonym)|uniprotkb:SRI(gene name)|psi-mi:SRI(display_short)	psi-mi:"MI:0047"(far western blotting)	Colotti et al. (2006)	pubmed:17029407|imex:IM-24155	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10817116|imex:IM-24155-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104264.1|refseq:NP_033804.2|interpro:IPR037104|ensembl:ENSMUSG00000021814(gene)|ensembl:ENSMUST00000065504(transcript)|ensembl:ENSMUST00000224975(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0007599"(hemostasis)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009651"(response to salt stress)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0031982"(vesicle)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0061025"(membrane fusion)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001464(Annexin)|interpro:IPR018252|interpro:IPR018502	rcsb pdb:1GJY|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016020"(membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)	-	-	-	figure legend:Figure 4B|comment:Interaction is calcium-dependent.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/04/27	2015/05/26	rogid:RjXq3uZiAK+sw2XgZ7zZUkKoLn410090	rogid:93Bpwy+ubS26SnjAwoQOK5w3LB010029	rigid:sgnp1KDb7DjYGs3DiurJ6bkQtXY	false	-	mutation:105-105	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:G3I2P8	uniprotkb:P05044	intact:EBI-10824179	intact:EBI-10816377	psi-mi:g3i2p8_crigr(display_long)|uniprotkb:I79_017691(orf name)	psi-mi:sorcn_crigr(display_long)|uniprotkb:22 kDa protein(gene name synonym)|uniprotkb:CP-22(gene name synonym)|uniprotkb:V19(gene name synonym)|uniprotkb:SRI(gene name)|psi-mi:SRI(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Colotti et al. (2006)	pubmed:17029407|imex:IM-24155	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10817134|imex:IM-24155-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|interpro:IPR001464(Annexin)|interpro:IPR018502|interpro:IPR018252|interpro:IPR037104	rcsb pdb:1GJY|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016020"(membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)	-	-	-	figure legend:Figure 5|comment:The W99G variant behaves like wt sorcin at <40 uM Ca2+ but yields lower Req values at higher cation concentrations.  Kd values are entered for results obtained using 20uM calcium.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.0x10^-6(molar)	2015/04/27	2015/05/26	rogid:Zihp5X5caRKXYQvy1FFsJ6bpK/Y10029	rogid:93Bpwy+ubS26SnjAwoQOK5w3LB010029	rigid:O5YJWQcuL/T0H6p6CSpwGbXlg3E	false	sufficient binding region:1-20	mutation decreasing interaction strength:105-105	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)