#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9NYX4 uniprotkb:P09496 intact:EBI-10904725|uniprotkb:Q5VWX3|uniprotkb:Q5VWY5|uniprotkb:Q5VWY6|ensembl:ENSP00000252939 intact:EBI-1171169|uniprotkb:Q2XPN5|uniprotkb:Q53XZ1|uniprotkb:A8K4W3|uniprotkb:B4DIN1|uniprotkb:F5H6N3|ensembl:ENSP00000242285|ensembl:ENSP00000401019 psi-mi:caly_human(display_long)|uniprotkb:CALY(gene name)|psi-mi:CALY(display_short)|uniprotkb:DRD1IP(gene name synonym) psi-mi:clca_human(display_long)|uniprotkb:CLTA(gene name)|psi-mi:CLTA(display_short) psi-mi:"MI:0018"(two hybrid) Xiao et al. (2006) imex:IM-25006|pubmed:16595675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10904750|imex:IM-25006-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056537.1|ensembl:ENSG00000130643(gene)|ensembl:ENST00000252939(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0098843"(postsynaptic endocytic zone)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2001019"(positive regulation of retrograde axon cargo transport)|interpro:IPR009431(D1 dopamine receptor-interacting) refseq:NP_001070145.1|refseq:NP_001824.1|refseq:NP_009027.1|refseq:NP_001171689.1|refseq:NP_001171691.1|ensembl:ENSG00000122705(gene)|ensembl:ENST00000242285(transcript)|ensembl:ENST00000433436(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042277"(peptide binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|mint:P09496|rcsb pdb:6E5N|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-3928665 - - - figure legend:no figure|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2015/07/17 2015/07/17 rogid:2e/T0vtLJ5CKM81UDPSt0fv5CDQ9606 rogid:RCF3QpQKI1yZFOTAyzhvRkR9ek49606 rigid:fnkC5zsaNv0wLaGQkznds0jXyM8 false sufficient binding region:123-217 - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9NYX4 uniprotkb:P09496 intact:EBI-10904725|uniprotkb:Q5VWX3|uniprotkb:Q5VWY5|uniprotkb:Q5VWY6|ensembl:ENSP00000252939 intact:EBI-1171169|uniprotkb:Q2XPN5|uniprotkb:Q53XZ1|uniprotkb:A8K4W3|uniprotkb:B4DIN1|uniprotkb:F5H6N3|ensembl:ENSP00000242285|ensembl:ENSP00000401019 psi-mi:caly_human(display_long)|uniprotkb:CALY(gene name)|psi-mi:CALY(display_short)|uniprotkb:DRD1IP(gene name synonym) psi-mi:clca_human(display_long)|uniprotkb:CLTA(gene name)|psi-mi:CLTA(display_short) psi-mi:"MI:0096"(pull down) Xiao et al. (2006) imex:IM-25006|pubmed:16595675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-10904928|imex:IM-25006-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056537.1|ensembl:ENSG00000130643(gene)|ensembl:ENST00000252939(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0098843"(postsynaptic endocytic zone)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2001019"(positive regulation of retrograde axon cargo transport)|interpro:IPR009431(D1 dopamine receptor-interacting) refseq:NP_001070145.1|refseq:NP_001824.1|refseq:NP_009027.1|refseq:NP_001171689.1|refseq:NP_001171691.1|ensembl:ENSG00000122705(gene)|ensembl:ENST00000242285(transcript)|ensembl:ENST00000433436(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042277"(peptide binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|mint:P09496|rcsb pdb:6E5N|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-3928665 - - - figure legend:Fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/07/17 2015/07/17 rogid:2e/T0vtLJ5CKM81UDPSt0fv5CDQ9606 rogid:RCF3QpQKI1yZFOTAyzhvRkR9ek49606 rigid:fnkC5zsaNv0wLaGQkznds0jXyM8 false sufficient binding region:114-217|s tag:?-? glutathione s tranferase tag:n-n|sufficient binding region:102-162,193-248 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9NYX4 uniprotkb:P09496 intact:EBI-10904725|uniprotkb:Q5VWX3|uniprotkb:Q5VWY5|uniprotkb:Q5VWY6|ensembl:ENSP00000252939 intact:EBI-1171169|uniprotkb:Q2XPN5|uniprotkb:Q53XZ1|uniprotkb:A8K4W3|uniprotkb:B4DIN1|uniprotkb:F5H6N3|ensembl:ENSP00000242285|ensembl:ENSP00000401019 psi-mi:caly_human(display_long)|uniprotkb:CALY(gene name)|psi-mi:CALY(display_short)|uniprotkb:DRD1IP(gene name synonym) psi-mi:clca_human(display_long)|uniprotkb:CLTA(gene name)|psi-mi:CLTA(display_short) psi-mi:"MI:0663"(confocal microscopy) Xiao et al. (2006) imex:IM-25006|pubmed:16595675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-10917947|imex:IM-25006-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056537.1|ensembl:ENSG00000130643(gene)|ensembl:ENST00000252939(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0098843"(postsynaptic endocytic zone)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2001019"(positive regulation of retrograde axon cargo transport)|interpro:IPR009431(D1 dopamine receptor-interacting) refseq:NP_001070145.1|refseq:NP_001824.1|refseq:NP_009027.1|refseq:NP_001171689.1|refseq:NP_001171691.1|ensembl:ENSG00000122705(gene)|ensembl:ENST00000242285(transcript)|ensembl:ENST00000433436(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042277"(peptide binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|mint:P09496|rcsb pdb:6E5N|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-3928665 go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044309"(neuron spine) - - figure legend:Fig. 3A-C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-neocortex)|taxid:10090(Mus musculus Neocortex) - 2015/07/17 2015/07/21 rogid:2e/T0vtLJ5CKM81UDPSt0fv5CDQ9606 rogid:RCF3QpQKI1yZFOTAyzhvRkR9ek49606 rigid:fnkC5zsaNv0wLaGQkznds0jXyM8 false myc tag:n-n enhanced green fluorescent protein tag:n-n - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q9NYX4 uniprotkb:O14617 intact:EBI-10904725|uniprotkb:Q5VWX3|uniprotkb:Q5VWY5|uniprotkb:Q5VWY6|ensembl:ENSP00000252939 intact:EBI-1051639|uniprotkb:O00202|uniprotkb:O75262|uniprotkb:Q59HF5|uniprotkb:Q96G11|uniprotkb:Q9H3C6|ensembl:ENSP00000344055 psi-mi:caly_human(display_long)|uniprotkb:CALY(gene name)|psi-mi:CALY(display_short)|uniprotkb:DRD1IP(gene name synonym) psi-mi:ap3d1_human(display_long)|uniprotkb:AP-3 complex subunit delta(gene name synonym)|uniprotkb:Delta-adaptin(gene name synonym)|uniprotkb:AP3D1(gene name)|psi-mi:AP3D1(display_short)|uniprotkb:PRO0039(orf name)|uniprotkb:Adaptor-related protein complex 3 subunit delta-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xiao et al. (2006) imex:IM-25006|pubmed:16595675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10918009|imex:IM-25006-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056537.1|ensembl:ENSG00000130643(gene)|ensembl:ENST00000252939(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0098843"(postsynaptic endocytic zone)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2001019"(positive regulation of retrograde axon cargo transport)|interpro:IPR009431(D1 dopamine receptor-interacting) refseq:NP_003929.4|refseq:NP_001248755.1|ensembl:ENSG00000065000(gene)|ensembl:ENST00000345016(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016182"(synaptic vesicle budding from endosome)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0032438"(melanosome organization)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043195"(terminal bouton)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048007"(antigen processing and presentation, exogenous lipid antigen via MHC class Ib)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048499"(synaptic vesicle membrane organization)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098943"(neurotransmitter receptor transport, postsynaptic endosome to lysosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR010474(Bovine leukaemia virus receptor)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017105(Adaptor protein complex AP-3, delta subunit)|mint:O14617|rcsb pdb:4AFI|dip:DIP-46793N - - - figure legend:Fig. 3E|comment:Alpha-adaptin was also identified in this complex but could not be ascribed to a single gene product.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/07/17 2015/09/14 rogid:2e/T0vtLJ5CKM81UDPSt0fv5CDQ9606 rogid:vw6bWz07cMYuwATlyDgx14oXzKY9606 rigid:51j7X2lii0mRR1Gqnu/xp2OTWg8 false myc tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NYX4 uniprotkb:O43747 intact:EBI-10904725|uniprotkb:Q5VWX3|uniprotkb:Q5VWY5|uniprotkb:Q5VWY6|ensembl:ENSP00000252939 intact:EBI-447609|uniprotkb:O75709|uniprotkb:O75842|uniprotkb:Q9UG09|uniprotkb:Q9Y3U4|ensembl:ENSP00000299980|ensembl:ENSP00000454523 psi-mi:caly_human(display_long)|uniprotkb:CALY(gene name)|psi-mi:CALY(display_short)|uniprotkb:DRD1IP(gene name synonym) psi-mi:ap1g1_human(display_long)|uniprotkb:Adaptor protein complex AP-1 subunit gamma-1(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin subunit gamma-1(gene name synonym)|uniprotkb:Gamma1-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 gamma-1 large chain(gene name synonym)|uniprotkb:AP1G1(gene name)|psi-mi:AP1G1(display_short)|uniprotkb:ADTG(gene name synonym)|uniprotkb:CLAPG1(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit gamma-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xiao et al. (2006) imex:IM-25006|pubmed:16595675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10918009|imex:IM-25006-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056537.1|ensembl:ENSG00000130643(gene)|ensembl:ENST00000252939(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0098843"(postsynaptic endocytic zone)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2001019"(positive regulation of retrograde axon cargo transport)|interpro:IPR009431(D1 dopamine receptor-interacting) refseq:NP_001025178.1|refseq:NP_001119.3|ensembl:ENSG00000166747(gene)|ensembl:ENST00000299980(transcript)|ensembl:ENST00000569748(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0030121"(AP-1 adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0140312"(cargo adaptor activity)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017107(Adaptor protein complex AP-1, gamma subunit)|mint:O43747|rcsb pdb:1IU1|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722 - - - figure legend:Fig. 3E|comment:Alpha-adaptin was also identified in this complex but could not be ascribed to a single gene product.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/07/17 2015/09/14 rogid:2e/T0vtLJ5CKM81UDPSt0fv5CDQ9606 rogid:E0niV91xZ1PV6Pr6Koq3Xs+9nKg9606 rigid:51j7X2lii0mRR1Gqnu/xp2OTWg8 false myc tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NYX4 uniprotkb:P09496 intact:EBI-10904725|uniprotkb:Q5VWX3|uniprotkb:Q5VWY5|uniprotkb:Q5VWY6|ensembl:ENSP00000252939 intact:EBI-1171169|uniprotkb:Q2XPN5|uniprotkb:Q53XZ1|uniprotkb:A8K4W3|uniprotkb:B4DIN1|uniprotkb:F5H6N3|ensembl:ENSP00000242285|ensembl:ENSP00000401019 psi-mi:caly_human(display_long)|uniprotkb:CALY(gene name)|psi-mi:CALY(display_short)|uniprotkb:DRD1IP(gene name synonym) psi-mi:clca_human(display_long)|uniprotkb:CLTA(gene name)|psi-mi:CLTA(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xiao et al. (2006) imex:IM-25006|pubmed:16595675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-10918009|imex:IM-25006-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056537.1|ensembl:ENSG00000130643(gene)|ensembl:ENST00000252939(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0098843"(postsynaptic endocytic zone)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2001019"(positive regulation of retrograde axon cargo transport)|interpro:IPR009431(D1 dopamine receptor-interacting) refseq:NP_001070145.1|refseq:NP_001824.1|refseq:NP_009027.1|refseq:NP_001171689.1|refseq:NP_001171691.1|ensembl:ENSG00000122705(gene)|ensembl:ENST00000242285(transcript)|ensembl:ENST00000433436(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042277"(peptide binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|mint:P09496|rcsb pdb:6E5N|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-3928665 - - - figure legend:Fig. 3E|comment:Alpha-adaptin was also identified in this complex but could not be ascribed to a single gene product.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2015/07/17 2015/09/14 rogid:2e/T0vtLJ5CKM81UDPSt0fv5CDQ9606 rogid:RCF3QpQKI1yZFOTAyzhvRkR9ek49606 rigid:51j7X2lii0mRR1Gqnu/xp2OTWg8 false myc tag:n-n flag tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0867"(tag visualisation by fluorescence)