#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-10821555	uniprotkb:Q05022	rnacentral:URS00004BEF81_559292	intact:EBI-16011|uniprotkb:D6W054|ensemblfungi:YMR229C	psi-mi:rrna 35s yeast(display_short)|psi-mi:EBI-10821555(display_long)	psi-mi:rrp5_yeast(display_long)|uniprotkb:RRP5(gene name)|psi-mi:RRP5(display_short)|uniprotkb:FMI1(gene name synonym)|uniprotkb:YMR229C(locus name)|uniprotkb:YM9959.11C(orf name)|uniprotkb:Ribosomal RNA-processing protein 5(gene name synonym)|uniprotkb:U3 small nucleolar RNA-associated protein RRP5(gene name synonym)	psi-mi:"MI:0096"(pull down)	de et al. (2006)	pubmed:16428605|imex:IM-26633	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10894663|imex:IM-26633-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0608"(ribosomal rna)	psi-mi:"MI:0326"(protein)	sgd:S000006486(see-also)	refseq:NP_013956.1|sgd:S000004842|ensemblfungi:YMR229C(gene)|ensemblfungi:YMR229C_mRNA(transcript)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000464"("endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000472"("endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000480"("endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030515"(snoRNA binding)|go:"GO:0030686"(90S preribosome)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034463"(90S preribosome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034512"(box C/D RNA binding)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0042134"(rRNA primary transcript binding)|interpro:IPR003029(S1, RNA binding)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|rcsb pdb:5C9S|rcsb pdb:5NLG|rcsb pdb:5WLC|rcsb pdb:5WWM|rcsb pdb:5WYJ|rcsb pdb:6LQQ|rcsb pdb:6LQR|rcsb pdb:6LQS|rcsb pdb:6LQT|rcsb pdb:6LQU|rcsb pdb:6ZQC|rcsb pdb:6ZQD|rcsb pdb:7AJT|rcsb pdb:7AJU|reactome:R-SCE-6791226|dip:DIP-6535N|mint:Q05022	-	-	crc64:39BF46E5587B3B0A	figure legend:Fig 3, Fig 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/06/25	2015/06/26	-	rogid:FUIsTk3NLRDu8llnVgX5cDLAbB8559292	-	false	32p radiolabel:?-?	protein a tag:n-n|mutation disrupting interaction:119-1336|mutation decreasing interaction:1455-1701	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q05022	intact:EBI-986894	intact:EBI-16011|uniprotkb:D6W054|ensemblfungi:YMR229C	-	psi-mi:rrp5_yeast(display_long)|uniprotkb:RRP5(gene name)|psi-mi:RRP5(display_short)|uniprotkb:FMI1(gene name synonym)|uniprotkb:YMR229C(locus name)|uniprotkb:YM9959.11C(orf name)|uniprotkb:Ribosomal RNA-processing protein 5(gene name synonym)|uniprotkb:U3 small nucleolar RNA-associated protein RRP5(gene name synonym)	psi-mi:polyu(display_short)|psi-mi:EBI-986894(display_long)	psi-mi:"MI:0096"(pull down)	de et al. (2006)	pubmed:16428605|imex:IM-26633	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10898564|imex:IM-26633-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0320"(ribonucleic acid)	refseq:NP_013956.1|sgd:S000004842|ensemblfungi:YMR229C(gene)|ensemblfungi:YMR229C_mRNA(transcript)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000464"("endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000472"("endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000480"("endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030515"(snoRNA binding)|go:"GO:0030686"(90S preribosome)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034463"(90S preribosome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034512"(box C/D RNA binding)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0042134"(rRNA primary transcript binding)|interpro:IPR003029(S1, RNA binding)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|rcsb pdb:5C9S|rcsb pdb:5NLG|rcsb pdb:5WLC|rcsb pdb:5WWM|rcsb pdb:5WYJ|rcsb pdb:6LQQ|rcsb pdb:6LQR|rcsb pdb:6LQS|rcsb pdb:6LQT|rcsb pdb:6LQU|rcsb pdb:6ZQC|rcsb pdb:6ZQD|rcsb pdb:7AJT|rcsb pdb:7AJU|reactome:R-SCE-6791226|dip:DIP-6535N|mint:Q05022	-	-	crc64:39BF46E5587B3B0A	-	figure legend:Fig 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/06/25	2015/07/07	rogid:FUIsTk3NLRDu8llnVgX5cDLAbB8559292	-	-	false	protein a tag:n-n|mutation disrupting interaction:119-1336|mutation decreasing interaction:1455-1701	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q05022	intact:EBI-10821555	intact:EBI-16011|uniprotkb:D6W054|ensemblfungi:YMR229C	rnacentral:URS00004BEF81_559292	psi-mi:rrp5_yeast(display_long)|uniprotkb:RRP5(gene name)|psi-mi:RRP5(display_short)|uniprotkb:FMI1(gene name synonym)|uniprotkb:YMR229C(locus name)|uniprotkb:YM9959.11C(orf name)|uniprotkb:Ribosomal RNA-processing protein 5(gene name synonym)|uniprotkb:U3 small nucleolar RNA-associated protein RRP5(gene name synonym)	psi-mi:rrna 35s yeast(display_short)|psi-mi:EBI-10821555(display_long)	psi-mi:"MI:0096"(pull down)	de et al. (2006)	pubmed:16428605|imex:IM-26633	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10898564|imex:IM-26633-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0608"(ribosomal rna)	refseq:NP_013956.1|sgd:S000004842|ensemblfungi:YMR229C(gene)|ensemblfungi:YMR229C_mRNA(transcript)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000464"("endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000472"("endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000480"("endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030515"(snoRNA binding)|go:"GO:0030686"(90S preribosome)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034463"(90S preribosome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034512"(box C/D RNA binding)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0042134"(rRNA primary transcript binding)|interpro:IPR003029(S1, RNA binding)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|rcsb pdb:5C9S|rcsb pdb:5NLG|rcsb pdb:5WLC|rcsb pdb:5WWM|rcsb pdb:5WYJ|rcsb pdb:6LQQ|rcsb pdb:6LQR|rcsb pdb:6LQS|rcsb pdb:6LQT|rcsb pdb:6LQU|rcsb pdb:6ZQC|rcsb pdb:6ZQD|rcsb pdb:7AJT|rcsb pdb:7AJU|reactome:R-SCE-6791226|dip:DIP-6535N|mint:Q05022	sgd:S000006486(see-also)	-	crc64:39BF46E5587B3B0A	-	figure legend:Fig 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/06/25	2015/07/07	rogid:FUIsTk3NLRDu8llnVgX5cDLAbB8559292	-	-	false	protein a tag:n-n|mutation disrupting interaction:119-1336|mutation decreasing interaction:1455-1701	32p radiolabel:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q05022	intact:EBI-10894903	intact:EBI-16011|uniprotkb:D6W054|ensemblfungi:YMR229C	-	psi-mi:rrp5_yeast(display_long)|uniprotkb:RRP5(gene name)|psi-mi:RRP5(display_short)|uniprotkb:FMI1(gene name synonym)|uniprotkb:YMR229C(locus name)|uniprotkb:YM9959.11C(orf name)|uniprotkb:Ribosomal RNA-processing protein 5(gene name synonym)|uniprotkb:U3 small nucleolar RNA-associated protein RRP5(gene name synonym)	psi-mi:rrna 27sa2(display_short)|psi-mi:EBI-10894903(display_long)	psi-mi:"MI:0004"(affinity chromatography technology)	de et al. (2006)	pubmed:16428605|imex:IM-26633	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10894957|imex:IM-26633-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0608"(ribosomal rna)	refseq:NP_013956.1|sgd:S000004842|ensemblfungi:YMR229C(gene)|ensemblfungi:YMR229C_mRNA(transcript)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000464"("endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000472"("endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000480"("endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030515"(snoRNA binding)|go:"GO:0030686"(90S preribosome)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034463"(90S preribosome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034512"(box C/D RNA binding)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0042134"(rRNA primary transcript binding)|interpro:IPR003029(S1, RNA binding)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|rcsb pdb:5C9S|rcsb pdb:5NLG|rcsb pdb:5WLC|rcsb pdb:5WWM|rcsb pdb:5WYJ|rcsb pdb:6LQQ|rcsb pdb:6LQR|rcsb pdb:6LQS|rcsb pdb:6LQT|rcsb pdb:6LQU|rcsb pdb:6ZQC|rcsb pdb:6ZQD|rcsb pdb:7AJT|rcsb pdb:7AJU|reactome:R-SCE-6791226|dip:DIP-6535N|mint:Q05022	-	-	crc64:39BF46E5587B3B0A	-	figure legend:Fig 6A, Fig 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2015/06/25	2015/06/26	rogid:FUIsTk3NLRDu8llnVgX5cDLAbB8559292	-	-	false	protein a tag:n-n	-	-	-	psi-mi:"MI:0929"(northern blot)	psi-mi:"MI:0929"(northern blot)