#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P51172	uniprotkb:P51170	intact:EBI-2547114|ensembl:ENSP00000368411|uniprotkb:A9Z1X6|uniprotkb:Q08AQ3|uniprotkb:Q5T7L3|uniprotkb:Q8NA24|uniprotkb:B1PS44|uniprotkb:Q09HT0|uniprotkb:A6NNF7|uniprotkb:B3KSD7	intact:EBI-2547354|ensembl:ENSP00000300061|uniprotkb:P78437|uniprotkb:Q6PCC2|uniprotkb:Q93023|uniprotkb:Q93024|uniprotkb:Q93025|uniprotkb:Q93026|uniprotkb:Q93027|uniprotkb:Q96TD2	psi-mi:scnnd_human(display_long)|uniprotkb:SCNN1D(gene name)|psi-mi:SCNN1D(display_short)|uniprotkb:DNACH(gene name synonym)|uniprotkb:"Epithelial Na(+) channel subunit delta"(gene name synonym)|uniprotkb:SCNED(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit delta(gene name synonym)|uniprotkb:Delta-NaCH(gene name synonym)	psi-mi:scnng_human(display_long)|uniprotkb:SCNN1G(gene name)|psi-mi:SCNN1G(display_short)|uniprotkb:"Epithelial Na(+) channel subunit gamma"(gene name synonym)|uniprotkb:SCNEG(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit gamma(gene name synonym)|uniprotkb:Gamma-NaCH(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ji et al. (2006)	pubmed:16423824|imex:IM-24742	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11424303|imex:IM-24742-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000162572(gene)|ensembl:ENST00000379116(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0050896"(response to stimulus)|go:"GO:0050909"(sensory perception of taste)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|reactome:R-HSA-2672351|refseq:XP_011540227.1|refseq:XP_011540234.1|refseq:XP_011540235.1|refseq:NP_001123885.2	ensembl:ENSG00000166828(gene)|ensembl:ENST00000300061(transcript)|go:"GO:0005272"(sodium channel activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007588"(excretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0005216"(ion channel activity)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|rcsb pdb:6BQN|rcsb pdb:6WTH|reactome:R-HSA-2672351|refseq:NP_001030.2	-	-	-	figure legend:Fig. 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nci_h441)|taxid:9606(Homo sapiens)	-	2015/11/25	2019/01/23	rogid:ci1OfIrlsgtIVnxmbQNMYg0DOq49606	rogid:y3n1CDg1c7oj3ugrx9Kur21BmNk9606	rigid:jIBCCurmHR8ePRok58Z5Z0gu7+Y	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P37088	uniprotkb:P51170	intact:EBI-7845444|ensembl:ENSP00000228916|intact:MINT-198663|uniprotkb:O43271|uniprotkb:Q9UM64|uniprotkb:C5HTZ0|uniprotkb:B4E2Q5|uniprotkb:A5X2U9|uniprotkb:Q6GSQ6	intact:EBI-2547354|ensembl:ENSP00000300061|uniprotkb:P78437|uniprotkb:Q6PCC2|uniprotkb:Q93023|uniprotkb:Q93024|uniprotkb:Q93025|uniprotkb:Q93026|uniprotkb:Q93027|uniprotkb:Q96TD2	psi-mi:scnna_human(display_long)|uniprotkb:SCNN1A(gene name)|psi-mi:SCNN1A(display_short)|uniprotkb:SCNN1(gene name synonym)|uniprotkb:"Epithelial Na(+) channel subunit alpha"(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit alpha(gene name synonym)|uniprotkb:SCNEA(gene name synonym)|uniprotkb:Alpha-NaCH(gene name synonym)	psi-mi:scnng_human(display_long)|uniprotkb:SCNN1G(gene name)|psi-mi:SCNN1G(display_short)|uniprotkb:"Epithelial Na(+) channel subunit gamma"(gene name synonym)|uniprotkb:SCNEG(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit gamma(gene name synonym)|uniprotkb:Gamma-NaCH(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ji et al. (2006)	pubmed:16423824|imex:IM-24742	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11424307|imex:IM-24742-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111319(gene)|ensembl:ENST00000228916(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050896"(response to stimulus)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097228"(sperm principal piece)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|rcsb pdb:2M3O|rcsb pdb:6BQN|rcsb pdb:6WTH|reactome:R-HSA-2672351|refseq:NP_001153048.1|refseq:NP_001153047.1|refseq:NP_001029.1	ensembl:ENSG00000166828(gene)|ensembl:ENST00000300061(transcript)|go:"GO:0005272"(sodium channel activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007588"(excretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0005216"(ion channel activity)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|rcsb pdb:6BQN|rcsb pdb:6WTH|reactome:R-HSA-2672351|refseq:NP_001030.2	-	comment:mint|function:"Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception"|function:"Defects in SCNN1A are a cause of autosomal recessive pseudohypoaldosteronism type 1 (PHA1) [MIM:264350]. PHA1 is a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. There are 2 forms of PHA1: the autosomal recessive form that is severe, and the dominant form which is more milder and due to defects in mineralocorticoid receptor. Autosomal recessive PHA1 is characterized by an often fulminant presentation in the neonatal period with dehydration, hyponatraemia, hyperkalaemia, metabolic acidosis, failure to thrive and weight loss"	-	figure legend:Fig. 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nci_h441)|taxid:9606(Homo sapiens)	-	2015/11/25	2015/11/25	rogid:gVnl0rzupzTZyIbIL8BogbWXkAU9606	rogid:y3n1CDg1c7oj3ugrx9Kur21BmNk9606	rigid:8Lnd1OpIlHDTZbR/aU+1BH6N3L0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P37088	uniprotkb:P51172	intact:EBI-7845444|ensembl:ENSP00000228916|intact:MINT-198663|uniprotkb:O43271|uniprotkb:Q9UM64|uniprotkb:C5HTZ0|uniprotkb:B4E2Q5|uniprotkb:A5X2U9|uniprotkb:Q6GSQ6	intact:EBI-2547114|ensembl:ENSP00000368411|uniprotkb:A9Z1X6|uniprotkb:Q08AQ3|uniprotkb:Q5T7L3|uniprotkb:Q8NA24|uniprotkb:B1PS44|uniprotkb:Q09HT0|uniprotkb:A6NNF7|uniprotkb:B3KSD7	psi-mi:scnna_human(display_long)|uniprotkb:SCNN1A(gene name)|psi-mi:SCNN1A(display_short)|uniprotkb:SCNN1(gene name synonym)|uniprotkb:"Epithelial Na(+) channel subunit alpha"(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit alpha(gene name synonym)|uniprotkb:SCNEA(gene name synonym)|uniprotkb:Alpha-NaCH(gene name synonym)	psi-mi:scnnd_human(display_long)|uniprotkb:SCNN1D(gene name)|psi-mi:SCNN1D(display_short)|uniprotkb:DNACH(gene name synonym)|uniprotkb:"Epithelial Na(+) channel subunit delta"(gene name synonym)|uniprotkb:SCNED(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit delta(gene name synonym)|uniprotkb:Delta-NaCH(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ji et al. (2006)	pubmed:16423824|imex:IM-24742	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11424311|imex:IM-24742-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000111319(gene)|ensembl:ENST00000228916(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031514"(motile cilium)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050896"(response to stimulus)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097228"(sperm principal piece)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|rcsb pdb:2M3O|rcsb pdb:6BQN|rcsb pdb:6WTH|reactome:R-HSA-2672351|refseq:NP_001153048.1|refseq:NP_001153047.1|refseq:NP_001029.1	ensembl:ENSG00000162572(gene)|ensembl:ENST00000379116(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0050896"(response to stimulus)|go:"GO:0050909"(sensory perception of taste)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|reactome:R-HSA-2672351|refseq:XP_011540227.1|refseq:XP_011540234.1|refseq:XP_011540235.1|refseq:NP_001123885.2	-	comment:mint|function:"Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception"|function:"Defects in SCNN1A are a cause of autosomal recessive pseudohypoaldosteronism type 1 (PHA1) [MIM:264350]. PHA1 is a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. There are 2 forms of PHA1: the autosomal recessive form that is severe, and the dominant form which is more milder and due to defects in mineralocorticoid receptor. Autosomal recessive PHA1 is characterized by an often fulminant presentation in the neonatal period with dehydration, hyponatraemia, hyperkalaemia, metabolic acidosis, failure to thrive and weight loss"	-	figure legend:Fig. 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nci_h441)|taxid:9606(Homo sapiens)	-	2015/11/25	2019/01/23	rogid:gVnl0rzupzTZyIbIL8BogbWXkAU9606	rogid:ci1OfIrlsgtIVnxmbQNMYg0DOq49606	rigid:VYhGpKOa1mm3jzEK/8sbEN0fveI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)