#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O08573	uniprotkb:Q8VIM0	intact:EBI-8377586|uniprotkb:Q99L83|uniprotkb:O08572|uniprotkb:Q3UKE5|intact:MINT-1864855	intact:EBI-6665112|ensembl:ENSMUSP00000020668	psi-mi:leg9_mouse(display_long)|uniprotkb:Lgals9(gene name)|psi-mi:Lgals9(display_short)	psi-mi:havr2_mouse(display_long)|uniprotkb:Havcr2(gene name)|psi-mi:Havcr2(display_short)|uniprotkb:Tim3(gene name synonym)|uniprotkb:Timd3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhu et al. (2005)	imex:IM-24630|pubmed:16286920	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11316561|imex:IM-24630-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034838.2|refseq:NP_001152773.1|mint:O08573|interpro:IPR044156|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002376"(immune system process)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006935"(chemotaxis)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007565"(female pregnancy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016936"(galactoside binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032823"(regulation of natural killer cell differentiation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043322"(negative regulation of natural killer cell degranulation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|rcsb pdb:2D6K|rcsb pdb:2D6L|rcsb pdb:2D6M|rcsb pdb:2D6N|rcsb pdb:2D6O|rcsb pdb:2D6P|interpro:IPR001079(Galectin, galactose-binding lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)	ensembl:ENSMUSG00000020399(gene)|ensembl:ENSMUST00000020668(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002838"(negative regulation of immune response to tumor cell)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3KAA|go:"GO:0045087"(innate immune response)|go:"GO:0043032"(positive regulation of macrophage activation)|refseq:NP_599011.2|dip:DIP-61460N	-	function:"Binds galactosides. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death"|comment:mint	-	figure legend:2B|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/26	2015/10/21	rogid:2PB+Evo2SVxKvHVd9AtSLOOGjgg10090	rogid:V3q4IXpUhw8geyuorfLavOrs2ew10090	rigid:spUHv/mX3rFaxObjAreg6vaPYa0	false	biotin tag:?-?	fc-igg tag:c-c|sufficient binding region:1-132,217-281|variant:217-217	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O08573	uniprotkb:Q8VIM0	intact:EBI-8377586|uniprotkb:Q99L83|uniprotkb:O08572|uniprotkb:Q3UKE5|intact:MINT-1864855	intact:EBI-6665112|ensembl:ENSMUSP00000020668	psi-mi:leg9_mouse(display_long)|uniprotkb:Lgals9(gene name)|psi-mi:Lgals9(display_short)	psi-mi:havr2_mouse(display_long)|uniprotkb:Havcr2(gene name)|psi-mi:Havcr2(display_short)|uniprotkb:Tim3(gene name synonym)|uniprotkb:Timd3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Zhu et al. (2005)	imex:IM-24630|pubmed:16286920	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11316586|imex:IM-24630-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034838.2|refseq:NP_001152773.1|mint:O08573|interpro:IPR044156|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002376"(immune system process)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006935"(chemotaxis)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007565"(female pregnancy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016936"(galactoside binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0032823"(regulation of natural killer cell differentiation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043322"(negative regulation of natural killer cell degranulation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|rcsb pdb:2D6K|rcsb pdb:2D6L|rcsb pdb:2D6M|rcsb pdb:2D6N|rcsb pdb:2D6O|rcsb pdb:2D6P|interpro:IPR001079(Galectin, galactose-binding lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)	ensembl:ENSMUSG00000020399(gene)|ensembl:ENSMUST00000020668(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002838"(negative regulation of immune response to tumor cell)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3KAA|go:"GO:0045087"(innate immune response)|go:"GO:0043032"(positive regulation of macrophage activation)|refseq:NP_599011.2|dip:DIP-61460N	-	function:"Binds galactosides. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death"|comment:mint	-	figure legend:3|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2015/08/26	2015/11/18	rogid:2PB+Evo2SVxKvHVd9AtSLOOGjgg10090	rogid:V3q4IXpUhw8geyuorfLavOrs2ew10090	rigid:spUHv/mX3rFaxObjAreg6vaPYa0	false	sufficient binding region:1-147,179-353	fc-igg tag:c-c|sufficient binding region:1-132,217-281|variant:217-217	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q8VIM0	uniprotkb:P16045	intact:EBI-6665112|ensembl:ENSMUSP00000020668	intact:EBI-1634185|uniprotkb:P05163|uniprotkb:P11946|uniprotkb:P17601|uniprotkb:Q4FZH4|uniprotkb:Q99M27|uniprotkb:Q9D0X0|ensembl:ENSMUSP00000086795	psi-mi:havr2_mouse(display_long)|uniprotkb:Havcr2(gene name)|psi-mi:Havcr2(display_short)|uniprotkb:Tim3(gene name synonym)|uniprotkb:Timd3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)	psi-mi:leg1_mouse(display_long)|uniprotkb:Lgals1(gene name)|psi-mi:Lgals1(display_short)|uniprotkb:Gbp(gene name synonym)|uniprotkb:Lectin galactoside-binding soluble 1(gene name synonym)|uniprotkb:Beta-galactoside-binding lectin L-14-I(gene name synonym)|uniprotkb:S-Lac lectin 1(gene name synonym)|uniprotkb:Galaptin(gene name synonym)|uniprotkb:14 kDa lectin(gene name synonym)|uniprotkb:Lactose-binding lectin 1(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Zhu et al. (2005)	imex:IM-24630|pubmed:16286920	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11316605|imex:IM-24630-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020399(gene)|ensembl:ENSMUST00000020668(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002838"(negative regulation of immune response to tumor cell)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3KAA|go:"GO:0045087"(innate immune response)|go:"GO:0043032"(positive regulation of macrophage activation)|refseq:NP_599011.2|dip:DIP-61460N	refseq:NP_032521.1|ensembl:ENSMUSG00000068220(gene)|ensembl:ENSMUST00000089377(transcript)|go:"GO:0002317"(plasma cell differentiation)|go:"GO:0005534"(galactose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030395"(lactose binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034120"(positive regulation of erythrocyte aggregation)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043236"(laminin binding)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0048678"(response to axon injury)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR001079(Galectin, galactose-binding lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR044156|mint:P16045|rcsb pdb:4LBQ|reactome:R-MMU-381426|reactome:R-MMU-8957275	-	-	-	figure legend:3C|comment:weak interaction|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2015/08/26	2015/11/18	rogid:V3q4IXpUhw8geyuorfLavOrs2ew10090	rogid:VMxhs6wVhql3NEex38RQeIwirZs10090	rigid:sH3nB1CgbTa+xxvM0ORmpyfeDRA	false	fc-igg tag:c-c|sufficient binding region:1-132,217-281|variant:217-217	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q8VIM0	uniprotkb:P16110	intact:EBI-6665112|ensembl:ENSMUSP00000020668	intact:EBI-3508325	psi-mi:havr2_mouse(display_long)|uniprotkb:Havcr2(gene name)|psi-mi:Havcr2(display_short)|uniprotkb:Tim3(gene name synonym)|uniprotkb:Timd3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)	psi-mi:leg3_mouse(display_long)|uniprotkb:Lgals3(gene name)|psi-mi:Lgals3(display_short)|uniprotkb:35 kDa lectin(gene name synonym)|uniprotkb:Carbohydrate-binding protein 35(gene name synonym)|uniprotkb:Galactose-specific lectin 3(gene name synonym)|uniprotkb:IgE-binding protein(gene name synonym)|uniprotkb:L-34 galactoside-binding lectin(gene name synonym)|uniprotkb:Laminin-binding protein(gene name synonym)|uniprotkb:Lectin L-29(gene name synonym)|uniprotkb:Mac-2 antigen(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Zhu et al. (2005)	imex:IM-24630|pubmed:16286920	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11316620|imex:IM-24630-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020399(gene)|ensembl:ENSMUST00000020668(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002838"(negative regulation of immune response to tumor cell)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3KAA|go:"GO:0045087"(innate immune response)|go:"GO:0043032"(positive regulation of macrophage activation)|refseq:NP_599011.2|dip:DIP-61460N	go:"GO:0001501"(skeletal system development)|go:"GO:0001772"(immunological synapse)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008380"(RNA splicing)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014064"(positive regulation of serotonin secretion)|go:"GO:0019863"(IgE binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0048030"(disaccharide binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050785"(advanced glycation end-product receptor activity)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070232"(regulation of T cell apoptotic process)|go:"GO:0070492"(oligosaccharide binding)|go:"GO:0071674"(mononuclear cell migration)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0097386"(glial cell projection)|go:"GO:1902041"(regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903769"(negative regulation of cell proliferation in bone marrow)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001079(Galectin, galactose-binding lectin)|interpro:IPR015534(Galectin-3)|interpro:IPR044156|rcsb pdb:7DF6|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|dip:DIP-2152N|reactome:R-MMU-6798695	-	-	-	figure legend:3Ci|comment:weak interaction|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2015/08/26	2015/11/18	rogid:V3q4IXpUhw8geyuorfLavOrs2ew10090	rogid:N2sijU2wqDkA5EeDJXVS4DGcTX810090	rigid:sae4ADaB0u2ArC/hIUdDVdWxVYE	false	fc-igg tag:c-c|sufficient binding region:1-132,217-281|variant:217-217	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q8VIM0	uniprotkb:Q8K419	intact:EBI-6665112|ensembl:ENSMUSP00000020668	intact:EBI-1183873|uniprotkb:O88353|uniprotkb:Q91X74|ensembl:ENSMUSP00000066461	psi-mi:havr2_mouse(display_long)|uniprotkb:Havcr2(gene name)|psi-mi:Havcr2(display_short)|uniprotkb:Tim3(gene name synonym)|uniprotkb:Timd3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)	psi-mi:leg4_mouse(display_long)|uniprotkb:Lgals4(gene name)|psi-mi:Lgals4(display_short)|uniprotkb:Lactose-binding lectin 4(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Zhu et al. (2005)	imex:IM-24630|pubmed:16286920	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11316632|imex:IM-24630-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020399(gene)|ensembl:ENSMUST00000020668(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002838"(negative regulation of immune response to tumor cell)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3KAA|go:"GO:0045087"(innate immune response)|go:"GO:0043032"(positive regulation of macrophage activation)|refseq:NP_599011.2|dip:DIP-61460N	refseq:NP_034836.1|ensembl:ENSMUSG00000053964(gene)|ensembl:ENSMUST00000066723(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0016936"(galactoside binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001079(Galectin, galactose-binding lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015533(Galectin-4/6)|interpro:IPR044156|rcsb pdb:2DYC|rcsb pdb:3I8T	-	-	-	figure legend:3Cii|comment:weak interaction|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2015/08/26	2015/11/18	rogid:V3q4IXpUhw8geyuorfLavOrs2ew10090	rogid:CxB7/h34xwEn/pCyuUyG5RQSJsQ10090	rigid:NJ+oF/idEpK/QZo+7OtrFhSzE9U	false	fc-igg tag:c-c|sufficient binding region:1-132,217-281|variant:217-217	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:36219"	uniprotkb:Q8VIM0	intact:EBI-11316764|chebi:"CHEBI:35461"|chebi:"CHEBI:43627"|chebi:"CHEBI:6353"	intact:EBI-6665112|ensembl:ENSMUSP00000020668	psi-mi:alpha-lactose(display_short)|psi-mi:"CHEBI:36219"(display_long)|intact:1-beta-D-Galactopyranosyl-4-alpha-D-glucopyranose(synonym)|intact:4-O-beta-D-galactopyranosyl-alpha-D-glucopyranose(synonym)|intact:alpha-Lactose(synonym)|intact:Anhydrous lactose(synonym)|intact:"beta-D-Galp-(1->4)-alpha-D-Glcp"(synonym)|intact:Lactose(synonym)|intact:LACTOSE(synonym)|intact:Milk sugar(synonym)|intact:"beta-D-galactopyranosyl-(1->4)-alpha-D-glucopyranose"(iupac name)|intact:"beta-D-galactopyranosyl-(1->4)-alpha-D-glucose"(iupac name)	psi-mi:havr2_mouse(display_long)|uniprotkb:Havcr2(gene name)|psi-mi:Havcr2(display_short)|uniprotkb:Tim3(gene name synonym)|uniprotkb:Timd3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	Zhu et al. (2005)	imex:IM-24630|pubmed:16286920	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11316783|imex:IM-24630-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSMUSG00000020399(gene)|ensembl:ENSMUST00000020668(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002838"(negative regulation of immune response to tumor cell)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3KAA|go:"GO:0045087"(innate immune response)|go:"GO:0043032"(positive regulation of macrophage activation)|refseq:NP_599011.2|dip:DIP-61460N	-	-	-	figure legend:4B|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2015/08/26	2015/11/18	-	rogid:V3q4IXpUhw8geyuorfLavOrs2ew10090	-	false	-	fc-igg tag:c-c|sufficient binding region:1-132,217-281|variant:217-217	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
chebi:"CHEBI:36219"	uniprotkb:O08573-2	intact:EBI-11316764|chebi:"CHEBI:35461"|chebi:"CHEBI:43627"|chebi:"CHEBI:6353"	intact:EBI-11316797|ensembl:ENSMUSP00000103903	psi-mi:alpha-lactose(display_short)|psi-mi:"CHEBI:36219"(display_long)|intact:1-beta-D-Galactopyranosyl-4-alpha-D-glucopyranose(synonym)|intact:4-O-beta-D-galactopyranosyl-alpha-D-glucopyranose(synonym)|intact:alpha-Lactose(synonym)|intact:Anhydrous lactose(synonym)|intact:"beta-D-Galp-(1->4)-alpha-D-Glcp"(synonym)|intact:Lactose(synonym)|intact:LACTOSE(synonym)|intact:Milk sugar(synonym)|intact:"beta-D-galactopyranosyl-(1->4)-alpha-D-glucopyranose"(iupac name)|intact:"beta-D-galactopyranosyl-(1->4)-alpha-D-glucose"(iupac name)	psi-mi:o08573-2(display_long)|uniprotkb:Lgals9(gene name)|psi-mi:Lgals9(display_short)|uniprotkb:Short(isoform synonym)|uniprotkb:D5(isoform synonym)	psi-mi:"MI:0051"(fluorescence technology)	Zhu et al. (2005)	imex:IM-24630|pubmed:16286920	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11316783|imex:IM-24630-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	intact:EBI-8377586(isoform-parent)|ensembl:ENSMUSG00000001123(gene)|ensembl:ENSMUST00000108268(transcript)	-	-	-	figure legend:4B|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2015/08/26	2015/11/18	-	rogid:Csm6E+gmh6Jpk0kCnZmd60nG/p410090	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q8VIM0	uniprotkb:O08573-2	intact:EBI-6665112|ensembl:ENSMUSP00000020668	intact:EBI-11316797|ensembl:ENSMUSP00000103903	psi-mi:havr2_mouse(display_long)|uniprotkb:Havcr2(gene name)|psi-mi:Havcr2(display_short)|uniprotkb:Tim3(gene name synonym)|uniprotkb:Timd3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)	psi-mi:o08573-2(display_long)|uniprotkb:Lgals9(gene name)|psi-mi:Lgals9(display_short)|uniprotkb:Short(isoform synonym)|uniprotkb:D5(isoform synonym)	psi-mi:"MI:0051"(fluorescence technology)	Zhu et al. (2005)	imex:IM-24630|pubmed:16286920	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11316810|imex:IM-24630-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020399(gene)|ensembl:ENSMUST00000020668(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002838"(negative regulation of immune response to tumor cell)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3KAA|go:"GO:0045087"(innate immune response)|go:"GO:0043032"(positive regulation of macrophage activation)|refseq:NP_599011.2|dip:DIP-61460N	intact:EBI-8377586(isoform-parent)|ensembl:ENSMUSG00000001123(gene)|ensembl:ENSMUST00000108268(transcript)	-	-	-	figure legend:4C|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2015/08/26	2015/11/18	rogid:V3q4IXpUhw8geyuorfLavOrs2ew10090	rogid:Csm6E+gmh6Jpk0kCnZmd60nG/p410090	rigid:++xvzx/gyleWM+rjWWuAX0trfVA	false	sufficient binding region:1-132,217-281|fc-igg tag:c-c|variant:217-217	mutation decreasing interaction strength:64-64|mutation decreasing interaction strength:238-238|mutation disrupting interaction strength:64-64,238-238	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O08573-2	uniprotkb:Q8VIM0	intact:EBI-11316797|ensembl:ENSMUSP00000103903	intact:EBI-6665112|ensembl:ENSMUSP00000020668	psi-mi:o08573-2(display_long)|uniprotkb:Lgals9(gene name)|psi-mi:Lgals9(display_short)|uniprotkb:Short(isoform synonym)|uniprotkb:D5(isoform synonym)	psi-mi:havr2_mouse(display_long)|uniprotkb:Havcr2(gene name)|psi-mi:Havcr2(display_short)|uniprotkb:Tim3(gene name synonym)|uniprotkb:Timd3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhu et al. (2005)	imex:IM-24630|pubmed:16286920	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11316736|imex:IM-24630-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-8377586(isoform-parent)|ensembl:ENSMUSG00000001123(gene)|ensembl:ENSMUST00000108268(transcript)	ensembl:ENSMUSG00000020399(gene)|ensembl:ENSMUST00000020668(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002838"(negative regulation of immune response to tumor cell)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3KAA|go:"GO:0045087"(innate immune response)|go:"GO:0043032"(positive regulation of macrophage activation)|refseq:NP_599011.2|dip:DIP-61460N	-	-	-	figure legend:4A|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/26	2015/10/21	rogid:Csm6E+gmh6Jpk0kCnZmd60nG/p410090	rogid:V3q4IXpUhw8geyuorfLavOrs2ew10090	rigid:++xvzx/gyleWM+rjWWuAX0trfVA	false	his tag:c-c	fc-igg tag:c-c|sufficient binding region:1-132,217-281|variant:217-217	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
chebi:"CHEBI:36219"	uniprotkb:Q8VIM0	intact:EBI-11316764|chebi:"CHEBI:35461"|chebi:"CHEBI:43627"|chebi:"CHEBI:6353"	intact:EBI-6665112|ensembl:ENSMUSP00000020668	psi-mi:alpha-lactose(display_short)|psi-mi:"CHEBI:36219"(display_long)|intact:1-beta-D-Galactopyranosyl-4-alpha-D-glucopyranose(synonym)|intact:4-O-beta-D-galactopyranosyl-alpha-D-glucopyranose(synonym)|intact:alpha-Lactose(synonym)|intact:Anhydrous lactose(synonym)|intact:"beta-D-Galp-(1->4)-alpha-D-Glcp"(synonym)|intact:Lactose(synonym)|intact:LACTOSE(synonym)|intact:Milk sugar(synonym)|intact:"beta-D-galactopyranosyl-(1->4)-alpha-D-glucopyranose"(iupac name)|intact:"beta-D-galactopyranosyl-(1->4)-alpha-D-glucose"(iupac name)	psi-mi:havr2_mouse(display_long)|uniprotkb:Havcr2(gene name)|psi-mi:Havcr2(display_short)|uniprotkb:Tim3(gene name synonym)|uniprotkb:Timd3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhu et al. (2005)	imex:IM-24630|pubmed:16286920	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11316751|imex:IM-24630-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSMUSG00000020399(gene)|ensembl:ENSMUST00000020668(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002838"(negative regulation of immune response to tumor cell)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3KAA|go:"GO:0045087"(innate immune response)|go:"GO:0043032"(positive regulation of macrophage activation)|refseq:NP_599011.2|dip:DIP-61460N	-	-	-	figure legend:4A|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/26	2015/10/21	-	rogid:V3q4IXpUhw8geyuorfLavOrs2ew10090	-	false	-	fc-igg tag:c-c|sufficient binding region:1-132,217-281|variant:217-217	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q8VIM0	uniprotkb:O08573-2	intact:EBI-6665112|ensembl:ENSMUSP00000020668	intact:EBI-11316797|ensembl:ENSMUSP00000103903	psi-mi:havr2_mouse(display_long)|uniprotkb:Havcr2(gene name)|psi-mi:Havcr2(display_short)|uniprotkb:Tim3(gene name synonym)|uniprotkb:Timd3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)	psi-mi:o08573-2(display_long)|uniprotkb:Lgals9(gene name)|psi-mi:Lgals9(display_short)|uniprotkb:Short(isoform synonym)|uniprotkb:D5(isoform synonym)	psi-mi:"MI:0096"(pull down)	Zhu et al. (2005)	imex:IM-24630|pubmed:16286920	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11316751|imex:IM-24630-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020399(gene)|ensembl:ENSMUST00000020668(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002838"(negative regulation of immune response to tumor cell)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3KAA|go:"GO:0045087"(innate immune response)|go:"GO:0043032"(positive regulation of macrophage activation)|refseq:NP_599011.2|dip:DIP-61460N	intact:EBI-8377586(isoform-parent)|ensembl:ENSMUSG00000001123(gene)|ensembl:ENSMUST00000108268(transcript)	-	-	-	figure legend:4A|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/26	2015/10/21	rogid:V3q4IXpUhw8geyuorfLavOrs2ew10090	rogid:Csm6E+gmh6Jpk0kCnZmd60nG/p410090	-	false	fc-igg tag:c-c|sufficient binding region:1-132,217-281|variant:217-217	his tag:c-c	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q8VIM0	uniprotkb:Q9XBM8	intact:EBI-6665112|ensembl:ENSMUSP00000020668	intact:EBI-11316843	psi-mi:havr2_mouse(display_long)|uniprotkb:Havcr2(gene name)|psi-mi:Havcr2(display_short)|uniprotkb:Tim3(gene name synonym)|uniprotkb:Timd3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)	psi-mi:q9xbm8_elime(display_long)|uniprotkb:png(gene name)|psi-mi:png(display_short)	psi-mi:"MI:0096"(pull down)	Zhu et al. (2005)	imex:IM-24630|pubmed:16286920	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:238(elime)|taxid:238(Elizabethkingia meningoseptica)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11316829|imex:IM-24630-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020399(gene)|ensembl:ENSMUST00000020668(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002838"(negative regulation of immune response to tumor cell)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3KAA|go:"GO:0045087"(innate immune response)|go:"GO:0043032"(positive regulation of macrophage activation)|refseq:NP_599011.2|dip:DIP-61460N	rcsb pdb:3PMS|interpro:IPR014784(Copper type II, ascorbate-dependent monooxygenase-like, C-terminal)|interpro:IPR008977(PHM/PNGase F-fold)|interpro:IPR015197(Peptide-N-glycosidase F, C-terminal)|interpro:IPR015196(Peptide-N-glycosidase F, N terminal)|go:"GO:0000224"("peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity")|go:"GO:0008152"(metabolic process)|go:"GO:0016715"(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen)|go:"GO:0016798"(hydrolase activity, acting on glycosyl bonds)	-	-	-	figure legend:4D|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/26	2015/10/21	rogid:V3q4IXpUhw8geyuorfLavOrs2ew10090	rogid:99MLTib2tYSqqeunL00m4wwjOkc238	rigid:qieCe1fotqdpnDkzltD/E5YdWBg	false	fc-igg tag:c-c|sufficient binding region:1-132,217-281|variant:217-217	-	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q8VIM0	uniprotkb:O08573-2	intact:EBI-6665112|ensembl:ENSMUSP00000020668	intact:EBI-11316797|ensembl:ENSMUSP00000103903	psi-mi:havr2_mouse(display_long)|uniprotkb:Havcr2(gene name)|psi-mi:Havcr2(display_short)|uniprotkb:Tim3(gene name synonym)|uniprotkb:Timd3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)	psi-mi:o08573-2(display_long)|uniprotkb:Lgals9(gene name)|psi-mi:Lgals9(display_short)|uniprotkb:Short(isoform synonym)|uniprotkb:D5(isoform synonym)	psi-mi:"MI:0096"(pull down)	Zhu et al. (2005)	imex:IM-24630|pubmed:16286920	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11316829|imex:IM-24630-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020399(gene)|ensembl:ENSMUST00000020668(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002838"(negative regulation of immune response to tumor cell)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3KAA|go:"GO:0045087"(innate immune response)|go:"GO:0043032"(positive regulation of macrophage activation)|refseq:NP_599011.2|dip:DIP-61460N	intact:EBI-8377586(isoform-parent)|ensembl:ENSMUSG00000001123(gene)|ensembl:ENSMUST00000108268(transcript)	-	-	-	figure legend:4D|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/26	2015/10/21	rogid:V3q4IXpUhw8geyuorfLavOrs2ew10090	rogid:Csm6E+gmh6Jpk0kCnZmd60nG/p410090	rigid:qieCe1fotqdpnDkzltD/E5YdWBg	false	fc-igg tag:c-c|sufficient binding region:1-132,217-281|variant:217-217	his tag:c-c	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)