#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q6SSD8 uniprotkb:P03347-1 intact:EBI-10687484 intact:EBI-10687478 psi-mi:q6ssd8_chlae(display_long) psi-mi:p03347-1(display_long)|uniprotkb:Pr55Gag(gene name synonym)|uniprotkb:gag(gene name)|psi-mi:gag(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lingappa et al. (2006) pubmed:16275648|imex:IM-24016 taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-10687499|imex:IM-24016-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR034348|interpro:IPR017896|interpro:IPR017900|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003439(ABC transporter-like)|interpro:IPR017871|interpro:IPR013283(ABC transporter, ABCE)|interpro:IPR027417|interpro:IPR007209(Possible metal-binding region in RNase L inhibitor, RLI)|go:"GO:0005524"(ATP binding)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity) intact:EBI-1220741(isoform-parent) - - isoform-comment:Produced by conventional translation. figure legend:1, 2, 3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2015/03/04 2015/03/04 rogid:wcpjJZFcDYw5mwRHDVCreZDNhbs9534 rogid:/QyeVkPxGb6ZIKDIy4vE/qfVCII11678 rigid:m8PMK6ksPBxeLMlgKbvfyQSDhd8 false - necessary binding region:392-405,413-426|binding-associated region:392-426|sufficient binding region:1-405|necessary binding region:391-424|mutation decreasing interaction:409-411|binding-associated region:406-411 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P03347-1 uniprotkb:P61221 intact:EBI-10687478 intact:EBI-2510446|ensembl:ENSP00000296577|uniprotkb:Q6NR76|uniprotkb:O88793|uniprotkb:Q13181|uniprotkb:Q99K66|uniprotkb:Q13864|uniprotkb:Q96AL0|uniprotkb:Q96B10 psi-mi:p03347-1(display_long)|uniprotkb:Pr55Gag(gene name synonym)|uniprotkb:gag(gene name)|psi-mi:gag(display_short) psi-mi:abce1_human(display_long)|uniprotkb:ABCE1(gene name)|psi-mi:ABCE1(display_short)|uniprotkb:RLI(gene name synonym)|uniprotkb:RNASEL1(gene name synonym)|uniprotkb:RNASELI(gene name synonym)|uniprotkb:RNS4I(gene name synonym)|uniprotkb:RNase L inhibitor(gene name synonym)|uniprotkb:Ribonuclease 4 inhibitor(gene name synonym)|uniprotkb:2'-5'-oligoadenylate-binding protein(gene name synonym)|uniprotkb:HuHP68(gene name synonym)|uniprotkb:OK/SW-cl.40(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lingappa et al. (2006) pubmed:16275648|imex:IM-24016 taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-10687538|imex:IM-24016-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1220741(isoform-parent) ensembl:ENSG00000164163(gene)|ensembl:ENST00000296577(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0005506"(iron ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006413"(translational initiation)|go:"GO:0006415"(translational termination)|go:"GO:0006417"(regulation of translation)|go:"GO:0016020"(membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060698"(endoribonuclease inhibitor activity)|go:"GO:0060702"(negative regulation of endoribonuclease activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR007209(Possible metal-binding region in RNase L inhibitor, RLI)|interpro:IPR013283(ABC transporter, ABCE)|interpro:IPR017871|interpro:IPR017896|interpro:IPR017900|interpro:IPR027417|interpro:IPR034348|mint:P61221|rcsb pdb:6ZME|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-8983711|reactome:R-HSA-909733|refseq:NP_001035809.1|refseq:NP_002931.2 - isoform-comment:Produced by conventional translation. - figure legend:4|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/04 2015/03/17 rogid:/QyeVkPxGb6ZIKDIy4vE/qfVCII11678 rogid:+6ykpRtI4p94M3TuoTzFBvdCsC09606 rigid:GQSQgpK5WhUUWXVVa8PvY8mygH4 false binding-associated region:413-426|binding-associated region:392-426|necessary binding region:391-424|sufficient binding region:1-437|binding-associated region:392-405|necessary binding region:362-437 flag tag:?-?|35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P03347-1 uniprotkb:P61221 intact:EBI-10687478 intact:EBI-2510446|ensembl:ENSP00000296577|uniprotkb:Q6NR76|uniprotkb:O88793|uniprotkb:Q13181|uniprotkb:Q99K66|uniprotkb:Q13864|uniprotkb:Q96AL0|uniprotkb:Q96B10 psi-mi:p03347-1(display_long)|uniprotkb:Pr55Gag(gene name synonym)|uniprotkb:gag(gene name)|psi-mi:gag(display_short) psi-mi:abce1_human(display_long)|uniprotkb:ABCE1(gene name)|psi-mi:ABCE1(display_short)|uniprotkb:RLI(gene name synonym)|uniprotkb:RNASEL1(gene name synonym)|uniprotkb:RNASELI(gene name synonym)|uniprotkb:RNS4I(gene name synonym)|uniprotkb:RNase L inhibitor(gene name synonym)|uniprotkb:Ribonuclease 4 inhibitor(gene name synonym)|uniprotkb:2'-5'-oligoadenylate-binding protein(gene name synonym)|uniprotkb:HuHP68(gene name synonym)|uniprotkb:OK/SW-cl.40(orf name) psi-mi:"MI:0096"(pull down) Lingappa et al. (2006) pubmed:16275648|imex:IM-24016 taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-10687773|imex:IM-24016-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1220741(isoform-parent) ensembl:ENSG00000164163(gene)|ensembl:ENST00000296577(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0005506"(iron ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006413"(translational initiation)|go:"GO:0006415"(translational termination)|go:"GO:0006417"(regulation of translation)|go:"GO:0016020"(membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060698"(endoribonuclease inhibitor activity)|go:"GO:0060702"(negative regulation of endoribonuclease activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR007209(Possible metal-binding region in RNase L inhibitor, RLI)|interpro:IPR013283(ABC transporter, ABCE)|interpro:IPR017871|interpro:IPR017896|interpro:IPR017900|interpro:IPR027417|interpro:IPR034348|mint:P61221|rcsb pdb:6ZME|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-8983711|reactome:R-HSA-909733|refseq:NP_001035809.1|refseq:NP_002931.2 - isoform-comment:Produced by conventional translation. - figure legend:4c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/03/04 2015/03/05 rogid:/QyeVkPxGb6ZIKDIy4vE/qfVCII11678 rogid:+6ykpRtI4p94M3TuoTzFBvdCsC09606 rigid:GQSQgpK5WhUUWXVVa8PvY8mygH4 false binding-associated region:413-426|binding-associated region:392-426|necessary binding region:391-424|binding-associated region:392-405 glutathione s tranferase tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P61221 uniprotkb:P03347-1 intact:EBI-2510446|ensembl:ENSP00000296577|uniprotkb:Q6NR76|uniprotkb:O88793|uniprotkb:Q13181|uniprotkb:Q99K66|uniprotkb:Q13864|uniprotkb:Q96AL0|uniprotkb:Q96B10 intact:EBI-10687478 psi-mi:abce1_human(display_long)|uniprotkb:ABCE1(gene name)|psi-mi:ABCE1(display_short)|uniprotkb:RLI(gene name synonym)|uniprotkb:RNASEL1(gene name synonym)|uniprotkb:RNASELI(gene name synonym)|uniprotkb:RNS4I(gene name synonym)|uniprotkb:RNase L inhibitor(gene name synonym)|uniprotkb:Ribonuclease 4 inhibitor(gene name synonym)|uniprotkb:2'-5'-oligoadenylate-binding protein(gene name synonym)|uniprotkb:HuHP68(gene name synonym)|uniprotkb:OK/SW-cl.40(orf name) psi-mi:p03347-1(display_long)|uniprotkb:Pr55Gag(gene name synonym)|uniprotkb:gag(gene name)|psi-mi:gag(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lingappa et al. (2006) pubmed:16275648|imex:IM-24016 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-10687803|imex:IM-24016-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000164163(gene)|ensembl:ENST00000296577(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0005506"(iron ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006413"(translational initiation)|go:"GO:0006415"(translational termination)|go:"GO:0006417"(regulation of translation)|go:"GO:0016020"(membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060698"(endoribonuclease inhibitor activity)|go:"GO:0060702"(negative regulation of endoribonuclease activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR007209(Possible metal-binding region in RNase L inhibitor, RLI)|interpro:IPR013283(ABC transporter, ABCE)|interpro:IPR017871|interpro:IPR017896|interpro:IPR017900|interpro:IPR027417|interpro:IPR034348|mint:P61221|rcsb pdb:6ZME|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-8983711|reactome:R-HSA-909733|refseq:NP_001035809.1|refseq:NP_002931.2 intact:EBI-1220741(isoform-parent) - - isoform-comment:Produced by conventional translation. figure legend:5|comment:Association is not sensitive to treatment with RNase A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/03/04 2015/03/05 rogid:+6ykpRtI4p94M3TuoTzFBvdCsC09606 rogid:/QyeVkPxGb6ZIKDIy4vE/qfVCII11678 rigid:GQSQgpK5WhUUWXVVa8PvY8mygH4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9HC16 uniprotkb:P03347-1 intact:EBI-717839|uniprotkb:Q45F02|uniprotkb:Q5TF77|uniprotkb:Q7Z2N1|uniprotkb:Q7Z2N4|uniprotkb:Q9H9H8|uniprotkb:B2RDR9|ensembl:ENSP00000385057 intact:EBI-10687478 psi-mi:abc3g_human(display_long)|uniprotkb:APOBEC-related cytidine deaminase(gene name synonym)|uniprotkb:APOBEC-related protein 9(gene name synonym)|uniprotkb:CEM-15(gene name synonym)|uniprotkb:APOBEC3G(gene name)|psi-mi:APOBEC3G(display_short)|uniprotkb:Deoxycytidine deaminase(gene name synonym)|uniprotkb:MDS019(orf name) psi-mi:p03347-1(display_long)|uniprotkb:Pr55Gag(gene name synonym)|uniprotkb:gag(gene name)|psi-mi:gag(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Lingappa et al. (2006) pubmed:16275648|imex:IM-24016 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-10687807|imex:IM-24016-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_068594.1|ensembl:ENSG00000239713(gene)|ensembl:ENST00000407997(transcript)|go:"GO:0000932"(P-body)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0004126"(cytidine deaminase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008829"(dCTP deaminase activity)|go:"GO:0009972"(cytidine deamination)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0016553"(base conversion or substitution editing)|go:"GO:0016554"(cytidine to uridine editing)|go:"GO:0030895"(apolipoprotein B mRNA editing enzyme complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0047844"(deoxycytidine deaminase activity)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0051607"(defense response to virus)|go:"GO:0070383"(DNA cytosine deamination)|go:"GO:0080111"(DNA demethylation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002125(CMP/dCMP deaminase, zinc-binding)|interpro:IPR016192(APOBEC/CMP deaminase, zinc-binding)|interpro:IPR016193(Cytidine deaminase-like)|interpro:IPR040551|rcsb pdb:2KBO|rcsb pdb:2KEM|rcsb pdb:3E1U|rcsb pdb:3IQS|rcsb pdb:3IR2|rcsb pdb:3V4J|rcsb pdb:3V4K|rcsb pdb:4ROV|rcsb pdb:4ROW|rcsb pdb:5ZVA|rcsb pdb:5ZVB|rcsb pdb:6BUX|rcsb pdb:6BWY|rcsb pdb:6K3J|rcsb pdb:6K3K|reactome:R-HSA-180585|reactome:R-HSA-180689|rcsb pdb:2JYW|dip:DIP-37519N intact:EBI-1220741(isoform-parent) - - isoform-comment:Produced by conventional translation. figure legend:5|comment:Association is lost upon treatment with RNase A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/03/04 2015/03/05 rogid:o6JWyu1Is1J9e0CiLKAudHeFC4Y9606 rogid:/QyeVkPxGb6ZIKDIy4vE/qfVCII11678 rigid:ol4D+fxf+fHXx5TWCfejgY0mm18 false tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)