#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P12682	uniprotkb:Q9QUN7	intact:EBI-10952962	intact:EBI-3505834|uniprotkb:Q3U400|uniprotkb:Q9DBC4	psi-mi:hmgb1_pig(display_long)|uniprotkb:HMGB1(gene name)|psi-mi:HMGB1(display_short)|uniprotkb:HMG1(gene name synonym)|uniprotkb:High mobility group protein 1(gene name synonym)	psi-mi:tlr2_mouse(display_long)|uniprotkb:Tlr2(gene name)|psi-mi:Tlr2(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Park et al. (2006)	imex:IM-24447|pubmed:16267105	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10919132|imex:IM-24447-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001004034.1|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR017967|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002840"(regulation of T cell mediated immune response to tumor cell)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0017055"(negative regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0032392"(DNA geometric change)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044378"(non-sequence-specific DNA binding, bending)|go:"GO:0045087"(innate immune response)|go:"GO:0051106"(positive regulation of DNA ligation)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0097350"(neutrophil clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904877"(positive regulation of DNA ligase activity)|interpro:IPR036910|interpro:IPR031076	refseq:NP_036035.3|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002752"(cell surface pattern recognition receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007612"(learning)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014005"(microglia development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0032493"(response to bacterial lipoprotein)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0035355"(Toll-like receptor 2-Toll-like receptor 6 protein complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042498"(diacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042995"(cell projection)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027185|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2Z81|rcsb pdb:2Z82|rcsb pdb:3A79|rcsb pdb:3A7B|rcsb pdb:3A7C|rcsb pdb:5D3I|dip:DIP-61222N|reactome:R-MMU-1461957|reactome:R-MMU-5686938|reactome:R-MMU-6798695	go:"GO:0009986"(cell surface)	-	-	figure legend:1A|comment:Association shown after 5 min of incubation, decreased intensity after 60 min.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264)	-	2015/07/23	2015/08/03	rogid:2d9pPRoL1uzEUHp2aJDbgYbPG4g9823	rogid:XtH/QtdMIz/JJ0Us/FwfC7quN8810090	rigid:Z39f51W8lISQltChrF8Ekhz5Gkk	false	-	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q9QUK6	uniprotkb:P12682	intact:EBI-1534575|uniprotkb:Q9D691|uniprotkb:Q9QZF5|uniprotkb:Q9Z203|ensembl:ENSMUSP00000045770	intact:EBI-10952962	psi-mi:tlr4_mouse(display_long)|uniprotkb:Tlr4(gene name)|psi-mi:Tlr4(display_short)|uniprotkb:Lps(gene name synonym)	psi-mi:hmgb1_pig(display_long)|uniprotkb:HMGB1(gene name)|psi-mi:HMGB1(display_short)|uniprotkb:HMG1(gene name synonym)|uniprotkb:High mobility group protein 1(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Park et al. (2006)	imex:IM-24447|pubmed:16267105	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10919136|imex:IM-24447-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067272.1|dip:DIP-38573N|ensembl:ENSMUSG00000039005(gene)|ensembl:ENSMUST00000048096(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001726"(ruffle)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045576"(mast cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2Z64|rcsb pdb:3VQ1|rcsb pdb:3VQ2|rcsb pdb:5IJB|rcsb pdb:5IJC|rcsb pdb:5IJD|reactome:R-MMU-140534|reactome:R-MMU-166016|reactome:R-MMU-166166|reactome:R-MMU-2562578|reactome:R-MMU-5686938|reactome:R-MMU-936964|reactome:R-MMU-937041|reactome:R-MMU-937072|reactome:R-MMU-9707616|reactome:R-MMU-975163	refseq:NP_001004034.1|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR017967|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002840"(regulation of T cell mediated immune response to tumor cell)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0017055"(negative regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0032392"(DNA geometric change)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044378"(non-sequence-specific DNA binding, bending)|go:"GO:0045087"(innate immune response)|go:"GO:0051106"(positive regulation of DNA ligation)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0097350"(neutrophil clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904877"(positive regulation of DNA ligase activity)|interpro:IPR036910|interpro:IPR031076	go:"GO:0009986"(cell surface)	-	-	figure legend:1B|comment:Association shown after 5 min of incubation, decreased intensity after 60 min.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264)	-	2015/07/23	2015/08/03	rogid:tVbu3ZsGm01Y4tO+vmeNtUXX7rc10090	rogid:2d9pPRoL1uzEUHp2aJDbgYbPG4g9823	rigid:CmDkgKmn2EFG7nBdStM3f+OEfx8	false	-	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P63158	uniprotkb:Q9QUN7	intact:EBI-6665811|ensembl:ENSMUSP00000082682|ensembl:ENSMUSP00000106131|ensembl:ENSMUSP00000106132|uniprotkb:P07155|uniprotkb:P27109|uniprotkb:P27428	intact:EBI-3505834|uniprotkb:Q3U400|uniprotkb:Q9DBC4	psi-mi:hmgb1_mouse(display_long)|uniprotkb:Hmgb1(gene name)|psi-mi:Hmgb1(display_short)|uniprotkb:Hmg-1(gene name synonym)|uniprotkb:Hmg1(gene name synonym)|uniprotkb:High mobility group protein 1(gene name synonym)	psi-mi:tlr2_mouse(display_long)|uniprotkb:Tlr2(gene name)|psi-mi:Tlr2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Park et al. (2006)	imex:IM-24447|pubmed:16267105	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10919168|imex:IM-24447-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001300823.1|ensembl:ENSMUSG00000066551(gene)|ensembl:ENSMUST00000085546(transcript)|ensembl:ENSMUST00000093196(transcript)|ensembl:ENSMUST00000110505(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000401"(open form four-way junction DNA binding)|go:"GO:0000402"(crossed form four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001654"(eye development)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002270"(plasmacytoid dendritic cell activation)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002643"(regulation of tolerance induction)|go:"GO:0002840"(regulation of T cell mediated immune response to tumor cell)|go:"GO:0003681"(bent DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006284"(base-excision repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008201"(heparin binding)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009986"(cell surface)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010858"(calcium-dependent protein kinase regulator activity)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016829"(lyase activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0017055"(negative regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032072"(regulation of restriction endodeoxyribonuclease activity)|go:"GO:0032392"(DNA geometric change)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0005576"(extracellular region)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051106"(positive regulation of DNA ligation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0097350"(neutrophil clearance)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000426"(negative regulation of apoptotic cell clearance)|go:"GO:2000819"(regulation of nucleotide-excision repair)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR017967|interpro:IPR031076|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|interpro:IPR036910|mint:P63158|rcsb pdb:5ZDZ|rcsb pdb:5ZE0|rcsb pdb:5ZE1|rcsb pdb:5ZE2|reactome:R-MMU-140342|reactome:R-MMU-445989|reactome:R-MMU-5620971|reactome:R-MMU-5686938|reactome:R-MMU-6798695|reactome:R-MMU-933542|reactome:R-MMU-879415|refseq:NP_034569.1|refseq:XP_003945388.1	refseq:NP_036035.3|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002752"(cell surface pattern recognition receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007612"(learning)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014005"(microglia development)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0032493"(response to bacterial lipoprotein)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035354"(Toll-like receptor 1-Toll-like receptor 2 protein complex)|go:"GO:0035355"(Toll-like receptor 2-Toll-like receptor 6 protein complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042495"(detection of triacyl bacterial lipopeptide)|go:"GO:0042496"(detection of diacyl bacterial lipopeptide)|go:"GO:0042497"(triacyl lipopeptide binding)|go:"GO:0042498"(diacyl lipopeptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042995"(cell projection)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071723"(lipopeptide binding)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:0071727"(cellular response to triacyl bacterial lipopeptide)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR027185|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2Z81|rcsb pdb:2Z82|rcsb pdb:3A79|rcsb pdb:3A7B|rcsb pdb:3A7C|rcsb pdb:5D3I|dip:DIP-61222N|reactome:R-MMU-1461957|reactome:R-MMU-5686938|reactome:R-MMU-6798695	-	-	-	figure legend:3A|comment:"Detected HMGB1 might derive from added pig HGMB1 protein or endogenous (mouse) HMGB1. However, an association of endogenous proteins is shown in the C60 Lane ."|comment:An increase of association is shown after 5 min of incubation, decreased intensity after 60 min.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264)	-	2015/07/23	2015/07/23	rogid:Ujrs2BBefbmNxZj+S9H8lhWjnNc10090	rogid:XtH/QtdMIz/JJ0Us/FwfC7quN8810090	rigid:n+kD8tRvzjQ5/SplWbb833QY2FE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QUK6	uniprotkb:P63158	intact:EBI-1534575|uniprotkb:Q9D691|uniprotkb:Q9QZF5|uniprotkb:Q9Z203|ensembl:ENSMUSP00000045770	intact:EBI-6665811|ensembl:ENSMUSP00000082682|ensembl:ENSMUSP00000106131|ensembl:ENSMUSP00000106132|uniprotkb:P07155|uniprotkb:P27109|uniprotkb:P27428	psi-mi:tlr4_mouse(display_long)|uniprotkb:Tlr4(gene name)|psi-mi:Tlr4(display_short)|uniprotkb:Lps(gene name synonym)	psi-mi:hmgb1_mouse(display_long)|uniprotkb:Hmgb1(gene name)|psi-mi:Hmgb1(display_short)|uniprotkb:Hmg-1(gene name synonym)|uniprotkb:Hmg1(gene name synonym)|uniprotkb:High mobility group protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Park et al. (2006)	imex:IM-24447|pubmed:16267105	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10919161|imex:IM-24447-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067272.1|dip:DIP-38573N|ensembl:ENSMUSG00000039005(gene)|ensembl:ENSMUST00000048096(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001726"(ruffle)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045576"(mast cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2Z64|rcsb pdb:3VQ1|rcsb pdb:3VQ2|rcsb pdb:5IJB|rcsb pdb:5IJC|rcsb pdb:5IJD|reactome:R-MMU-140534|reactome:R-MMU-166016|reactome:R-MMU-166166|reactome:R-MMU-2562578|reactome:R-MMU-5686938|reactome:R-MMU-936964|reactome:R-MMU-937041|reactome:R-MMU-937072|reactome:R-MMU-9707616|reactome:R-MMU-975163	refseq:NP_001300823.1|ensembl:ENSMUSG00000066551(gene)|ensembl:ENSMUST00000085546(transcript)|ensembl:ENSMUST00000093196(transcript)|ensembl:ENSMUST00000110505(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000401"(open form four-way junction DNA binding)|go:"GO:0000402"(crossed form four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001654"(eye development)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002270"(plasmacytoid dendritic cell activation)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002643"(regulation of tolerance induction)|go:"GO:0002840"(regulation of T cell mediated immune response to tumor cell)|go:"GO:0003681"(bent DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006284"(base-excision repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008201"(heparin binding)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009986"(cell surface)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010858"(calcium-dependent protein kinase regulator activity)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016829"(lyase activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0017055"(negative regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032072"(regulation of restriction endodeoxyribonuclease activity)|go:"GO:0032392"(DNA geometric change)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0005576"(extracellular region)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051106"(positive regulation of DNA ligation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0097350"(neutrophil clearance)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000426"(negative regulation of apoptotic cell clearance)|go:"GO:2000819"(regulation of nucleotide-excision repair)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR017967|interpro:IPR031076|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|interpro:IPR036910|mint:P63158|rcsb pdb:5ZDZ|rcsb pdb:5ZE0|rcsb pdb:5ZE1|rcsb pdb:5ZE2|reactome:R-MMU-140342|reactome:R-MMU-445989|reactome:R-MMU-5620971|reactome:R-MMU-5686938|reactome:R-MMU-6798695|reactome:R-MMU-933542|reactome:R-MMU-879415|refseq:NP_034569.1|refseq:XP_003945388.1	-	-	-	figure legend:3B|comment:"Detected HMGB1 might derive from added pig HGMB1 protein or endogenous (mouse) HMGB1. However, an association of endogenous proteins is shown in the C60 lane."|comment:An increase of association shown after 5 min of incubation, decreased intensity after 60 min.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264)	-	2015/07/23	2015/07/23	rogid:tVbu3ZsGm01Y4tO+vmeNtUXX7rc10090	rogid:Ujrs2BBefbmNxZj+S9H8lhWjnNc10090	rigid:IIUBxhUi9D4DLszEUzvfLYjg3K4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)