#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q53HV7 uniprotkb:P69726 intact:EBI-749970|uniprotkb:O95862|uniprotkb:Q8NB71|uniprotkb:Q9BWC8|uniprotkb:A8K2K9|uniprotkb:Q0D2M0|ensembl:ENSP00000338606|ensembl:ENSP00000424191|ensembl:ENSP00000507590|ensembl:ENSP00000384828|intact:EBI-16429121 intact:EBI-9097571|uniprotkb:P05926|uniprotkb:Q85577 psi-mi:smug1_human(display_long)|uniprotkb:SMUG1(gene name)|psi-mi:SMUG1(display_short) psi-mi:vpr_hv1h2(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Schröfelbauer et al. (2005) pubmed:16103149|imex:IM-24456 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-10634863|imex:IM-24456-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055126.1|refseq:XP_011536411.1|refseq:XP_011536412.1|refseq:XP_011536413.1|refseq:XP_011536414.1|refseq:XP_011536415.1|refseq:XP_011536416.1|refseq:XP_011536417.1|refseq:XP_011536418.1|refseq:XP_011536419.1|refseq:XP_011536420.1|refseq:XP_011536421.1|refseq:XP_011536422.1|refseq:XP_011536423.1|refseq:NP_001230716.1|refseq:NP_001230717.1|refseq:NP_001230718.1|refseq:NP_001230719.1|refseq:NP_001230720.1|refseq:XP_006719382.1|refseq:XP_006719383.1|refseq:XP_006719384.1|refseq:XP_016874602.1|refseq:XP_016874603.1|refseq:XP_016874604.1|refseq:XP_016874605.1|refseq:XP_016874608.1|ensembl:ENSG00000123415(gene)|ensembl:ENST00000337581(transcript)|ensembl:ENST00000401977(transcript)|ensembl:ENST00000508394(transcript)|ensembl:ENST00000682136(transcript)|go:"GO:0000703"(oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0004844"(uracil DNA N-glycosylase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0017065"(single-strand selective uracil DNA N-glycosylase activity)|go:"GO:0019104"(DNA N-glycosylase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045008"(depyrimidination)|interpro:IPR036895|interpro:IPR039134|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110357|refseq:XP_006719385.1|refseq:XP_011536424.1|refseq:XP_016874606.1|refseq:XP_016874607.1|refseq:XP_016874609.1 interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:4U1S|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180897|reactome:R-HSA-180910|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0044423"(virion component)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051701"(biological process involved in interaction with host)|go:"GO:0075732"(viral penetration into host nucleus) - - - figure legend:4A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/02/16 2015/08/07 rogid:spkw9KcBN2lpT8wBFBWzIdlhgtg9606 rogid:KbuLGrH+zNV14uCZ1mVwEPoZQJU11706 intact-crc:0DA2E6905B13BB4D|rigid:lmZRPoT11K1ST5Rc4OLWhrza1N8 false ha tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P69726 uniprotkb:P13051-1 intact:EBI-9097571|uniprotkb:P05926|uniprotkb:Q85577 intact:EBI-10169958|ensembl:ENSP00000242576 psi-mi:vpr_hv1h2(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:p13051-1(display_long)|uniprotkb:UNG2(isoform synonym)|uniprotkb:UNG(gene name)|psi-mi:UNG(display_short)|uniprotkb:DGU(gene name synonym)|uniprotkb:UNG1(gene name synonym)|uniprotkb:UNG15(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Schröfelbauer et al. (2005) pubmed:16103149|imex:IM-24456 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-10634852|imex:IM-24456-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:4U1S|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180897|reactome:R-HSA-180910|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0044423"(virion component)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051701"(biological process involved in interaction with host)|go:"GO:0075732"(viral penetration into host nucleus) intact:EBI-1025947(isoform-parent)|ensembl:ENSG00000076248(gene)|ensembl:ENST00000242576(transcript) - - - figure legend:4A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2015/02/16 2015/08/07 rogid:KbuLGrH+zNV14uCZ1mVwEPoZQJU11706 rogid:pjzUi17Vpmhp1JddThFwPvNhZCE9606 intact-crc:F79862464FBA600B|rigid:RYbo4i+B2POACJrnkhy6SNu4o/0 false - ha tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P13051 uniprotkb:P69726 intact:EBI-1025947|uniprotkb:O00637|uniprotkb:O00719|uniprotkb:Q93028|uniprotkb:A8K5M6|uniprotkb:B2R8Y1|ensembl:ENSP00000242576 intact:EBI-9097571|uniprotkb:P05926|uniprotkb:Q85577 psi-mi:ung_human(display_long)|uniprotkb:UNG(gene name)|psi-mi:UNG(display_short)|uniprotkb:DGU(gene name synonym)|uniprotkb:UNG15(gene name synonym)|uniprotkb:UNG1(gene name synonym) psi-mi:vpr_hv1h2(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Schröfelbauer et al. (2005) pubmed:16103149|imex:IM-24456 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-10634892|imex:IM-24456-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003353.1|refseq:NP_550433.1|ensembl:ENSG00000076248(gene)|ensembl:ENST00000242576(transcript)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0004844"(uracil DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045008"(depyrimidination)|go:"GO:0045190"(isotype switching)|go:"GO:0097510"(base-excision repair, AP site formation via deaminated base removal)|interpro:IPR002043(Uracil-DNA glycosylase)|interpro:IPR005122(Uracil-DNA glycosylase-like)|interpro:IPR018085|interpro:IPR036895|rcsb pdb:1AKZ|rcsb pdb:1DPU|rcsb pdb:1EMH|rcsb pdb:1EMJ|rcsb pdb:1Q3F|rcsb pdb:1SSP|rcsb pdb:1UGH|rcsb pdb:1YUO|rcsb pdb:2HXM|rcsb pdb:2OXM|rcsb pdb:2OYT|rcsb pdb:2SSP|rcsb pdb:3FCF|rcsb pdb:3FCI|rcsb pdb:3FCK|rcsb pdb:3FCL|rcsb pdb:3TKB|rcsb pdb:4SKN|rcsb pdb:5AYR|rcsb pdb:5JK7|rcsb pdb:6VBA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110357|dip:DIP-24194N interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:4U1S|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180897|reactome:R-HSA-180910|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0044423"(virion component)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051701"(biological process involved in interaction with host)|go:"GO:0075732"(viral penetration into host nucleus) go:"GO:0005634"(nucleus) - - figure legend:2|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2015/02/16 2015/02/16 rogid:pjzUi17Vpmhp1JddThFwPvNhZCE9606 rogid:KbuLGrH+zNV14uCZ1mVwEPoZQJU11706 intact-crc:2C3D71C7FBE504E1|rigid:RYbo4i+B2POACJrnkhy6SNu4o/0 false - ha tag:?-? - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)