#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q6VVB1	uniprotkb:P61077	intact:EBI-6426628|ensembl:ENSP00000345464|uniprotkb:Q6IMH1|uniprotkb:Q5VUK7|uniprotkb:Q3SYB1	intact:EBI-348268|ensembl:ENSP00000318494|ensembl:ENSP00000337208|ensembl:ENSP00000378283|ensembl:ENSP00000396901|ensembl:ENSP00000344069|ensembl:ENSP00000378280|ensembl:ENSP00000378282|uniprotkb:A6NM99|intact:EBI-2809412|uniprotkb:P47986|uniprotkb:Q6IB88|uniprotkb:Q6NXS4|uniprotkb:Q8N924|uniprotkb:A6NJ93|uniprotkb:A6NJB1	psi-mi:nhlc1_human(display_long)|uniprotkb:NHLRC1(gene name)|psi-mi:NHLRC1(display_short)|uniprotkb:EPM2B(gene name synonym)|uniprotkb:Malin(gene name synonym)|uniprotkb:NHL repeat-containing protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NHLRC1(gene name synonym)	psi-mi:ub2d3_human(display_long)|uniprotkb:UBC5C(gene name synonym)|uniprotkb:Ubiquitin-protein ligase D3(gene name synonym)|uniprotkb:Ubiquitin carrier protein D3(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 3(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 3"(gene name synonym)|uniprotkb:UBE2D3(gene name)|psi-mi:UBE2D3(display_short)|uniprotkb:UBCH5C(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D3"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D3(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Gentry et al. (2005)	imex:IM-23854|pubmed:15930137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10102349|imex:IM-23854-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000187566(gene)|ensembl:ENST00000340650(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_940988.2	ensembl:ENSG00000109332(gene)|ensembl:ENST00000321805(transcript)|ensembl:ENST00000338145(transcript)|ensembl:ENST00000349311(transcript)|ensembl:ENST00000394801(transcript)|ensembl:ENST00000394803(transcript)|ensembl:ENST00000394804(transcript)|ensembl:ENST00000453744(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006915"(apoptotic process)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:2FUH|rcsb pdb:3L1Z|rcsb pdb:3RPG|rcsb pdb:3UGB|rcsb pdb:4BVU|rcsb pdb:4R8P|rcsb pdb:4S3O|rcsb pdb:5EGG|rcsb pdb:5IFR|rcsb pdb:6CP0|rcsb pdb:6T7F|rcsb pdb:7JZV|reactome:R-HSA-1234176|reactome:R-HSA-168927|reactome:R-HSA-201451|reactome:R-HSA-2173795|reactome:R-HSA-8866654|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:1X23|refseq:NP_003331.1|refseq:NP_871615.1|refseq:NP_871616.1|refseq:NP_871617.1|refseq:NP_871618.1|refseq:NP_871619.1|refseq:NP_871620.1|refseq:NP_871621.1|refseq:NP_871622.1|dip:DIP-29062N	-	-	-	figure legend:2|comment:"The authors state that the respective GST-tagged E2 enzyme is largely the ubiquitinated substrate (data not shown)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/03	2015/02/13	rogid:jLFXF8B5yGb+VWcX1MkEFOm8hUU9606	rogid:jSQ4I+Cgli7HaN5S0OLUP+J5YXs9606	intact-crc:2E499F2DE087FD3F|rigid:9sfZ1Fgj+tK+oQRjepWTrblnfus	false	glutathione s tranferase tag:n-n|his tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6VVB1	uniprotkb:P22314	intact:EBI-6426628|ensembl:ENSP00000345464|uniprotkb:Q6IMH1|uniprotkb:Q5VUK7|uniprotkb:Q3SYB1	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:nhlc1_human(display_long)|uniprotkb:NHLRC1(gene name)|psi-mi:NHLRC1(display_short)|uniprotkb:EPM2B(gene name synonym)|uniprotkb:Malin(gene name synonym)|uniprotkb:NHL repeat-containing protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NHLRC1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Gentry et al. (2005)	imex:IM-23854|pubmed:15930137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10102349|imex:IM-23854-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000187566(gene)|ensembl:ENST00000340650(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_940988.2	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	-	-	-	figure legend:2|comment:"The authors state that the respective GST-tagged E2 enzyme is largely the ubiquitinated substrate (data not shown)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/03	2015/02/13	rogid:jLFXF8B5yGb+VWcX1MkEFOm8hUU9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:2E499F2DE087FD3F|rigid:9sfZ1Fgj+tK+oQRjepWTrblnfus	false	glutathione s tranferase tag:n-n|his tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6VVB1	uniprotkb:P51668	intact:EBI-6426628|ensembl:ENSP00000345464|uniprotkb:Q6IMH1|uniprotkb:Q5VUK7|uniprotkb:Q3SYB1	intact:EBI-743540|ensembl:ENSP00000363019|uniprotkb:A6NLF6|uniprotkb:A8K786	psi-mi:nhlc1_human(display_long)|uniprotkb:NHLRC1(gene name)|psi-mi:NHLRC1(display_short)|uniprotkb:EPM2B(gene name synonym)|uniprotkb:Malin(gene name synonym)|uniprotkb:NHL repeat-containing protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NHLRC1(gene name synonym)	psi-mi:ub2d1_human(display_long)|uniprotkb:Ubiquitin-protein ligase D1(gene name synonym)|uniprotkb:Ubiquitin carrier protein D1(gene name synonym)|uniprotkb:UbcH5(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 1(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 1"(gene name synonym)|uniprotkb:UBC4/5 homolog(gene name synonym)|uniprotkb:Stimulator of Fe transport(gene name synonym)|uniprotkb:UBE2D1(gene name)|psi-mi:UBE2D1(display_short)|uniprotkb:UBCH5(gene name synonym)|uniprotkb:UBCH5A(gene name synonym)|uniprotkb:SFT(gene name synonym)|uniprotkb:UBC5A(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D1"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Gentry et al. (2005)	imex:IM-23854|pubmed:15930137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10102334|imex:IM-23854-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000187566(gene)|ensembl:ENST00000340650(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_940988.2	ensembl:ENSG00000072401(gene)|ensembl:ENST00000373910(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|refseq:NP_003329.1|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P51668|rcsb pdb:2C4P|rcsb pdb:2YHO|rcsb pdb:3OJ4|rcsb pdb:3PTF|rcsb pdb:4AP4|rcsb pdb:4QPL|rcsb pdb:5FER|rcsb pdb:5TUT|rcsb pdb:6D4P|reactome:R-HSA-1234176|reactome:R-HSA-141430|reactome:R-HSA-168927|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-201451|reactome:R-HSA-202424|reactome:R-HSA-2173795|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-8866654|reactome:R-HSA-2871837|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9687136|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-5607764|reactome:R-HSA-5689896|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-8866652|dip:DIP-44088N	-	-	-	figure legend:2 and 6|comment:"The authors state that the respective GST-tagged E2 enzyme islargely the ubiquitinated substrate (data not shown)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/03	2015/02/13	rogid:jLFXF8B5yGb+VWcX1MkEFOm8hUU9606	rogid:5BHbufBexJFsiV5kEhqOvdTfvio9606	intact-crc:6266805ABA6D4144|rigid:QI2B27Pmsa9sDNTKnsR0e4bfytw	false	glutathione s tranferase tag:n-n|his tag:c-c|sufficient binding region:1-128	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6VVB1	uniprotkb:P22314	intact:EBI-6426628|ensembl:ENSP00000345464|uniprotkb:Q6IMH1|uniprotkb:Q5VUK7|uniprotkb:Q3SYB1	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:nhlc1_human(display_long)|uniprotkb:NHLRC1(gene name)|psi-mi:NHLRC1(display_short)|uniprotkb:EPM2B(gene name synonym)|uniprotkb:Malin(gene name synonym)|uniprotkb:NHL repeat-containing protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NHLRC1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Gentry et al. (2005)	imex:IM-23854|pubmed:15930137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10102334|imex:IM-23854-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000187566(gene)|ensembl:ENST00000340650(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_940988.2	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	-	-	-	figure legend:2 and 6|comment:"The authors state that the respective GST-tagged E2 enzyme islargely the ubiquitinated substrate (data not shown)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/03	2015/02/13	rogid:jLFXF8B5yGb+VWcX1MkEFOm8hUU9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:6266805ABA6D4144|rigid:QI2B27Pmsa9sDNTKnsR0e4bfytw	false	glutathione s tranferase tag:n-n|his tag:c-c|sufficient binding region:1-128	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95278	uniprotkb:Q6VVB1	intact:EBI-2506661|uniprotkb:O95483|uniprotkb:Q5T3F5|uniprotkb:Q8IU96|uniprotkb:Q8IX24|uniprotkb:Q8IX25|uniprotkb:Q9BS66|uniprotkb:Q9UEN2|ensembl:ENSP00000356489|uniprotkb:B3KMU5|uniprotkb:B4DRZ2|uniprotkb:Q6IS15	intact:EBI-6426628|ensembl:ENSP00000345464|uniprotkb:Q6IMH1|uniprotkb:Q5VUK7|uniprotkb:Q3SYB1	psi-mi:epm2a_human(display_long)|uniprotkb:EPM2A(gene name)|psi-mi:EPM2A(display_short)|uniprotkb:Lafora PTPase(gene name synonym)|uniprotkb:Glycogen phosphatase(gene name synonym)|uniprotkb:Glucan phosphatase(gene name synonym)	psi-mi:nhlc1_human(display_long)|uniprotkb:NHLRC1(gene name)|psi-mi:NHLRC1(display_short)|uniprotkb:EPM2B(gene name synonym)|uniprotkb:Malin(gene name synonym)|uniprotkb:NHL repeat-containing protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NHLRC1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Gentry et al. (2005)	imex:IM-23854|pubmed:15930137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10102733|imex:IM-23854-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011534418.1|ensembl:ENSG00000112425(gene)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019203"(carbohydrate phosphatase activity)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030425"(dendrite)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035305"(negative regulation of dephosphorylation)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046835"(carbohydrate phosphorylation)|go:"GO:0046838"(phosphorylated carbohydrate dephosphorylation)|go:"GO:0046959"(habituation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0098556"(cytoplasmic side of rough endoplasmic reticulum membrane)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904666"(regulation of ubiquitin protein ligase activity)|go:"GO:2000465"("regulation of glycogen (starch) synthase activity")|go:"GO:2001069"(glycogen binding)|go:"GO:2001070"(starch binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|ensembl:ENST00000367519(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004373"("glycogen (starch) synthase activity")|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0014009"(glial cell proliferation)|interpro:IPR002044(Glycoside hydrolase, carbohydrate-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013784(Carbohydrate-binding-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR034831|interpro:IPR042942|rcsb pdb:4R30|rcsb pdb:4RKK|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_001018051.1|refseq:NP_005661.1|refseq:XP_006715627.1|refseq:XP_016866789.1|refseq:XP_016866790.1|refseq:XP_016866791.1	ensembl:ENSG00000187566(gene)|ensembl:ENST00000340650(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_940988.2	-	-	-	figure legend:5|comment:Human E2 ubuquitin ligase added but not specified|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/03	2015/02/03	rogid:SzLH6Z+48utiGISu59PgvgBzXD49606	rogid:jLFXF8B5yGb+VWcX1MkEFOm8hUU9606	intact-crc:010DAA3A7C8802D7|rigid:WeiieOs4X26ySkOeRdJKuqWl6Ws	false	flag tag:n-n|35s radiolabel:?-?	his tag:c-c|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95278	uniprotkb:P22314	intact:EBI-2506661|uniprotkb:O95483|uniprotkb:Q5T3F5|uniprotkb:Q8IU96|uniprotkb:Q8IX24|uniprotkb:Q8IX25|uniprotkb:Q9BS66|uniprotkb:Q9UEN2|ensembl:ENSP00000356489|uniprotkb:B3KMU5|uniprotkb:B4DRZ2|uniprotkb:Q6IS15	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:epm2a_human(display_long)|uniprotkb:EPM2A(gene name)|psi-mi:EPM2A(display_short)|uniprotkb:Lafora PTPase(gene name synonym)|uniprotkb:Glycogen phosphatase(gene name synonym)|uniprotkb:Glucan phosphatase(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Gentry et al. (2005)	imex:IM-23854|pubmed:15930137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10102733|imex:IM-23854-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011534418.1|ensembl:ENSG00000112425(gene)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019203"(carbohydrate phosphatase activity)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030425"(dendrite)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035305"(negative regulation of dephosphorylation)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046835"(carbohydrate phosphorylation)|go:"GO:0046838"(phosphorylated carbohydrate dephosphorylation)|go:"GO:0046959"(habituation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0098556"(cytoplasmic side of rough endoplasmic reticulum membrane)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904666"(regulation of ubiquitin protein ligase activity)|go:"GO:2000465"("regulation of glycogen (starch) synthase activity")|go:"GO:2001069"(glycogen binding)|go:"GO:2001070"(starch binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|ensembl:ENST00000367519(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004373"("glycogen (starch) synthase activity")|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0014009"(glial cell proliferation)|interpro:IPR002044(Glycoside hydrolase, carbohydrate-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013784(Carbohydrate-binding-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR034831|interpro:IPR042942|rcsb pdb:4R30|rcsb pdb:4RKK|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_001018051.1|refseq:NP_005661.1|refseq:XP_006715627.1|refseq:XP_016866789.1|refseq:XP_016866790.1|refseq:XP_016866791.1	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	-	-	-	figure legend:5|comment:Human E2 ubuquitin ligase added but not specified|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/03	2015/02/03	rogid:SzLH6Z+48utiGISu59PgvgBzXD49606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:010DAA3A7C8802D7|rigid:WeiieOs4X26ySkOeRdJKuqWl6Ws	false	flag tag:n-n|35s radiolabel:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6VVB1	uniprotkb:P51965	intact:EBI-6426628|ensembl:ENSP00000345464|uniprotkb:Q6IMH1|uniprotkb:Q5VUK7|uniprotkb:Q3SYB1	intact:EBI-348546|uniprotkb:B2RBX4|ensembl:ENSP00000303709|uniprotkb:C9J8K2|uniprotkb:K4DI90	psi-mi:nhlc1_human(display_long)|uniprotkb:NHLRC1(gene name)|psi-mi:NHLRC1(display_short)|uniprotkb:EPM2B(gene name synonym)|uniprotkb:Malin(gene name synonym)|uniprotkb:NHL repeat-containing protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NHLRC1(gene name synonym)	psi-mi:ub2e1_human(display_long)|uniprotkb:UBE2E1(gene name)|psi-mi:UBE2E1(display_short)|uniprotkb:UBCH6(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E1(gene name synonym)|uniprotkb:Ubiquitin carrier protein E1(gene name synonym)|uniprotkb:UbcH6(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme E1"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme E1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Gentry et al. (2005)	imex:IM-23854|pubmed:15930137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10102359|imex:IM-23854-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000187566(gene)|ensembl:ENST00000340650(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_940988.2	refseq:NP_003332.1|refseq:NP_872607.1|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR023313|rcsb pdb:1XR9|rcsb pdb:3BZH|rcsb pdb:4JJQ|rcsb pdb:5LBN|rcsb pdb:6FGA|reactome:R-HSA-1169408|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-9687136|reactome:R-HSA-983168|ensembl:ENST00000306627(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042296"(ISG15 transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|ensembl:ENSG00000170142(gene)|refseq:NP_001189405.1	-	-	-	figure legend:2|comment:"The authors state that the respective GST-tagged E2 enzyme islargely the ubiquitinated substrate (data not shown)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/03	2015/02/13	rogid:jLFXF8B5yGb+VWcX1MkEFOm8hUU9606	rogid:pPIqYniSQn5Jh7u5x0Lm2NXppQU9606	intact-crc:B78F3C6C8232D18D|rigid:ZOgAwoSvAiFsRetAggAIqyzsX2Q	false	glutathione s tranferase tag:n-n|his tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6VVB1	uniprotkb:P22314	intact:EBI-6426628|ensembl:ENSP00000345464|uniprotkb:Q6IMH1|uniprotkb:Q5VUK7|uniprotkb:Q3SYB1	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:nhlc1_human(display_long)|uniprotkb:NHLRC1(gene name)|psi-mi:NHLRC1(display_short)|uniprotkb:EPM2B(gene name synonym)|uniprotkb:Malin(gene name synonym)|uniprotkb:NHL repeat-containing protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NHLRC1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Gentry et al. (2005)	imex:IM-23854|pubmed:15930137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10102359|imex:IM-23854-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000187566(gene)|ensembl:ENST00000340650(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_940988.2	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	-	-	-	figure legend:2|comment:"The authors state that the respective GST-tagged E2 enzyme islargely the ubiquitinated substrate (data not shown)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/03	2015/02/13	rogid:jLFXF8B5yGb+VWcX1MkEFOm8hUU9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:B78F3C6C8232D18D|rigid:ZOgAwoSvAiFsRetAggAIqyzsX2Q	false	glutathione s tranferase tag:n-n|his tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6VVB1	uniprotkb:P22314	intact:EBI-6426628|ensembl:ENSP00000345464|uniprotkb:Q6IMH1|uniprotkb:Q5VUK7|uniprotkb:Q3SYB1	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:nhlc1_human(display_long)|uniprotkb:NHLRC1(gene name)|psi-mi:NHLRC1(display_short)|uniprotkb:EPM2B(gene name synonym)|uniprotkb:Malin(gene name synonym)|uniprotkb:NHL repeat-containing protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NHLRC1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Gentry et al. (2005)	imex:IM-23854|pubmed:15930137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10102237|imex:IM-23854-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000187566(gene)|ensembl:ENST00000340650(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_940988.2	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	-	-	-	figure legend:2|comment:"The authors state that the respective GST-tagged E2 enzyme islargely the ubiquitinated substrate (data not shown)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/03	2015/02/13	rogid:jLFXF8B5yGb+VWcX1MkEFOm8hUU9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:5AEFF4676CB54F37|rigid:aQTQB971bR1xxHe2W3tpQoF+u90	false	glutathione s tranferase tag:n-n|his tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6VVB1	uniprotkb:P62256	intact:EBI-6426628|ensembl:ENSP00000345464|uniprotkb:Q6IMH1|uniprotkb:Q5VUK7|uniprotkb:Q3SYB1	intact:EBI-2129909|uniprotkb:P37286|uniprotkb:A4D1L6|uniprotkb:C9JY93|uniprotkb:Q7Z6F4|ensembl:ENSP00000347836	psi-mi:nhlc1_human(display_long)|uniprotkb:NHLRC1(gene name)|psi-mi:NHLRC1(display_short)|uniprotkb:EPM2B(gene name synonym)|uniprotkb:Malin(gene name synonym)|uniprotkb:NHL repeat-containing protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NHLRC1(gene name synonym)	psi-mi:ube2h_human(display_long)|uniprotkb:UBE2H(gene name)|psi-mi:UBE2H(display_short)|uniprotkb:Ubiquitin-protein ligase H(gene name synonym)|uniprotkb:Ubiquitin carrier protein H(gene name synonym)|uniprotkb:UbcH2(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-20K(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme H"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme H(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Gentry et al. (2005)	imex:IM-23854|pubmed:15930137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10102237|imex:IM-23854-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000187566(gene)|ensembl:ENST00000340650(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_940988.2	refseq:NP_001189427.1|refseq:NP_003335.1|refseq:NP_874356.1|ensembl:ENSG00000186591(gene)|ensembl:ENST00000355621(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:2Z5D|reactome:R-HSA-8866652|reactome:R-HSA-983168	-	-	-	figure legend:2|comment:"The authors state that the respective GST-tagged E2 enzyme islargely the ubiquitinated substrate (data not shown)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/03	2015/02/13	rogid:jLFXF8B5yGb+VWcX1MkEFOm8hUU9606	rogid:hNy9GrFWU6iHxt0qjop7unBnlWQ9606	intact-crc:5AEFF4676CB54F37|rigid:aQTQB971bR1xxHe2W3tpQoF+u90	false	glutathione s tranferase tag:n-n|his tag:c-c	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6VVB1	uniprotkb:O95278	intact:EBI-6426628|ensembl:ENSP00000345464|uniprotkb:Q6IMH1|uniprotkb:Q5VUK7|uniprotkb:Q3SYB1	intact:EBI-2506661|uniprotkb:O95483|uniprotkb:Q5T3F5|uniprotkb:Q8IU96|uniprotkb:Q8IX24|uniprotkb:Q8IX25|uniprotkb:Q9BS66|uniprotkb:Q9UEN2|ensembl:ENSP00000356489|uniprotkb:B3KMU5|uniprotkb:B4DRZ2|uniprotkb:Q6IS15	psi-mi:nhlc1_human(display_long)|uniprotkb:NHLRC1(gene name)|psi-mi:NHLRC1(display_short)|uniprotkb:EPM2B(gene name synonym)|uniprotkb:Malin(gene name synonym)|uniprotkb:NHL repeat-containing protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NHLRC1(gene name synonym)	psi-mi:epm2a_human(display_long)|uniprotkb:EPM2A(gene name)|psi-mi:EPM2A(display_short)|uniprotkb:Lafora PTPase(gene name synonym)|uniprotkb:Glycogen phosphatase(gene name synonym)|uniprotkb:Glucan phosphatase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Gentry et al. (2005)	imex:IM-23854|pubmed:15930137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10102390|imex:IM-23854-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000187566(gene)|ensembl:ENST00000340650(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_940988.2	refseq:XP_011534418.1|ensembl:ENSG00000112425(gene)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019203"(carbohydrate phosphatase activity)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030425"(dendrite)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035305"(negative regulation of dephosphorylation)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046835"(carbohydrate phosphorylation)|go:"GO:0046838"(phosphorylated carbohydrate dephosphorylation)|go:"GO:0046959"(habituation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0098556"(cytoplasmic side of rough endoplasmic reticulum membrane)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904666"(regulation of ubiquitin protein ligase activity)|go:"GO:2000465"("regulation of glycogen (starch) synthase activity")|go:"GO:2001069"(glycogen binding)|go:"GO:2001070"(starch binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|ensembl:ENST00000367519(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004373"("glycogen (starch) synthase activity")|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0014009"(glial cell proliferation)|interpro:IPR002044(Glycoside hydrolase, carbohydrate-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013784(Carbohydrate-binding-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR034831|interpro:IPR042942|rcsb pdb:4R30|rcsb pdb:4RKK|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_001018051.1|refseq:NP_005661.1|refseq:XP_006715627.1|refseq:XP_016866789.1|refseq:XP_016866790.1|refseq:XP_016866791.1	-	-	-	figure legend:no figure|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2015/02/03	2015/02/03	rogid:jLFXF8B5yGb+VWcX1MkEFOm8hUU9606	rogid:SzLH6Z+48utiGISu59PgvgBzXD49606	intact-crc:16B95876A0935907|rigid:E8FR0twVOuYoyIAMvCIh47stEi4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6VVB1	uniprotkb:O95278	intact:EBI-6426628|ensembl:ENSP00000345464|uniprotkb:Q6IMH1|uniprotkb:Q5VUK7|uniprotkb:Q3SYB1	intact:EBI-2506661|uniprotkb:O95483|uniprotkb:Q5T3F5|uniprotkb:Q8IU96|uniprotkb:Q8IX24|uniprotkb:Q8IX25|uniprotkb:Q9BS66|uniprotkb:Q9UEN2|ensembl:ENSP00000356489|uniprotkb:B3KMU5|uniprotkb:B4DRZ2|uniprotkb:Q6IS15	psi-mi:nhlc1_human(display_long)|uniprotkb:NHLRC1(gene name)|psi-mi:NHLRC1(display_short)|uniprotkb:EPM2B(gene name synonym)|uniprotkb:Malin(gene name synonym)|uniprotkb:NHL repeat-containing protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NHLRC1(gene name synonym)	psi-mi:epm2a_human(display_long)|uniprotkb:EPM2A(gene name)|psi-mi:EPM2A(display_short)|uniprotkb:Lafora PTPase(gene name synonym)|uniprotkb:Glycogen phosphatase(gene name synonym)|uniprotkb:Glucan phosphatase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Gentry et al. (2005)	imex:IM-23854|pubmed:15930137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10102404|imex:IM-23854-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000187566(gene)|ensembl:ENST00000340650(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_940988.2	refseq:XP_011534418.1|ensembl:ENSG00000112425(gene)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019203"(carbohydrate phosphatase activity)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030425"(dendrite)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035305"(negative regulation of dephosphorylation)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046835"(carbohydrate phosphorylation)|go:"GO:0046838"(phosphorylated carbohydrate dephosphorylation)|go:"GO:0046959"(habituation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0098556"(cytoplasmic side of rough endoplasmic reticulum membrane)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904666"(regulation of ubiquitin protein ligase activity)|go:"GO:2000465"("regulation of glycogen (starch) synthase activity")|go:"GO:2001069"(glycogen binding)|go:"GO:2001070"(starch binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|ensembl:ENST00000367519(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004373"("glycogen (starch) synthase activity")|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0014009"(glial cell proliferation)|interpro:IPR002044(Glycoside hydrolase, carbohydrate-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013784(Carbohydrate-binding-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR034831|interpro:IPR042942|rcsb pdb:4R30|rcsb pdb:4RKK|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_001018051.1|refseq:NP_005661.1|refseq:XP_006715627.1|refseq:XP_016866789.1|refseq:XP_016866790.1|refseq:XP_016866791.1	omim:254780(see-also)	-	-	figure legend:3A and B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2015/02/03	2015/02/03	rogid:jLFXF8B5yGb+VWcX1MkEFOm8hUU9606	rogid:SzLH6Z+48utiGISu59PgvgBzXD49606	intact-crc:56636CAA54AB8CB5|rigid:E8FR0twVOuYoyIAMvCIh47stEi4	false	sufficient binding region:78-395(IPR013017)|mutation disrupting interaction:280-280|mutation disrupting interaction:302-302	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6VVB1	uniprotkb:O95278	intact:EBI-6426628|ensembl:ENSP00000345464|uniprotkb:Q6IMH1|uniprotkb:Q5VUK7|uniprotkb:Q3SYB1	intact:EBI-2506661|uniprotkb:O95483|uniprotkb:Q5T3F5|uniprotkb:Q8IU96|uniprotkb:Q8IX24|uniprotkb:Q8IX25|uniprotkb:Q9BS66|uniprotkb:Q9UEN2|ensembl:ENSP00000356489|uniprotkb:B3KMU5|uniprotkb:B4DRZ2|uniprotkb:Q6IS15	psi-mi:nhlc1_human(display_long)|uniprotkb:NHLRC1(gene name)|psi-mi:NHLRC1(display_short)|uniprotkb:EPM2B(gene name synonym)|uniprotkb:Malin(gene name synonym)|uniprotkb:NHL repeat-containing protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NHLRC1(gene name synonym)	psi-mi:epm2a_human(display_long)|uniprotkb:EPM2A(gene name)|psi-mi:EPM2A(display_short)|uniprotkb:Lafora PTPase(gene name synonym)|uniprotkb:Glycogen phosphatase(gene name synonym)|uniprotkb:Glucan phosphatase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Gentry et al. (2005)	imex:IM-23854|pubmed:15930137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10102545|imex:IM-23854-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000187566(gene)|ensembl:ENST00000340650(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_940988.2	refseq:XP_011534418.1|ensembl:ENSG00000112425(gene)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019203"(carbohydrate phosphatase activity)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030425"(dendrite)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035305"(negative regulation of dephosphorylation)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046835"(carbohydrate phosphorylation)|go:"GO:0046838"(phosphorylated carbohydrate dephosphorylation)|go:"GO:0046959"(habituation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0098556"(cytoplasmic side of rough endoplasmic reticulum membrane)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904666"(regulation of ubiquitin protein ligase activity)|go:"GO:2000465"("regulation of glycogen (starch) synthase activity")|go:"GO:2001069"(glycogen binding)|go:"GO:2001070"(starch binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|ensembl:ENST00000367519(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004373"("glycogen (starch) synthase activity")|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0014009"(glial cell proliferation)|interpro:IPR002044(Glycoside hydrolase, carbohydrate-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013784(Carbohydrate-binding-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR034831|interpro:IPR042942|rcsb pdb:4R30|rcsb pdb:4RKK|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_001018051.1|refseq:NP_005661.1|refseq:XP_006715627.1|refseq:XP_016866789.1|refseq:XP_016866790.1|refseq:XP_016866791.1	-	-	-	figure legend:3C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/02/03	2015/02/03	rogid:jLFXF8B5yGb+VWcX1MkEFOm8hUU9606	rogid:SzLH6Z+48utiGISu59PgvgBzXD49606	intact-crc:CC8B21792DA441BC|rigid:E8FR0twVOuYoyIAMvCIh47stEi4	false	35s radiolabel:?-?	his tag:c-c	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q6VVB1	uniprotkb:O95278	intact:EBI-6426628|ensembl:ENSP00000345464|uniprotkb:Q6IMH1|uniprotkb:Q5VUK7|uniprotkb:Q3SYB1	intact:EBI-2506661|uniprotkb:O95483|uniprotkb:Q5T3F5|uniprotkb:Q8IU96|uniprotkb:Q8IX24|uniprotkb:Q8IX25|uniprotkb:Q9BS66|uniprotkb:Q9UEN2|ensembl:ENSP00000356489|uniprotkb:B3KMU5|uniprotkb:B4DRZ2|uniprotkb:Q6IS15	psi-mi:nhlc1_human(display_long)|uniprotkb:NHLRC1(gene name)|psi-mi:NHLRC1(display_short)|uniprotkb:EPM2B(gene name synonym)|uniprotkb:Malin(gene name synonym)|uniprotkb:NHL repeat-containing protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NHLRC1(gene name synonym)	psi-mi:epm2a_human(display_long)|uniprotkb:EPM2A(gene name)|psi-mi:EPM2A(display_short)|uniprotkb:Lafora PTPase(gene name synonym)|uniprotkb:Glycogen phosphatase(gene name synonym)|uniprotkb:Glucan phosphatase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Gentry et al. (2005)	imex:IM-23854|pubmed:15930137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10102666|imex:IM-23854-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000187566(gene)|ensembl:ENST00000340650(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_940988.2	refseq:XP_011534418.1|ensembl:ENSG00000112425(gene)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019203"(carbohydrate phosphatase activity)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030425"(dendrite)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035305"(negative regulation of dephosphorylation)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046835"(carbohydrate phosphorylation)|go:"GO:0046838"(phosphorylated carbohydrate dephosphorylation)|go:"GO:0046959"(habituation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0098556"(cytoplasmic side of rough endoplasmic reticulum membrane)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904666"(regulation of ubiquitin protein ligase activity)|go:"GO:2000465"("regulation of glycogen (starch) synthase activity")|go:"GO:2001069"(glycogen binding)|go:"GO:2001070"(starch binding)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|ensembl:ENST00000367519(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004373"("glycogen (starch) synthase activity")|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0014009"(glial cell proliferation)|interpro:IPR002044(Glycoside hydrolase, carbohydrate-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013784(Carbohydrate-binding-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR034831|interpro:IPR042942|rcsb pdb:4R30|rcsb pdb:4RKK|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_001018051.1|refseq:NP_005661.1|refseq:XP_006715627.1|refseq:XP_016866789.1|refseq:XP_016866790.1|refseq:XP_016866791.1	omim:254780(see-also)	-	-	figure legend:3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2015/02/03	2015/02/03	rogid:jLFXF8B5yGb+VWcX1MkEFOm8hUU9606	rogid:SzLH6Z+48utiGISu59PgvgBzXD49606	intact-crc:05118F7BE728475B|rigid:E8FR0twVOuYoyIAMvCIh47stEi4	false	myc tag:c-c|mutation decreasing interaction:26-26|mutation decreasing interaction:280-280|mutation decreasing interaction:302-302|mutation decreasing interaction:33-33	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)