#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q03518 uniprotkb:Q77CE4 intact:EBI-747259|uniprotkb:Q16149|intact:EBI-780739|uniprotkb:Q96CP4|ensembl:ENSP00000346206|ensembl:ENSP00000372722|ensembl:ENSP00000401149|ensembl:ENSP00000402316|ensembl:ENSP00000405356|ensembl:ENSP00000413080|ensembl:ENSP00000415660 intact:EBI-11303846 psi-mi:tap1_human(display_long)|uniprotkb:ABCB2(gene name synonym)|uniprotkb:PSF1(gene name synonym)|uniprotkb:RING4(gene name synonym)|uniprotkb:Y3(gene name synonym)|uniprotkb:TAP1(gene name)|psi-mi:TAP1(display_short)|uniprotkb:Peptide transporter TAP1(gene name synonym)|uniprotkb:ATP-binding cassette sub-family B member 2(gene name synonym)|uniprotkb:Peptide supply factor 1(gene name synonym)|uniprotkb:Peptide transporter PSF1(gene name synonym)|uniprotkb:Peptide transporter involved in antigen processing 1(gene name synonym)|uniprotkb:Really interesting new gene 4 protein(gene name synonym) psi-mi:gn_bhv1c(display_long)|uniprotkb:gN(gene name)|psi-mi:gN(display_short)|uniprotkb:UL49.5(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Koppers-Lalic et al. (2005) pubmed:15793001|imex:IM-26110 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10323(bhv1c)|taxid:10323("Bovine herpesvirus 1.1 (strain Cooper)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-11313783|imex:IM-26110-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000584.2|refseq:NP_001278951.1|ensembl:ENSG00000168394(gene)|ensembl:ENSG00000206297(gene)|ensembl:ENSG00000224212(gene)|ensembl:ENSG00000226173(gene)|ensembl:ENSG00000227816(gene)|ensembl:ENSG00000230705(gene)|ensembl:ENSG00000232367(gene)|ensembl:ENST00000354258(transcript)|ensembl:ENST00000383235(transcript)|ensembl:ENST00000414467(transcript)|ensembl:ENST00000418205(transcript)|ensembl:ENST00000424897(transcript)|ensembl:ENST00000439781(transcript)|ensembl:ENST00000440894(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006952"(defense response)|go:"GO:0015031"(protein transport)|go:"GO:0015433"(ABC-type peptide antigen transporter activity)|go:"GO:0015440"(ABC-type peptide transporter activity)|go:"GO:0015833"(peptide transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0042825"(TAP complex)|go:"GO:0043531"(ADP binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046967"(cytosol to endoplasmic reticulum transport)|go:"GO:0046978"(TAP1 binding)|go:"GO:0046979"(TAP2 binding)|go:"GO:0055085"(transmembrane transport)|go:"GO:1904680"(peptide transmembrane transporter activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR013305(ABC transporter, ABCB2)|interpro:IPR013306(ABC transporter, B3)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|interpro:IPR039421|mint:Q03518|rcsb pdb:1JJ7|rcsb pdb:5U1D|reactome:R-HSA-1236974|reactome:R-HSA-983170|dip:DIP-35626N interpro:IPR008647(Herpesvirus UL49.5 envelope tegument)|refseq:NP_045309.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0033644"(host cell membrane)|go:"GO:0039591"|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0046978"(TAP1 binding)|go:"GO:0046979"(TAP2 binding)|go:"GO:0046980"(tapasin binding)|go:"GO:0055036"(virion membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0090087"(regulation of peptide transport)|go:"GO:1903317"(regulation of protein maturation)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|interpro:IPR034707 - - - figure legend:1C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mel_juso)|taxid:9606(Homo sapiens) - 2015/10/13 2015/10/14 rogid:fkl1VU1VSl8sEjURg8kRj0joZlY9606 rogid:brFrlT3zDyQkbow2F4gbLa3yn5o10323 rigid:x3OOpt8ItErzP13onXhNu0Zwz0Q false 35s radiolabel:?-?|green fluorescent protein tag:c-c 35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:Q03519 uniprotkb:Q77CE4 intact:EBI-780781|uniprotkb:Q9UQ83|uniprotkb:O95410|uniprotkb:B0V2J8|uniprotkb:Q53FI6|uniprotkb:Q5HY71|uniprotkb:Q96PT8|ensembl:ENSP00000364032|ensembl:ENSP00000372599|ensembl:ENSP00000372726|ensembl:ENSP00000390013|ensembl:ENSP00000394101 intact:EBI-11303846 psi-mi:tap2_human(display_long)|uniprotkb:ATP-binding cassette sub-family B member 3(gene name synonym)|uniprotkb:Peptide transporter TAP2(gene name synonym)|uniprotkb:Peptide supply factor 2(gene name synonym)|uniprotkb:Peptide transporter PSF2(gene name synonym)|uniprotkb:Peptide transporter involved in antigen processing 2(gene name synonym)|uniprotkb:TAP2(gene name)|psi-mi:TAP2(display_short)|uniprotkb:ABCB3(gene name synonym)|uniprotkb:PSF2(gene name synonym)|uniprotkb:RING11(gene name synonym)|uniprotkb:Y1(gene name synonym)|uniprotkb:Really interesting new gene 11 protein(gene name synonym) psi-mi:gn_bhv1c(display_long)|uniprotkb:gN(gene name)|psi-mi:gN(display_short)|uniprotkb:UL49.5(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Koppers-Lalic et al. (2005) pubmed:15793001|imex:IM-26110 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10323(bhv1c)|taxid:10323("Bovine herpesvirus 1.1 (strain Cooper)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-11313798|imex:IM-26110-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276972.1|refseq:NP_000535.3|refseq:NP_061313.2|dip:DIP-322N|ensembl:ENSG00000204267(gene)|ensembl:ENSG00000206235(gene)|ensembl:ENSG00000206299(gene)|ensembl:ENSG00000228582(gene)|ensembl:ENSG00000237599(gene)|ensembl:ENST00000374897(transcript)|ensembl:ENST00000383118(transcript)|ensembl:ENST00000383239(transcript)|ensembl:ENST00000419142(transcript)|ensembl:ENST00000443713(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002489"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0015031"(protein transport)|go:"GO:0015433"(ABC-type peptide antigen transporter activity)|go:"GO:0015440"(ABC-type peptide transporter activity)|go:"GO:0015833"(peptide transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0042825"(TAP complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0046967"(cytosol to endoplasmic reticulum transport)|go:"GO:0046968"(peptide antigen transport)|go:"GO:0046978"(TAP1 binding)|go:"GO:0046980"(tapasin binding)|go:"GO:0055085"(transmembrane transport)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR005293(Antigen peptide transporter 2)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR013305(ABC transporter, ABCB2)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|interpro:IPR039421|mint:Q03519|rcsb pdb:5U1D|reactome:R-HSA-1236974|reactome:R-HSA-983170 interpro:IPR008647(Herpesvirus UL49.5 envelope tegument)|refseq:NP_045309.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0033644"(host cell membrane)|go:"GO:0039591"|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0046978"(TAP1 binding)|go:"GO:0046979"(TAP2 binding)|go:"GO:0046980"(tapasin binding)|go:"GO:0055036"(virion membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0090087"(regulation of peptide transport)|go:"GO:1903317"(regulation of protein maturation)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|interpro:IPR034707 - - - figure legend:1C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mel_juso)|taxid:9606(Homo sapiens) - 2015/10/13 2015/10/14 rogid:w7pDqjoSODoB8qMag1ycxcapvQ09606 rogid:brFrlT3zDyQkbow2F4gbLa3yn5o10323 rigid:GAJwkeIdDgS92tExM5piB84zs2w false 35s radiolabel:?-? 35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:O15533 uniprotkb:Q77CE4 intact:EBI-874801|uniprotkb:O15210|uniprotkb:O15272|uniprotkb:Q5STJ8|uniprotkb:Q5STK6|uniprotkb:Q5STQ5|uniprotkb:Q5STQ6|uniprotkb:Q66K65|uniprotkb:Q96KK7|uniprotkb:Q9HAN8|uniprotkb:Q9UEE0|uniprotkb:Q9UEE4|uniprotkb:Q9UIZ6|uniprotkb:Q9Y6K2|uniprotkb:B2ZUA4|uniprotkb:E9PGM2|uniprotkb:B0V0A6|uniprotkb:A2AB91|uniprotkb:A2ABC0|uniprotkb:B0V003|ensembl:ENSP00000363700|ensembl:ENSP00000372543|ensembl:ENSP00000372685|ensembl:ENSP00000395701|ensembl:ENSP00000402087 intact:EBI-11303846 psi-mi:tpsn_human(display_long)|uniprotkb:TAP-binding protein(gene name synonym)|uniprotkb:TAP-associated protein(gene name synonym)|uniprotkb:NGS-17(gene name synonym)|uniprotkb:TAPBP(gene name)|psi-mi:TAPBP(display_short)|uniprotkb:NGS17(gene name synonym)|uniprotkb:TAPA(gene name synonym) psi-mi:gn_bhv1c(display_long)|uniprotkb:gN(gene name)|psi-mi:gN(display_short)|uniprotkb:UL49.5(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Koppers-Lalic et al. (2005) pubmed:15793001|imex:IM-26110 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10323(bhv1c)|taxid:10323("Bovine herpesvirus 1.1 (strain Cooper)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-11313817|imex:IM-26110-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003181.3|refseq:NP_757345.2|refseq:NP_757346.2|ensembl:ENSG00000112493(gene)|ensembl:ENSG00000206208(gene)|ensembl:ENSG00000206281(gene)|ensembl:ENSG00000231925(gene)|ensembl:ENSG00000236490(gene)|ensembl:ENST00000374572(transcript)|ensembl:ENST00000383066(transcript)|ensembl:ENST00000383198(transcript)|ensembl:ENST00000417059(transcript)|ensembl:ENST00000434618(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002397"(MHC class I protein complex assembly)|go:"GO:0002398"(MHC class Ib protein complex assembly)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006955"(immune response)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015433"(ABC-type peptide antigen transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0046978"(TAP1 binding)|go:"GO:0046979"(TAP2 binding)|go:"GO:0050823"(peptide antigen stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0062061"(TAP complex binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008056(Tapasin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:O15533|rcsb pdb:3F8U|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-983170 interpro:IPR008647(Herpesvirus UL49.5 envelope tegument)|refseq:NP_045309.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0033644"(host cell membrane)|go:"GO:0039591"|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0044165"(host cell endoplasmic reticulum)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0046978"(TAP1 binding)|go:"GO:0046979"(TAP2 binding)|go:"GO:0046980"(tapasin binding)|go:"GO:0055036"(virion membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0090087"(regulation of peptide transport)|go:"GO:1903317"(regulation of protein maturation)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|interpro:IPR034707 - - - figure legend:1C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mel_juso)|taxid:9606(Homo sapiens) - 2015/10/13 2015/10/14 rogid:lLhN57K0WaKuMuUou77SSsQSBOs9606 rogid:brFrlT3zDyQkbow2F4gbLa3yn5o10323 rigid:wvvl9kQkFUViZbFxHh7Xg53nLSo false 35s radiolabel:?-? 35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)