#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8N6P7	uniprotkb:Q9GZX6-PRO_0000015383	intact:EBI-3940749|uniprotkb:Q9HB22|uniprotkb:A8K839|uniprotkb:B2R9Y9|intact:EBI-28982117|ensembl:ENSP00000270800	intact:EBI-11315863	psi-mi:i22r1_human(display_long)|uniprotkb:IL22RA1(gene name)|psi-mi:IL22RA1(display_short)|uniprotkb:IL22R(gene name synonym)|uniprotkb:Cytokine receptor class-II member 9(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 9(gene name synonym)|uniprotkb:ZcytoR11(gene name synonym)	psi-mi:q9gzx6-pro_0000015383(display_long)|uniprotkb:Cytokine Zcyto18(gene name synonym)|uniprotkb:IL-10-related T-cell-derived-inducible factor(gene name synonym)|uniprotkb:IL22(gene name)|psi-mi:IL22(display_short)|uniprotkb:ILTIF(gene name synonym)|uniprotkb:ZCYTO18(gene name synonym)|uniprotkb:UNQ3099/PRO10096(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Li et al. (2004)	imex:IM-24527|pubmed:15120653	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11167879|imex:IM-24527-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000270800|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q8N6P7|rcsb pdb:3DGC|rcsb pdb:3DLQ|ensembl:ENSG00000142677(gene)|ensembl:ENST00000270800(transcript)|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:6DF3|reactome:R-HSA-8854691|go:"GO:0004904"(interferon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|refseq:NP_067081.2|dip:DIP-42031N	intact:EBI-8040250(chain-parent)	-	-	chain-seq-start:34|chain-seq-end:179	figure legend:"Fig. 1A, Fig. 3A and 3B (black square), Fig 4A (black triangle) Fig. 4B (solid line), Fig. 5B (black circle, black triangle), Fig6. A (broken line)"|dataset:IBD - Inflammatory bowel disease|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/20	2015/10/19	rogid:mM7lurDGnIyLP+XnqXH5UcuqEuw9606	rogid:YduGB/U/ZL8AM2ro9+MxJqqLDR49606	rigid:Qt1Rm93HFWfXlUDOKKDxUWlgGtE	false	sufficient binding region:16..16-228|fc-igg tag:?-?	his tag:n-n|biotin tag:?-?|flag tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9GZX6-PRO_0000015383	uniprotkb:Q8N6P7	intact:EBI-11315863	intact:EBI-3940749|uniprotkb:Q9HB22|uniprotkb:A8K839|uniprotkb:B2R9Y9|intact:EBI-28982117|ensembl:ENSP00000270800	psi-mi:q9gzx6-pro_0000015383(display_long)|uniprotkb:Cytokine Zcyto18(gene name synonym)|uniprotkb:IL-10-related T-cell-derived-inducible factor(gene name synonym)|uniprotkb:IL22(gene name)|psi-mi:IL22(display_short)|uniprotkb:ILTIF(gene name synonym)|uniprotkb:ZCYTO18(gene name synonym)|uniprotkb:UNQ3099/PRO10096(orf name)	psi-mi:i22r1_human(display_long)|uniprotkb:IL22RA1(gene name)|psi-mi:IL22RA1(display_short)|uniprotkb:IL22R(gene name synonym)|uniprotkb:Cytokine receptor class-II member 9(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 9(gene name synonym)|uniprotkb:ZcytoR11(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Li et al. (2004)	imex:IM-24527|pubmed:15120653	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11167917|imex:IM-24527-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-8040250(chain-parent)	ensembl:ENSP00000270800|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q8N6P7|rcsb pdb:3DGC|rcsb pdb:3DLQ|ensembl:ENSG00000142677(gene)|ensembl:ENST00000270800(transcript)|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:6DF3|reactome:R-HSA-8854691|go:"GO:0004904"(interferon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|refseq:NP_067081.2|dip:DIP-42031N	-	chain-seq-start:34|chain-seq-end:179	-	figure legend:Fig. 1B|dataset:IBD - Inflammatory bowel disease|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/20	2015/10/19	rogid:YduGB/U/ZL8AM2ro9+MxJqqLDR49606	rogid:mM7lurDGnIyLP+XnqXH5UcuqEuw9606	rigid:Qt1Rm93HFWfXlUDOKKDxUWlgGtE	false	his tag:n-n|biotin tag:?-?|flag tag:n-n	fc-igg tag:?-?|sufficient binding region:16..16-228	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q08334	uniprotkb:Q8N6P7	intact:EBI-11175900|uniprotkb:Q9BUU4|intact:EBI-28985523|ensembl:ENSP00000290200	intact:EBI-3940749|uniprotkb:Q9HB22|uniprotkb:A8K839|uniprotkb:B2R9Y9|intact:EBI-28982117|ensembl:ENSP00000270800	psi-mi:i10r2_human(display_long)|uniprotkb:IL10RB(gene name)|psi-mi:IL10RB(display_short)|uniprotkb:CRFB4(gene name synonym)|uniprotkb:D21S58(gene name synonym)|uniprotkb:D21S66(gene name synonym)|uniprotkb:Cytokine receptor class-II member 4(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 4(gene name synonym)|uniprotkb:Interleukin-10 receptor subunit 2(gene name synonym)	psi-mi:i22r1_human(display_long)|uniprotkb:IL22RA1(gene name)|psi-mi:IL22RA1(display_short)|uniprotkb:IL22R(gene name synonym)|uniprotkb:Cytokine receptor class-II member 9(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 9(gene name synonym)|uniprotkb:ZcytoR11(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Li et al. (2004)	imex:IM-24527|pubmed:15120653	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11169803|imex:IM-24527-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000619.3|ensembl:ENSP00000290200|ensembl:ENSG00000243646(gene)|ensembl:ENST00000290200(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004920"(interleukin-10 receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032002"(interleukin-28 receptor complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0051607"(defense response to virus)|go:"GO:1901857"(positive regulation of cellular respiration)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:3LQM|rcsb pdb:5T5W|rcsb pdb:6X93|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8854691|dip:DIP-6016N	ensembl:ENSP00000270800|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q8N6P7|rcsb pdb:3DGC|rcsb pdb:3DLQ|ensembl:ENSG00000142677(gene)|ensembl:ENST00000270800(transcript)|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:6DF3|reactome:R-HSA-8854691|go:"GO:0004904"(interferon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|refseq:NP_067081.2|dip:DIP-42031N	-	-	-	figure legend:"Fig. 2B (black triangle)"|comment:"Condition media (CM) from CHO cells co-expressing heterodimers IL22R and Il10R2 gave a positive signal. Signal was not positive from CM from CHO cells secreting IL-22R-Fc,  IL-10R2-Fc or when CM from both was mixed together."|dataset:IBD - Inflammatory bowel disease|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/20	2015/09/17	rogid:wT7f/hpi5gDfMYRRLXrO5VC5Qlg9606	rogid:mM7lurDGnIyLP+XnqXH5UcuqEuw9606	rigid:afDQOpxK/756ou5WHBMHci/XJNc	false	sufficient binding region:20..20-220|fc-igg tag:?-?	sufficient binding region:16..16-228|fc-igg tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q08334	uniprotkb:Q8N6P7	intact:EBI-11175900|uniprotkb:Q9BUU4|intact:EBI-28985523|ensembl:ENSP00000290200	intact:EBI-3940749|uniprotkb:Q9HB22|uniprotkb:A8K839|uniprotkb:B2R9Y9|intact:EBI-28982117|ensembl:ENSP00000270800	psi-mi:i10r2_human(display_long)|uniprotkb:IL10RB(gene name)|psi-mi:IL10RB(display_short)|uniprotkb:CRFB4(gene name synonym)|uniprotkb:D21S58(gene name synonym)|uniprotkb:D21S66(gene name synonym)|uniprotkb:Cytokine receptor class-II member 4(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 4(gene name synonym)|uniprotkb:Interleukin-10 receptor subunit 2(gene name synonym)	psi-mi:i22r1_human(display_long)|uniprotkb:IL22RA1(gene name)|psi-mi:IL22RA1(display_short)|uniprotkb:IL22R(gene name synonym)|uniprotkb:Cytokine receptor class-II member 9(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 9(gene name synonym)|uniprotkb:ZcytoR11(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Li et al. (2004)	imex:IM-24527|pubmed:15120653	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11176488|imex:IM-24527-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000619.3|ensembl:ENSP00000290200|ensembl:ENSG00000243646(gene)|ensembl:ENST00000290200(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004920"(interleukin-10 receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032002"(interleukin-28 receptor complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0051607"(defense response to virus)|go:"GO:1901857"(positive regulation of cellular respiration)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:3LQM|rcsb pdb:5T5W|rcsb pdb:6X93|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8854691|dip:DIP-6016N	ensembl:ENSP00000270800|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q8N6P7|rcsb pdb:3DGC|rcsb pdb:3DLQ|ensembl:ENSG00000142677(gene)|ensembl:ENST00000270800(transcript)|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:6DF3|reactome:R-HSA-8854691|go:"GO:0004904"(interferon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|refseq:NP_067081.2|dip:DIP-42031N	-	-	-	figure legend:"Fig.3A (black triangle curve), Fig. 3B (black and white triangle), Fig. 5C (black triangle) Fig. 6B (broken line)"|comment:"Fig. 3A, Fig 3B: Positive results were observed with Immobilized Fc-receptor from CM of CHO cells expressing IL22R or  co-expressing IL-22R-Fc and IL-10R2-Fc,  but not from CM of cells expressing IL10R-fc."|dataset:IBD - Inflammatory bowel disease|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/20	2015/10/19	rogid:wT7f/hpi5gDfMYRRLXrO5VC5Qlg9606	rogid:mM7lurDGnIyLP+XnqXH5UcuqEuw9606	rigid:moDuvTWPdD++gS+z1q1lQ4HvwGc	false	sufficient binding region:20..20-220|fc-igg tag:?-?	fc-igg tag:?-?|sufficient binding region:16..16-228	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q08334	uniprotkb:Q9GZX6-PRO_0000015383	intact:EBI-11175900|uniprotkb:Q9BUU4|intact:EBI-28985523|ensembl:ENSP00000290200	intact:EBI-11315863	psi-mi:i10r2_human(display_long)|uniprotkb:IL10RB(gene name)|psi-mi:IL10RB(display_short)|uniprotkb:CRFB4(gene name synonym)|uniprotkb:D21S58(gene name synonym)|uniprotkb:D21S66(gene name synonym)|uniprotkb:Cytokine receptor class-II member 4(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 4(gene name synonym)|uniprotkb:Interleukin-10 receptor subunit 2(gene name synonym)	psi-mi:q9gzx6-pro_0000015383(display_long)|uniprotkb:Cytokine Zcyto18(gene name synonym)|uniprotkb:IL-10-related T-cell-derived-inducible factor(gene name synonym)|uniprotkb:IL22(gene name)|psi-mi:IL22(display_short)|uniprotkb:ILTIF(gene name synonym)|uniprotkb:ZCYTO18(gene name synonym)|uniprotkb:UNQ3099/PRO10096(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Li et al. (2004)	imex:IM-24527|pubmed:15120653	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11176488|imex:IM-24527-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000619.3|ensembl:ENSP00000290200|ensembl:ENSG00000243646(gene)|ensembl:ENST00000290200(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004920"(interleukin-10 receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032002"(interleukin-28 receptor complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0051607"(defense response to virus)|go:"GO:1901857"(positive regulation of cellular respiration)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:3LQM|rcsb pdb:5T5W|rcsb pdb:6X93|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8854691|dip:DIP-6016N	intact:EBI-8040250(chain-parent)	-	-	chain-seq-start:34|chain-seq-end:179	figure legend:"Fig.3A (black triangle curve), Fig. 3B (black and white triangle), Fig. 5C (black triangle) Fig. 6B (broken line)"|comment:"Fig. 3A, Fig 3B: Positive results were observed with Immobilized Fc-receptor from CM of CHO cells expressing IL22R or  co-expressing IL-22R-Fc and IL-10R2-Fc,  but not from CM of cells expressing IL10R-fc."|dataset:IBD - Inflammatory bowel disease|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/20	2015/10/19	rogid:wT7f/hpi5gDfMYRRLXrO5VC5Qlg9606	rogid:YduGB/U/ZL8AM2ro9+MxJqqLDR49606	rigid:moDuvTWPdD++gS+z1q1lQ4HvwGc	false	sufficient binding region:20..20-220|fc-igg tag:?-?	his tag:n-n|biotin tag:?-?|flag tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q8N6P7	uniprotkb:Q9GZX6-PRO_0000015383	intact:EBI-3940749|uniprotkb:Q9HB22|uniprotkb:A8K839|uniprotkb:B2R9Y9|intact:EBI-28982117|ensembl:ENSP00000270800	intact:EBI-11315863	psi-mi:i22r1_human(display_long)|uniprotkb:IL22RA1(gene name)|psi-mi:IL22RA1(display_short)|uniprotkb:IL22R(gene name synonym)|uniprotkb:Cytokine receptor class-II member 9(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 9(gene name synonym)|uniprotkb:ZcytoR11(gene name synonym)	psi-mi:q9gzx6-pro_0000015383(display_long)|uniprotkb:Cytokine Zcyto18(gene name synonym)|uniprotkb:IL-10-related T-cell-derived-inducible factor(gene name synonym)|uniprotkb:IL22(gene name)|psi-mi:IL22(display_short)|uniprotkb:ILTIF(gene name synonym)|uniprotkb:ZCYTO18(gene name synonym)|uniprotkb:UNQ3099/PRO10096(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Li et al. (2004)	imex:IM-24527|pubmed:15120653	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11176650|imex:IM-24527-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000270800|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q8N6P7|rcsb pdb:3DGC|rcsb pdb:3DLQ|ensembl:ENSG00000142677(gene)|ensembl:ENST00000270800(transcript)|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:6DF3|reactome:R-HSA-8854691|go:"GO:0004904"(interferon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|refseq:NP_067081.2|dip:DIP-42031N	intact:EBI-8040250(chain-parent)	-	-	chain-seq-start:34|chain-seq-end:179	figure legend:Fig. 5C|dataset:IBD - Inflammatory bowel disease|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/20	2015/10/19	rogid:mM7lurDGnIyLP+XnqXH5UcuqEuw9606	rogid:YduGB/U/ZL8AM2ro9+MxJqqLDR49606	rigid:moDuvTWPdD++gS+z1q1lQ4HvwGc	false	fc-igg tag:?-?|sufficient binding region:16..16-228	biotin tag:?-?|his tag:n-n|flag tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q8N6P7	uniprotkb:Q08334	intact:EBI-3940749|uniprotkb:Q9HB22|uniprotkb:A8K839|uniprotkb:B2R9Y9|intact:EBI-28982117|ensembl:ENSP00000270800	intact:EBI-11175900|uniprotkb:Q9BUU4|intact:EBI-28985523|ensembl:ENSP00000290200	psi-mi:i22r1_human(display_long)|uniprotkb:IL22RA1(gene name)|psi-mi:IL22RA1(display_short)|uniprotkb:IL22R(gene name synonym)|uniprotkb:Cytokine receptor class-II member 9(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 9(gene name synonym)|uniprotkb:ZcytoR11(gene name synonym)	psi-mi:i10r2_human(display_long)|uniprotkb:IL10RB(gene name)|psi-mi:IL10RB(display_short)|uniprotkb:CRFB4(gene name synonym)|uniprotkb:D21S58(gene name synonym)|uniprotkb:D21S66(gene name synonym)|uniprotkb:Cytokine receptor class-II member 4(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 4(gene name synonym)|uniprotkb:Interleukin-10 receptor subunit 2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Li et al. (2004)	imex:IM-24527|pubmed:15120653	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11176650|imex:IM-24527-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000270800|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q8N6P7|rcsb pdb:3DGC|rcsb pdb:3DLQ|ensembl:ENSG00000142677(gene)|ensembl:ENST00000270800(transcript)|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:6DF3|reactome:R-HSA-8854691|go:"GO:0004904"(interferon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|refseq:NP_067081.2|dip:DIP-42031N	refseq:NP_000619.3|ensembl:ENSP00000290200|ensembl:ENSG00000243646(gene)|ensembl:ENST00000290200(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004920"(interleukin-10 receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032002"(interleukin-28 receptor complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0051607"(defense response to virus)|go:"GO:1901857"(positive regulation of cellular respiration)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:3LQM|rcsb pdb:5T5W|rcsb pdb:6X93|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8854691|dip:DIP-6016N	-	-	-	figure legend:Fig. 5C|dataset:IBD - Inflammatory bowel disease|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/20	2015/10/19	rogid:mM7lurDGnIyLP+XnqXH5UcuqEuw9606	rogid:wT7f/hpi5gDfMYRRLXrO5VC5Qlg9606	rigid:moDuvTWPdD++gS+z1q1lQ4HvwGc	false	fc-igg tag:?-?|sufficient binding region:16..16-228	fc-igg tag:?-?|sufficient binding region:20..20-220	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q8N6P7	uniprotkb:Q969J5-1	intact:EBI-3940749|uniprotkb:Q9HB22|uniprotkb:A8K839|uniprotkb:B2R9Y9|intact:EBI-28982117|ensembl:ENSP00000270800	intact:EBI-11177052|ensembl:ENSP00000296980	psi-mi:i22r1_human(display_long)|uniprotkb:IL22RA1(gene name)|psi-mi:IL22RA1(display_short)|uniprotkb:IL22R(gene name synonym)|uniprotkb:Cytokine receptor class-II member 9(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 9(gene name synonym)|uniprotkb:ZcytoR11(gene name synonym)	psi-mi:q969j5-1(display_long)|uniprotkb:IL22RA2(gene name)|psi-mi:IL22RA2(display_short)|uniprotkb:Cytokine receptor class-II member 10(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 10(gene name synonym)|uniprotkb:Cytokine receptor family type 2, soluble 1(gene name synonym)|uniprotkb:Interleukin-22-binding protein(gene name synonym)|uniprotkb:ZcytoR16(gene name synonym)|uniprotkb:UNQ5793/PRO19598/PRO19822(orf name)|uniprotkb:CRF2-10L(isoform synonym)|uniprotkb:CRF2-s1-long(isoform synonym)|uniprotkb:Long(isoform synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Li et al. (2004)	imex:IM-24527|pubmed:15120653	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11176743|imex:IM-24527-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000270800|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q8N6P7|rcsb pdb:3DGC|rcsb pdb:3DLQ|ensembl:ENSG00000142677(gene)|ensembl:ENST00000270800(transcript)|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:6DF3|reactome:R-HSA-8854691|go:"GO:0004904"(interferon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|refseq:NP_067081.2|dip:DIP-42031N	ensembl:ENSG00000164485(gene)|ensembl:ENST00000296980(transcript)|intact:EBI-8591719(isoform-parent)	-	-	-	figure legend:"Fig. 6A (white square)"|dataset:IBD - Inflammatory bowel disease|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/20	2015/10/19	rogid:mM7lurDGnIyLP+XnqXH5UcuqEuw9606	rogid:HoOE3pGPkA/9Pplg8wPXJhgTdGM9606	rigid:AVC7kqSziWE8rgejIp87PIPaFv4	false	sufficient binding region:16..16-228|fc-igg tag:?-?	fc-igg tag:?-?|sufficient binding region:?-263	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q8N6P7	uniprotkb:Q9GZX6-PRO_0000015383	intact:EBI-3940749|uniprotkb:Q9HB22|uniprotkb:A8K839|uniprotkb:B2R9Y9|intact:EBI-28982117|ensembl:ENSP00000270800	intact:EBI-11315863	psi-mi:i22r1_human(display_long)|uniprotkb:IL22RA1(gene name)|psi-mi:IL22RA1(display_short)|uniprotkb:IL22R(gene name synonym)|uniprotkb:Cytokine receptor class-II member 9(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 9(gene name synonym)|uniprotkb:ZcytoR11(gene name synonym)	psi-mi:q9gzx6-pro_0000015383(display_long)|uniprotkb:Cytokine Zcyto18(gene name synonym)|uniprotkb:IL-10-related T-cell-derived-inducible factor(gene name synonym)|uniprotkb:IL22(gene name)|psi-mi:IL22(display_short)|uniprotkb:ILTIF(gene name synonym)|uniprotkb:ZCYTO18(gene name synonym)|uniprotkb:UNQ3099/PRO10096(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Li et al. (2004)	imex:IM-24527|pubmed:15120653	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11176743|imex:IM-24527-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000270800|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q8N6P7|rcsb pdb:3DGC|rcsb pdb:3DLQ|ensembl:ENSG00000142677(gene)|ensembl:ENST00000270800(transcript)|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:6DF3|reactome:R-HSA-8854691|go:"GO:0004904"(interferon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|refseq:NP_067081.2|dip:DIP-42031N	intact:EBI-8040250(chain-parent)	-	-	chain-seq-start:34|chain-seq-end:179	figure legend:"Fig. 6A (white square)"|dataset:IBD - Inflammatory bowel disease|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/20	2015/10/19	rogid:mM7lurDGnIyLP+XnqXH5UcuqEuw9606	rogid:YduGB/U/ZL8AM2ro9+MxJqqLDR49606	rigid:AVC7kqSziWE8rgejIp87PIPaFv4	false	sufficient binding region:16..16-228|fc-igg tag:?-?	his tag:n-n|biotin tag:?-?|flag tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q08334	uniprotkb:Q8N6P7	intact:EBI-11175900|uniprotkb:Q9BUU4|intact:EBI-28985523|ensembl:ENSP00000290200	intact:EBI-3940749|uniprotkb:Q9HB22|uniprotkb:A8K839|uniprotkb:B2R9Y9|intact:EBI-28982117|ensembl:ENSP00000270800	psi-mi:i10r2_human(display_long)|uniprotkb:IL10RB(gene name)|psi-mi:IL10RB(display_short)|uniprotkb:CRFB4(gene name synonym)|uniprotkb:D21S58(gene name synonym)|uniprotkb:D21S66(gene name synonym)|uniprotkb:Cytokine receptor class-II member 4(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 4(gene name synonym)|uniprotkb:Interleukin-10 receptor subunit 2(gene name synonym)	psi-mi:i22r1_human(display_long)|uniprotkb:IL22RA1(gene name)|psi-mi:IL22RA1(display_short)|uniprotkb:IL22R(gene name synonym)|uniprotkb:Cytokine receptor class-II member 9(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 9(gene name synonym)|uniprotkb:ZcytoR11(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Li et al. (2004)	imex:IM-24527|pubmed:15120653	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11177239|imex:IM-24527-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000619.3|ensembl:ENSP00000290200|ensembl:ENSG00000243646(gene)|ensembl:ENST00000290200(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004920"(interleukin-10 receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032002"(interleukin-28 receptor complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0051607"(defense response to virus)|go:"GO:1901857"(positive regulation of cellular respiration)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:3LQM|rcsb pdb:5T5W|rcsb pdb:6X93|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8854691|dip:DIP-6016N	ensembl:ENSP00000270800|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q8N6P7|rcsb pdb:3DGC|rcsb pdb:3DLQ|ensembl:ENSG00000142677(gene)|ensembl:ENST00000270800(transcript)|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:6DF3|reactome:R-HSA-8854691|go:"GO:0004904"(interferon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|refseq:NP_067081.2|dip:DIP-42031N	-	-	-	figure legend:"Fig. 6B (white square)"|dataset:IBD - Inflammatory bowel disease|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/20	2015/10/19	rogid:wT7f/hpi5gDfMYRRLXrO5VC5Qlg9606	rogid:mM7lurDGnIyLP+XnqXH5UcuqEuw9606	rigid:bSSopGekq1SG6IWOc2D/dXTi0hQ	false	sufficient binding region:20..20-220|fc-igg tag:?-?	sufficient binding region:16..16-228|fc-igg tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q08334	uniprotkb:Q969J5-1	intact:EBI-11175900|uniprotkb:Q9BUU4|intact:EBI-28985523|ensembl:ENSP00000290200	intact:EBI-11177052|ensembl:ENSP00000296980	psi-mi:i10r2_human(display_long)|uniprotkb:IL10RB(gene name)|psi-mi:IL10RB(display_short)|uniprotkb:CRFB4(gene name synonym)|uniprotkb:D21S58(gene name synonym)|uniprotkb:D21S66(gene name synonym)|uniprotkb:Cytokine receptor class-II member 4(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 4(gene name synonym)|uniprotkb:Interleukin-10 receptor subunit 2(gene name synonym)	psi-mi:q969j5-1(display_long)|uniprotkb:IL22RA2(gene name)|psi-mi:IL22RA2(display_short)|uniprotkb:Cytokine receptor class-II member 10(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 10(gene name synonym)|uniprotkb:Cytokine receptor family type 2, soluble 1(gene name synonym)|uniprotkb:Interleukin-22-binding protein(gene name synonym)|uniprotkb:ZcytoR16(gene name synonym)|uniprotkb:UNQ5793/PRO19598/PRO19822(orf name)|uniprotkb:CRF2-10L(isoform synonym)|uniprotkb:CRF2-s1-long(isoform synonym)|uniprotkb:Long(isoform synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Li et al. (2004)	imex:IM-24527|pubmed:15120653	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11177239|imex:IM-24527-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000619.3|ensembl:ENSP00000290200|ensembl:ENSG00000243646(gene)|ensembl:ENST00000290200(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004920"(interleukin-10 receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032002"(interleukin-28 receptor complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0051607"(defense response to virus)|go:"GO:1901857"(positive regulation of cellular respiration)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:3LQM|rcsb pdb:5T5W|rcsb pdb:6X93|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8854691|dip:DIP-6016N	ensembl:ENSG00000164485(gene)|ensembl:ENST00000296980(transcript)|intact:EBI-8591719(isoform-parent)	-	-	-	figure legend:"Fig. 6B (white square)"|dataset:IBD - Inflammatory bowel disease|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/20	2015/10/19	rogid:wT7f/hpi5gDfMYRRLXrO5VC5Qlg9606	rogid:HoOE3pGPkA/9Pplg8wPXJhgTdGM9606	rigid:bSSopGekq1SG6IWOc2D/dXTi0hQ	false	sufficient binding region:20..20-220|fc-igg tag:?-?	fc-igg tag:?-?|sufficient binding region:?-263	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q08334	uniprotkb:Q9GZX6-PRO_0000015383	intact:EBI-11175900|uniprotkb:Q9BUU4|intact:EBI-28985523|ensembl:ENSP00000290200	intact:EBI-11315863	psi-mi:i10r2_human(display_long)|uniprotkb:IL10RB(gene name)|psi-mi:IL10RB(display_short)|uniprotkb:CRFB4(gene name synonym)|uniprotkb:D21S58(gene name synonym)|uniprotkb:D21S66(gene name synonym)|uniprotkb:Cytokine receptor class-II member 4(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 4(gene name synonym)|uniprotkb:Interleukin-10 receptor subunit 2(gene name synonym)	psi-mi:q9gzx6-pro_0000015383(display_long)|uniprotkb:Cytokine Zcyto18(gene name synonym)|uniprotkb:IL-10-related T-cell-derived-inducible factor(gene name synonym)|uniprotkb:IL22(gene name)|psi-mi:IL22(display_short)|uniprotkb:ILTIF(gene name synonym)|uniprotkb:ZCYTO18(gene name synonym)|uniprotkb:UNQ3099/PRO10096(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Li et al. (2004)	imex:IM-24527|pubmed:15120653	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11177239|imex:IM-24527-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000619.3|ensembl:ENSP00000290200|ensembl:ENSG00000243646(gene)|ensembl:ENST00000290200(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004920"(interleukin-10 receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032002"(interleukin-28 receptor complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0051607"(defense response to virus)|go:"GO:1901857"(positive regulation of cellular respiration)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:3LQM|rcsb pdb:5T5W|rcsb pdb:6X93|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8854691|dip:DIP-6016N	intact:EBI-8040250(chain-parent)	-	-	chain-seq-start:34|chain-seq-end:179	figure legend:"Fig. 6B (white square)"|dataset:IBD - Inflammatory bowel disease|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/20	2015/10/19	rogid:wT7f/hpi5gDfMYRRLXrO5VC5Qlg9606	rogid:YduGB/U/ZL8AM2ro9+MxJqqLDR49606	rigid:bSSopGekq1SG6IWOc2D/dXTi0hQ	false	sufficient binding region:20..20-220|fc-igg tag:?-?	biotin tag:?-?|his tag:n-n|flag tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q969J5-1	uniprotkb:Q9GZX6-PRO_0000015383	intact:EBI-11177052|ensembl:ENSP00000296980	intact:EBI-11315863	psi-mi:q969j5-1(display_long)|uniprotkb:IL22RA2(gene name)|psi-mi:IL22RA2(display_short)|uniprotkb:Cytokine receptor class-II member 10(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 10(gene name synonym)|uniprotkb:Cytokine receptor family type 2, soluble 1(gene name synonym)|uniprotkb:Interleukin-22-binding protein(gene name synonym)|uniprotkb:ZcytoR16(gene name synonym)|uniprotkb:UNQ5793/PRO19598/PRO19822(orf name)|uniprotkb:CRF2-10L(isoform synonym)|uniprotkb:CRF2-s1-long(isoform synonym)|uniprotkb:Long(isoform synonym)	psi-mi:q9gzx6-pro_0000015383(display_long)|uniprotkb:Cytokine Zcyto18(gene name synonym)|uniprotkb:IL-10-related T-cell-derived-inducible factor(gene name synonym)|uniprotkb:IL22(gene name)|psi-mi:IL22(display_short)|uniprotkb:ILTIF(gene name synonym)|uniprotkb:ZCYTO18(gene name synonym)|uniprotkb:UNQ3099/PRO10096(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Li et al. (2004)	imex:IM-24527|pubmed:15120653	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11177779|imex:IM-24527-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164485(gene)|ensembl:ENST00000296980(transcript)|intact:EBI-8591719(isoform-parent)	intact:EBI-8040250(chain-parent)	-	-	chain-seq-start:34|chain-seq-end:179	figure legend:Fig. 6C|dataset:IBD - Inflammatory bowel disease|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/20	2015/10/19	rogid:HoOE3pGPkA/9Pplg8wPXJhgTdGM9606	rogid:YduGB/U/ZL8AM2ro9+MxJqqLDR49606	rigid:bHcg/Y08BTxsSAdMtjcEJrz3sKs	false	fc-igg tag:?-?	his tag:n-n|biotin tag:?-?|flag tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q8N6P7	uniprotkb:Q9GZX6-PRO_0000015383	intact:EBI-3940749|uniprotkb:Q9HB22|uniprotkb:A8K839|uniprotkb:B2R9Y9|intact:EBI-28982117|ensembl:ENSP00000270800	intact:EBI-11315863	psi-mi:i22r1_human(display_long)|uniprotkb:IL22RA1(gene name)|psi-mi:IL22RA1(display_short)|uniprotkb:IL22R(gene name synonym)|uniprotkb:Cytokine receptor class-II member 9(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 9(gene name synonym)|uniprotkb:ZcytoR11(gene name synonym)	psi-mi:q9gzx6-pro_0000015383(display_long)|uniprotkb:Cytokine Zcyto18(gene name synonym)|uniprotkb:IL-10-related T-cell-derived-inducible factor(gene name synonym)|uniprotkb:IL22(gene name)|psi-mi:IL22(display_short)|uniprotkb:ILTIF(gene name synonym)|uniprotkb:ZCYTO18(gene name synonym)|uniprotkb:UNQ3099/PRO10096(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Li et al. (2004)	imex:IM-24527|pubmed:15120653	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11178820|imex:IM-24527-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000270800|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q8N6P7|rcsb pdb:3DGC|rcsb pdb:3DLQ|ensembl:ENSG00000142677(gene)|ensembl:ENST00000270800(transcript)|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:6DF3|reactome:R-HSA-8854691|go:"GO:0004904"(interferon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|refseq:NP_067081.2|dip:DIP-42031N	intact:EBI-8040250(chain-parent)	-	-	chain-seq-start:34|chain-seq-end:179	figure legend:"Fig.4A (black diamond), Fig. 4B (black circle)"|comment:A dose dependent positive signal was observed when IL-10R2-Fc was added with bio-IL-22 to immobilized IL-22R-Fc.|dataset:IBD - Inflammatory bowel disease|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/20	2015/10/19	rogid:mM7lurDGnIyLP+XnqXH5UcuqEuw9606	rogid:YduGB/U/ZL8AM2ro9+MxJqqLDR49606	rigid:moDuvTWPdD++gS+z1q1lQ4HvwGc	false	fc-igg tag:?-?|sufficient binding region:16..16-228	his tag:n-n|biotin tag:?-?|flag tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q8N6P7	uniprotkb:Q08334	intact:EBI-3940749|uniprotkb:Q9HB22|uniprotkb:A8K839|uniprotkb:B2R9Y9|intact:EBI-28982117|ensembl:ENSP00000270800	intact:EBI-11175900|uniprotkb:Q9BUU4|intact:EBI-28985523|ensembl:ENSP00000290200	psi-mi:i22r1_human(display_long)|uniprotkb:IL22RA1(gene name)|psi-mi:IL22RA1(display_short)|uniprotkb:IL22R(gene name synonym)|uniprotkb:Cytokine receptor class-II member 9(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 9(gene name synonym)|uniprotkb:ZcytoR11(gene name synonym)	psi-mi:i10r2_human(display_long)|uniprotkb:IL10RB(gene name)|psi-mi:IL10RB(display_short)|uniprotkb:CRFB4(gene name synonym)|uniprotkb:D21S58(gene name synonym)|uniprotkb:D21S66(gene name synonym)|uniprotkb:Cytokine receptor class-II member 4(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 4(gene name synonym)|uniprotkb:Interleukin-10 receptor subunit 2(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Li et al. (2004)	imex:IM-24527|pubmed:15120653	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11178820|imex:IM-24527-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000270800|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q8N6P7|rcsb pdb:3DGC|rcsb pdb:3DLQ|ensembl:ENSG00000142677(gene)|ensembl:ENST00000270800(transcript)|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:6DF3|reactome:R-HSA-8854691|go:"GO:0004904"(interferon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|refseq:NP_067081.2|dip:DIP-42031N	refseq:NP_000619.3|ensembl:ENSP00000290200|ensembl:ENSG00000243646(gene)|ensembl:ENST00000290200(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004920"(interleukin-10 receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032002"(interleukin-28 receptor complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0051607"(defense response to virus)|go:"GO:1901857"(positive regulation of cellular respiration)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:3LQM|rcsb pdb:5T5W|rcsb pdb:6X93|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8854691|dip:DIP-6016N	-	-	-	figure legend:"Fig.4A (black diamond), Fig. 4B (black circle)"|comment:A dose dependent positive signal was observed when IL-10R2-Fc was added with bio-IL-22 to immobilized IL-22R-Fc.|dataset:IBD - Inflammatory bowel disease|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/20	2015/10/19	rogid:mM7lurDGnIyLP+XnqXH5UcuqEuw9606	rogid:wT7f/hpi5gDfMYRRLXrO5VC5Qlg9606	rigid:moDuvTWPdD++gS+z1q1lQ4HvwGc	false	fc-igg tag:?-?|sufficient binding region:16..16-228	sufficient binding region:20..20-220|fc-igg tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)