#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P18910	uniprotkb:P01161-PRO_0000391785	intact:EBI-7945470|uniprotkb:A1A5N8|intact:UNK-5360342|ensembl:ENSRNOP00000020307	intact:EBI-10095597	psi-mi:anpra_rat(display_long)|uniprotkb:Atrial natriuretic peptide receptor type A(gene name synonym)|uniprotkb:Guanylate cyclase A(gene name synonym)|uniprotkb:Npr1(gene name)|psi-mi:Npr1(display_short)	psi-mi:pro_0000391785(display_long)|uniprotkb:Nppa(gene name)|psi-mi:Nppa(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Ogawa et al. (2004)	imex:IM-23803|pubmed:15117952	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10061556|imex:IM-23803-1|wwpdb:1t34	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036745.1|rgd:3195|refseq:XP_006232653.1|go:"GO:0006182"(cGMP biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007168"(receptor guanylyl cyclase signaling pathway)|go:"GO:0010753"(positive regulation of cGMP-mediated signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016941"(natriuretic peptide receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042562"(hormone binding)|go:"GO:0043235"(receptor complex)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR001170(Natriuretic peptide receptor, N-terminal)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR018297|interpro:IPR028082|ensembl:ENSRNOG00000014684(gene)|ensembl:ENSRNOT00000020307(transcript)|go:"GO:0001653"(peptide receptor activity)|go:"GO:0004383"(guanylate cyclase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|rcsb pdb:1DP4|rcsb pdb:1T34|rcsb pdb:3A3K|rcsb pdb:7BRG|rcsb pdb:7BRH|rcsb pdb:7BRI|rcsb pdb:7BRJ|rcsb pdb:7BRK|rcsb pdb:7BRL|reactome:R-RNO-5578768|interpro:IPR029787	uniprotkb:P01161(chain-parent)	-	comment:mint|function:"Receptor for atrial natriuretic peptide (NPPA/ANF). Has guanylate cyclase activity on binding of NPPA/ANF"	-	figure legend:Table 1, Fig. 1|3d-r-factors:"Rcryst: 23.9 (26.9)  Rfree: 26.9 (30.1)  Rmerge (%): 5.4 (55.4)"|3d-resolution:2.95 angstrom|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/01/16	2015/01/30	rogid:9JEcr11NKKmpR8aSLIfXbviexK010116	rogid:gnXqhMgw45BQfMaY8+xlq+Ul66Q10116	intact-crc:FC33E1639CD40C07|rigid:eGQrjL/Z3shGY3WtcuKa49HjuCU	false	sufficient binding region:29-463(IPR001828)	sufficient binding region:7-27	2	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)