#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01100	uniprotkb:P42224	intact:EBI-852851|uniprotkb:P18849|uniprotkb:A8K4E2|uniprotkb:B4DQ65|ensembl:ENSP00000306245	intact:EBI-1057697|uniprotkb:Q53S88|uniprotkb:Q53XW4|uniprotkb:B2RCA0|uniprotkb:Q9UDL5|uniprotkb:A8K989|uniprotkb:D2KFR8|uniprotkb:Q68D00|uniprotkb:D3DPI7|ensembl:ENSP00000354394|ensembl:ENSP00000386244|ensembl:ENSP00000388240|ensembl:ENSP00000438703	psi-mi:fos_human(display_long)|uniprotkb:Cellular oncogene fos(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 7(gene name synonym)|uniprotkb:FOS(gene name)|psi-mi:FOS(display_short)|uniprotkb:G0S7(gene name synonym)	psi-mi:stat1_human(display_long)|uniprotkb:STAT1(gene name)|psi-mi:STAT1(display_short)|uniprotkb:Transcription factor ISGF-3 components p91/p84(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xu et al. (2003)	pubmed:12788789|imex:IM-23711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10095999|imex:IM-23711-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005243.1|dip:DIP-1047N|ensembl:ENSG00000170345(gene)|ensembl:ENST00000303562(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009409"(response to cold)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009629"(response to gravity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016020"(membrane)|go:"GO:0030431"(sleep)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051591"(response to cAMP)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029816|rcsb pdb:1A02|rcsb pdb:1FOS|rcsb pdb:1S9K|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2871796|reactome:R-HSA-450341|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-9018519|reactome:R-HSA-9031628|reactome:R-HSA-9634638	refseq:NP_009330.1|refseq:NP_644671.1|rcsb pdb:1YVL|rcsb pdb:2KA6|rcsb pdb:3WWT|reactome:R-HSA-1059683|reactome:R-HSA-1169408|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8939902|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9013508|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-909733|rcsb pdb:1BF5|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-912694|refseq:XP_006712781.1|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|ensembl:ENSG00000115415(gene)|ensembl:ENST00000361099(transcript)|ensembl:ENST00000409465(transcript)|ensembl:ENST00000415035(transcript)|ensembl:ENST00000540176(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|interpro:IPR035859|interpro:IPR036535|interpro:IPR036860|interpro:IPR038295|mint:P42224|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|dip:DIP-46140N	-	-	-	figure legend:Fig. 9a, 9b|agonist:"human interferon gamma (IFNgamma) (P01579)"|agonist:"cytokine mixture containing human interferon gamma (IFNgamma) (P01579), interleukin-1 beta (IL-1beta) (P01584) and tumor necrosis factor alpha (TNF-alpha) (P01375)"|comment:An IFN-gamma dose of 100 U/ml was necessary to detect STAT1 coimmunoprecipitation with c-Fos.|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-bronchial_epithelial)|taxid:9606(Homo sapiens)	-	2015/01/26	2015/01/26	rogid:R09jzTKeAyzIQYTQAsps2UWFyFE9606	rogid:a2ZnhdFZkctbjaXLpsYNJ3q5Cv49606	intact-crc:3EC042A49718663E|rigid:7M/WETHzenZHpyn1a4ZbjiK55ss	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42224	uniprotkb:P01100	intact:EBI-1057697|uniprotkb:Q53S88|uniprotkb:Q53XW4|uniprotkb:B2RCA0|uniprotkb:Q9UDL5|uniprotkb:A8K989|uniprotkb:D2KFR8|uniprotkb:Q68D00|uniprotkb:D3DPI7|ensembl:ENSP00000354394|ensembl:ENSP00000386244|ensembl:ENSP00000388240|ensembl:ENSP00000438703	intact:EBI-852851|uniprotkb:P18849|uniprotkb:A8K4E2|uniprotkb:B4DQ65|ensembl:ENSP00000306245	psi-mi:stat1_human(display_long)|uniprotkb:STAT1(gene name)|psi-mi:STAT1(display_short)|uniprotkb:Transcription factor ISGF-3 components p91/p84(gene name synonym)	psi-mi:fos_human(display_long)|uniprotkb:Cellular oncogene fos(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 7(gene name synonym)|uniprotkb:FOS(gene name)|psi-mi:FOS(display_short)|uniprotkb:G0S7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xu et al. (2003)	pubmed:12788789|imex:IM-23711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10096022|imex:IM-23711-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009330.1|refseq:NP_644671.1|rcsb pdb:1YVL|rcsb pdb:2KA6|rcsb pdb:3WWT|reactome:R-HSA-1059683|reactome:R-HSA-1169408|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8939902|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9013508|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-909733|rcsb pdb:1BF5|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-912694|refseq:XP_006712781.1|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|ensembl:ENSG00000115415(gene)|ensembl:ENST00000361099(transcript)|ensembl:ENST00000409465(transcript)|ensembl:ENST00000415035(transcript)|ensembl:ENST00000540176(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|interpro:IPR035859|interpro:IPR036535|interpro:IPR036860|interpro:IPR038295|mint:P42224|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|dip:DIP-46140N	refseq:NP_005243.1|dip:DIP-1047N|ensembl:ENSG00000170345(gene)|ensembl:ENST00000303562(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009409"(response to cold)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009629"(response to gravity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016020"(membrane)|go:"GO:0030431"(sleep)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051591"(response to cAMP)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029816|rcsb pdb:1A02|rcsb pdb:1FOS|rcsb pdb:1S9K|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2871796|reactome:R-HSA-450341|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-9018519|reactome:R-HSA-9031628|reactome:R-HSA-9634638	-	-	-	figure legend:Fig. 9c|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2015/01/26	2015/01/26	rogid:a2ZnhdFZkctbjaXLpsYNJ3q5Cv49606	rogid:R09jzTKeAyzIQYTQAsps2UWFyFE9606	intact-crc:F76BB91F4D4715AF|rigid:7M/WETHzenZHpyn1a4ZbjiK55ss	false	ha tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P42224	uniprotkb:P01100	intact:EBI-1057697|uniprotkb:Q53S88|uniprotkb:Q53XW4|uniprotkb:B2RCA0|uniprotkb:Q9UDL5|uniprotkb:A8K989|uniprotkb:D2KFR8|uniprotkb:Q68D00|uniprotkb:D3DPI7|ensembl:ENSP00000354394|ensembl:ENSP00000386244|ensembl:ENSP00000388240|ensembl:ENSP00000438703	intact:EBI-852851|uniprotkb:P18849|uniprotkb:A8K4E2|uniprotkb:B4DQ65|ensembl:ENSP00000306245	psi-mi:stat1_human(display_long)|uniprotkb:STAT1(gene name)|psi-mi:STAT1(display_short)|uniprotkb:Transcription factor ISGF-3 components p91/p84(gene name synonym)	psi-mi:fos_human(display_long)|uniprotkb:Cellular oncogene fos(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 7(gene name synonym)|uniprotkb:FOS(gene name)|psi-mi:FOS(display_short)|uniprotkb:G0S7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xu et al. (2003)	pubmed:12788789|imex:IM-23711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10096040|imex:IM-23711-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009330.1|refseq:NP_644671.1|rcsb pdb:1YVL|rcsb pdb:2KA6|rcsb pdb:3WWT|reactome:R-HSA-1059683|reactome:R-HSA-1169408|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8939902|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9013508|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-909733|rcsb pdb:1BF5|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-912694|refseq:XP_006712781.1|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|ensembl:ENSG00000115415(gene)|ensembl:ENST00000361099(transcript)|ensembl:ENST00000409465(transcript)|ensembl:ENST00000415035(transcript)|ensembl:ENST00000540176(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|interpro:IPR035859|interpro:IPR036535|interpro:IPR036860|interpro:IPR038295|mint:P42224|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|dip:DIP-46140N	refseq:NP_005243.1|dip:DIP-1047N|ensembl:ENSG00000170345(gene)|ensembl:ENST00000303562(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009409"(response to cold)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009629"(response to gravity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016020"(membrane)|go:"GO:0030431"(sleep)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051591"(response to cAMP)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029816|rcsb pdb:1A02|rcsb pdb:1FOS|rcsb pdb:1S9K|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2871796|reactome:R-HSA-450341|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-9018519|reactome:R-HSA-9031628|reactome:R-HSA-9634638	-	-	-	figure legend:Fig. 9c|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2015/01/26	2015/01/26	rogid:a2ZnhdFZkctbjaXLpsYNJ3q5Cv49606	rogid:R09jzTKeAyzIQYTQAsps2UWFyFE9606	intact-crc:B99492786D4714AB|rigid:7M/WETHzenZHpyn1a4ZbjiK55ss	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01100	uniprotkb:P42224	intact:EBI-852851|uniprotkb:P18849|uniprotkb:A8K4E2|uniprotkb:B4DQ65|ensembl:ENSP00000306245	intact:EBI-1057697|uniprotkb:Q53S88|uniprotkb:Q53XW4|uniprotkb:B2RCA0|uniprotkb:Q9UDL5|uniprotkb:A8K989|uniprotkb:D2KFR8|uniprotkb:Q68D00|uniprotkb:D3DPI7|ensembl:ENSP00000354394|ensembl:ENSP00000386244|ensembl:ENSP00000388240|ensembl:ENSP00000438703	psi-mi:fos_human(display_long)|uniprotkb:Cellular oncogene fos(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 7(gene name synonym)|uniprotkb:FOS(gene name)|psi-mi:FOS(display_short)|uniprotkb:G0S7(gene name synonym)	psi-mi:stat1_human(display_long)|uniprotkb:STAT1(gene name)|psi-mi:STAT1(display_short)|uniprotkb:Transcription factor ISGF-3 components p91/p84(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xu et al. (2003)	pubmed:12788789|imex:IM-23711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10096057|imex:IM-23711-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005243.1|dip:DIP-1047N|ensembl:ENSG00000170345(gene)|ensembl:ENST00000303562(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009409"(response to cold)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009629"(response to gravity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016020"(membrane)|go:"GO:0030431"(sleep)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051591"(response to cAMP)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029816|rcsb pdb:1A02|rcsb pdb:1FOS|rcsb pdb:1S9K|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2871796|reactome:R-HSA-450341|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-9018519|reactome:R-HSA-9031628|reactome:R-HSA-9634638	refseq:NP_009330.1|refseq:NP_644671.1|rcsb pdb:1YVL|rcsb pdb:2KA6|rcsb pdb:3WWT|reactome:R-HSA-1059683|reactome:R-HSA-1169408|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8939902|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9013508|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-909733|rcsb pdb:1BF5|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-912694|refseq:XP_006712781.1|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|ensembl:ENSG00000115415(gene)|ensembl:ENST00000361099(transcript)|ensembl:ENST00000409465(transcript)|ensembl:ENST00000415035(transcript)|ensembl:ENST00000540176(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|interpro:IPR035859|interpro:IPR036535|interpro:IPR036860|interpro:IPR038295|mint:P42224|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|dip:DIP-46140N	-	-	-	figure legend:Fig. 9d|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a_549)|taxid:9606(Homo sapiens Caucasian lung carcinoma cell line)	-	2015/01/26	2015/01/26	rogid:R09jzTKeAyzIQYTQAsps2UWFyFE9606	rogid:a2ZnhdFZkctbjaXLpsYNJ3q5Cv49606	intact-crc:98D73F21F6E377C6|rigid:7M/WETHzenZHpyn1a4ZbjiK55ss	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42224	uniprotkb:P01100	intact:EBI-1057697|uniprotkb:Q53S88|uniprotkb:Q53XW4|uniprotkb:B2RCA0|uniprotkb:Q9UDL5|uniprotkb:A8K989|uniprotkb:D2KFR8|uniprotkb:Q68D00|uniprotkb:D3DPI7|ensembl:ENSP00000354394|ensembl:ENSP00000386244|ensembl:ENSP00000388240|ensembl:ENSP00000438703	intact:EBI-852851|uniprotkb:P18849|uniprotkb:A8K4E2|uniprotkb:B4DQ65|ensembl:ENSP00000306245	psi-mi:stat1_human(display_long)|uniprotkb:STAT1(gene name)|psi-mi:STAT1(display_short)|uniprotkb:Transcription factor ISGF-3 components p91/p84(gene name synonym)	psi-mi:fos_human(display_long)|uniprotkb:Cellular oncogene fos(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 7(gene name synonym)|uniprotkb:FOS(gene name)|psi-mi:FOS(display_short)|uniprotkb:G0S7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xu et al. (2003)	pubmed:12788789|imex:IM-23711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10096061|imex:IM-23711-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009330.1|refseq:NP_644671.1|rcsb pdb:1YVL|rcsb pdb:2KA6|rcsb pdb:3WWT|reactome:R-HSA-1059683|reactome:R-HSA-1169408|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8939902|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9013508|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-909733|rcsb pdb:1BF5|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-912694|refseq:XP_006712781.1|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|ensembl:ENSG00000115415(gene)|ensembl:ENST00000361099(transcript)|ensembl:ENST00000409465(transcript)|ensembl:ENST00000415035(transcript)|ensembl:ENST00000540176(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|interpro:IPR035859|interpro:IPR036535|interpro:IPR036860|interpro:IPR038295|mint:P42224|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|dip:DIP-46140N	refseq:NP_005243.1|dip:DIP-1047N|ensembl:ENSG00000170345(gene)|ensembl:ENST00000303562(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009409"(response to cold)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009629"(response to gravity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016020"(membrane)|go:"GO:0030431"(sleep)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051591"(response to cAMP)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029816|rcsb pdb:1A02|rcsb pdb:1FOS|rcsb pdb:1S9K|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2871796|reactome:R-HSA-450341|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-9018519|reactome:R-HSA-9031628|reactome:R-HSA-9634638	-	-	-	figure legend:Fig. 9d|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a_549)|taxid:9606(Homo sapiens Caucasian lung carcinoma cell line)	-	2015/01/26	2015/01/26	rogid:a2ZnhdFZkctbjaXLpsYNJ3q5Cv49606	rogid:R09jzTKeAyzIQYTQAsps2UWFyFE9606	intact-crc:4C733A26AA484B16|rigid:7M/WETHzenZHpyn1a4ZbjiK55ss	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-10096074	uniprotkb:P01100	-	intact:EBI-852851|uniprotkb:P18849|uniprotkb:A8K4E2|uniprotkb:B4DQ65|ensembl:ENSP00000306245	psi-mi:nos2_human_ap1u/gas-site_dna-probe(display_short)|psi-mi:EBI-10096074(display_long)	psi-mi:fos_human(display_long)|uniprotkb:Cellular oncogene fos(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 7(gene name synonym)|uniprotkb:FOS(gene name)|psi-mi:FOS(display_short)|uniprotkb:G0S7(gene name synonym)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Xu et al. (2003)	pubmed:12788789|imex:IM-23711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10096091|imex:IM-23711-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000007171(see-also)	refseq:NP_005243.1|dip:DIP-1047N|ensembl:ENSG00000170345(gene)|ensembl:ENST00000303562(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009409"(response to cold)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009629"(response to gravity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016020"(membrane)|go:"GO:0030431"(sleep)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051591"(response to cAMP)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029816|rcsb pdb:1A02|rcsb pdb:1FOS|rcsb pdb:1S9K|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2871796|reactome:R-HSA-450341|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-9018519|reactome:R-HSA-9031628|reactome:R-HSA-9634638	-	-	-	figure legend:Fig. 5|agonist:"human interferon gamma (IFNgamma) (P01579)"|causality statement:P01579 indirectly increases expression at RNA level of ENSG00000007171|causality statement:P01579 indirectly increases expression at protein level of ENSG00000007171|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/01/26	2015/01/26	-	rogid:R09jzTKeAyzIQYTQAsps2UWFyFE9606	intact-crc:27F29ED921034364	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
intact:EBI-10096074	uniprotkb:P05412	-	intact:EBI-852823|uniprotkb:Q96G93|uniprotkb:Q6FHM7|ensembl:ENSP00000360266|ensembl:ENSP00000503132	psi-mi:nos2_human_ap1u/gas-site_dna-probe(display_short)|psi-mi:EBI-10096074(display_long)	psi-mi:jun_human(display_long)|uniprotkb:JUN(gene name)|psi-mi:JUN(display_short)|uniprotkb:Activator protein 1(gene name synonym)|uniprotkb:Proto-oncogene c-Jun(gene name synonym)|uniprotkb:V-jun avian sarcoma virus 17 oncogene homolog(gene name synonym)|uniprotkb:p39(gene name synonym)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Xu et al. (2003)	pubmed:12788789|imex:IM-23711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10096097|imex:IM-23711-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000007171(see-also)	refseq:NP_002219.1|ensembl:ENSP00000360266|ensembl:ENSP00000503132|dip:DIP-5961N|ensembl:ENSG00000177606(gene)|ensembl:ENST00000371222(transcript)|ensembl:ENST00000678696(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051365"(cellular response to potassium ion starvation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR002112(Transcription factor Jun)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR005643(Jun-like transcription factor)|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR015558(c-Jun Transcription Factor)|mint:P05412|rcsb pdb:1A02|rcsb pdb:1FOS|rcsb pdb:1JNM|rcsb pdb:1JUN|rcsb pdb:1S9K|rcsb pdb:1T2K|rcsb pdb:5FV8|rcsb pdb:5T01|rcsb pdb:6Y3V|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2871796|reactome:R-HSA-450341|reactome:R-HSA-5617472|reactome:R-HSA-5687128|reactome:R-HSA-6796648|reactome:R-HSA-8862803|reactome:R-HSA-8943724|reactome:R-HSA-9018519|reactome:R-HSA-9673324	-	-	-	figure legend:Fig. 5|agonist:"human interferon gamma (IFNgamma) (P01579)"|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/01/26	2015/01/26	-	rogid:zAVYwedHKKdvPPGttBP4XZkbCXA9606	intact-crc:D5FCCE50A3B8D9EB	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
intact:EBI-10096074	uniprotkb:P42224	-	intact:EBI-1057697|uniprotkb:Q53S88|uniprotkb:Q53XW4|uniprotkb:B2RCA0|uniprotkb:Q9UDL5|uniprotkb:A8K989|uniprotkb:D2KFR8|uniprotkb:Q68D00|uniprotkb:D3DPI7|ensembl:ENSP00000354394|ensembl:ENSP00000386244|ensembl:ENSP00000388240|ensembl:ENSP00000438703	psi-mi:nos2_human_ap1u/gas-site_dna-probe(display_short)|psi-mi:EBI-10096074(display_long)	psi-mi:stat1_human(display_long)|uniprotkb:STAT1(gene name)|psi-mi:STAT1(display_short)|uniprotkb:Transcription factor ISGF-3 components p91/p84(gene name synonym)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Xu et al. (2003)	pubmed:12788789|imex:IM-23711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10096105|imex:IM-23711-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000007171(see-also)	refseq:NP_009330.1|refseq:NP_644671.1|rcsb pdb:1YVL|rcsb pdb:2KA6|rcsb pdb:3WWT|reactome:R-HSA-1059683|reactome:R-HSA-1169408|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8939902|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9013508|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-909733|rcsb pdb:1BF5|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-912694|refseq:XP_006712781.1|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|ensembl:ENSG00000115415(gene)|ensembl:ENST00000361099(transcript)|ensembl:ENST00000409465(transcript)|ensembl:ENST00000415035(transcript)|ensembl:ENST00000540176(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|interpro:IPR035859|interpro:IPR036535|interpro:IPR036860|interpro:IPR038295|mint:P42224|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|dip:DIP-46140N	-	-	-	figure legend:Fig. 5|agonist:"human interferon gamma (IFNgamma) (P01579)"|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/01/26	2015/01/26	-	rogid:a2ZnhdFZkctbjaXLpsYNJ3q5Cv49606	intact-crc:3D647E12432E9EED	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P42224	intact:EBI-10096065	intact:EBI-1057697|uniprotkb:Q53S88|uniprotkb:Q53XW4|uniprotkb:B2RCA0|uniprotkb:Q9UDL5|uniprotkb:A8K989|uniprotkb:D2KFR8|uniprotkb:Q68D00|uniprotkb:D3DPI7|ensembl:ENSP00000354394|ensembl:ENSP00000386244|ensembl:ENSP00000388240|ensembl:ENSP00000438703	-	psi-mi:stat1_human(display_long)|uniprotkb:STAT1(gene name)|psi-mi:STAT1(display_short)|uniprotkb:Transcription factor ISGF-3 components p91/p84(gene name synonym)	psi-mi:nos2_human_gas_dna-probe(display_short)|psi-mi:EBI-10096065(display_long)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Xu et al. (2003)	pubmed:12788789|imex:IM-23711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10096112|imex:IM-23711-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_009330.1|refseq:NP_644671.1|rcsb pdb:1YVL|rcsb pdb:2KA6|rcsb pdb:3WWT|reactome:R-HSA-1059683|reactome:R-HSA-1169408|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8939902|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9013508|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-909733|rcsb pdb:1BF5|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-912694|refseq:XP_006712781.1|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|ensembl:ENSG00000115415(gene)|ensembl:ENST00000361099(transcript)|ensembl:ENST00000409465(transcript)|ensembl:ENST00000415035(transcript)|ensembl:ENST00000540176(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|interpro:IPR035859|interpro:IPR036535|interpro:IPR036860|interpro:IPR038295|mint:P42224|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|dip:DIP-46140N	ensembl:ENSG00000007171(see-also)	-	-	-	figure legend:Fig. 5, 6a, 6b|agonist:"human interferon gamma (IFNgamma) (P01579)"|comment:"Binding was also detected using cell extracts from cells stimulated with a cytokine mixture containing human interferon gamma (IFNgamma) (P01579), interleukin-1 beta (IL-1beta) (P01584) and tumor necrosis factor alpha (TNF-alpha) (P01375)."|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/01/26	2015/01/26	rogid:a2ZnhdFZkctbjaXLpsYNJ3q5Cv49606	-	intact-crc:0D19BA95A56977DA	false	-	32p radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
intact:EBI-10096065	uniprotkb:P01100	-	intact:EBI-852851|uniprotkb:P18849|uniprotkb:A8K4E2|uniprotkb:B4DQ65|ensembl:ENSP00000306245	psi-mi:nos2_human_gas_dna-probe(display_short)|psi-mi:EBI-10096065(display_long)	psi-mi:fos_human(display_long)|uniprotkb:Cellular oncogene fos(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 7(gene name synonym)|uniprotkb:FOS(gene name)|psi-mi:FOS(display_short)|uniprotkb:G0S7(gene name synonym)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Xu et al. (2003)	pubmed:12788789|imex:IM-23711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10096117|imex:IM-23711-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000007171(see-also)	refseq:NP_005243.1|dip:DIP-1047N|ensembl:ENSG00000170345(gene)|ensembl:ENST00000303562(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009409"(response to cold)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009629"(response to gravity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016020"(membrane)|go:"GO:0030431"(sleep)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051591"(response to cAMP)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029816|rcsb pdb:1A02|rcsb pdb:1FOS|rcsb pdb:1S9K|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2871796|reactome:R-HSA-450341|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-9018519|reactome:R-HSA-9031628|reactome:R-HSA-9634638	-	-	-	figure legend:Fig. 5, 6a, 6b|agonist:"human interferon gamma (IFNgamma) (P01579)"|comment:"Binding was also detected using cell extracts from cells stimulated with a cytokine mixture containing human interferon gamma (IFNgamma) (P01579), interleukin-1 beta (IL-1beta) (P01584) and tumor necrosis factor alpha (TNF-alpha) (P01375)."|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/01/26	2015/01/26	-	rogid:R09jzTKeAyzIQYTQAsps2UWFyFE9606	intact-crc:1A93805CAF840A8E	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
intact:EBI-10096068	uniprotkb:P01100	-	intact:EBI-852851|uniprotkb:P18849|uniprotkb:A8K4E2|uniprotkb:B4DQ65|ensembl:ENSP00000306245	psi-mi:nos2_human_ap1u-site_dna-probe(display_short)|psi-mi:EBI-10096068(display_long)	psi-mi:fos_human(display_long)|uniprotkb:Cellular oncogene fos(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 7(gene name synonym)|uniprotkb:FOS(gene name)|psi-mi:FOS(display_short)|uniprotkb:G0S7(gene name synonym)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Xu et al. (2003)	pubmed:12788789|imex:IM-23711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10096168|imex:IM-23711-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000007171(see-also)	refseq:NP_005243.1|dip:DIP-1047N|ensembl:ENSG00000170345(gene)|ensembl:ENST00000303562(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009409"(response to cold)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009629"(response to gravity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016020"(membrane)|go:"GO:0030431"(sleep)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051591"(response to cAMP)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029816|rcsb pdb:1A02|rcsb pdb:1FOS|rcsb pdb:1S9K|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2871796|reactome:R-HSA-450341|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-9018519|reactome:R-HSA-9031628|reactome:R-HSA-9634638	-	-	-	figure legend:Fig. 7a, 7c|agonist:"cytokine mixture containing human interferon gamma (IFNgamma) (P01579), interleukin-1 beta (IL-1beta) (P01584) and tumor necrosis factor alpha (TNF-alpha) (P01375)"|causality statement:P01100 increases expression at RNA level of ENSG00000007171|causality statement:P01579 and P01584 and P01375 indirectly increases expression at RNA level of ENSG00000007171|causality statement:P01579 and P01584 and P01375 indirectly increases expression at protein level of ENSG00000007171|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/01/26	2015/01/26	-	rogid:R09jzTKeAyzIQYTQAsps2UWFyFE9606	intact-crc:AE7CE7BC64E4E09C	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
intact:EBI-10096068	uniprotkb:P15408	-	intact:EBI-3893419|uniprotkb:B2RD58|uniprotkb:B3KP27|uniprotkb:B4DYV4|uniprotkb:Q6FG46|ensembl:ENSP00000264716	psi-mi:nos2_human_ap1u-site_dna-probe(display_short)|psi-mi:EBI-10096068(display_long)	psi-mi:fosl2_human(display_long)|uniprotkb:FOSL2(gene name)|psi-mi:FOSL2(display_short)|uniprotkb:FRA2(gene name synonym)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Xu et al. (2003)	pubmed:12788789|imex:IM-23711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10096175|imex:IM-23711-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000007171(see-also)	refseq:XP_016859226.1|refseq:NP_005244.1|dip:DIP-48788N|ensembl:ENSG00000075426(gene)|ensembl:ENST00000264716(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003334"(keratinocyte development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008219"(cell death)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029814	-	-	-	figure legend:Fig. 7a|agonist:"cytokine mixture containing human interferon gamma (IFNgamma) (P01579), interleukin-1 beta (IL-1beta) (P01584) and tumor necrosis factor alpha (TNF-alpha) (P01375)"|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/01/26	2015/01/26	-	rogid:+iPQyqskvPskPMg378TYKhOJ86s9606	intact-crc:D1DE3F0C0A498F88	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
intact:EBI-10096068	uniprotkb:P05412	-	intact:EBI-852823|uniprotkb:Q96G93|uniprotkb:Q6FHM7|ensembl:ENSP00000360266|ensembl:ENSP00000503132	psi-mi:nos2_human_ap1u-site_dna-probe(display_short)|psi-mi:EBI-10096068(display_long)	psi-mi:jun_human(display_long)|uniprotkb:JUN(gene name)|psi-mi:JUN(display_short)|uniprotkb:Activator protein 1(gene name synonym)|uniprotkb:Proto-oncogene c-Jun(gene name synonym)|uniprotkb:V-jun avian sarcoma virus 17 oncogene homolog(gene name synonym)|uniprotkb:p39(gene name synonym)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Xu et al. (2003)	pubmed:12788789|imex:IM-23711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10096182|imex:IM-23711-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000007171(see-also)	refseq:NP_002219.1|ensembl:ENSP00000360266|ensembl:ENSP00000503132|dip:DIP-5961N|ensembl:ENSG00000177606(gene)|ensembl:ENST00000371222(transcript)|ensembl:ENST00000678696(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051365"(cellular response to potassium ion starvation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|interpro:IPR002112(Transcription factor Jun)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR005643(Jun-like transcription factor)|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR015558(c-Jun Transcription Factor)|mint:P05412|rcsb pdb:1A02|rcsb pdb:1FOS|rcsb pdb:1JNM|rcsb pdb:1JUN|rcsb pdb:1S9K|rcsb pdb:1T2K|rcsb pdb:5FV8|rcsb pdb:5T01|rcsb pdb:6Y3V|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2871796|reactome:R-HSA-450341|reactome:R-HSA-5617472|reactome:R-HSA-5687128|reactome:R-HSA-6796648|reactome:R-HSA-8862803|reactome:R-HSA-8943724|reactome:R-HSA-9018519|reactome:R-HSA-9673324	-	-	-	figure legend:Fig. 7a|agonist:"cytokine mixture containing human interferon gamma (IFNgamma) (P01579), interleukin-1 beta (IL-1beta) (P01584) and tumor necrosis factor alpha (TNF-alpha) (P01375)"|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/01/26	2015/01/26	-	rogid:zAVYwedHKKdvPPGttBP4XZkbCXA9606	intact-crc:306E72AF52DB8FE4	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P17535	intact:EBI-10096068	intact:EBI-2682803|uniprotkb:Q53EK9|ensembl:ENSP00000252818	-	psi-mi:jund_human(display_long)|uniprotkb:JUND(gene name)|psi-mi:JUND(display_short)	psi-mi:nos2_human_ap1u-site_dna-probe(display_short)|psi-mi:EBI-10096068(display_long)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Xu et al. (2003)	pubmed:12788789|imex:IM-23711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10096189|imex:IM-23711-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_001273897.1|refseq:NP_005345.3|ensembl:ENSG00000130522(gene)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|ensembl:ENST00000252818(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002112(Transcription factor Jun)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR005643(Jun-like transcription factor)|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR029823|mint:P17535|rcsb pdb:3U86|rcsb pdb:5VPA|rcsb pdb:5VPB|rcsb pdb:5VPC|rcsb pdb:5VPD|rcsb pdb:5VPE|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|rcsb pdb:5VPF|reactome:R-HSA-9018519|reactome:R-HSA-9031628|go:"GO:0002076"(osteoblast development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007568"(aging)|dip:DIP-1053N	ensembl:ENSG00000007171(see-also)	-	-	-	figure legend:Fig. 7a|agonist:"cytokine mixture containing human interferon gamma (IFNgamma) (P01579), interleukin-1 beta (IL-1beta) (P01584) and tumor necrosis factor alpha (TNF-alpha) (P01375)"|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/01/26	2015/01/26	rogid:npmTGULvlKr4hC8HfmK19GUopf49606	-	intact-crc:597CD6EB2CCABAD6	false	-	32p radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P01100	intact:EBI-10096068	intact:EBI-852851|uniprotkb:P18849|uniprotkb:A8K4E2|uniprotkb:B4DQ65|ensembl:ENSP00000306245	-	psi-mi:fos_human(display_long)|uniprotkb:Cellular oncogene fos(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 7(gene name synonym)|uniprotkb:FOS(gene name)|psi-mi:FOS(display_short)|uniprotkb:G0S7(gene name synonym)	psi-mi:nos2_human_ap1u-site_dna-probe(display_short)|psi-mi:EBI-10096068(display_long)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Xu et al. (2003)	pubmed:12788789|imex:IM-23711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10096196|imex:IM-23711-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_005243.1|dip:DIP-1047N|ensembl:ENSG00000170345(gene)|ensembl:ENST00000303562(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009409"(response to cold)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009629"(response to gravity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016020"(membrane)|go:"GO:0030431"(sleep)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051591"(response to cAMP)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029816|rcsb pdb:1A02|rcsb pdb:1FOS|rcsb pdb:1S9K|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2871796|reactome:R-HSA-450341|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-9018519|reactome:R-HSA-9031628|reactome:R-HSA-9634638	ensembl:ENSG00000007171(see-also)	-	-	-	figure legend:Fig. 7b|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/01/26	2015/01/26	rogid:R09jzTKeAyzIQYTQAsps2UWFyFE9606	-	intact-crc:6738DD015D14C9B2	false	-	32p radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
intact:EBI-10096068	uniprotkb:P42224	-	intact:EBI-1057697|uniprotkb:Q53S88|uniprotkb:Q53XW4|uniprotkb:B2RCA0|uniprotkb:Q9UDL5|uniprotkb:A8K989|uniprotkb:D2KFR8|uniprotkb:Q68D00|uniprotkb:D3DPI7|ensembl:ENSP00000354394|ensembl:ENSP00000386244|ensembl:ENSP00000388240|ensembl:ENSP00000438703	psi-mi:nos2_human_ap1u-site_dna-probe(display_short)|psi-mi:EBI-10096068(display_long)	psi-mi:stat1_human(display_long)|uniprotkb:STAT1(gene name)|psi-mi:STAT1(display_short)|uniprotkb:Transcription factor ISGF-3 components p91/p84(gene name synonym)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Xu et al. (2003)	pubmed:12788789|imex:IM-23711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10096203|imex:IM-23711-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000007171(see-also)	refseq:NP_009330.1|refseq:NP_644671.1|rcsb pdb:1YVL|rcsb pdb:2KA6|rcsb pdb:3WWT|reactome:R-HSA-1059683|reactome:R-HSA-1169408|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8939902|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9013508|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-909733|rcsb pdb:1BF5|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-912694|refseq:XP_006712781.1|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|ensembl:ENSG00000115415(gene)|ensembl:ENST00000361099(transcript)|ensembl:ENST00000409465(transcript)|ensembl:ENST00000415035(transcript)|ensembl:ENST00000540176(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|interpro:IPR035859|interpro:IPR036535|interpro:IPR036860|interpro:IPR038295|mint:P42224|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|dip:DIP-46140N	-	-	-	figure legend:Fig. 7b|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/01/26	2015/03/04	-	rogid:a2ZnhdFZkctbjaXLpsYNJ3q5Cv49606	intact-crc:4FB693099FDE373E	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P01100	intact:EBI-10096071	intact:EBI-852851|uniprotkb:P18849|uniprotkb:A8K4E2|uniprotkb:B4DQ65|ensembl:ENSP00000306245	-	psi-mi:fos_human(display_long)|uniprotkb:Cellular oncogene fos(gene name synonym)|uniprotkb:G0/G1 switch regulatory protein 7(gene name synonym)|uniprotkb:FOS(gene name)|psi-mi:FOS(display_short)|uniprotkb:G0S7(gene name synonym)	psi-mi:nos2_human_ap1d-site_dna-probe(display_short)|psi-mi:EBI-10096071(display_long)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Xu et al. (2003)	pubmed:12788789|imex:IM-23711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10096213|imex:IM-23711-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_005243.1|dip:DIP-1047N|ensembl:ENSG00000170345(gene)|ensembl:ENST00000303562(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009409"(response to cold)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009629"(response to gravity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016020"(membrane)|go:"GO:0030431"(sleep)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034097"(response to cytokine)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035976"(transcription factor AP-1 complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051591"(response to cAMP)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029816|rcsb pdb:1A02|rcsb pdb:1FOS|rcsb pdb:1S9K|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2871796|reactome:R-HSA-450341|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-9018519|reactome:R-HSA-9031628|reactome:R-HSA-9634638	ensembl:ENSG00000007171(see-also)	-	-	-	figure legend:Fig. 7c|agonist:"cytokine mixture containing human interferon gamma (IFNgamma) (P01579), interleukin-1 beta (IL-1beta) (P01584) and tumor necrosis factor alpha (TNF-alpha) (P01375)"|comment:The interaction of c-Fos with the oligonucleotide probe containing the downstream AP-1 binding site of the human NOS2 gene promoter was much weaker compared to the interaction with the probe containing the upstream AP-1 binding site.|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/01/26	2015/01/26	rogid:R09jzTKeAyzIQYTQAsps2UWFyFE9606	-	intact-crc:C0526E6340EF7A37	false	-	32p radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)