#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O96007 uniprotkb:O96007 intact:EBI-723640|ensembl:ENSP00000380157|uniprotkb:Q6IAI3 intact:EBI-723640|ensembl:ENSP00000380157|uniprotkb:Q6IAI3 psi-mi:moc2b_human(display_long)|uniprotkb:Molybdenum cofactor synthesis protein 2 large subunit(gene name synonym)|uniprotkb:Molybdopterin-synthase large subunit(gene name synonym)|uniprotkb:Molybdenum cofactor synthesis protein 2B(gene name synonym)|uniprotkb:MOCO1-B(gene name synonym)|uniprotkb:MOCS2(gene name)|psi-mi:MOCS2(display_short)|uniprotkb:MCBPE(gene name synonym)|uniprotkb:MOCO1(gene name synonym) psi-mi:moc2b_human(display_long)|uniprotkb:Molybdenum cofactor synthesis protein 2 large subunit(gene name synonym)|uniprotkb:Molybdopterin-synthase large subunit(gene name synonym)|uniprotkb:Molybdenum cofactor synthesis protein 2B(gene name synonym)|uniprotkb:MOCO1-B(gene name synonym)|uniprotkb:MOCS2(gene name)|psi-mi:MOCS2(display_short)|uniprotkb:MCBPE(gene name synonym)|uniprotkb:MOCO1(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Leimkuhler et al. (2003) pubmed:12732628|imex:IM-23716 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-10096156|imex:IM-23716-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004522.1|ensembl:ENSG00000164172(gene)|ensembl:ENST00000396954(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0019008"(molybdopterin synthase complex)|go:"GO:0032324"(molybdopterin cofactor biosynthetic process)|go:"GO:0030366"(molybdopterin synthase activity)|interpro:IPR003448(Molybdopterin biosynthesis MoaE)|interpro:IPR028888|interpro:IPR036563|rcsb pdb:4AP8|rcsb pdb:5MPO|reactome:R-HSA-947581 refseq:NP_004522.1|ensembl:ENSG00000164172(gene)|ensembl:ENST00000396954(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0019008"(molybdopterin synthase complex)|go:"GO:0032324"(molybdopterin cofactor biosynthetic process)|go:"GO:0030366"(molybdopterin synthase activity)|interpro:IPR003448(Molybdopterin biosynthesis MoaE)|interpro:IPR028888|interpro:IPR036563|rcsb pdb:4AP8|rcsb pdb:5MPO|reactome:R-HSA-947581 - - - figure legend:2|comment:Elution position is suggesting homodimer formation in solution|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/01/26 2015/01/26 rogid:/++dYHIJG1TsPULtnLVHgcvhuf49606 rogid:/++dYHIJG1TsPULtnLVHgcvhuf49606 intact-crc:75E57240E29E7DDF|rigid:QA9xdPIRLv/hifsC3wA+wuw9iYU false his tag:n-n his tag:n-n 2 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O96033 uniprotkb:O96007 intact:EBI-9056334|ensembl:ENSP00000355160|ensembl:ENSP00000411022|ensembl:ENSP00000424267|ensembl:ENSP00000426274|ensembl:ENSP00000462870|ensembl:ENSP00000464663 intact:EBI-723640|ensembl:ENSP00000380157|uniprotkb:Q6IAI3 psi-mi:moc2a_human(display_long)|uniprotkb:MOCS2(gene name)|psi-mi:MOCS2(display_short)|uniprotkb:MOCO1(gene name synonym)|uniprotkb:MOCO1-A(gene name synonym)|uniprotkb:Molybdenum cofactor synthesis protein 2 small subunit(gene name synonym)|uniprotkb:Molybdenum cofactor synthesis protein 2A(gene name synonym)|uniprotkb:Molybdopterin-synthase small subunit(gene name synonym)|uniprotkb:Sulfur carrier protein MOCS2A(gene name synonym) psi-mi:moc2b_human(display_long)|uniprotkb:Molybdenum cofactor synthesis protein 2 large subunit(gene name synonym)|uniprotkb:Molybdopterin-synthase large subunit(gene name synonym)|uniprotkb:Molybdenum cofactor synthesis protein 2B(gene name synonym)|uniprotkb:MOCO1-B(gene name synonym)|uniprotkb:MOCS2(gene name)|psi-mi:MOCS2(display_short)|uniprotkb:MCBPE(gene name synonym)|uniprotkb:MOCO1(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Leimkuhler et al. (2003) pubmed:12732628|imex:IM-23716 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-10096146|imex:IM-23716-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_789776.1|ensembl:ENSG00000164172(gene)|ensembl:ENST00000361377(transcript)|ensembl:ENST00000450852(transcript)|ensembl:ENST00000508922(transcript)|ensembl:ENST00000510818(transcript)|ensembl:ENST00000582677(transcript)|ensembl:ENST00000584946(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0005829"(cytosol)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0019008"(molybdopterin synthase complex)|go:"GO:0030366"(molybdopterin synthase activity)|interpro:IPR003749(ThiamineS)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR016155(Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp)|interpro:IPR028887|interpro:IPR044672|rcsb pdb:5MPO|reactome:R-HSA-947581 refseq:NP_004522.1|ensembl:ENSG00000164172(gene)|ensembl:ENST00000396954(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0019008"(molybdopterin synthase complex)|go:"GO:0032324"(molybdopterin cofactor biosynthetic process)|go:"GO:0030366"(molybdopterin synthase activity)|interpro:IPR003448(Molybdopterin biosynthesis MoaE)|interpro:IPR028888|interpro:IPR036563|rcsb pdb:4AP8|rcsb pdb:5MPO|reactome:R-HSA-947581 omim:252160(see-also) - - figure legend:2, 6A|comment:Whereas the the MOCS2A-V7F variant did not form a complex with MOCS2B; the MPT synthase tetramer was readily formed in mixtures of MOCS2B-E168K and equimolar amounts of MOCS2A.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/01/26 2015/01/28 rogid:h0EZ73g+ejtx3nMPdAI4MfolDoQ9606 rogid:/++dYHIJG1TsPULtnLVHgcvhuf49606 intact-crc:05B3FCFD9E3DB4D8|rigid:bgjfHH/KCINm1FDRNQZuNeq18b8 false mutation disrupting interaction:7-7 his tag:n-n 2 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O96033 uniprotkb:O96033 intact:EBI-9056334|ensembl:ENSP00000355160|ensembl:ENSP00000411022|ensembl:ENSP00000424267|ensembl:ENSP00000426274|ensembl:ENSP00000462870|ensembl:ENSP00000464663 intact:EBI-9056334|ensembl:ENSP00000355160|ensembl:ENSP00000411022|ensembl:ENSP00000424267|ensembl:ENSP00000426274|ensembl:ENSP00000462870|ensembl:ENSP00000464663 psi-mi:moc2a_human(display_long)|uniprotkb:MOCS2(gene name)|psi-mi:MOCS2(display_short)|uniprotkb:MOCO1(gene name synonym)|uniprotkb:MOCO1-A(gene name synonym)|uniprotkb:Molybdenum cofactor synthesis protein 2 small subunit(gene name synonym)|uniprotkb:Molybdenum cofactor synthesis protein 2A(gene name synonym)|uniprotkb:Molybdopterin-synthase small subunit(gene name synonym)|uniprotkb:Sulfur carrier protein MOCS2A(gene name synonym) psi-mi:moc2a_human(display_long)|uniprotkb:MOCS2(gene name)|psi-mi:MOCS2(display_short)|uniprotkb:MOCO1(gene name synonym)|uniprotkb:MOCO1-A(gene name synonym)|uniprotkb:Molybdenum cofactor synthesis protein 2 small subunit(gene name synonym)|uniprotkb:Molybdenum cofactor synthesis protein 2A(gene name synonym)|uniprotkb:Molybdopterin-synthase small subunit(gene name synonym)|uniprotkb:Sulfur carrier protein MOCS2A(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Leimkuhler et al. (2003) pubmed:12732628|imex:IM-23716 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-10096152|imex:IM-23716-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_789776.1|ensembl:ENSG00000164172(gene)|ensembl:ENST00000361377(transcript)|ensembl:ENST00000450852(transcript)|ensembl:ENST00000508922(transcript)|ensembl:ENST00000510818(transcript)|ensembl:ENST00000582677(transcript)|ensembl:ENST00000584946(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0005829"(cytosol)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0019008"(molybdopterin synthase complex)|go:"GO:0030366"(molybdopterin synthase activity)|interpro:IPR003749(ThiamineS)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR016155(Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp)|interpro:IPR028887|interpro:IPR044672|rcsb pdb:5MPO|reactome:R-HSA-947581 refseq:NP_789776.1|ensembl:ENSG00000164172(gene)|ensembl:ENST00000361377(transcript)|ensembl:ENST00000450852(transcript)|ensembl:ENST00000508922(transcript)|ensembl:ENST00000510818(transcript)|ensembl:ENST00000582677(transcript)|ensembl:ENST00000584946(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0005829"(cytosol)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0019008"(molybdopterin synthase complex)|go:"GO:0030366"(molybdopterin synthase activity)|interpro:IPR003749(ThiamineS)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR016155(Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp)|interpro:IPR028887|interpro:IPR044672|rcsb pdb:5MPO|reactome:R-HSA-947581 - - - figure legend:2|comment:Elution position is suggesting homodimer formation in solution|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2015/01/26 2015/01/26 rogid:h0EZ73g+ejtx3nMPdAI4MfolDoQ9606 rogid:h0EZ73g+ejtx3nMPdAI4MfolDoQ9606 intact-crc:8BA347EA3F80B997|rigid:OCfkUkgxcpZL2rMNy+UZtNGHpqY false - - 2 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)