#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P43681	uniprotkb:P17787	intact:EBI-7132379|ensembl:ENSP00000359285|uniprotkb:Q4JGR7|intact:MINT-3015931|uniprotkb:Q4VAQ6|intact:MINT-4869480|uniprotkb:Q4VAQ5	intact:EBI-9008612|uniprotkb:Q9UEH9|ensembl:ENSP00000357461	psi-mi:acha4_human(display_long)|uniprotkb:CHRNA4(gene name)|psi-mi:CHRNA4(display_short)|uniprotkb:NACRA4(gene name synonym)	psi-mi:achb2_human(display_long)|uniprotkb:CHRNB2(gene name)|psi-mi:CHRNB2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Nelson et al. (2003)	pubmed:12527804|imex:IM-24011	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10690292|imex:IM-24011-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011526826.1|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042113"(B cell activation)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060080"(inhibitory postsynaptic potential)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:2GVT|rcsb pdb:2LLY|rcsb pdb:5KXI|rcsb pdb:6CNJ|rcsb pdb:6CNK|rcsb pdb:6UR8|rcsb pdb:6USF|reactome:R-HSA-629587|reactome:R-HSA-629594|reactome:R-HSA-629597|ensembl:ENSG00000101204(gene)|ensembl:ENST00000370263(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006811"(ion transport)|go:"GO:0006816"(calcium ion transport)|refseq:NP_001243502.1|refseq:NP_000735.1	refseq:NP_000739.1|ensembl:ENSG00000160716(gene)|ensembl:ENST00000368476(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006811"(ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008306"(associative learning)|go:"GO:0008542"(visual learning)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021562"(vestibulocochlear nerve development)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021771"(lateral geniculate nucleus development)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032225"(regulation of synaptic transmission, dopaminergic)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0035176"(social behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042113"(B cell activation)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0042320"(regulation of circadian sleep/wake cycle, REM sleep)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060084"(synaptic transmission involved in micturition)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1905144"(response to acetylcholine)|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR032932|interpro:IPR036719|interpro:IPR036734|rcsb pdb:2GVT|go:"GO:0009897"(external side of plasma membrane)|rcsb pdb:2K58|rcsb pdb:2K59|rcsb pdb:2KSR|rcsb pdb:2LM2|rcsb pdb:5KXI|rcsb pdb:6CNJ|rcsb pdb:6CNK|rcsb pdb:6UR8|rcsb pdb:6USF|reactome:R-HSA-629587|reactome:R-HSA-629594|reactome:R-HSA-629597	-	comment:mint|comment:homomint|function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane|function:"Defects in CHRNA4 are the cause of autosomal dominant nocturnal frontal lobe epilepsy type 1 (ENFL1) [MIM:600513]; also symbolized ADNFLE. ENFL1 is a disease characterized by clusters of motor seizures during sleep"	-	figure legend:Fig. 8|comment:"The addition of nicotine alters the ratio of the alpha4:beta2 subunits from 1.5:1 to 1:1. This has been interpreted as an increase of (alpha4)3(beta2)2 receptors compared to (alpha4)2(beta2)3 receptors."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-tsa201)|taxid:9606(Homo sapiens subclone of human embryonic kidney 293 cell line that expresses simian virus 40 T antigen)	-	2015/03/13	2015/03/25	rogid:1mIuzGVLlNQeGoCu/fI+lbDZir49606	rogid:Ru/U+9R/PxJ2AZ3QQJ7fsoFhX9c9606	rigid:vl+eGRHAnnCPyK8f1Yx0oReR62A	false	35s radiolabel:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)